Trichohyalin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Trichohyalin

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4S1_LEIBR

TriTrypDb:

LbrM.06.1070 , LBRM2903_060018000

Length:

613

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0034451	centriolar satellite	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H4S1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4S1

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.578
CLV_NRD_NRD_1	398	400	PF00675	0.428
CLV_NRD_NRD_1	545	547	PF00675	0.495
CLV_NRD_NRD_1	565	567	PF00675	0.671
CLV_NRD_NRD_1	579	581	PF00675	0.466
CLV_NRD_NRD_1	73	75	PF00675	0.614
CLV_NRD_NRD_1	9	11	PF00675	0.584
CLV_NRD_NRD_1	96	98	PF00675	0.467
CLV_PCSK_KEX2_1	13	15	PF00082	0.578
CLV_PCSK_KEX2_1	197	199	PF00082	0.454
CLV_PCSK_KEX2_1	409	411	PF00082	0.430
CLV_PCSK_KEX2_1	579	581	PF00082	0.498
CLV_PCSK_KEX2_1	73	75	PF00082	0.614
CLV_PCSK_KEX2_1	9	11	PF00082	0.584
CLV_PCSK_KEX2_1	96	98	PF00082	0.467
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.513
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.423
CLV_PCSK_PC7_1	5	11	PF00082	0.754
CLV_PCSK_SKI1_1	443	447	PF00082	0.410
CLV_PCSK_SKI1_1	496	500	PF00082	0.401
CLV_PCSK_SKI1_1	509	513	PF00082	0.364
CLV_PCSK_SKI1_1	81	85	PF00082	0.537
CLV_Separin_Metazoa	504	508	PF03568	0.389
DEG_APCC_DBOX_1	442	450	PF00400	0.566
DEG_APCC_DBOX_1	501	509	PF00400	0.376
DEG_APCC_DBOX_1	80	88	PF00400	0.557
DEG_SCF_FBW7_1	595	602	PF00400	0.486
DEG_SPOP_SBC_1	50	54	PF00917	0.759
DEG_SPOP_SBC_1	55	59	PF00917	0.602
DOC_CYCLIN_RxL_1	407	415	PF00134	0.376
DOC_CYCLIN_RxL_1	507	519	PF00134	0.467
DOC_MAPK_FxFP_2	521	524	PF00069	0.626
DOC_MAPK_gen_1	397	407	PF00069	0.406
DOC_MAPK_gen_1	481	488	PF00069	0.586
DOC_MAPK_gen_1	507	517	PF00069	0.437
DOC_MAPK_gen_1	546	552	PF00069	0.688
DOC_MAPK_gen_1	9	17	PF00069	0.481
DOC_MAPK_MEF2A_6	144	151	PF00069	0.595
DOC_MAPK_MEF2A_6	481	488	PF00069	0.446
DOC_MAPK_NFAT4_5	481	489	PF00069	0.446
DOC_PP2B_LxvP_1	393	396	PF13499	0.458
DOC_PP4_FxxP_1	521	524	PF00568	0.669
DOC_USP7_MATH_1	135	139	PF00917	0.452
DOC_USP7_MATH_1	32	36	PF00917	0.542
DOC_USP7_MATH_1	364	368	PF00917	0.516
DOC_USP7_MATH_1	55	59	PF00917	0.724
DOC_USP7_MATH_1	586	590	PF00917	0.551
DOC_USP7_UBL2_3	233	237	PF12436	0.332
DOC_WW_Pin1_4	44	49	PF00397	0.737
DOC_WW_Pin1_4	448	453	PF00397	0.408
DOC_WW_Pin1_4	559	564	PF00397	0.511
DOC_WW_Pin1_4	595	600	PF00397	0.720
DOC_WW_Pin1_4	87	92	PF00397	0.560
LIG_14-3-3_CanoR_1	132	140	PF00244	0.446
LIG_14-3-3_CanoR_1	239	248	PF00244	0.418
LIG_14-3-3_CanoR_1	288	292	PF00244	0.444
LIG_14-3-3_CanoR_1	496	501	PF00244	0.493
LIG_14-3-3_CanoR_1	566	571	PF00244	0.675
LIG_Actin_WH2_2	174	191	PF00022	0.543
LIG_Actin_WH2_2	504	520	PF00022	0.483
LIG_APCC_ABBAyCdc20_2	409	415	PF00400	0.528
LIG_BRCT_BRCA1_1	355	359	PF00533	0.409
LIG_CtBP_PxDLS_1	608	612	PF00389	0.588
LIG_DLG_GKlike_1	566	573	PF00625	0.474
LIG_eIF4E_1	500	506	PF01652	0.294
LIG_EVH1_2	599	603	PF00568	0.483
LIG_FHA_1	124	130	PF00498	0.343
LIG_FHA_1	276	282	PF00498	0.394
LIG_FHA_1	402	408	PF00498	0.445
LIG_FHA_1	547	553	PF00498	0.587
LIG_FHA_2	154	160	PF00498	0.474
LIG_FHA_2	254	260	PF00498	0.379
LIG_FHA_2	346	352	PF00498	0.450
LIG_LIR_Apic_2	519	524	PF02991	0.659
LIG_LIR_Gen_1	157	166	PF02991	0.534
LIG_LIR_Gen_1	390	396	PF02991	0.462
LIG_LIR_Gen_1	451	461	PF02991	0.401
LIG_LIR_LC3C_4	404	407	PF02991	0.546
LIG_LIR_Nem_3	157	163	PF02991	0.463
LIG_LIR_Nem_3	319	324	PF02991	0.371
LIG_LIR_Nem_3	390	395	PF02991	0.464
LIG_LIR_Nem_3	451	456	PF02991	0.402
LIG_LIR_Nem_3	602	606	PF02991	0.699
LIG_PCNA_yPIPBox_3	170	183	PF02747	0.460
LIG_SH2_CRK	182	186	PF00017	0.403
LIG_SH2_PTP2	453	456	PF00017	0.548
LIG_SH2_STAP1	322	326	PF00017	0.359
LIG_SH2_STAP1	491	495	PF00017	0.290
LIG_SH2_STAT3	223	226	PF00017	0.336
LIG_SH2_STAT3	266	269	PF00017	0.389
LIG_SH2_STAT5	266	269	PF00017	0.448
LIG_SH2_STAT5	272	275	PF00017	0.447
LIG_SH2_STAT5	453	456	PF00017	0.548
LIG_SH3_3	12	18	PF00018	0.647
LIG_SH3_3	5	11	PF00018	0.715
LIG_SH3_3	530	536	PF00018	0.535
LIG_SH3_3	557	563	PF00018	0.477
LIG_SH3_3	85	91	PF00018	0.544
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.458
LIG_SUMO_SIM_par_1	331	337	PF11976	0.432
LIG_SUMO_SIM_par_1	403	408	PF11976	0.439
LIG_TRAF2_1	156	159	PF00917	0.506
LIG_TRAF2_1	225	228	PF00917	0.339
LIG_TRAF2_1	341	344	PF00917	0.423
LIG_UBA3_1	505	510	PF00899	0.480
LIG_UBA3_1	83	92	PF00899	0.513
LIG_WW_3	10	14	PF00397	0.623
MOD_CDK_SPK_2	87	92	PF00069	0.608
MOD_CDK_SPxxK_3	559	566	PF00069	0.480
MOD_CK1_1	123	129	PF00069	0.389
MOD_CK1_1	377	383	PF00069	0.518
MOD_CK1_1	42	48	PF00069	0.710
MOD_CK1_1	54	60	PF00069	0.638
MOD_CK1_1	569	575	PF00069	0.640
MOD_CK1_1	602	608	PF00069	0.656
MOD_CK2_1	153	159	PF00069	0.490
MOD_CK2_1	222	228	PF00069	0.456
MOD_CK2_1	253	259	PF00069	0.343
MOD_CK2_1	364	370	PF00069	0.500
MOD_CK2_1	472	478	PF00069	0.404
MOD_Cter_Amidation	544	547	PF01082	0.492
MOD_DYRK1A_RPxSP_1	44	48	PF00069	0.746
MOD_GlcNHglycan	273	276	PF01048	0.552
MOD_GlcNHglycan	336	339	PF01048	0.516
MOD_GlcNHglycan	34	37	PF01048	0.593
MOD_GlcNHglycan	376	379	PF01048	0.532
MOD_GlcNHglycan	53	56	PF01048	0.658
MOD_GlcNHglycan	555	558	PF01048	0.612
MOD_GlcNHglycan	574	577	PF01048	0.725
MOD_GlcNHglycan	59	62	PF01048	0.625
MOD_GSK3_1	149	156	PF00069	0.549
MOD_GSK3_1	184	191	PF00069	0.407
MOD_GSK3_1	271	278	PF00069	0.409
MOD_GSK3_1	293	300	PF00069	0.478
MOD_GSK3_1	30	37	PF00069	0.680
MOD_GSK3_1	40	47	PF00069	0.621
MOD_GSK3_1	401	408	PF00069	0.446
MOD_GSK3_1	49	56	PF00069	0.533
MOD_GSK3_1	568	575	PF00069	0.648
MOD_GSK3_1	595	602	PF00069	0.749
MOD_N-GLC_1	133	138	PF02516	0.555
MOD_NEK2_1	149	154	PF00069	0.607
MOD_NEK2_1	188	193	PF00069	0.528
MOD_NEK2_1	202	207	PF00069	0.556
MOD_NEK2_1	358	363	PF00069	0.434
MOD_NEK2_1	401	406	PF00069	0.414
MOD_NEK2_2	287	292	PF00069	0.454
MOD_PIKK_1	133	139	PF00454	0.409
MOD_PIKK_1	188	194	PF00454	0.572
MOD_PIKK_1	222	228	PF00454	0.549
MOD_PIKK_1	240	246	PF00454	0.541
MOD_PIKK_1	297	303	PF00454	0.530
MOD_PIKK_1	353	359	PF00454	0.461
MOD_PIKK_1	364	370	PF00454	0.443
MOD_PIKK_1	561	567	PF00454	0.671
MOD_PKA_1	546	552	PF00069	0.491
MOD_PKA_1	566	572	PF00069	0.476
MOD_PKA_2	188	194	PF00069	0.410
MOD_PKA_2	287	293	PF00069	0.503
MOD_PKA_2	64	70	PF00069	0.394
MOD_Plk_1	120	126	PF00069	0.471
MOD_Plk_4	261	267	PF00069	0.501
MOD_Plk_4	401	407	PF00069	0.489
MOD_Plk_4	472	478	PF00069	0.413
MOD_Plk_4	64	70	PF00069	0.563
MOD_ProDKin_1	44	50	PF00069	0.736
MOD_ProDKin_1	448	454	PF00069	0.402
MOD_ProDKin_1	559	565	PF00069	0.513
MOD_ProDKin_1	595	601	PF00069	0.719
MOD_ProDKin_1	87	93	PF00069	0.557
MOD_SUMO_for_1	108	111	PF00179	0.441
MOD_SUMO_for_1	317	320	PF00179	0.361
MOD_SUMO_rev_2	212	218	PF00179	0.545
MOD_SUMO_rev_2	230	238	PF00179	0.598
MOD_SUMO_rev_2	308	314	PF00179	0.383
MOD_SUMO_rev_2	319	326	PF00179	0.370
MOD_SUMO_rev_2	337	346	PF00179	0.394
MOD_SUMO_rev_2	475	484	PF00179	0.527
TRG_DiLeu_BaEn_1	110	115	PF01217	0.464
TRG_DiLeu_BaEn_2	354	360	PF01217	0.398
TRG_DiLeu_BaEn_4	110	116	PF01217	0.316
TRG_ENDOCYTIC_2	160	163	PF00928	0.493
TRG_ENDOCYTIC_2	182	185	PF00928	0.425
TRG_ENDOCYTIC_2	321	324	PF00928	0.383
TRG_ENDOCYTIC_2	453	456	PF00928	0.548
TRG_ER_diArg_1	12	14	PF00400	0.566
TRG_ER_diArg_1	396	399	PF00400	0.462
TRG_ER_diArg_1	579	581	PF00400	0.473
TRG_ER_diArg_1	72	74	PF00400	0.626
TRG_ER_diArg_1	8	10	PF00400	0.598
TRG_ER_diArg_1	95	97	PF00400	0.467
TRG_NES_CRM1_1	172	184	PF08389	0.519
TRG_NES_CRM1_1	344	355	PF08389	0.391
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	331	336	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	410	415	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	81	86	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3D2	Leptomonas seymouri	59%	100%
A0A0S4KJ48	Bodo saltans	38%	100%
A0A1X0NFW7	Trypanosomatidae	51%	100%
A0A1X0NGS8	Trypanosomatidae	52%	100%
A0A3R7KEX6	Trypanosoma rangeli	50%	100%
A0A3S7WPN7	Leishmania donovani	80%	100%
A4HT01	Leishmania infantum	80%	100%
C9ZTN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AKY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QIW7	Leishmania major	80%	97%
V5BXW3	Trypanosoma cruzi	51%	100%