Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich Repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4H4R1_LEIBR

TriTrypDb:

LbrM.06.0960 , LBRM2903_060016500

Length:

968

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H4R1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4R1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	561	565	PF00656	0.661
CLV_C14_Caspase3-7	600	604	PF00656	0.637
CLV_C14_Caspase3-7	748	752	PF00656	0.529
CLV_NRD_NRD_1	567	569	PF00675	0.656
CLV_NRD_NRD_1	801	803	PF00675	0.682
CLV_NRD_NRD_1	946	948	PF00675	0.627
CLV_NRD_NRD_1	954	956	PF00675	0.687
CLV_PCSK_FUR_1	128	132	PF00082	0.437
CLV_PCSK_KEX2_1	130	132	PF00082	0.439
CLV_PCSK_KEX2_1	149	151	PF00082	0.571
CLV_PCSK_KEX2_1	224	226	PF00082	0.707
CLV_PCSK_KEX2_1	297	299	PF00082	0.489
CLV_PCSK_KEX2_1	567	569	PF00082	0.603
CLV_PCSK_KEX2_1	591	593	PF00082	0.659
CLV_PCSK_KEX2_1	806	808	PF00082	0.668
CLV_PCSK_KEX2_1	954	956	PF00082	0.702
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.439
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.571
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.707
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.480
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.685
CLV_PCSK_PC1ET2_1	806	808	PF00082	0.714
CLV_PCSK_PC7_1	802	808	PF00082	0.532
CLV_PCSK_SKI1_1	149	153	PF00082	0.392
CLV_PCSK_SKI1_1	221	225	PF00082	0.653
CLV_PCSK_SKI1_1	342	346	PF00082	0.314
CLV_PCSK_SKI1_1	452	456	PF00082	0.626
CLV_PCSK_SKI1_1	459	463	PF00082	0.586
CLV_PCSK_SKI1_1	464	468	PF00082	0.566
CLV_PCSK_SKI1_1	492	496	PF00082	0.520
CLV_PCSK_SKI1_1	546	550	PF00082	0.627
CLV_PCSK_SKI1_1	694	698	PF00082	0.545
CLV_PCSK_SKI1_1	764	768	PF00082	0.706
CLV_PCSK_SKI1_1	83	87	PF00082	0.497
CLV_PCSK_SKI1_1	9	13	PF00082	0.585
CLV_PCSK_SKI1_1	955	959	PF00082	0.683
DEG_APCC_DBOX_1	149	157	PF00400	0.534
DEG_Nend_Nbox_1	1	3	PF02207	0.485
DEG_SPOP_SBC_1	729	733	PF00917	0.636
DOC_AGCK_PIF_3	965	968	PF00069	0.706
DOC_CDC14_PxL_1	51	59	PF14671	0.460
DOC_CDC14_PxL_1	73	81	PF14671	0.517
DOC_CYCLIN_RxL_1	149	159	PF00134	0.428
DOC_CYCLIN_RxL_1	20	32	PF00134	0.405
DOC_CYCLIN_RxL_1	75	86	PF00134	0.451
DOC_MAPK_FxFP_2	460	463	PF00069	0.677
DOC_MAPK_gen_1	125	134	PF00069	0.519
DOC_MAPK_gen_1	149	158	PF00069	0.530
DOC_MAPK_gen_1	391	398	PF00069	0.552
DOC_MAPK_gen_1	402	411	PF00069	0.587
DOC_MAPK_gen_1	43	52	PF00069	0.407
DOC_MAPK_gen_1	567	574	PF00069	0.638
DOC_MAPK_MEF2A_6	149	158	PF00069	0.317
DOC_MAPK_MEF2A_6	177	184	PF00069	0.409
DOC_MAPK_MEF2A_6	391	398	PF00069	0.552
DOC_MAPK_MEF2A_6	43	52	PF00069	0.460
DOC_PP1_RVXF_1	490	497	PF00149	0.508
DOC_PP1_RVXF_1	577	584	PF00149	0.556
DOC_PP1_RVXF_1	692	699	PF00149	0.657
DOC_PP1_RVXF_1	952	959	PF00149	0.688
DOC_PP2B_LxvP_1	189	192	PF13499	0.522
DOC_PP2B_LxvP_1	727	730	PF13499	0.738
DOC_PP2B_PxIxI_1	819	825	PF00149	0.604
DOC_PP4_FxxP_1	165	168	PF00568	0.499
DOC_PP4_FxxP_1	460	463	PF00568	0.677
DOC_USP7_MATH_1	357	361	PF00917	0.661
DOC_USP7_MATH_1	597	601	PF00917	0.620
DOC_USP7_MATH_1	651	655	PF00917	0.667
DOC_USP7_MATH_1	66	70	PF00917	0.537
DOC_USP7_MATH_1	759	763	PF00917	0.698
DOC_USP7_MATH_1	876	880	PF00917	0.686
DOC_USP7_MATH_1	937	941	PF00917	0.671
DOC_USP7_UBL2_3	311	315	PF12436	0.490
DOC_USP7_UBL2_3	754	758	PF12436	0.704
DOC_WW_Pin1_4	385	390	PF00397	0.574
DOC_WW_Pin1_4	791	796	PF00397	0.613
DOC_WW_Pin1_4	814	819	PF00397	0.619
DOC_WW_Pin1_4	897	902	PF00397	0.647
LIG_14-3-3_CanoR_1	275	279	PF00244	0.692
LIG_14-3-3_CanoR_1	298	302	PF00244	0.463
LIG_14-3-3_CanoR_1	342	347	PF00244	0.319
LIG_14-3-3_CanoR_1	402	407	PF00244	0.572
LIG_14-3-3_CanoR_1	59	65	PF00244	0.451
LIG_14-3-3_CanoR_1	78	83	PF00244	0.489
LIG_14-3-3_CanoR_1	793	799	PF00244	0.706
LIG_14-3-3_CanoR_1	832	839	PF00244	0.544
LIG_14-3-3_CanoR_1	891	895	PF00244	0.701
LIG_14-3-3_CanoR_1	9	15	PF00244	0.407
LIG_Actin_WH2_2	168	185	PF00022	0.351
LIG_APCC_ABBA_1	870	875	PF00400	0.645
LIG_BRCT_BRCA1_1	412	416	PF00533	0.396
LIG_Clathr_ClatBox_1	153	157	PF01394	0.330
LIG_Clathr_ClatBox_1	635	639	PF01394	0.464
LIG_Clathr_ClatBox_1	844	848	PF01394	0.574
LIG_deltaCOP1_diTrp_1	580	589	PF00928	0.577
LIG_deltaCOP1_diTrp_1	682	692	PF00928	0.672
LIG_DLG_GKlike_1	78	85	PF00625	0.511
LIG_eIF4E_1	839	845	PF01652	0.596
LIG_FHA_1	212	218	PF00498	0.484
LIG_FHA_1	230	236	PF00498	0.676
LIG_FHA_1	289	295	PF00498	0.572
LIG_FHA_1	343	349	PF00498	0.575
LIG_FHA_1	415	421	PF00498	0.534
LIG_FHA_1	614	620	PF00498	0.669
LIG_FHA_1	623	629	PF00498	0.579
LIG_FHA_1	732	738	PF00498	0.729
LIG_FHA_1	819	825	PF00498	0.612
LIG_FHA_1	831	837	PF00498	0.575
LIG_FHA_2	162	168	PF00498	0.565
LIG_FHA_2	403	409	PF00498	0.579
LIG_FHA_2	453	459	PF00498	0.613
LIG_FHA_2	463	469	PF00498	0.529
LIG_FHA_2	622	628	PF00498	0.604
LIG_FHA_2	686	692	PF00498	0.465
LIG_FHA_2	84	90	PF00498	0.461
LIG_FHA_2	869	875	PF00498	0.564
LIG_FHA_2	905	911	PF00498	0.619
LIG_IRF3_LxIS_1	153	159	PF10401	0.411
LIG_LIR_Apic_2	164	168	PF02991	0.501
LIG_LIR_Apic_2	458	463	PF02991	0.681
LIG_LIR_Apic_2	777	783	PF02991	0.552
LIG_LIR_Gen_1	240	247	PF02991	0.558
LIG_LIR_Gen_1	491	501	PF02991	0.557
LIG_LIR_Gen_1	629	638	PF02991	0.669
LIG_LIR_Gen_1	693	703	PF02991	0.632
LIG_LIR_Nem_3	240	246	PF02991	0.559
LIG_LIR_Nem_3	363	367	PF02991	0.478
LIG_LIR_Nem_3	429	435	PF02991	0.529
LIG_LIR_Nem_3	491	496	PF02991	0.531
LIG_LIR_Nem_3	542	548	PF02991	0.673
LIG_LIR_Nem_3	580	586	PF02991	0.566
LIG_LIR_Nem_3	629	635	PF02991	0.547
LIG_LIR_Nem_3	63	67	PF02991	0.460
LIG_LIR_Nem_3	689	695	PF02991	0.602
LIG_LIR_Nem_3	856	862	PF02991	0.534
LIG_LIR_Nem_3	883	889	PF02991	0.695
LIG_LIR_Nem_3	919	924	PF02991	0.603
LIG_LIR_Nem_3	962	968	PF02991	0.691
LIG_Pex14_1	869	873	PF04695	0.596
LIG_PTB_Apo_2	743	750	PF02174	0.665
LIG_PTB_Apo_2	923	930	PF02174	0.508
LIG_PTB_Phospho_1	923	929	PF10480	0.505
LIG_REV1ctd_RIR_1	168	175	PF16727	0.603
LIG_SH2_CRK	504	508	PF00017	0.593
LIG_SH2_CRK	519	523	PF00017	0.647
LIG_SH2_CRK	741	745	PF00017	0.498
LIG_SH2_CRK	839	843	PF00017	0.469
LIG_SH2_CRK	859	863	PF00017	0.602
LIG_SH2_NCK_1	741	745	PF00017	0.498
LIG_SH2_NCK_1	873	877	PF00017	0.680
LIG_SH2_PTP2	780	783	PF00017	0.546
LIG_SH2_SRC	780	783	PF00017	0.546
LIG_SH2_SRC	873	876	PF00017	0.699
LIG_SH2_STAP1	504	508	PF00017	0.628
LIG_SH2_STAP1	873	877	PF00017	0.638
LIG_SH2_STAP1	929	933	PF00017	0.682
LIG_SH2_STAT5	312	315	PF00017	0.460
LIG_SH2_STAT5	432	435	PF00017	0.506
LIG_SH2_STAT5	493	496	PF00017	0.550
LIG_SH2_STAT5	695	698	PF00017	0.540
LIG_SH2_STAT5	715	718	PF00017	0.483
LIG_SH2_STAT5	755	758	PF00017	0.648
LIG_SH2_STAT5	780	783	PF00017	0.546
LIG_SH2_STAT5	877	880	PF00017	0.571
LIG_SH2_STAT5	888	891	PF00017	0.579
LIG_SH2_STAT5	929	932	PF00017	0.686
LIG_SH3_1	224	230	PF00018	0.508
LIG_SH3_1	780	786	PF00018	0.549
LIG_SH3_3	224	230	PF00018	0.732
LIG_SH3_3	287	293	PF00018	0.600
LIG_SH3_3	49	55	PF00018	0.450
LIG_SH3_3	504	510	PF00018	0.553
LIG_SH3_3	780	786	PF00018	0.688
LIG_SH3_3	891	897	PF00018	0.737
LIG_SUMO_SIM_anti_2	213	219	PF11976	0.440
LIG_SUMO_SIM_anti_2	513	518	PF11976	0.641
LIG_SUMO_SIM_anti_2	848	854	PF11976	0.670
LIG_SUMO_SIM_par_1	152	157	PF11976	0.324
LIG_SUMO_SIM_par_1	194	200	PF11976	0.387
LIG_SUMO_SIM_par_1	633	640	PF11976	0.485
LIG_SUMO_SIM_par_1	78	84	PF11976	0.452
LIG_TRAF2_1	247	250	PF00917	0.699
LIG_TRAF2_1	721	724	PF00917	0.668
LIG_TYR_ITIM	517	522	PF00017	0.658
MOD_CDC14_SPxK_1	388	391	PF00782	0.590
MOD_CDK_SPxK_1	385	391	PF00069	0.603
MOD_CK1_1	231	237	PF00069	0.697
MOD_CK1_1	270	276	PF00069	0.650
MOD_CK1_1	279	285	PF00069	0.630
MOD_CK1_1	288	294	PF00069	0.541
MOD_CK1_1	637	643	PF00069	0.697
MOD_CK1_1	732	738	PF00069	0.600
MOD_CK1_1	788	794	PF00069	0.677
MOD_CK1_1	81	87	PF00069	0.463
MOD_CK1_1	960	966	PF00069	0.728
MOD_CK2_1	175	181	PF00069	0.432
MOD_CK2_1	322	328	PF00069	0.461
MOD_CK2_1	357	363	PF00069	0.687
MOD_CK2_1	402	408	PF00069	0.579
MOD_CK2_1	435	441	PF00069	0.602
MOD_CK2_1	452	458	PF00069	0.473
MOD_CK2_1	462	468	PF00069	0.622
MOD_CK2_1	621	627	PF00069	0.613
MOD_CK2_1	767	773	PF00069	0.766
MOD_CK2_1	904	910	PF00069	0.715
MOD_CMANNOS	378	381	PF00535	0.540
MOD_Cter_Amidation	589	592	PF01082	0.463
MOD_Cter_Amidation	762	765	PF01082	0.563
MOD_Cter_Amidation	952	955	PF01082	0.751
MOD_GlcNHglycan	157	161	PF01048	0.506
MOD_GlcNHglycan	269	272	PF01048	0.680
MOD_GlcNHglycan	575	578	PF01048	0.638
MOD_GlcNHglycan	595	598	PF01048	0.697
MOD_GlcNHglycan	599	602	PF01048	0.698
MOD_GlcNHglycan	639	642	PF01048	0.672
MOD_GlcNHglycan	68	71	PF01048	0.368
MOD_GlcNHglycan	751	754	PF01048	0.750
MOD_GlcNHglycan	761	764	PF01048	0.695
MOD_GlcNHglycan	769	772	PF01048	0.658
MOD_GlcNHglycan	777	780	PF01048	0.795
MOD_GlcNHglycan	787	790	PF01048	0.783
MOD_GlcNHglycan	910	915	PF01048	0.719
MOD_GlcNHglycan	959	962	PF01048	0.668
MOD_GSK3_1	10	17	PF00069	0.471
MOD_GSK3_1	140	147	PF00069	0.503
MOD_GSK3_1	152	159	PF00069	0.444
MOD_GSK3_1	229	236	PF00069	0.683
MOD_GSK3_1	237	244	PF00069	0.773
MOD_GSK3_1	262	269	PF00069	0.672
MOD_GSK3_1	270	277	PF00069	0.623
MOD_GSK3_1	342	349	PF00069	0.320
MOD_GSK3_1	385	392	PF00069	0.549
MOD_GSK3_1	410	417	PF00069	0.403
MOD_GSK3_1	464	471	PF00069	0.469
MOD_GSK3_1	593	600	PF00069	0.610
MOD_GSK3_1	622	629	PF00069	0.626
MOD_GSK3_1	681	688	PF00069	0.470
MOD_GSK3_1	728	735	PF00069	0.633
MOD_GSK3_1	745	752	PF00069	0.671
MOD_GSK3_1	765	772	PF00069	0.680
MOD_GSK3_1	781	788	PF00069	0.713
MOD_GSK3_1	794	801	PF00069	0.601
MOD_GSK3_1	814	821	PF00069	0.556
MOD_GSK3_1	912	919	PF00069	0.758
MOD_GSK3_1	937	944	PF00069	0.591
MOD_N-GLC_1	187	192	PF02516	0.454
MOD_N-GLC_1	333	338	PF02516	0.503
MOD_N-GLC_1	346	351	PF02516	0.434
MOD_N-GLC_1	371	376	PF02516	0.506
MOD_N-GLC_1	385	390	PF02516	0.549
MOD_N-GLC_1	60	65	PF02516	0.348
MOD_N-GLC_1	622	627	PF02516	0.514
MOD_N-GLC_1	745	750	PF02516	0.612
MOD_N-GLC_2	675	677	PF02516	0.643
MOD_NEK2_1	14	19	PF00069	0.199
MOD_NEK2_1	156	161	PF00069	0.393
MOD_NEK2_1	187	192	PF00069	0.511
MOD_NEK2_1	266	271	PF00069	0.714
MOD_NEK2_1	346	351	PF00069	0.401
MOD_NEK2_1	573	578	PF00069	0.579
MOD_NEK2_1	593	598	PF00069	0.643
MOD_NEK2_1	664	669	PF00069	0.588
MOD_NEK2_1	690	695	PF00069	0.462
MOD_NEK2_1	7	12	PF00069	0.602
MOD_NEK2_1	749	754	PF00069	0.720
MOD_NEK2_1	767	772	PF00069	0.570
MOD_NEK2_1	798	803	PF00069	0.588
MOD_NEK2_1	862	867	PF00069	0.638
MOD_NEK2_2	333	338	PF00069	0.528
MOD_NEK2_2	868	873	PF00069	0.471
MOD_PIKK_1	288	294	PF00454	0.609
MOD_PIKK_1	355	361	PF00454	0.682
MOD_PIKK_1	626	632	PF00454	0.669
MOD_PIKK_1	862	868	PF00454	0.639
MOD_PKA_1	297	303	PF00069	0.479
MOD_PKA_2	124	130	PF00069	0.320
MOD_PKA_2	274	280	PF00069	0.693
MOD_PKA_2	297	303	PF00069	0.487
MOD_PKA_2	593	599	PF00069	0.630
MOD_PKA_2	801	807	PF00069	0.830
MOD_PKA_2	831	837	PF00069	0.544
MOD_PKA_2	890	896	PF00069	0.542
MOD_Plk_1	333	339	PF00069	0.496
MOD_Plk_1	435	441	PF00069	0.619
MOD_Plk_1	579	585	PF00069	0.511
MOD_Plk_1	60	66	PF00069	0.372
MOD_Plk_1	681	687	PF00069	0.672
MOD_Plk_1	690	696	PF00069	0.450
MOD_Plk_1	711	717	PF00069	0.677
MOD_Plk_1	745	751	PF00069	0.623
MOD_Plk_2-3	558	564	PF00069	0.680
MOD_Plk_4	333	339	PF00069	0.508
MOD_Plk_4	420	426	PF00069	0.514
MOD_Plk_4	579	585	PF00069	0.481
MOD_Plk_4	681	687	PF00069	0.672
MOD_Plk_4	697	703	PF00069	0.628
MOD_Plk_4	711	717	PF00069	0.736
MOD_Plk_4	732	738	PF00069	0.660
MOD_Plk_4	794	800	PF00069	0.600
MOD_Plk_4	840	846	PF00069	0.649
MOD_Plk_4	868	874	PF00069	0.606
MOD_Plk_4	890	896	PF00069	0.507
MOD_Plk_4	916	922	PF00069	0.534
MOD_ProDKin_1	385	391	PF00069	0.578
MOD_ProDKin_1	791	797	PF00069	0.611
MOD_ProDKin_1	814	820	PF00069	0.613
MOD_ProDKin_1	897	903	PF00069	0.654
MOD_SUMO_rev_2	109	119	PF00179	0.526
MOD_SUMO_rev_2	874	884	PF00179	0.689
TRG_DiLeu_BaEn_1	723	728	PF01217	0.674
TRG_DiLeu_BaEn_1	848	853	PF01217	0.599
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.405
TRG_DiLeu_BaLyEn_6	615	620	PF01217	0.699
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.473
TRG_ENDOCYTIC_2	432	435	PF00928	0.539
TRG_ENDOCYTIC_2	493	496	PF00928	0.516
TRG_ENDOCYTIC_2	504	507	PF00928	0.554
TRG_ENDOCYTIC_2	519	522	PF00928	0.573
TRG_ENDOCYTIC_2	545	548	PF00928	0.602
TRG_ENDOCYTIC_2	695	698	PF00928	0.529
TRG_ENDOCYTIC_2	741	744	PF00928	0.659
TRG_ENDOCYTIC_2	839	842	PF00928	0.557
TRG_ENDOCYTIC_2	859	862	PF00928	0.666
TRG_ER_diArg_1	401	404	PF00400	0.613
TRG_ER_diArg_1	567	569	PF00400	0.656
TRG_ER_diArg_1	954	956	PF00400	0.741
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	35	40	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	860	864	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY3	Leptomonas seymouri	68%	92%
A0A0S4JW61	Bodo saltans	28%	100%
A0A3S7WPK9	Leishmania donovani	80%	94%
A0A422NZ80	Trypanosoma rangeli	40%	100%
C9ZTM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	94%
E9AG69	Leishmania infantum	80%	94%
E9AKX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	93%
Q4QIX9	Leishmania major	80%	100%
V5BNJ3	Trypanosoma cruzi	40%	100%