Protein disulfide isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein disulfide isomerase

Species:

Leishmania braziliensis

UniProt:

A4H4R8_LEIBR

TriTrypDb:

LbrM.06.1030 , LBRM2903_060017300

Length:

133

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 2
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H4R8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4R8

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003756	protein disulfide isomerase activity	3	10
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	12
GO:0016860	intramolecular oxidoreductase activity	3	10
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.163
CLV_NRD_NRD_1	4	6	PF00675	0.536
CLV_PCSK_KEX2_1	106	108	PF00082	0.417
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.373
CLV_PCSK_SKI1_1	35	39	PF00082	0.267
CLV_PCSK_SKI1_1	42	46	PF00082	0.238
CLV_PCSK_SKI1_1	5	9	PF00082	0.438
DOC_MAPK_gen_1	5	12	PF00069	0.522
DOC_MAPK_JIP1_4	60	66	PF00069	0.296
DOC_MAPK_MEF2A_6	5	14	PF00069	0.494
DOC_PP4_FxxP_1	48	51	PF00568	0.304
DOC_USP7_MATH_1	123	127	PF00917	0.354
DOC_USP7_UBL2_3	102	106	PF12436	0.361
DOC_USP7_UBL2_3	38	42	PF12436	0.320
LIG_APCC_ABBA_1	17	22	PF00400	0.338
LIG_BIR_II_1	1	5	PF00653	0.585
LIG_LIR_Nem_3	122	127	PF02991	0.431
LIG_LIR_Nem_3	84	89	PF02991	0.329
LIG_LIR_Nem_3	96	101	PF02991	0.329
LIG_Pex14_2	16	20	PF04695	0.308
LIG_Pex14_2	4	8	PF04695	0.353
LIG_Pex14_2	48	52	PF04695	0.304
LIG_SH2_CRK	115	119	PF00017	0.241
LIG_SH2_CRK	86	90	PF00017	0.320
LIG_SH2_STAT5	127	130	PF00017	0.320
LIG_SH3_3	34	40	PF00018	0.269
LIG_Vh1_VBS_1	3	21	PF01044	0.346
MOD_GlcNHglycan	108	112	PF01048	0.358
MOD_GlcNHglycan	115	118	PF01048	0.312
MOD_GlcNHglycan	120	124	PF01048	0.280
MOD_GlcNHglycan	82	86	PF01048	0.287
MOD_GlcNHglycan	95	98	PF01048	0.115
MOD_GSK3_1	119	126	PF00069	0.255
MOD_GSK3_1	93	100	PF00069	0.299
MOD_NEK2_1	93	98	PF00069	0.163
MOD_Plk_1	119	125	PF00069	0.372
MOD_Plk_1	81	87	PF00069	0.342
TRG_ENDOCYTIC_2	86	89	PF00928	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I216	Leptomonas seymouri	32%	94%
A0A0N1I5T9	Leptomonas seymouri	53%	100%
A0A0N1IJS7	Leptomonas seymouri	25%	81%
A0A0S4JA26	Bodo saltans	46%	80%
A0A1X0NGQ4	Trypanosomatidae	33%	90%
A0A1X0NT33	Trypanosomatidae	30%	80%
A0A3R7NHA8	Trypanosoma rangeli	48%	73%
A0A422NM49	Trypanosoma rangeli	33%	89%
A4H4T0	Leishmania braziliensis	28%	90%
A4HES2	Leishmania braziliensis	25%	80%
A4HSZ7	Leishmania infantum	77%	100%
A4HT10	Leishmania infantum	28%	90%
C9ZTP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	88%
C9ZTP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	99%
E9AKY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E9AKZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	90%
O96952	Geodia cydonium	29%	100%
Q10N04	Oryza sativa subsp. japonica	27%	90%
Q1RQI9	Malassezia sympodialis	31%	100%
Q4QIV7	Leishmania major	29%	70%
Q4QIX1	Leishmania major	78%	100%
Q7M1B9	Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)	30%	100%
Q8GYD1	Arabidopsis thaliana	23%	91%
Q8I7Z7	Leishmania donovani	78%	100%