TLDc domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4Q7_LEIBR

TriTrypDb:

LbrM.06.0920 , LBRM2903_060016100

Length:

660

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4Q7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Q7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.472
CLV_C14_Caspase3-7	213	217	PF00656	0.464
CLV_C14_Caspase3-7	329	333	PF00656	0.630
CLV_C14_Caspase3-7	370	374	PF00656	0.546
CLV_C14_Caspase3-7	548	552	PF00656	0.741
CLV_NRD_NRD_1	179	181	PF00675	0.531
CLV_NRD_NRD_1	247	249	PF00675	0.804
CLV_NRD_NRD_1	311	313	PF00675	0.453
CLV_NRD_NRD_1	40	42	PF00675	0.544
CLV_NRD_NRD_1	452	454	PF00675	0.694
CLV_NRD_NRD_1	594	596	PF00675	0.455
CLV_NRD_NRD_1	68	70	PF00675	0.607
CLV_NRD_NRD_1	82	84	PF00675	0.535
CLV_PCSK_FUR_1	245	249	PF00082	0.581
CLV_PCSK_FUR_1	592	596	PF00082	0.413
CLV_PCSK_FUR_1	80	84	PF00082	0.454
CLV_PCSK_KEX2_1	179	181	PF00082	0.531
CLV_PCSK_KEX2_1	247	249	PF00082	0.804
CLV_PCSK_KEX2_1	310	312	PF00082	0.454
CLV_PCSK_KEX2_1	337	339	PF00082	0.632
CLV_PCSK_KEX2_1	40	42	PF00082	0.544
CLV_PCSK_KEX2_1	451	453	PF00082	0.710
CLV_PCSK_KEX2_1	483	485	PF00082	0.372
CLV_PCSK_KEX2_1	591	593	PF00082	0.560
CLV_PCSK_KEX2_1	594	596	PF00082	0.559
CLV_PCSK_KEX2_1	80	82	PF00082	0.523
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.454
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.632
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.265
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.661
CLV_PCSK_PC7_1	77	83	PF00082	0.472
CLV_PCSK_SKI1_1	118	122	PF00082	0.419
CLV_PCSK_SKI1_1	192	196	PF00082	0.315
CLV_PCSK_SKI1_1	40	44	PF00082	0.538
DEG_APCC_DBOX_1	141	149	PF00400	0.575
DOC_ANK_TNKS_1	615	622	PF00023	0.516
DOC_CKS1_1	32	37	PF01111	0.534
DOC_CYCLIN_yClb1_LxF_4	160	165	PF00134	0.462
DOC_MAPK_DCC_7	567	577	PF00069	0.661
DOC_MAPK_gen_1	457	467	PF00069	0.513
DOC_PP1_RVXF_1	160	166	PF00149	0.457
DOC_PP1_RVXF_1	190	197	PF00149	0.574
DOC_PP1_RVXF_1	579	586	PF00149	0.446
DOC_PP2B_LxvP_1	11	14	PF13499	0.490
DOC_PP2B_LxvP_1	150	153	PF13499	0.338
DOC_PP4_FxxP_1	282	285	PF00568	0.546
DOC_PP4_FxxP_1	438	441	PF00568	0.692
DOC_PP4_FxxP_1	445	448	PF00568	0.490
DOC_PP4_FxxP_1	46	49	PF00568	0.538
DOC_PP4_FxxP_1	522	525	PF00568	0.512
DOC_SPAK_OSR1_1	484	488	PF12202	0.265
DOC_USP7_MATH_1	186	190	PF00917	0.636
DOC_USP7_MATH_1	223	227	PF00917	0.656
DOC_USP7_MATH_1	343	347	PF00917	0.751
DOC_USP7_MATH_1	379	383	PF00917	0.764
DOC_USP7_MATH_1	540	544	PF00917	0.700
DOC_USP7_MATH_1	642	646	PF00917	0.557
DOC_USP7_MATH_1	90	94	PF00917	0.731
DOC_WW_Pin1_4	227	232	PF00397	0.561
DOC_WW_Pin1_4	233	238	PF00397	0.657
DOC_WW_Pin1_4	254	259	PF00397	0.647
DOC_WW_Pin1_4	264	269	PF00397	0.469
DOC_WW_Pin1_4	281	286	PF00397	0.522
DOC_WW_Pin1_4	295	300	PF00397	0.454
DOC_WW_Pin1_4	31	36	PF00397	0.528
DOC_WW_Pin1_4	416	421	PF00397	0.646
DOC_WW_Pin1_4	444	449	PF00397	0.673
DOC_WW_Pin1_4	535	540	PF00397	0.698
LIG_14-3-3_CanoR_1	114	121	PF00244	0.446
LIG_14-3-3_CanoR_1	209	215	PF00244	0.678
LIG_14-3-3_CanoR_1	275	282	PF00244	0.467
LIG_14-3-3_CanoR_1	416	420	PF00244	0.646
LIG_14-3-3_CanoR_1	567	575	PF00244	0.477
LIG_14-3-3_CanoR_1	592	598	PF00244	0.627
LIG_Actin_WH2_2	324	339	PF00022	0.568
LIG_BIR_II_1	1	5	PF00653	0.522
LIG_BIR_III_4	439	443	PF00653	0.515
LIG_BRCT_BRCA1_1	434	438	PF00533	0.702
LIG_BRCT_BRCA1_1	489	493	PF00533	0.265
LIG_CtBP_PxDLS_1	425	429	PF00389	0.538
LIG_FHA_1	193	199	PF00498	0.300
LIG_FHA_1	213	219	PF00498	0.487
LIG_FHA_1	265	271	PF00498	0.479
LIG_FHA_1	275	281	PF00498	0.568
LIG_FHA_1	421	427	PF00498	0.714
LIG_FHA_1	512	518	PF00498	0.265
LIG_FHA_1	567	573	PF00498	0.569
LIG_FHA_2	127	133	PF00498	0.598
LIG_FHA_2	165	171	PF00498	0.460
LIG_FHA_2	603	609	PF00498	0.446
LIG_FHA_2	624	630	PF00498	0.776
LIG_LIR_Apic_2	435	441	PF02991	0.695
LIG_LIR_Apic_2	520	525	PF02991	0.411
LIG_LIR_Gen_1	124	134	PF02991	0.343
LIG_LIR_Nem_3	124	130	PF02991	0.343
LIG_LIR_Nem_3	155	159	PF02991	0.551
LIG_LIR_Nem_3	193	199	PF02991	0.446
LIG_LIR_Nem_3	490	495	PF02991	0.265
LIG_LIR_Nem_3	626	631	PF02991	0.534
LIG_MAD2	41	49	PF02301	0.553
LIG_MLH1_MIPbox_1	489	493	PF16413	0.265
LIG_PDZ_Class_2	655	660	PF00595	0.663
LIG_Pex14_1	161	165	PF04695	0.458
LIG_Pex14_1	518	522	PF04695	0.411
LIG_Pex14_2	196	200	PF04695	0.445
LIG_PTB_Apo_2	486	493	PF02174	0.404
LIG_SH2_CRK	363	367	PF00017	0.793
LIG_SH2_STAP1	363	367	PF00017	0.752
LIG_SH2_STAT5	281	284	PF00017	0.549
LIG_SH2_STAT5	505	508	PF00017	0.512
LIG_SH3_1	41	47	PF00018	0.559
LIG_SH3_1	452	458	PF00018	0.604
LIG_SH3_1	463	469	PF00018	0.689
LIG_SH3_2	389	394	PF14604	0.573
LIG_SH3_2	455	460	PF14604	0.740
LIG_SH3_3	131	137	PF00018	0.503
LIG_SH3_3	26	32	PF00018	0.593
LIG_SH3_3	265	271	PF00018	0.479
LIG_SH3_3	373	379	PF00018	0.636
LIG_SH3_3	386	392	PF00018	0.646
LIG_SH3_3	41	47	PF00018	0.454
LIG_SH3_3	452	458	PF00018	0.722
LIG_SH3_3	463	469	PF00018	0.570
LIG_TRAF2_1	605	608	PF00917	0.451
LIG_WRC_WIRS_1	544	549	PF05994	0.493
LIG_WW_2	136	139	PF00397	0.499
LIG_WW_3	419	423	PF00397	0.546
MOD_CDC14_SPxK_1	419	422	PF00782	0.790
MOD_CDK_SPxK_1	295	301	PF00069	0.454
MOD_CDK_SPxK_1	416	422	PF00069	0.801
MOD_CDK_SPxxK_3	444	451	PF00069	0.751
MOD_CK1_1	173	179	PF00069	0.474
MOD_CK1_1	2	8	PF00069	0.544
MOD_CK1_1	219	225	PF00069	0.651
MOD_CK1_1	284	290	PF00069	0.474
MOD_CK1_1	382	388	PF00069	0.815
MOD_CK1_1	447	453	PF00069	0.529
MOD_CK1_1	543	549	PF00069	0.682
MOD_CK1_1	643	649	PF00069	0.603
MOD_CK2_1	138	144	PF00069	0.488
MOD_CK2_1	236	242	PF00069	0.798
MOD_CK2_1	405	411	PF00069	0.553
MOD_CK2_1	443	449	PF00069	0.558
MOD_CK2_1	583	589	PF00069	0.454
MOD_CK2_1	602	608	PF00069	0.486
MOD_GlcNHglycan	218	221	PF01048	0.649
MOD_GlcNHglycan	233	236	PF01048	0.741
MOD_GlcNHglycan	338	341	PF01048	0.781
MOD_GlcNHglycan	345	348	PF01048	0.632
MOD_GlcNHglycan	402	405	PF01048	0.657
MOD_GlcNHglycan	407	410	PF01048	0.528
MOD_GlcNHglycan	548	551	PF01048	0.598
MOD_GlcNHglycan	564	567	PF01048	0.662
MOD_GlcNHglycan	569	572	PF01048	0.643
MOD_GlcNHglycan	642	645	PF01048	0.540
MOD_GlcNHglycan	92	95	PF01048	0.699
MOD_GSK3_1	166	173	PF00069	0.569
MOD_GSK3_1	186	193	PF00069	0.289
MOD_GSK3_1	2	9	PF00069	0.501
MOD_GSK3_1	210	217	PF00069	0.640
MOD_GSK3_1	219	226	PF00069	0.604
MOD_GSK3_1	227	234	PF00069	0.648
MOD_GSK3_1	23	30	PF00069	0.530
MOD_GSK3_1	293	300	PF00069	0.686
MOD_GSK3_1	332	339	PF00069	0.619
MOD_GSK3_1	343	350	PF00069	0.607
MOD_GSK3_1	416	423	PF00069	0.679
MOD_GSK3_1	443	450	PF00069	0.575
MOD_GSK3_1	535	542	PF00069	0.650
MOD_GSK3_1	562	569	PF00069	0.548
MOD_GSK3_1	629	636	PF00069	0.787
MOD_GSK3_1	90	97	PF00069	0.639
MOD_N-GLC_1	210	215	PF02516	0.471
MOD_N-GLC_1	416	421	PF02516	0.719
MOD_N-GLC_1	6	11	PF02516	0.499
MOD_NEK2_1	121	126	PF00069	0.461
MOD_NEK2_1	172	177	PF00069	0.479
MOD_NEK2_1	210	215	PF00069	0.612
MOD_NEK2_1	218	223	PF00069	0.682
MOD_NEK2_1	336	341	PF00069	0.587
MOD_NEK2_1	405	410	PF00069	0.652
MOD_NEK2_1	415	420	PF00069	0.605
MOD_NEK2_1	545	550	PF00069	0.632
MOD_NEK2_1	577	582	PF00069	0.419
MOD_NEK2_1	6	11	PF00069	0.499
MOD_PIKK_1	16	22	PF00454	0.528
MOD_PIKK_1	186	192	PF00454	0.628
MOD_PKA_2	113	119	PF00069	0.424
MOD_PKA_2	274	280	PF00069	0.621
MOD_PKA_2	322	328	PF00069	0.558
MOD_PKA_2	382	388	PF00069	0.777
MOD_PKA_2	415	421	PF00069	0.658
MOD_PKA_2	566	572	PF00069	0.587
MOD_PKA_2	593	599	PF00069	0.416
MOD_PKB_1	81	89	PF00069	0.481
MOD_Plk_1	205	211	PF00069	0.405
MOD_Plk_1	506	512	PF00069	0.265
MOD_Plk_1	575	581	PF00069	0.342
MOD_Plk_1	6	12	PF00069	0.494
MOD_Plk_1	623	629	PF00069	0.531
MOD_Plk_2-3	624	630	PF00069	0.529
MOD_Plk_4	173	179	PF00069	0.474
MOD_Plk_4	284	290	PF00069	0.483
MOD_Plk_4	513	519	PF00069	0.278
MOD_Plk_4	540	546	PF00069	0.724
MOD_Plk_4	643	649	PF00069	0.763
MOD_ProDKin_1	227	233	PF00069	0.564
MOD_ProDKin_1	254	260	PF00069	0.633
MOD_ProDKin_1	264	270	PF00069	0.467
MOD_ProDKin_1	281	287	PF00069	0.512
MOD_ProDKin_1	295	301	PF00069	0.446
MOD_ProDKin_1	31	37	PF00069	0.527
MOD_ProDKin_1	416	422	PF00069	0.646
MOD_ProDKin_1	444	450	PF00069	0.671
MOD_ProDKin_1	535	541	PF00069	0.697
MOD_SUMO_rev_2	182	189	PF00179	0.625
TRG_DiLeu_BaLyEn_6	466	471	PF01217	0.472
TRG_ENDOCYTIC_2	178	181	PF00928	0.500
TRG_ENDOCYTIC_2	363	366	PF00928	0.741
TRG_ER_diArg_1	178	180	PF00400	0.531
TRG_ER_diArg_1	245	248	PF00400	0.783
TRG_ER_diArg_1	40	42	PF00400	0.544
TRG_ER_diArg_1	451	453	PF00400	0.756
TRG_ER_diArg_1	592	595	PF00400	0.451
TRG_ER_diArg_1	80	83	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P572	Leptomonas seymouri	40%	100%
A0A3S7WPK2	Leishmania donovani	61%	100%
A4HSY6	Leishmania infantum	61%	100%
E9AKX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4QIY3	Leishmania major	60%	97%