2OG-FeII_Oxy_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4H4R9_LEIBR

TriTrypDb:

LbrM.06.1040 , LBRM2903_060017400

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4R9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4R9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0016491	oxidoreductase activity	2	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0051213	dioxygenase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	8	12	PF00656	0.654
CLV_NRD_NRD_1	234	236	PF00675	0.444
CLV_NRD_NRD_1	306	308	PF00675	0.694
CLV_PCSK_KEX2_1	233	235	PF00082	0.439
CLV_PCSK_KEX2_1	306	308	PF00082	0.705
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.741
CLV_PCSK_SKI1_1	178	182	PF00082	0.404
CLV_PCSK_SKI1_1	303	307	PF00082	0.746
DOC_CKS1_1	218	223	PF01111	0.476
DOC_CYCLIN_RxL_1	175	185	PF00134	0.393
DOC_MAPK_FxFP_2	191	194	PF00069	0.395
DOC_MAPK_MEF2A_6	165	174	PF00069	0.376
DOC_PP1_RVXF_1	176	183	PF00149	0.374
DOC_PP1_SILK_1	57	62	PF00149	0.501
DOC_PP4_FxxP_1	110	113	PF00568	0.465
DOC_PP4_FxxP_1	191	194	PF00568	0.395
DOC_SPAK_OSR1_1	225	229	PF12202	0.387
DOC_USP7_MATH_1	13	17	PF00917	0.466
DOC_USP7_MATH_1	176	180	PF00917	0.411
DOC_USP7_MATH_1	287	291	PF00917	0.707
DOC_WW_Pin1_4	217	222	PF00397	0.477
LIG_14-3-3_CanoR_1	233	238	PF00244	0.455
LIG_BRCT_BRCA1_1	116	120	PF00533	0.390
LIG_BRCT_BRCA1_1	178	182	PF00533	0.404
LIG_deltaCOP1_diTrp_1	103	110	PF00928	0.478
LIG_FHA_1	167	173	PF00498	0.365
LIG_FHA_1	175	181	PF00498	0.374
LIG_FHA_1	202	208	PF00498	0.378
LIG_FHA_1	210	216	PF00498	0.405
LIG_FHA_1	297	303	PF00498	0.528
LIG_FHA_2	117	123	PF00498	0.463
LIG_FHA_2	234	240	PF00498	0.498
LIG_FHA_2	257	263	PF00498	0.524
LIG_FHA_2	287	293	PF00498	0.736
LIG_FHA_2	6	12	PF00498	0.664
LIG_LIR_Apic_2	190	194	PF02991	0.525
LIG_LIR_Gen_1	117	128	PF02991	0.371
LIG_LIR_Gen_1	223	230	PF02991	0.399
LIG_LIR_Gen_1	28	37	PF02991	0.335
LIG_LIR_Gen_1	54	64	PF02991	0.466
LIG_LIR_Nem_3	117	123	PF02991	0.378
LIG_LIR_Nem_3	129	133	PF02991	0.353
LIG_LIR_Nem_3	223	229	PF02991	0.401
LIG_LIR_Nem_3	28	32	PF02991	0.537
LIG_LIR_Nem_3	54	59	PF02991	0.406
LIG_SH2_CRK	80	84	PF00017	0.428
LIG_SH2_STAP1	136	140	PF00017	0.386
LIG_SH2_STAP1	298	302	PF00017	0.509
LIG_SH2_STAT5	130	133	PF00017	0.322
LIG_SH2_STAT5	298	301	PF00017	0.509
LIG_SH2_STAT5	66	69	PF00017	0.364
LIG_TRAF2_1	290	293	PF00917	0.523
MOD_CK1_1	4	10	PF00069	0.476
MOD_CK2_1	184	190	PF00069	0.451
MOD_CK2_1	233	239	PF00069	0.470
MOD_CK2_1	286	292	PF00069	0.636
MOD_CK2_1	79	85	PF00069	0.504
MOD_Cter_Amidation	231	234	PF01082	0.412
MOD_GlcNHglycan	246	249	PF01048	0.676
MOD_GlcNHglycan	289	292	PF01048	0.745
MOD_GlcNHglycan	97	100	PF01048	0.653
MOD_GSK3_1	1	8	PF00069	0.598
MOD_GSK3_1	166	173	PF00069	0.385
MOD_GSK3_1	220	227	PF00069	0.319
MOD_GSK3_1	287	294	PF00069	0.731
MOD_GSK3_1	95	102	PF00069	0.411
MOD_NEK2_1	1	6	PF00069	0.717
MOD_NEK2_1	174	179	PF00069	0.386
MOD_NEK2_1	79	84	PF00069	0.528
MOD_NEK2_1	87	92	PF00069	0.524
MOD_NEK2_1	95	100	PF00069	0.550
MOD_PIKK_1	1	7	PF00454	0.667
MOD_PIKK_1	114	120	PF00454	0.540
MOD_PIKK_1	144	150	PF00454	0.540
MOD_PIKK_1	184	190	PF00454	0.542
MOD_PKA_1	233	239	PF00069	0.458
MOD_PKA_2	224	230	PF00069	0.396
MOD_PKA_2	233	239	PF00069	0.464
MOD_Plk_1	166	172	PF00069	0.372
MOD_Plk_1	54	60	PF00069	0.530
MOD_Plk_4	14	20	PF00069	0.452
MOD_Plk_4	55	61	PF00069	0.469
MOD_ProDKin_1	217	223	PF00069	0.477
MOD_SUMO_for_1	83	86	PF00179	0.414
MOD_SUMO_rev_2	72	77	PF00179	0.392
TRG_ENDOCYTIC_2	130	133	PF00928	0.364
TRG_ENDOCYTIC_2	80	83	PF00928	0.406
TRG_ER_diArg_1	19	22	PF00400	0.556
TRG_ER_diArg_1	233	235	PF00400	0.454
TRG_NES_CRM1_1	122	134	PF08389	0.383
TRG_NLS_MonoCore_2	305	310	PF00514	0.592
TRG_NLS_MonoExtC_3	306	311	PF00514	0.623
TRG_NLS_MonoExtN_4	303	310	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKD0	Leptomonas seymouri	74%	85%
A0A0S4JRX9	Bodo saltans	48%	100%
A0A1X0NKP4	Trypanosomatidae	60%	100%
A0A3R7KF49	Trypanosoma rangeli	59%	92%
A0A3S7WPM5	Leishmania donovani	83%	99%
A4HSZ8	Leishmania infantum	83%	91%
C9ZTN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9AKY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	94%
Q4QIX0	Leishmania major	82%	100%
V5BXY4	Trypanosoma cruzi	59%	99%