SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H4R3_LEIBR

TriTrypDb:

LbrM.06.0980 , LBRM2903_060016800

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4R3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4R3

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0040029	epigenetic regulation of gene expression	6	1
GO:0045814	negative regulation of gene expression, epigenetic	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	2
GO:0042054	histone methyltransferase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0042799	histone H4K20 methyltransferase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.492
CLV_NRD_NRD_1	171	173	PF00675	0.498
CLV_NRD_NRD_1	482	484	PF00675	0.411
CLV_NRD_NRD_1	83	85	PF00675	0.442
CLV_PCSK_KEX2_1	171	173	PF00082	0.498
CLV_PCSK_KEX2_1	31	33	PF00082	0.553
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.359
CLV_PCSK_SKI1_1	176	180	PF00082	0.500
CLV_PCSK_SKI1_1	297	301	PF00082	0.333
CLV_PCSK_SKI1_1	325	329	PF00082	0.239
CLV_PCSK_SKI1_1	483	487	PF00082	0.304
CLV_Separin_Metazoa	92	96	PF03568	0.406
DEG_APCC_DBOX_1	150	158	PF00400	0.342
DEG_APCC_DBOX_1	324	332	PF00400	0.438
DEG_SPOP_SBC_1	106	110	PF00917	0.490
DOC_CDC14_PxL_1	210	218	PF14671	0.383
DOC_MAPK_gen_1	458	468	PF00069	0.428
DOC_PP2B_LxvP_1	348	351	PF13499	0.450
DOC_USP7_MATH_1	104	108	PF00917	0.490
DOC_USP7_MATH_1	145	149	PF00917	0.499
DOC_USP7_MATH_1	162	166	PF00917	0.455
DOC_USP7_MATH_1	205	209	PF00917	0.559
DOC_USP7_MATH_1	428	432	PF00917	0.492
DOC_USP7_MATH_1	459	463	PF00917	0.386
DOC_USP7_UBL2_3	477	481	PF12436	0.288
DOC_WW_Pin1_4	102	107	PF00397	0.622
DOC_WW_Pin1_4	176	181	PF00397	0.424
DOC_WW_Pin1_4	432	437	PF00397	0.577
LIG_14-3-3_CanoR_1	325	333	PF00244	0.547
LIG_14-3-3_CanoR_1	63	70	PF00244	0.434
LIG_14-3-3_CanoR_1	95	99	PF00244	0.398
LIG_Actin_WH2_2	163	178	PF00022	0.377
LIG_CaM_IQ_9	72	87	PF13499	0.276
LIG_EH1_1	412	420	PF00400	0.492
LIG_FHA_1	145	151	PF00498	0.717
LIG_FHA_1	177	183	PF00498	0.358
LIG_FHA_1	198	204	PF00498	0.504
LIG_FHA_1	241	247	PF00498	0.383
LIG_FHA_1	405	411	PF00498	0.529
LIG_FHA_1	473	479	PF00498	0.407
LIG_FHA_1	50	56	PF00498	0.404
LIG_FHA_1	73	79	PF00498	0.300
LIG_FHA_1	89	95	PF00498	0.398
LIG_FHA_1	98	104	PF00498	0.428
LIG_FHA_2	63	69	PF00498	0.408
LIG_GBD_Chelix_1	374	382	PF00786	0.228
LIG_LIR_Gen_1	114	123	PF02991	0.367
LIG_LIR_Gen_1	394	404	PF02991	0.446
LIG_LIR_Nem_3	114	120	PF02991	0.407
LIG_LIR_Nem_3	271	277	PF02991	0.473
LIG_LIR_Nem_3	394	399	PF02991	0.458
LIG_PCNA_PIPBox_1	389	398	PF02747	0.431
LIG_SH2_CRK	413	417	PF00017	0.445
LIG_SH2_NCK_1	34	38	PF00017	0.323
LIG_SH2_NCK_1	362	366	PF00017	0.467
LIG_SH2_SRC	362	365	PF00017	0.533
LIG_SH2_STAP1	34	38	PF00017	0.333
LIG_SH2_STAT3	12	15	PF00017	0.478
LIG_SH2_STAT3	20	23	PF00017	0.347
LIG_SH2_STAT3	64	67	PF00017	0.332
LIG_SH2_STAT5	20	23	PF00017	0.391
LIG_SH2_STAT5	264	267	PF00017	0.467
LIG_SH2_STAT5	495	498	PF00017	0.479
LIG_SH2_STAT5	64	67	PF00017	0.332
LIG_SH3_3	100	106	PF00018	0.488
LIG_SH3_3	243	249	PF00018	0.411
LIG_SH3_3	251	257	PF00018	0.519
LIG_TRAF2_1	13	16	PF00917	0.384
LIG_WW_3	203	207	PF00397	0.280
MOD_CK1_1	105	111	PF00069	0.636
MOD_CK1_1	115	121	PF00069	0.660
MOD_CK1_1	208	214	PF00069	0.246
MOD_CK1_1	220	226	PF00069	0.268
MOD_CK1_1	236	242	PF00069	0.387
MOD_CK1_1	244	250	PF00069	0.399
MOD_CK1_1	281	287	PF00069	0.482
MOD_CK1_1	329	335	PF00069	0.422
MOD_CK1_1	338	344	PF00069	0.451
MOD_CK1_1	414	420	PF00069	0.401
MOD_CK1_1	431	437	PF00069	0.401
MOD_CK1_1	66	72	PF00069	0.542
MOD_CK2_1	317	323	PF00069	0.403
MOD_CK2_1	445	451	PF00069	0.288
MOD_DYRK1A_RPxSP_1	176	180	PF00069	0.384
MOD_GlcNHglycan	109	112	PF01048	0.514
MOD_GlcNHglycan	121	124	PF01048	0.406
MOD_GlcNHglycan	146	150	PF01048	0.509
MOD_GlcNHglycan	176	179	PF01048	0.545
MOD_GlcNHglycan	243	246	PF01048	0.305
MOD_GlcNHglycan	265	268	PF01048	0.305
MOD_GlcNHglycan	302	305	PF01048	0.410
MOD_GlcNHglycan	319	322	PF01048	0.414
MOD_GlcNHglycan	378	381	PF01048	0.420
MOD_GlcNHglycan	407	410	PF01048	0.285
MOD_GlcNHglycan	431	434	PF01048	0.390
MOD_GlcNHglycan	447	450	PF01048	0.354
MOD_GlcNHglycan	461	464	PF01048	0.200
MOD_GSK3_1	102	109	PF00069	0.485
MOD_GSK3_1	111	118	PF00069	0.463
MOD_GSK3_1	204	211	PF00069	0.212
MOD_GSK3_1	235	242	PF00069	0.345
MOD_GSK3_1	428	435	PF00069	0.432
MOD_GSK3_1	62	69	PF00069	0.401
MOD_GSK3_1	94	101	PF00069	0.393
MOD_N-GLC_1	115	120	PF02516	0.397
MOD_N-GLC_1	419	424	PF02516	0.309
MOD_NEK2_1	112	117	PF00069	0.749
MOD_NEK2_1	189	194	PF00069	0.536
MOD_NEK2_1	197	202	PF00069	0.335
MOD_NEK2_1	300	305	PF00069	0.192
MOD_NEK2_1	404	409	PF00069	0.357
MOD_NEK2_1	429	434	PF00069	0.298
MOD_NEK2_1	450	455	PF00069	0.197
MOD_NEK2_1	78	83	PF00069	0.436
MOD_NEK2_1	98	103	PF00069	0.312
MOD_NEK2_2	26	31	PF00069	0.346
MOD_PIKK_1	11	17	PF00454	0.284
MOD_PIKK_1	115	121	PF00454	0.474
MOD_PIKK_1	63	69	PF00454	0.443
MOD_PIKK_1	72	78	PF00454	0.430
MOD_PKA_2	205	211	PF00069	0.369
MOD_PKA_2	356	362	PF00069	0.459
MOD_PKA_2	62	68	PF00069	0.360
MOD_PKA_2	94	100	PF00069	0.548
MOD_Plk_1	115	121	PF00069	0.377
MOD_Plk_1	450	456	PF00069	0.192
MOD_Plk_4	205	211	PF00069	0.440
MOD_Plk_4	228	234	PF00069	0.193
MOD_Plk_4	391	397	PF00069	0.288
MOD_Plk_4	411	417	PF00069	0.173
MOD_Plk_4	450	456	PF00069	0.203
MOD_ProDKin_1	102	108	PF00069	0.624
MOD_ProDKin_1	176	182	PF00069	0.417
MOD_ProDKin_1	432	438	PF00069	0.463
MOD_SUMO_rev_2	220	226	PF00179	0.375
TRG_DiLeu_BaEn_1	212	217	PF01217	0.401
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.288
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.319
TRG_ENDOCYTIC_2	413	416	PF00928	0.262
TRG_ER_diArg_1	170	172	PF00400	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P571	Leptomonas seymouri	62%	100%
A0A0S4JRV8	Bodo saltans	37%	100%
A0A1X0NL17	Trypanosomatidae	48%	100%
A0A3R7KQ99	Trypanosoma rangeli	46%	100%
A0A3S7WPJ6	Leishmania donovani	80%	100%
A0A3S7WYH0	Leishmania donovani	26%	100%
A4HDM9	Leishmania braziliensis	28%	100%
A4HSZ2	Leishmania infantum	80%	100%
C9ZTM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AH76	Leishmania infantum	26%	100%
E9AKX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9AX14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4QAG2	Leishmania major	28%	100%
Q4QIX6	Leishmania major	79%	100%
V5BT58	Trypanosoma cruzi	44%	100%