G-patch domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

G-patch domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H4R5_LEIBR

TriTrypDb:

LbrM.06.1000 , LBRM2903_060017000

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4R5

Function

Biological processes
Term	Name	Level	Count
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0090069	regulation of ribosome biogenesis	5	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.545
CLV_NRD_NRD_1	47	49	PF00675	0.263
CLV_PCSK_KEX2_1	122	124	PF00082	0.429
CLV_PCSK_KEX2_1	142	144	PF00082	0.302
CLV_PCSK_KEX2_1	155	157	PF00082	0.470
CLV_PCSK_KEX2_1	170	172	PF00082	0.622
CLV_PCSK_KEX2_1	23	25	PF00082	0.221
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.341
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.458
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.622
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.277
CLV_PCSK_SKI1_1	123	127	PF00082	0.440
CLV_PCSK_SKI1_1	19	23	PF00082	0.308
DOC_CYCLIN_RxL_1	15	25	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	181	187	PF00134	0.634
DOC_MAPK_gen_1	122	130	PF00069	0.359
DOC_MAPK_gen_1	45	55	PF00069	0.266
DOC_MAPK_gen_1	78	87	PF00069	0.375
DOC_MAPK_MEF2A_6	182	191	PF00069	0.519
DOC_SPAK_OSR1_1	143	147	PF12202	0.365
DOC_USP7_MATH_1	102	106	PF00917	0.544
DOC_USP7_UBL2_3	15	19	PF12436	0.358
DOC_USP7_UBL2_3	45	49	PF12436	0.276
DOC_WW_Pin1_4	180	185	PF00397	0.455
DOC_WW_Pin1_4	203	208	PF00397	0.635
DOC_WW_Pin1_4	223	228	PF00397	0.510
DOC_WW_Pin1_4	94	99	PF00397	0.623
LIG_14-3-3_CanoR_1	115	120	PF00244	0.348
LIG_14-3-3_CanoR_1	171	181	PF00244	0.431
LIG_14-3-3_CanoR_1	192	200	PF00244	0.695
LIG_14-3-3_CanoR_1	24	33	PF00244	0.310
LIG_14-3-3_CanoR_1	78	87	PF00244	0.485
LIG_BIR_II_1	1	5	PF00653	0.520
LIG_BRCT_BRCA1_1	68	72	PF00533	0.381
LIG_deltaCOP1_diTrp_1	63	72	PF00928	0.430
LIG_FHA_1	224	230	PF00498	0.554
LIG_FHA_1	65	71	PF00498	0.471
LIG_FHA_1	82	88	PF00498	0.462
LIG_FHA_2	102	108	PF00498	0.612
LIG_FHA_2	192	198	PF00498	0.670
LIG_FHA_2	199	205	PF00498	0.554
LIG_LIR_Gen_1	69	79	PF02991	0.373
LIG_LIR_Nem_3	114	120	PF02991	0.572
LIG_LIR_Nem_3	69	75	PF02991	0.376
LIG_MAD2	210	218	PF02301	0.513
LIG_PDZ_Class_2	225	230	PF00595	0.581
LIG_SH2_STAP1	117	121	PF00017	0.332
LIG_SH2_STAT5	117	120	PF00017	0.462
LIG_SH3_1	215	221	PF00018	0.475
LIG_SH3_3	215	221	PF00018	0.473
LIG_SUMO_SIM_par_1	82	93	PF11976	0.381
LIG_TRAF2_1	206	209	PF00917	0.524
MOD_CDK_SPxxK_3	203	210	PF00069	0.517
MOD_CK1_1	149	155	PF00069	0.443
MOD_CK1_1	172	178	PF00069	0.672
MOD_CK1_1	25	31	PF00069	0.298
MOD_CK1_1	97	103	PF00069	0.638
MOD_CK2_1	101	107	PF00069	0.733
MOD_CK2_1	191	197	PF00069	0.690
MOD_CK2_1	203	209	PF00069	0.607
MOD_CK2_1	8	14	PF00069	0.473
MOD_GlcNHglycan	104	107	PF01048	0.510
MOD_GlcNHglycan	135	138	PF01048	0.532
MOD_GlcNHglycan	148	151	PF01048	0.446
MOD_GlcNHglycan	176	179	PF01048	0.661
MOD_GlcNHglycan	24	27	PF01048	0.279
MOD_GSK3_1	111	118	PF00069	0.589
MOD_GSK3_1	169	176	PF00069	0.602
MOD_GSK3_1	81	88	PF00069	0.545
MOD_GSK3_1	96	103	PF00069	0.588
MOD_NEK2_1	22	27	PF00069	0.288
MOD_PIKK_1	64	70	PF00454	0.431
MOD_PKA_2	172	178	PF00069	0.470
MOD_PKA_2	191	197	PF00069	0.669
MOD_PKA_2	8	14	PF00069	0.488
MOD_PKB_1	171	179	PF00069	0.442
MOD_Plk_4	115	121	PF00069	0.464
MOD_ProDKin_1	180	186	PF00069	0.450
MOD_ProDKin_1	203	209	PF00069	0.634
MOD_ProDKin_1	223	229	PF00069	0.512
MOD_ProDKin_1	94	100	PF00069	0.624
MOD_SUMO_for_1	126	129	PF00179	0.449
MOD_SUMO_rev_2	105	111	PF00179	0.446
MOD_SUMO_rev_2	135	144	PF00179	0.517
MOD_SUMO_rev_2	162	172	PF00179	0.626
MOD_SUMO_rev_2	196	201	PF00179	0.589
TRG_DiLeu_BaEn_1	208	213	PF01217	0.411
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.452
TRG_NLS_Bipartite_1	155	174	PF00514	0.463
TRG_NLS_MonoExtN_4	167	174	PF00514	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L2	Leptomonas seymouri	71%	89%
A0A0S4JRZ3	Bodo saltans	42%	100%
A0A1X0NMG7	Trypanosomatidae	41%	95%
A0A3R7RBC9	Trypanosoma rangeli	51%	100%
A0A3S7WPL1	Leishmania donovani	80%	100%
A4HSZ4	Leishmania infantum	80%	100%
A4R0T9	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	26%	66%
C9ZTM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	85%
E9AKY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QIX4	Leishmania major	80%	100%
V5BNM6	Trypanosoma cruzi	49%	100%