Deoxyribose-phosphate aldolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

deoxyribose-phosphate aldolase, putative

Species:

Leishmania braziliensis

UniProt:

A4H4S0_LEIBR

TriTrypDb:

LbrM.06.1050 , LBRM2903_060017600

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

A4H4S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4S0

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	1
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006753	nucleoside phosphate metabolic process	4	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009117	nucleotide metabolic process	5	7

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004139	deoxyribose-phosphate aldolase activity	5	7
GO:0016829	lyase activity	2	7
GO:0016830	carbon-carbon lyase activity	3	7
GO:0016832	aldehyde-lyase activity	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.385
CLV_C14_Caspase3-7	62	66	PF00656	0.537
CLV_PCSK_KEX2_1	268	270	PF00082	0.301
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.301
CLV_PCSK_SKI1_1	190	194	PF00082	0.227
DEG_SPOP_SBC_1	218	222	PF00917	0.447
DOC_PP1_RVXF_1	29	35	PF00149	0.338
DOC_PP1_RVXF_1	7	13	PF00149	0.416
DOC_PP2B_LxvP_1	39	42	PF13499	0.364
DOC_PP4_FxxP_1	12	15	PF00568	0.345

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAW0	Leptomonas seymouri	68%	100%
A0A1X0NLL0	Trypanosomatidae	50%	100%
A0A3S5H5U0	Leishmania donovani	80%	100%
A0A422N1B0	Trypanosoma rangeli	57%	100%
A0AKA1	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	52%	100%
A0KCV5	Burkholderia cenocepacia (strain HI2424)	53%	100%
A0KPE4	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	34%	100%
A0KU07	Shewanella sp. (strain ANA-3)	29%	100%
A0PVY3	Mycobacterium ulcerans (strain Agy99)	42%	100%
A0PYX5	Clostridium novyi (strain NT)	52%	100%

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