Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4R4_LEIBR

TriTrypDb:

LbrM.06.0990 , LBRM2903_060016900

Length:

749

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4R4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4R4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.679
CLV_C14_Caspase3-7	216	220	PF00656	0.432
CLV_C14_Caspase3-7	444	448	PF00656	0.450
CLV_C14_Caspase3-7	477	481	PF00656	0.464
CLV_C14_Caspase3-7	563	567	PF00656	0.674
CLV_C14_Caspase3-7	573	577	PF00656	0.596
CLV_NRD_NRD_1	122	124	PF00675	0.687
CLV_NRD_NRD_1	2	4	PF00675	0.645
CLV_NRD_NRD_1	297	299	PF00675	0.631
CLV_NRD_NRD_1	46	48	PF00675	0.538
CLV_NRD_NRD_1	484	486	PF00675	0.513
CLV_NRD_NRD_1	641	643	PF00675	0.357
CLV_NRD_NRD_1	743	745	PF00675	0.595
CLV_PCSK_KEX2_1	122	124	PF00082	0.691
CLV_PCSK_KEX2_1	2	4	PF00082	0.645
CLV_PCSK_KEX2_1	46	48	PF00082	0.445
CLV_PCSK_KEX2_1	484	486	PF00082	0.513
CLV_PCSK_KEX2_1	641	643	PF00082	0.357
CLV_PCSK_KEX2_1	743	745	PF00082	0.576
CLV_PCSK_SKI1_1	108	112	PF00082	0.481
CLV_PCSK_SKI1_1	208	212	PF00082	0.414
CLV_PCSK_SKI1_1	274	278	PF00082	0.454
CLV_PCSK_SKI1_1	341	345	PF00082	0.371
CLV_PCSK_SKI1_1	376	380	PF00082	0.409
CLV_PCSK_SKI1_1	484	488	PF00082	0.520
CLV_PCSK_SKI1_1	633	637	PF00082	0.405
CLV_PCSK_SKI1_1	684	688	PF00082	0.431
CLV_PCSK_SKI1_1	720	724	PF00082	0.542
CLV_PCSK_SKI1_1	94	98	PF00082	0.439
DEG_APCC_DBOX_1	211	219	PF00400	0.310
DEG_APCC_DBOX_1	340	348	PF00400	0.368
DEG_APCC_DBOX_1	483	491	PF00400	0.511
DEG_APCC_DBOX_1	683	691	PF00400	0.424
DEG_Nend_UBRbox_1	1	4	PF02207	0.538
DEG_SPOP_SBC_1	134	138	PF00917	0.637
DEG_SPOP_SBC_1	311	315	PF00917	0.513
DOC_CYCLIN_RxL_1	373	382	PF00134	0.405
DOC_CYCLIN_RxL_1	506	517	PF00134	0.523
DOC_CYCLIN_RxL_1	717	727	PF00134	0.588
DOC_CYCLIN_yCln2_LP_2	256	262	PF00134	0.417
DOC_MAPK_gen_1	543	552	PF00069	0.452
DOC_MAPK_gen_1	682	689	PF00069	0.487
DOC_MAPK_gen_1	94	102	PF00069	0.301
DOC_MAPK_HePTP_8	638	655	PF00069	0.401
DOC_MAPK_MEF2A_6	646	655	PF00069	0.368
DOC_PP2B_LxvP_1	256	259	PF13499	0.484
DOC_PP2B_LxvP_1	715	718	PF13499	0.514
DOC_USP7_MATH_1	117	121	PF00917	0.658
DOC_USP7_MATH_1	127	131	PF00917	0.609
DOC_USP7_MATH_1	134	138	PF00917	0.702
DOC_USP7_MATH_1	25	29	PF00917	0.544
DOC_USP7_MATH_1	312	316	PF00917	0.639
DOC_USP7_MATH_1	398	402	PF00917	0.556
DOC_WW_Pin1_4	307	312	PF00397	0.679
DOC_WW_Pin1_4	391	396	PF00397	0.560
DOC_WW_Pin1_4	401	406	PF00397	0.769
LIG_14-3-3_CanoR_1	128	133	PF00244	0.582
LIG_14-3-3_CanoR_1	212	222	PF00244	0.341
LIG_14-3-3_CanoR_1	274	283	PF00244	0.532
LIG_14-3-3_CanoR_1	46	53	PF00244	0.372
LIG_14-3-3_CanoR_1	492	498	PF00244	0.417
LIG_14-3-3_CanoR_1	646	651	PF00244	0.397
LIG_14-3-3_CanoR_1	682	687	PF00244	0.356
LIG_Actin_WH2_2	258	276	PF00022	0.387
LIG_APCC_ABBAyCdc20_2	523	529	PF00400	0.492
LIG_BIR_III_2	219	223	PF00653	0.409
LIG_BIR_III_4	292	296	PF00653	0.591
LIG_BRCT_BRCA1_1	347	351	PF00533	0.347
LIG_Clathr_ClatBox_1	510	514	PF01394	0.529
LIG_DLG_GKlike_1	128	135	PF00625	0.586
LIG_DLG_GKlike_1	646	653	PF00625	0.406
LIG_FHA_1	179	185	PF00498	0.485
LIG_FHA_1	316	322	PF00498	0.532
LIG_FHA_1	584	590	PF00498	0.511
LIG_FHA_1	626	632	PF00498	0.431
LIG_FHA_1	664	670	PF00498	0.453
LIG_FHA_1	67	73	PF00498	0.438
LIG_FHA_1	671	677	PF00498	0.455
LIG_FHA_1	7	13	PF00498	0.365
LIG_FHA_2	142	148	PF00498	0.741
LIG_FHA_2	16	22	PF00498	0.350
LIG_FHA_2	214	220	PF00498	0.388
LIG_FHA_2	295	301	PF00498	0.635
LIG_FHA_2	355	361	PF00498	0.513
LIG_FHA_2	442	448	PF00498	0.448
LIG_FHA_2	515	521	PF00498	0.559
LIG_FHA_2	724	730	PF00498	0.527
LIG_Integrin_RGD_1	642	644	PF01839	0.345
LIG_IRF3_LxIS_1	460	466	PF10401	0.259
LIG_LIR_Gen_1	263	271	PF02991	0.534
LIG_LIR_Gen_1	348	355	PF02991	0.473
LIG_LIR_Gen_1	612	622	PF02991	0.471
LIG_LIR_Gen_1	685	694	PF02991	0.369
LIG_LIR_Nem_3	263	267	PF02991	0.536
LIG_LIR_Nem_3	348	354	PF02991	0.476
LIG_LIR_Nem_3	612	617	PF02991	0.365
LIG_LIR_Nem_3	685	689	PF02991	0.363
LIG_NRBOX	75	81	PF00104	0.492
LIG_PCNA_PIPBox_1	386	395	PF02747	0.465
LIG_PCNA_yPIPBox_3	227	235	PF02747	0.379
LIG_Pex14_2	206	210	PF04695	0.451
LIG_Rb_pABgroove_1	427	435	PF01858	0.470
LIG_SH2_CRK	393	397	PF00017	0.446
LIG_SH2_CRK	614	618	PF00017	0.348
LIG_SH2_CRK	622	626	PF00017	0.374
LIG_SH2_GRB2like	657	660	PF00017	0.508
LIG_SH2_NCK_1	433	437	PF00017	0.467
LIG_SH2_NCK_1	657	661	PF00017	0.319
LIG_SH2_SRC	433	436	PF00017	0.475
LIG_SH2_STAP1	527	531	PF00017	0.373
LIG_SH2_STAT3	371	374	PF00017	0.464
LIG_SH2_STAT5	346	349	PF00017	0.473
LIG_SH2_STAT5	377	380	PF00017	0.452
LIG_SH2_STAT5	393	396	PF00017	0.602
LIG_SH2_STAT5	482	485	PF00017	0.508
LIG_SH3_3	111	117	PF00018	0.517
LIG_SH3_3	21	27	PF00018	0.366
LIG_SH3_3	305	311	PF00018	0.589
LIG_SH3_3	696	702	PF00018	0.480
LIG_SUMO_SIM_anti_2	434	440	PF11976	0.466
LIG_SUMO_SIM_anti_2	666	671	PF11976	0.438
LIG_SUMO_SIM_anti_2	68	77	PF11976	0.321
LIG_SUMO_SIM_par_1	180	185	PF11976	0.590
LIG_SUMO_SIM_par_1	258	263	PF11976	0.350
LIG_SUMO_SIM_par_1	269	275	PF11976	0.384
LIG_SUMO_SIM_par_1	377	382	PF11976	0.448
LIG_SUMO_SIM_par_1	509	517	PF11976	0.505
LIG_SUMO_SIM_par_1	634	640	PF11976	0.391
LIG_TRAF2_1	286	289	PF00917	0.650
LIG_TRAF2_1	357	360	PF00917	0.403
LIG_TRAF2_1	708	711	PF00917	0.400
LIG_TRFH_1	173	177	PF08558	0.594
LIG_TYR_ITIM	262	267	PF00017	0.461
LIG_UBA3_1	75	82	PF00899	0.439
LIG_WW_3	717	721	PF00397	0.581
MOD_CK1_1	136	142	PF00069	0.739
MOD_CK1_1	160	166	PF00069	0.744
MOD_CK1_1	178	184	PF00069	0.598
MOD_CK1_1	310	316	PF00069	0.698
MOD_CK1_1	401	407	PF00069	0.727
MOD_CK1_1	533	539	PF00069	0.438
MOD_CK2_1	15	21	PF00069	0.320
MOD_CK2_1	354	360	PF00069	0.457
MOD_CK2_1	514	520	PF00069	0.563
MOD_CK2_1	533	539	PF00069	0.477
MOD_CK2_1	701	707	PF00069	0.428
MOD_GlcNHglycan	12	15	PF01048	0.482
MOD_GlcNHglycan	159	162	PF01048	0.546
MOD_GlcNHglycan	184	187	PF01048	0.532
MOD_GlcNHglycan	191	194	PF01048	0.453
MOD_GlcNHglycan	238	241	PF01048	0.441
MOD_GlcNHglycan	27	30	PF01048	0.538
MOD_GlcNHglycan	279	282	PF01048	0.437
MOD_GlcNHglycan	347	350	PF01048	0.279
MOD_GlcNHglycan	4	7	PF01048	0.516
MOD_GlcNHglycan	411	414	PF01048	0.452
MOD_GlcNHglycan	465	468	PF01048	0.531
MOD_GlcNHglycan	475	479	PF01048	0.415
MOD_GlcNHglycan	48	51	PF01048	0.578
MOD_GSK3_1	10	17	PF00069	0.420
MOD_GSK3_1	153	160	PF00069	0.723
MOD_GSK3_1	171	178	PF00069	0.591
MOD_GSK3_1	2	9	PF00069	0.461
MOD_GSK3_1	244	251	PF00069	0.482
MOD_GSK3_1	306	313	PF00069	0.710
MOD_GSK3_1	394	401	PF00069	0.638
MOD_GSK3_1	42	49	PF00069	0.603
MOD_GSK3_1	529	536	PF00069	0.548
MOD_GSK3_1	701	708	PF00069	0.483
MOD_LATS_1	680	686	PF00433	0.434
MOD_NEK2_1	182	187	PF00069	0.485
MOD_NEK2_1	213	218	PF00069	0.379
MOD_NEK2_1	320	325	PF00069	0.498
MOD_NEK2_1	379	384	PF00069	0.469
MOD_NEK2_1	419	424	PF00069	0.457
MOD_NEK2_1	463	468	PF00069	0.257
MOD_NEK2_1	530	535	PF00069	0.343
MOD_NEK2_1	670	675	PF00069	0.441
MOD_PIKK_1	213	219	PF00454	0.407
MOD_PIKK_1	583	589	PF00454	0.514
MOD_PIKK_1	6	12	PF00454	0.444
MOD_PKA_1	2	8	PF00069	0.593
MOD_PKA_1	46	52	PF00069	0.371
MOD_PKA_2	127	133	PF00069	0.577
MOD_PKA_2	178	184	PF00069	0.536
MOD_PKA_2	2	8	PF00069	0.518
MOD_PKA_2	45	51	PF00069	0.395
MOD_PKA_2	542	548	PF00069	0.595
MOD_PKA_2	66	72	PF00069	0.528
MOD_Plk_1	117	123	PF00069	0.612
MOD_Plk_1	455	461	PF00069	0.530
MOD_Plk_2-3	514	520	PF00069	0.563
MOD_Plk_4	171	177	PF00069	0.619
MOD_Plk_4	178	184	PF00069	0.463
MOD_Plk_4	585	591	PF00069	0.444
MOD_Plk_4	68	74	PF00069	0.460
MOD_ProDKin_1	307	313	PF00069	0.676
MOD_ProDKin_1	391	397	PF00069	0.574
MOD_ProDKin_1	401	407	PF00069	0.768
MOD_SUMO_rev_2	707	715	PF00179	0.386
TRG_DiLeu_BaEn_4	21	27	PF01217	0.323
TRG_DiLeu_BaEn_4	455	461	PF01217	0.446
TRG_DiLeu_BaLyEn_6	506	511	PF01217	0.475
TRG_ENDOCYTIC_2	264	267	PF00928	0.491
TRG_ENDOCYTIC_2	393	396	PF00928	0.429
TRG_ENDOCYTIC_2	433	436	PF00928	0.467
TRG_ENDOCYTIC_2	527	530	PF00928	0.354
TRG_ENDOCYTIC_2	614	617	PF00928	0.343
TRG_ENDOCYTIC_2	622	625	PF00928	0.369
TRG_ER_diArg_1	1	3	PF00400	0.667
TRG_ER_diArg_1	121	123	PF00400	0.678
TRG_ER_diArg_1	483	485	PF00400	0.522
TRG_ER_diArg_1	540	543	PF00400	0.425
TRG_ER_diArg_1	681	684	PF00400	0.368
TRG_ER_diArg_1	742	744	PF00400	0.583
TRG_NES_CRM1_1	502	516	PF08389	0.442
TRG_Pf-PMV_PEXEL_1	470	475	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	509	514	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	535	539	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	733	737	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXP3	Leptomonas seymouri	54%	98%
A0A3R7K270	Trypanosoma rangeli	34%	100%
A0A3S5H5T7	Leishmania donovani	81%	98%
A4HSZ3	Leishmania infantum	81%	98%
C9ZTM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AKY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
Q4QIX5	Leishmania major	80%	100%
V5BXV7	Trypanosoma cruzi	34%	100%