Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative

Species:

Leishmania braziliensis

UniProt:

A4H4R6_LEIBR

TriTrypDb:

LbrM.06.1010 , LBRM2903_060017100

Length:

883

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	2
GO:0005875	microtubule associated complex	2	3
GO:0032991	protein-containing complex	1	3
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	3
GO:0035869	ciliary transition zone	2	1

Expansion

Sequence features

A4H4R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4R6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	16
GO:0007018	microtubule-based movement	3	16
GO:0009987	cellular process	1	16
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007051	spindle organization	3	1
GO:0007052	mitotic spindle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0051231	spindle elongation	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003774	cytoskeletal motor activity	1	16
GO:0003777	microtubule motor activity	2	16
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	16
GO:0005515	protein binding	2	16
GO:0005524	ATP binding	5	16
GO:0008017	microtubule binding	5	16
GO:0008092	cytoskeletal protein binding	3	16
GO:0015631	tubulin binding	4	16
GO:0016787	hydrolase activity	2	13
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0140657	ATP-dependent activity	1	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:0016462	pyrophosphatase activity	5	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.202
CLV_C14_Caspase3-7	35	39	PF00656	0.202
CLV_C14_Caspase3-7	553	557	PF00656	0.535
CLV_C14_Caspase3-7	559	563	PF00656	0.470
CLV_C14_Caspase3-7	574	578	PF00656	0.463
CLV_C14_Caspase3-7	625	629	PF00656	0.594
CLV_C14_Caspase3-7	763	767	PF00656	0.585
CLV_NRD_NRD_1	156	158	PF00675	0.248
CLV_NRD_NRD_1	231	233	PF00675	0.338
CLV_NRD_NRD_1	390	392	PF00675	0.530
CLV_NRD_NRD_1	398	400	PF00675	0.538
CLV_NRD_NRD_1	481	483	PF00675	0.520
CLV_NRD_NRD_1	507	509	PF00675	0.520
CLV_NRD_NRD_1	654	656	PF00675	0.547
CLV_NRD_NRD_1	738	740	PF00675	0.480
CLV_NRD_NRD_1	770	772	PF00675	0.588
CLV_NRD_NRD_1	816	818	PF00675	0.600
CLV_PCSK_FUR_1	388	392	PF00082	0.505
CLV_PCSK_FUR_1	814	818	PF00082	0.512
CLV_PCSK_KEX2_1	156	158	PF00082	0.216
CLV_PCSK_KEX2_1	231	233	PF00082	0.347
CLV_PCSK_KEX2_1	390	392	PF00082	0.530
CLV_PCSK_KEX2_1	398	400	PF00082	0.538
CLV_PCSK_KEX2_1	506	508	PF00082	0.467
CLV_PCSK_KEX2_1	654	656	PF00082	0.547
CLV_PCSK_KEX2_1	770	772	PF00082	0.588
CLV_PCSK_KEX2_1	816	818	PF00082	0.600
CLV_PCSK_PC7_1	227	233	PF00082	0.293
CLV_PCSK_SKI1_1	144	148	PF00082	0.482
CLV_PCSK_SKI1_1	166	170	PF00082	0.274
CLV_PCSK_SKI1_1	231	235	PF00082	0.293
CLV_PCSK_SKI1_1	40	44	PF00082	0.376
CLV_PCSK_SKI1_1	473	477	PF00082	0.527
CLV_PCSK_SKI1_1	508	512	PF00082	0.543
CLV_PCSK_SKI1_1	548	552	PF00082	0.563
CLV_PCSK_SKI1_1	558	562	PF00082	0.571
CLV_PCSK_SKI1_1	697	701	PF00082	0.527
CLV_PCSK_SKI1_1	87	91	PF00082	0.293
CLV_PCSK_SKI1_1	878	882	PF00082	0.459
CLV_Separin_Metazoa	838	842	PF03568	0.429
DEG_APCC_DBOX_1	178	186	PF00400	0.202
DEG_APCC_DBOX_1	505	513	PF00400	0.393
DEG_APCC_DBOX_1	870	878	PF00400	0.422
DOC_ANK_TNKS_1	572	579	PF00023	0.455
DOC_CKS1_1	433	438	PF01111	0.430
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.279
DOC_MAPK_gen_1	179	187	PF00069	0.202
DOC_MAPK_gen_1	271	280	PF00069	0.293
DOC_MAPK_gen_1	863	872	PF00069	0.433
DOC_MAPK_MEF2A_6	273	282	PF00069	0.293
DOC_MAPK_MEF2A_6	4	11	PF00069	0.507
DOC_MAPK_MEF2A_6	865	874	PF00069	0.427
DOC_PP2B_LxvP_1	683	686	PF13499	0.490
DOC_PP4_MxPP_1	791	794	PF00568	0.535
DOC_USP7_MATH_1	152	156	PF00917	0.260
DOC_USP7_MATH_1	197	201	PF00917	0.210
DOC_USP7_MATH_1	329	333	PF00917	0.267
DOC_USP7_MATH_1	445	449	PF00917	0.476
DOC_USP7_MATH_1	543	547	PF00917	0.551
DOC_USP7_MATH_1	550	554	PF00917	0.516
DOC_USP7_MATH_1	587	591	PF00917	0.617
DOC_USP7_MATH_1	669	673	PF00917	0.524
DOC_USP7_MATH_1	688	692	PF00917	0.442
DOC_USP7_MATH_1	754	758	PF00917	0.557
DOC_USP7_MATH_2	802	808	PF00917	0.508
DOC_WW_Pin1_4	120	125	PF00397	0.211
DOC_WW_Pin1_4	391	396	PF00397	0.549
DOC_WW_Pin1_4	398	403	PF00397	0.548
DOC_WW_Pin1_4	405	410	PF00397	0.517
DOC_WW_Pin1_4	432	437	PF00397	0.436
DOC_WW_Pin1_4	579	584	PF00397	0.509
DOC_WW_Pin1_4	612	617	PF00397	0.711
DOC_WW_Pin1_4	656	661	PF00397	0.632
DOC_WW_Pin1_4	789	794	PF00397	0.552
LIG_14-3-3_CanoR_1	166	173	PF00244	0.286
LIG_14-3-3_CanoR_1	321	330	PF00244	0.259
LIG_14-3-3_CanoR_1	608	616	PF00244	0.600
LIG_14-3-3_CanoR_1	732	742	PF00244	0.451
LIG_14-3-3_CanoR_1	788	792	PF00244	0.595
LIG_Actin_WH2_2	87	102	PF00022	0.257
LIG_APCC_ABBA_1	136	141	PF00400	0.496
LIG_BIR_II_1	1	5	PF00653	0.524
LIG_BIR_III_4	562	566	PF00653	0.463
LIG_Clathr_ClatBox_1	869	873	PF01394	0.430
LIG_CtBP_PxDLS_1	409	413	PF00389	0.600
LIG_EH1_1	88	96	PF00400	0.293
LIG_FHA_1	125	131	PF00498	0.459
LIG_FHA_1	167	173	PF00498	0.202
LIG_FHA_1	24	30	PF00498	0.511
LIG_FHA_1	273	279	PF00498	0.263
LIG_FHA_1	288	294	PF00498	0.263
LIG_FHA_1	334	340	PF00498	0.496
LIG_FHA_1	347	353	PF00498	0.287
LIG_FHA_1	402	408	PF00498	0.531
LIG_FHA_1	487	493	PF00498	0.423
LIG_FHA_1	52	58	PF00498	0.306
LIG_FHA_1	559	565	PF00498	0.643
LIG_FHA_1	65	71	PF00498	0.216
LIG_FHA_1	659	665	PF00498	0.535
LIG_FHA_1	796	802	PF00498	0.572
LIG_FHA_1	86	92	PF00498	0.461
LIG_FHA_2	140	146	PF00498	0.258
LIG_FHA_2	467	473	PF00498	0.474
LIG_FHA_2	795	801	PF00498	0.545
LIG_Integrin_RGD_1	227	229	PF01839	0.251
LIG_Integrin_RGD_1	538	540	PF01839	0.512
LIG_Integrin_RGD_1	771	773	PF01839	0.526
LIG_LIR_Gen_1	368	379	PF02991	0.293
LIG_LIR_Gen_1	444	453	PF02991	0.448
LIG_LIR_Nem_3	368	374	PF02991	0.298
LIG_LIR_Nem_3	444	449	PF02991	0.455
LIG_LIR_Nem_3	694	698	PF02991	0.650
LIG_MYND_1	583	587	PF01753	0.514
LIG_NRBOX	334	340	PF00104	0.496
LIG_PCNA_yPIPBox_3	732	742	PF02747	0.392
LIG_Pex14_2	69	73	PF04695	0.293
LIG_SH2_CRK	371	375	PF00017	0.293
LIG_SH2_CRK	446	450	PF00017	0.448
LIG_SH2_PTP2	135	138	PF00017	0.293
LIG_SH2_PTP2	632	635	PF00017	0.552
LIG_SH2_SRC	135	138	PF00017	0.293
LIG_SH2_SRC	58	61	PF00017	0.258
LIG_SH2_STAP1	257	261	PF00017	0.293
LIG_SH2_STAP1	453	457	PF00017	0.402
LIG_SH2_STAP1	58	62	PF00017	0.258
LIG_SH2_STAT3	453	456	PF00017	0.403
LIG_SH2_STAT5	132	135	PF00017	0.293
LIG_SH2_STAT5	371	374	PF00017	0.293
LIG_SH2_STAT5	513	516	PF00017	0.382
LIG_SH2_STAT5	632	635	PF00017	0.636
LIG_SH2_STAT5	698	701	PF00017	0.568
LIG_SH3_3	25	31	PF00018	0.408
LIG_SH3_3	529	535	PF00018	0.553
LIG_SH3_3	603	609	PF00018	0.643
LIG_SH3_3	613	619	PF00018	0.635
LIG_SH3_3	657	663	PF00018	0.640
LIG_SUMO_SIM_anti_2	828	836	PF11976	0.487
LIG_SUMO_SIM_par_1	408	416	PF11976	0.595
LIG_SUMO_SIM_par_1	95	101	PF11976	0.293
LIG_TRAF2_1	634	637	PF00917	0.588
LIG_TRAF2_1	797	800	PF00917	0.547
LIG_TYR_ITIM	133	138	PF00017	0.293
LIG_TYR_ITIM	369	374	PF00017	0.293
LIG_UBA3_1	433	438	PF00899	0.430
MOD_CDC14_SPxK_1	615	618	PF00782	0.630
MOD_CDK_SPK_2	579	584	PF00069	0.509
MOD_CDK_SPxK_1	432	438	PF00069	0.433
MOD_CDK_SPxK_1	612	618	PF00069	0.632
MOD_CDK_SPxxK_3	391	398	PF00069	0.556
MOD_CK1_1	117	123	PF00069	0.230
MOD_CK1_1	200	206	PF00069	0.209
MOD_CK1_1	243	249	PF00069	0.467
MOD_CK1_1	333	339	PF00069	0.496
MOD_CK1_1	401	407	PF00069	0.560
MOD_CK1_1	408	414	PF00069	0.638
MOD_CK1_1	432	438	PF00069	0.458
MOD_CK1_1	466	472	PF00069	0.409
MOD_CK1_1	612	618	PF00069	0.632
MOD_CK1_1	691	697	PF00069	0.409
MOD_CK1_1	733	739	PF00069	0.474
MOD_CK1_1	783	789	PF00069	0.576
MOD_CK2_1	266	272	PF00069	0.433
MOD_CK2_1	408	414	PF00069	0.616
MOD_CK2_1	466	472	PF00069	0.409
MOD_CK2_1	664	670	PF00069	0.535
MOD_CK2_1	794	800	PF00069	0.602
MOD_CK2_1	804	810	PF00069	0.566
MOD_Cter_Amidation	396	399	PF01082	0.493
MOD_Cter_Amidation	652	655	PF01082	0.543
MOD_DYRK1A_RPxSP_1	391	395	PF00069	0.544
MOD_GlcNHglycan	109	112	PF01048	0.293
MOD_GlcNHglycan	199	202	PF01048	0.233
MOD_GlcNHglycan	346	349	PF01048	0.293
MOD_GlcNHglycan	443	446	PF01048	0.463
MOD_GlcNHglycan	516	519	PF01048	0.406
MOD_GlcNHglycan	545	548	PF01048	0.516
MOD_GlcNHglycan	597	600	PF01048	0.625
MOD_GlcNHglycan	611	614	PF01048	0.566
MOD_GlcNHglycan	664	667	PF01048	0.547
MOD_GlcNHglycan	679	682	PF01048	0.584
MOD_GlcNHglycan	690	693	PF01048	0.481
MOD_GlcNHglycan	806	809	PF01048	0.497
MOD_GlcNHglycan	821	824	PF01048	0.531
MOD_GlcNHglycan	828	832	PF01048	0.471
MOD_GSK3_1	120	127	PF00069	0.398
MOD_GSK3_1	227	234	PF00069	0.374
MOD_GSK3_1	239	246	PF00069	0.425
MOD_GSK3_1	248	255	PF00069	0.301
MOD_GSK3_1	329	336	PF00069	0.466
MOD_GSK3_1	401	408	PF00069	0.545
MOD_GSK3_1	441	448	PF00069	0.544
MOD_GSK3_1	463	470	PF00069	0.532
MOD_GSK3_1	516	523	PF00069	0.510
MOD_GSK3_1	600	607	PF00069	0.649
MOD_GSK3_1	658	665	PF00069	0.531
MOD_GSK3_1	730	737	PF00069	0.488
MOD_GSK3_1	783	790	PF00069	0.537
MOD_GSK3_1	804	811	PF00069	0.500
MOD_N-GLC_1	73	78	PF02516	0.293
MOD_NEK2_1	167	172	PF00069	0.293
MOD_NEK2_1	252	257	PF00069	0.273
MOD_NEK2_1	282	287	PF00069	0.293
MOD_NEK2_1	339	344	PF00069	0.405
MOD_NEK2_1	463	468	PF00069	0.457
MOD_NEK2_1	640	645	PF00069	0.566
MOD_NEK2_1	664	669	PF00069	0.547
MOD_NEK2_1	73	78	PF00069	0.293
MOD_NEK2_1	734	739	PF00069	0.457
MOD_NEK2_1	741	746	PF00069	0.449
MOD_NEK2_2	139	144	PF00069	0.289
MOD_NEK2_2	248	253	PF00069	0.293
MOD_NEK2_2	520	525	PF00069	0.434
MOD_PIKK_1	486	492	PF00454	0.442
MOD_PIKK_1	587	593	PF00454	0.619
MOD_PIKK_1	808	814	PF00454	0.497
MOD_PKA_1	231	237	PF00069	0.294
MOD_PKA_2	231	237	PF00069	0.496
MOD_PKA_2	330	336	PF00069	0.496
MOD_PKA_2	783	789	PF00069	0.576
MOD_PKA_2	826	832	PF00069	0.448
MOD_Plk_1	362	368	PF00069	0.293
MOD_Plk_1	429	435	PF00069	0.473
MOD_Plk_1	73	79	PF00069	0.293
MOD_Plk_4	23	29	PF00069	0.474
MOD_Plk_4	248	254	PF00069	0.293
MOD_Plk_4	346	352	PF00069	0.496
MOD_Plk_4	429	435	PF00069	0.523
MOD_Plk_4	691	697	PF00069	0.467
MOD_Plk_4	73	79	PF00069	0.314
MOD_Plk_4	90	96	PF00069	0.466
MOD_ProDKin_1	120	126	PF00069	0.211
MOD_ProDKin_1	391	397	PF00069	0.553
MOD_ProDKin_1	398	404	PF00069	0.548
MOD_ProDKin_1	405	411	PF00069	0.515
MOD_ProDKin_1	432	438	PF00069	0.433
MOD_ProDKin_1	579	585	PF00069	0.512
MOD_ProDKin_1	612	618	PF00069	0.711
MOD_ProDKin_1	656	662	PF00069	0.635
MOD_ProDKin_1	789	795	PF00069	0.551
MOD_SUMO_for_1	428	431	PF00179	0.497
MOD_SUMO_rev_2	269	275	PF00179	0.371
MOD_SUMO_rev_2	553	560	PF00179	0.456
MOD_SUMO_rev_2	873	880	PF00179	0.428
TRG_DiLeu_BaEn_1	23	28	PF01217	0.411
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.293
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.496
TRG_DiLeu_BaLyEn_6	532	537	PF01217	0.545
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.293
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.293
TRG_ENDOCYTIC_2	135	138	PF00928	0.293
TRG_ENDOCYTIC_2	371	374	PF00928	0.266
TRG_ENDOCYTIC_2	386	389	PF00928	0.559
TRG_ENDOCYTIC_2	446	449	PF00928	0.452
TRG_ENDOCYTIC_2	632	635	PF00928	0.602
TRG_ER_diArg_1	179	182	PF00400	0.202
TRG_ER_diArg_1	388	391	PF00400	0.572
TRG_ER_diArg_1	505	508	PF00400	0.455
TRG_ER_diArg_1	813	816	PF00400	0.507
TRG_ER_diArg_1	9	12	PF00400	0.519
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	479	484	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBS7	Leishmania donovani	24%	100%
A0A3Q8IEL2	Leishmania donovani	29%	100%
A0A3Q8IHG6	Leishmania donovani	29%	100%
A0A3S7WPL3	Leishmania donovani	74%	99%
A0A3S7X2P9	Leishmania donovani	29%	100%
A4HHN8	Leishmania braziliensis	28%	100%
A4HHY2	Leishmania braziliensis	25%	100%
A4HSZ5	Leishmania infantum	75%	99%
A4I4V2	Leishmania infantum	29%	100%
A4I4V3	Leishmania infantum	29%	100%
A4I562	Leishmania infantum	24%	100%
E9AEA0	Leishmania major	30%	100%
E9AEA1	Leishmania major	30%	100%
E9AKY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
E9ALI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q0DV28	Oryza sativa subsp. japonica	25%	93%
Q4QIX3	Leishmania major	75%	100%