Putative cell cycle associated protein MOB1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cell cycle associated protein MOB1, putative

Species:

Leishmania braziliensis

UniProt:

A4H4Q9_LEIBR

TriTrypDb:

LbrM.06.0940 , LBRM2903_060016300

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 2
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4Q9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Q9

Function

Biological processes
Term	Name	Level	Count
GO:0001932	regulation of protein phosphorylation	7	1
GO:0001934	positive regulation of protein phosphorylation	8	1
GO:0007165	signal transduction	2	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010562	positive regulation of phosphorus metabolic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031399	regulation of protein modification process	6	1
GO:0031401	positive regulation of protein modification process	7	1
GO:0042325	regulation of phosphorylation	7	1
GO:0042327	positive regulation of phosphorylation	8	1
GO:0045937	positive regulation of phosphate metabolic process	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0008047	enzyme activator activity	3	1
GO:0019207	kinase regulator activity	3	1
GO:0019209	kinase activator activity	4	1
GO:0019887	protein kinase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0030295	protein kinase activator activity	5	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.320
CLV_NRD_NRD_1	215	217	PF00675	0.365
CLV_NRD_NRD_1	237	239	PF00675	0.477
CLV_PCSK_FUR_1	235	239	PF00082	0.479
CLV_PCSK_KEX2_1	155	157	PF00082	0.264
CLV_PCSK_KEX2_1	214	216	PF00082	0.395
CLV_PCSK_KEX2_1	235	237	PF00082	0.483
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.395
CLV_PCSK_PC7_1	231	237	PF00082	0.488
CLV_PCSK_SKI1_1	151	155	PF00082	0.274
CLV_PCSK_SKI1_1	211	215	PF00082	0.388
DEG_APCC_DBOX_1	199	207	PF00400	0.531
DEG_Nend_UBRbox_1	1	4	PF02207	0.567
DEG_SCF_FBW7_2	203	208	PF00400	0.558
DOC_USP7_MATH_1	87	91	PF00917	0.469
DOC_USP7_UBL2_3	147	151	PF12436	0.509
DOC_USP7_UBL2_3	18	22	PF12436	0.480
DOC_WW_Pin1_4	201	206	PF00397	0.477
LIG_14-3-3_CanoR_1	110	114	PF00244	0.558
LIG_Actin_WH2_2	30	46	PF00022	0.449
LIG_BIR_III_2	225	229	PF00653	0.480
LIG_BRCT_BRCA1_1	5	9	PF00533	0.556
LIG_FHA_1	68	74	PF00498	0.464
LIG_IBAR_NPY_1	140	142	PF08397	0.464
LIG_LIR_Apic_2	96	102	PF02991	0.485
LIG_LIR_Gen_1	167	175	PF02991	0.464
LIG_LIR_Gen_1	194	203	PF02991	0.464
LIG_LIR_Gen_1	56	66	PF02991	0.443
LIG_LIR_Nem_3	136	142	PF02991	0.537
LIG_LIR_Nem_3	145	149	PF02991	0.479
LIG_LIR_Nem_3	167	172	PF02991	0.486
LIG_LIR_Nem_3	183	188	PF02991	0.464
LIG_LIR_Nem_3	194	198	PF02991	0.434
LIG_LIR_Nem_3	56	61	PF02991	0.518
LIG_LIR_Nem_3	63	69	PF02991	0.437
LIG_Pex14_2	154	158	PF04695	0.464
LIG_Pex14_2	191	195	PF04695	0.464
LIG_PTB_Apo_2	68	75	PF02174	0.464
LIG_PTB_Phospho_1	68	74	PF10480	0.464
LIG_SH2_CRK	74	78	PF00017	0.464
LIG_SH2_NCK_1	161	165	PF00017	0.464
LIG_SH2_SRC	161	164	PF00017	0.464
LIG_SH2_STAP1	161	165	PF00017	0.464
LIG_SH2_STAP1	95	99	PF00017	0.464
LIG_SH2_STAT5	116	119	PF00017	0.544
LIG_SH2_STAT5	149	152	PF00017	0.558
LIG_SH2_STAT5	190	193	PF00017	0.477
LIG_SH2_STAT5	80	83	PF00017	0.543
LIG_SH2_STAT5	97	100	PF00017	0.395
LIG_SH3_1	100	106	PF00018	0.477
LIG_SH3_3	100	106	PF00018	0.457
LIG_SH3_3	108	114	PF00018	0.457
LIG_SH3_3	44	50	PF00018	0.474
LIG_SH3_3	81	87	PF00018	0.564
LIG_SH3_5	135	139	PF00018	0.558
LIG_TRAF2_1	199	202	PF00917	0.477
LIG_TRAF2_1	205	208	PF00917	0.548
LIG_TRFH_1	195	199	PF08558	0.477
LIG_TYR_ITIM	72	77	PF00017	0.464
LIG_UBA3_1	209	214	PF00899	0.391
LIG_WW_1	102	105	PF00397	0.477
MOD_CK1_1	11	17	PF00069	0.567
MOD_CK1_1	167	173	PF00069	0.558
MOD_CK1_1	60	66	PF00069	0.464
MOD_GlcNHglycan	111	114	PF01048	0.271
MOD_GlcNHglycan	39	42	PF01048	0.264
MOD_GlcNHglycan	90	93	PF01048	0.284
MOD_GSK3_1	33	40	PF00069	0.444
MOD_GSK3_1	4	11	PF00069	0.620
MOD_GSK3_1	53	60	PF00069	0.412
MOD_GSK3_1	75	82	PF00069	0.490
MOD_N-GLC_1	67	72	PF02516	0.264
MOD_NEK2_1	3	8	PF00069	0.587
MOD_NEK2_1	33	38	PF00069	0.442
MOD_PKA_2	109	115	PF00069	0.558
MOD_Plk_1	11	17	PF00069	0.543
MOD_Plk_1	53	59	PF00069	0.399
MOD_Plk_4	4	10	PF00069	0.619
MOD_ProDKin_1	201	207	PF00069	0.477
TRG_DiLeu_BaEn_4	201	207	PF01217	0.477
TRG_ENDOCYTIC_2	116	119	PF00928	0.464
TRG_ENDOCYTIC_2	161	164	PF00928	0.464
TRG_ENDOCYTIC_2	166	169	PF00928	0.464
TRG_ENDOCYTIC_2	74	77	PF00928	0.464
TRG_ENDOCYTIC_2	95	98	PF00928	0.464
TRG_ER_diArg_1	154	156	PF00400	0.520
TRG_ER_diArg_1	235	238	PF00400	0.482
TRG_NLS_MonoExtC_3	17	22	PF00514	0.478
TRG_NLS_MonoExtN_4	16	22	PF00514	0.491
TRG_NLS_MonoExtN_4	211	218	PF00514	0.352
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJX4	Leptomonas seymouri	97%	100%
A0A0S4JRY9	Bodo saltans	71%	100%
A0A1X0NMF7	Trypanosomatidae	77%	100%
A0A3R7LB49	Trypanosoma rangeli	73%	100%
A0A3S5H5T5	Leishmania donovani	97%	100%
A4HSY8	Leishmania infantum	97%	100%
C9ZTL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9AKX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
F4K495	Arabidopsis thaliana	44%	100%
O74558	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
O94360	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
P40484	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	79%
P43563	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	86%
Q29RK9	Bos taurus	49%	100%
Q2WBN3	Medicago sativa subsp. falcata	49%	100%
Q3T1J9	Rattus norvegicus	51%	100%
Q4QIY1	Leishmania major	97%	100%
Q54BM4	Dictyostelium discoideum	47%	100%
Q54CR8	Dictyostelium discoideum	50%	100%
Q54QV0	Dictyostelium discoideum	34%	100%
Q54XJ0	Dictyostelium discoideum	49%	100%
Q58D63	Bos taurus	50%	100%
Q5ABC6	Candida albicans (strain SC5314 / ATCC MYA-2876)	37%	79%
Q5EAA4	Bos taurus	45%	100%
Q5R5Z0	Pongo abelii	51%	100%
Q5RAE0	Pongo abelii	51%	100%
Q70IA6	Homo sapiens	30%	100%
Q70IA8	Homo sapiens	45%	100%
Q7L9L4	Homo sapiens	50%	100%
Q86TA1	Homo sapiens	49%	100%
Q8BJG4	Mus musculus	45%	100%
Q8BPB0	Mus musculus	50%	100%
Q8BSU7	Mus musculus	51%	100%
Q8GYX0	Arabidopsis thaliana	51%	100%
Q8VE04	Mus musculus	49%	100%
Q8VI63	Mus musculus	29%	100%
Q921Y0	Mus musculus	51%	100%
Q949G5	Medicago sativa subsp. falcata	49%	100%
Q95RA8	Drosophila melanogaster	50%	100%
Q96BX8	Homo sapiens	51%	100%
Q9FHI1	Arabidopsis thaliana	51%	100%
Q9H8S9	Homo sapiens	51%	100%
Q9P601	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	40%	100%
Q9VL13	Drosophila melanogaster	48%	100%