Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4R7_LEIBR

TriTrypDb:

LbrM.06.1020 , LBRM2903_060017200

Length:

717

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H4R7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4R7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	521	525	PF00656	0.402
CLV_NRD_NRD_1	106	108	PF00675	0.564
CLV_NRD_NRD_1	126	128	PF00675	0.322
CLV_NRD_NRD_1	129	131	PF00675	0.532
CLV_NRD_NRD_1	134	136	PF00675	0.525
CLV_NRD_NRD_1	215	217	PF00675	0.518
CLV_NRD_NRD_1	25	27	PF00675	0.543
CLV_NRD_NRD_1	282	284	PF00675	0.552
CLV_NRD_NRD_1	311	313	PF00675	0.664
CLV_NRD_NRD_1	316	318	PF00675	0.731
CLV_NRD_NRD_1	384	386	PF00675	0.623
CLV_NRD_NRD_1	644	646	PF00675	0.642
CLV_NRD_NRD_1	8	10	PF00675	0.584
CLV_PCSK_KEX2_1	104	106	PF00082	0.565
CLV_PCSK_KEX2_1	134	136	PF00082	0.445
CLV_PCSK_KEX2_1	214	216	PF00082	0.519
CLV_PCSK_KEX2_1	25	27	PF00082	0.551
CLV_PCSK_KEX2_1	282	284	PF00082	0.552
CLV_PCSK_KEX2_1	311	313	PF00082	0.671
CLV_PCSK_KEX2_1	316	318	PF00082	0.740
CLV_PCSK_KEX2_1	384	386	PF00082	0.383
CLV_PCSK_KEX2_1	420	422	PF00082	0.396
CLV_PCSK_KEX2_1	644	646	PF00082	0.642
CLV_PCSK_KEX2_1	7	9	PF00082	0.591
CLV_PCSK_KEX2_1	711	713	PF00082	0.620
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.443
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.519
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.396
CLV_PCSK_PC1ET2_1	711	713	PF00082	0.531
CLV_PCSK_PC7_1	130	136	PF00082	0.420
CLV_PCSK_PC7_1	312	318	PF00082	0.588
CLV_PCSK_SKI1_1	430	434	PF00082	0.505
CLV_PCSK_SKI1_1	569	573	PF00082	0.670
CLV_PCSK_SKI1_1	711	715	PF00082	0.628
CLV_PCSK_SKI1_1	8	12	PF00082	0.425
DEG_APCC_DBOX_1	45	53	PF00400	0.672
DEG_APCC_DBOX_1	6	14	PF00400	0.678
DEG_SCF_FBW7_2	360	366	PF00400	0.763
DEG_SPOP_SBC_1	468	472	PF00917	0.525
DEG_SPOP_SBC_1	505	509	PF00917	0.599
DOC_CKS1_1	360	365	PF01111	0.804
DOC_MAPK_gen_1	409	418	PF00069	0.395
DOC_MAPK_gen_1	420	426	PF00069	0.392
DOC_MAPK_gen_1	428	437	PF00069	0.388
DOC_PIKK_1	274	281	PF02985	0.406
DOC_USP7_MATH_1	140	144	PF00917	0.598
DOC_USP7_MATH_1	145	149	PF00917	0.523
DOC_USP7_MATH_1	247	251	PF00917	0.544
DOC_USP7_MATH_1	327	331	PF00917	0.561
DOC_USP7_MATH_1	455	459	PF00917	0.582
DOC_USP7_MATH_1	468	472	PF00917	0.578
DOC_USP7_MATH_1	490	494	PF00917	0.631
DOC_USP7_MATH_1	496	500	PF00917	0.722
DOC_USP7_MATH_1	505	509	PF00917	0.539
DOC_USP7_MATH_1	627	631	PF00917	0.569
DOC_USP7_MATH_1	683	687	PF00917	0.632
DOC_USP7_MATH_1	80	84	PF00917	0.577
DOC_WW_Pin1_4	359	364	PF00397	0.810
DOC_WW_Pin1_4	451	456	PF00397	0.563
LIG_14-3-3_CanoR_1	25	30	PF00244	0.485
LIG_14-3-3_CanoR_1	311	318	PF00244	0.783
LIG_14-3-3_CanoR_1	421	427	PF00244	0.392
LIG_14-3-3_CanoR_1	444	450	PF00244	0.738
LIG_14-3-3_CanoR_1	592	600	PF00244	0.637
LIG_14-3-3_CanoR_1	668	676	PF00244	0.692
LIG_14-3-3_CanoR_1	697	704	PF00244	0.635
LIG_14-3-3_CanoR_1	7	17	PF00244	0.419
LIG_Actin_WH2_2	3	20	PF00022	0.424
LIG_APCC_ABBA_1	376	381	PF00400	0.643
LIG_APCC_ABBA_1	608	613	PF00400	0.526
LIG_APCC_ABBAyCdc20_2	409	415	PF00400	0.657
LIG_BRCT_BRCA1_1	333	337	PF00533	0.548
LIG_BRCT_BRCA1_1	516	520	PF00533	0.424
LIG_BRCT_BRCA1_1	686	690	PF00533	0.564
LIG_FHA_1	137	143	PF00498	0.389
LIG_FHA_1	190	196	PF00498	0.483
LIG_FHA_1	313	319	PF00498	0.724
LIG_FHA_1	470	476	PF00498	0.756
LIG_FHA_2	186	192	PF00498	0.558
LIG_FHA_2	196	202	PF00498	0.540
LIG_FHA_2	286	292	PF00498	0.546
LIG_FHA_2	402	408	PF00498	0.397
LIG_FHA_2	481	487	PF00498	0.598
LIG_FHA_2	505	511	PF00498	0.528
LIG_FHA_2	570	576	PF00498	0.570
LIG_FHA_2	630	636	PF00498	0.534
LIG_FHA_2	686	692	PF00498	0.718
LIG_FHA_2	9	15	PF00498	0.416
LIG_LIR_Gen_1	250	260	PF02991	0.555
LIG_LIR_Gen_1	517	528	PF02991	0.402
LIG_LIR_Gen_1	687	698	PF02991	0.555
LIG_LIR_Nem_3	152	157	PF02991	0.629
LIG_LIR_Nem_3	160	165	PF02991	0.495
LIG_LIR_Nem_3	250	256	PF02991	0.552
LIG_LIR_Nem_3	380	386	PF02991	0.487
LIG_LIR_Nem_3	407	413	PF02991	0.644
LIG_LIR_Nem_3	517	523	PF02991	0.414
LIG_LIR_Nem_3	556	561	PF02991	0.413
LIG_LIR_Nem_3	68	72	PF02991	0.496
LIG_LIR_Nem_3	687	693	PF02991	0.565
LIG_Rb_LxCxE_1	223	241	PF01857	0.613
LIG_SH2_CRK	154	158	PF00017	0.628
LIG_SH2_CRK	383	387	PF00017	0.622
LIG_SH2_GRB2like	95	98	PF00017	0.583
LIG_SH2_NCK_1	253	257	PF00017	0.549
LIG_SH2_SRC	596	599	PF00017	0.647
LIG_SH2_SRC	95	98	PF00017	0.583
LIG_SH2_STAP1	253	257	PF00017	0.549
LIG_SH2_STAT3	600	603	PF00017	0.409
LIG_SH2_STAT5	220	223	PF00017	0.423
LIG_SH2_STAT5	449	452	PF00017	0.553
LIG_SH2_STAT5	596	599	PF00017	0.647
LIG_SH3_3	462	468	PF00018	0.761
LIG_SH3_3	616	622	PF00018	0.534
LIG_SUMO_SIM_par_1	191	196	PF11976	0.484
LIG_SUMO_SIM_par_1	422	427	PF11976	0.605
MOD_CK1_1	196	202	PF00069	0.435
MOD_CK1_1	330	336	PF00069	0.754
MOD_CK1_1	365	371	PF00069	0.687
MOD_CK1_1	448	454	PF00069	0.547
MOD_CK1_1	457	463	PF00069	0.551
MOD_CK1_1	499	505	PF00069	0.725
MOD_CK1_1	612	618	PF00069	0.642
MOD_CK1_1	686	692	PF00069	0.645
MOD_CK2_1	285	291	PF00069	0.541
MOD_CK2_1	33	39	PF00069	0.404
MOD_CK2_1	457	463	PF00069	0.633
MOD_CK2_1	504	510	PF00069	0.546
MOD_CK2_1	56	62	PF00069	0.599
MOD_CK2_1	561	567	PF00069	0.538
MOD_CK2_1	569	575	PF00069	0.571
MOD_CK2_1	629	635	PF00069	0.539
MOD_CK2_1	685	691	PF00069	0.668
MOD_CK2_1	697	703	PF00069	0.683
MOD_CK2_1	8	14	PF00069	0.420
MOD_GlcNHglycan	141	145	PF01048	0.539
MOD_GlcNHglycan	147	150	PF01048	0.521
MOD_GlcNHglycan	327	330	PF01048	0.726
MOD_GlcNHglycan	334	337	PF01048	0.746
MOD_GlcNHglycan	386	389	PF01048	0.595
MOD_GlcNHglycan	437	440	PF01048	0.559
MOD_GlcNHglycan	457	460	PF01048	0.584
MOD_GlcNHglycan	472	475	PF01048	0.744
MOD_GlcNHglycan	497	501	PF01048	0.706
MOD_GlcNHglycan	539	545	PF01048	0.579
MOD_GlcNHglycan	629	632	PF01048	0.542
MOD_GlcNHglycan	75	78	PF01048	0.546
MOD_GSK3_1	136	143	PF00069	0.388
MOD_GSK3_1	185	192	PF00069	0.480
MOD_GSK3_1	195	202	PF00069	0.387
MOD_GSK3_1	327	334	PF00069	0.752
MOD_GSK3_1	445	452	PF00069	0.648
MOD_GSK3_1	455	462	PF00069	0.613
MOD_GSK3_1	486	493	PF00069	0.733
MOD_GSK3_1	496	503	PF00069	0.710
MOD_GSK3_1	634	641	PF00069	0.561
MOD_GSK3_1	666	673	PF00069	0.717
MOD_GSK3_1	68	75	PF00069	0.666
MOD_GSK3_1	681	688	PF00069	0.611
MOD_LATS_1	310	316	PF00433	0.613
MOD_N-GLC_1	136	141	PF02516	0.391
MOD_N-GLC_1	199	204	PF02516	0.370
MOD_N-GLC_1	330	335	PF02516	0.703
MOD_NEK2_1	116	121	PF00069	0.389
MOD_NEK2_1	193	198	PF00069	0.638
MOD_NEK2_1	332	337	PF00069	0.550
MOD_NEK2_1	401	406	PF00069	0.395
MOD_NEK2_1	433	438	PF00069	0.485
MOD_NEK2_1	469	474	PF00069	0.599
MOD_NEK2_1	87	92	PF00069	0.647
MOD_NEK2_2	89	94	PF00069	0.726
MOD_PIKK_1	1	7	PF00454	0.613
MOD_PIKK_1	116	122	PF00454	0.392
MOD_PIKK_1	193	199	PF00454	0.636
MOD_PIKK_1	267	273	PF00454	0.574
MOD_PIKK_1	8	14	PF00454	0.571
MOD_PK_1	25	31	PF00069	0.399
MOD_PKA_1	25	31	PF00069	0.461
MOD_PKA_1	311	317	PF00069	0.708
MOD_PKA_1	384	390	PF00069	0.628
MOD_PKA_1	8	14	PF00069	0.420
MOD_PKA_2	25	31	PF00069	0.648
MOD_PKA_2	310	316	PF00069	0.688
MOD_PKA_2	322	328	PF00069	0.674
MOD_PKA_2	384	390	PF00069	0.375
MOD_PKA_2	443	449	PF00069	0.538
MOD_PKA_2	514	520	PF00069	0.432
MOD_PKA_2	591	597	PF00069	0.596
MOD_PKA_2	667	673	PF00069	0.797
MOD_PKA_2	681	687	PF00069	0.578
MOD_PKA_2	73	79	PF00069	0.612
MOD_PKA_2	8	14	PF00069	0.471
MOD_Plk_1	199	205	PF00069	0.373
MOD_Plk_1	258	264	PF00069	0.565
MOD_Plk_1	365	371	PF00069	0.668
MOD_Plk_1	670	676	PF00069	0.630
MOD_Plk_2-3	185	191	PF00069	0.381
MOD_Plk_2-3	56	62	PF00069	0.701
MOD_Plk_2-3	68	74	PF00069	0.561
MOD_Plk_4	189	195	PF00069	0.485
MOD_Plk_4	445	451	PF00069	0.545
MOD_Plk_4	578	584	PF00069	0.639
MOD_Plk_4	638	644	PF00069	0.523
MOD_Plk_4	657	663	PF00069	0.691
MOD_Plk_4	671	677	PF00069	0.553
MOD_ProDKin_1	359	365	PF00069	0.806
MOD_ProDKin_1	451	457	PF00069	0.564
MOD_SUMO_for_1	98	101	PF00179	0.664
MOD_SUMO_rev_2	160	170	PF00179	0.601
MOD_SUMO_rev_2	703	713	PF00179	0.591
MOD_SUMO_rev_2	83	88	PF00179	0.669
TRG_DiLeu_BaEn_1	189	194	PF01217	0.537
TRG_DiLeu_BaEn_1	217	222	PF01217	0.505
TRG_DiLeu_BaEn_1	223	228	PF01217	0.500
TRG_DiLeu_BaEn_1	429	434	PF01217	0.625
TRG_DiLeu_BaEn_3	279	285	PF01217	0.401
TRG_DiLeu_BaEn_4	55	61	PF01217	0.702
TRG_ENDOCYTIC_2	154	157	PF00928	0.629
TRG_ENDOCYTIC_2	253	256	PF00928	0.397
TRG_ENDOCYTIC_2	383	386	PF00928	0.632
TRG_ENDOCYTIC_2	410	413	PF00928	0.555
TRG_ER_diArg_1	105	107	PF00400	0.655
TRG_ER_diArg_1	133	135	PF00400	0.516
TRG_ER_diArg_1	15	18	PF00400	0.560
TRG_ER_diArg_1	25	27	PF00400	0.551
TRG_ER_diArg_1	281	283	PF00400	0.557
TRG_ER_diArg_1	316	318	PF00400	0.717
TRG_ER_diArg_1	383	385	PF00400	0.384
TRG_ER_diArg_1	6	9	PF00400	0.591
TRG_ER_diArg_1	643	645	PF00400	0.638
TRG_ER_diArg_1	648	651	PF00400	0.600
TRG_NLS_MonoExtC_3	126	131	PF00514	0.650
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	155	160	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	697	701	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	712	716	PF00026	0.713
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4C6	Leptomonas seymouri	45%	95%
A0A3S5H5T8	Leishmania donovani	65%	99%
A4HSZ6	Leishmania infantum	65%	99%
E9AKY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	99%
Q4QIX2	Leishmania major	63%	100%