Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4S3_LEIBR

TriTrypDb:

LbrM.06.1100 , LBRM2903_060018400

Length:

273

Annotations

LeishMANIAdb annotations

A short well-folded TM protein, possibly with GPI anchor. Structurally weakly similar to PBN1, a GPI anchor biogenesis protein.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 0
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005789	endoplasmic reticulum membrane	4	3
GO:0031090	organelle membrane	3	3

Expansion

Sequence features

A4H4S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4S3

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	3
GO:0006505	GPI anchor metabolic process	6	3
GO:0006506	GPI anchor biosynthetic process	6	3
GO:0006629	lipid metabolic process	3	3
GO:0006643	membrane lipid metabolic process	4	3
GO:0006644	phospholipid metabolic process	4	3
GO:0006650	glycerophospholipid metabolic process	5	3
GO:0006661	phosphatidylinositol biosynthetic process	6	3
GO:0006664	glycolipid metabolic process	5	3
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0008610	lipid biosynthetic process	4	3
GO:0008654	phospholipid biosynthetic process	5	3
GO:0009058	biosynthetic process	2	3
GO:0009247	glycolipid biosynthetic process	5	3
GO:0009987	cellular process	1	3
GO:0019538	protein metabolic process	3	3
GO:0019637	organophosphate metabolic process	3	3
GO:0036211	protein modification process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044255	cellular lipid metabolic process	3	3
GO:0045017	glycerolipid biosynthetic process	4	3
GO:0046467	membrane lipid biosynthetic process	4	3
GO:0046474	glycerophospholipid biosynthetic process	5	3
GO:0046486	glycerolipid metabolic process	4	3
GO:0046488	phosphatidylinositol metabolic process	6	3
GO:0071704	organic substance metabolic process	2	3
GO:0090407	organophosphate biosynthetic process	4	3
GO:1901135	carbohydrate derivative metabolic process	3	3
GO:1901137	carbohydrate derivative biosynthetic process	4	3
GO:1901564	organonitrogen compound metabolic process	3	3
GO:1901576	organic substance biosynthetic process	3	3
GO:1903509	liposaccharide metabolic process	4	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	200	202	PF00675	0.545
CLV_PCSK_KEX2_1	200	202	PF00082	0.545
CLV_PCSK_SKI1_1	48	52	PF00082	0.406
CLV_PCSK_SKI1_1	68	72	PF00082	0.489
DEG_APCC_DBOX_1	199	207	PF00400	0.352
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.398
DOC_CYCLIN_yCln2_LP_2	51	57	PF00134	0.320
DOC_MAPK_gen_1	166	173	PF00069	0.303
DOC_MAPK_gen_1	200	208	PF00069	0.334
DOC_MAPK_HePTP_8	230	242	PF00069	0.250
DOC_MAPK_MEF2A_6	166	173	PF00069	0.262
DOC_MAPK_MEF2A_6	233	242	PF00069	0.349
DOC_PP1_RVXF_1	7	14	PF00149	0.393
DOC_PP2B_LxvP_1	169	172	PF13499	0.255
DOC_PP2B_LxvP_1	240	243	PF13499	0.387
DOC_PP4_FxxP_1	64	67	PF00568	0.315
DOC_USP7_MATH_1	172	176	PF00917	0.370
DOC_USP7_MATH_1	214	218	PF00917	0.495
DOC_USP7_MATH_1	23	27	PF00917	0.439
DOC_WW_Pin1_4	105	110	PF00397	0.302
DOC_WW_Pin1_4	181	186	PF00397	0.327
DOC_WW_Pin1_4	234	239	PF00397	0.399
DOC_WW_Pin1_4	31	36	PF00397	0.371
DOC_WW_Pin1_4	86	91	PF00397	0.429
LIG_14-3-3_CanoR_1	215	221	PF00244	0.425
LIG_14-3-3_CanoR_1	61	65	PF00244	0.357
LIG_Actin_WH2_2	96	113	PF00022	0.370
LIG_BRCT_BRCA1_1	27	31	PF00533	0.349
LIG_BRCT_BRCA1_1	36	40	PF00533	0.248
LIG_Clathr_ClatBox_1	117	121	PF01394	0.261
LIG_eIF4E_1	252	258	PF01652	0.398
LIG_FHA_1	235	241	PF00498	0.324
LIG_FHA_1	5	11	PF00498	0.445
LIG_FHA_2	227	233	PF00498	0.335
LIG_LIR_Apic_2	52	56	PF02991	0.340
LIG_LIR_Apic_2	63	67	PF02991	0.272
LIG_LIR_Gen_1	175	185	PF02991	0.409
LIG_LIR_Gen_1	37	45	PF02991	0.341
LIG_LIR_Nem_3	104	110	PF02991	0.284
LIG_LIR_Nem_3	175	180	PF02991	0.388
LIG_LIR_Nem_3	183	189	PF02991	0.437
LIG_LIR_Nem_3	37	41	PF02991	0.347
LIG_NRBOX	256	262	PF00104	0.398
LIG_SH2_CRK	107	111	PF00017	0.283
LIG_SH2_CRK	254	258	PF00017	0.307
LIG_SH2_CRK	38	42	PF00017	0.354
LIG_SH2_SRC	252	255	PF00017	0.398
LIG_SH2_STAP1	221	225	PF00017	0.381
LIG_SH2_STAT5	107	110	PF00017	0.232
LIG_SH2_STAT5	116	119	PF00017	0.280
LIG_SH2_STAT5	129	132	PF00017	0.422
LIG_SH2_STAT5	153	156	PF00017	0.432
LIG_SH2_STAT5	198	201	PF00017	0.390
LIG_SH2_STAT5	236	239	PF00017	0.225
LIG_SH2_STAT5	252	255	PF00017	0.264
LIG_SH2_STAT5	38	41	PF00017	0.342
LIG_SUMO_SIM_par_1	265	271	PF11976	0.233
LIG_TRAF2_1	229	232	PF00917	0.339
LIG_WW_1	35	38	PF00397	0.353
MOD_CDK_SPxK_1	105	111	PF00069	0.361
MOD_CK1_1	105	111	PF00069	0.408
MOD_CK1_1	217	223	PF00069	0.431
MOD_CK1_1	34	40	PF00069	0.364
MOD_CK1_1	89	95	PF00069	0.345
MOD_CK2_1	125	131	PF00069	0.329
MOD_CK2_1	226	232	PF00069	0.339
MOD_GlcNHglycan	104	107	PF01048	0.469
MOD_GlcNHglycan	147	150	PF01048	0.599
MOD_GlcNHglycan	208	211	PF01048	0.565
MOD_GlcNHglycan	223	226	PF01048	0.566
MOD_GlcNHglycan	25	28	PF01048	0.631
MOD_GlcNHglycan	254	257	PF01048	0.233
MOD_GlcNHglycan	86	89	PF01048	0.600
MOD_GSK3_1	101	108	PF00069	0.336
MOD_GSK3_1	145	152	PF00069	0.353
MOD_GSK3_1	180	187	PF00069	0.323
MOD_GSK3_1	19	26	PF00069	0.501
MOD_GSK3_1	215	222	PF00069	0.403
MOD_GSK3_1	30	37	PF00069	0.365
MOD_NEK2_1	110	115	PF00069	0.330
MOD_NEK2_1	125	130	PF00069	0.394
MOD_NEK2_1	180	185	PF00069	0.369
MOD_NEK2_1	4	9	PF00069	0.596
MOD_NEK2_2	161	166	PF00069	0.258
MOD_PIKK_1	111	117	PF00454	0.351
MOD_PIKK_1	89	95	PF00454	0.365
MOD_PKA_2	214	220	PF00069	0.443
MOD_PKA_2	60	66	PF00069	0.352
MOD_Plk_1	134	140	PF00069	0.285
MOD_Plk_4	149	155	PF00069	0.376
MOD_Plk_4	36	42	PF00069	0.358
MOD_Plk_4	66	72	PF00069	0.289
MOD_ProDKin_1	105	111	PF00069	0.306
MOD_ProDKin_1	181	187	PF00069	0.323
MOD_ProDKin_1	234	240	PF00069	0.396
MOD_ProDKin_1	31	37	PF00069	0.367
MOD_ProDKin_1	86	92	PF00069	0.428
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.396
TRG_ENDOCYTIC_2	107	110	PF00928	0.276
TRG_ENDOCYTIC_2	177	180	PF00928	0.338
TRG_ENDOCYTIC_2	254	257	PF00928	0.283
TRG_ENDOCYTIC_2	38	41	PF00928	0.342
TRG_ER_diArg_1	165	168	PF00400	0.421
TRG_ER_diArg_1	199	201	PF00400	0.360
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4M9	Leptomonas seymouri	58%	98%
A0A1X0NHE9	Trypanosomatidae	36%	98%
A0A422NM30	Trypanosoma rangeli	38%	100%
A4HT04	Leishmania infantum	77%	100%
C9ZTN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	92%
E9AKZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QIW4	Leishmania major	77%	100%