2,4-dienoyl-coa reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2,4-dienoyl-coa reductase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H4Q6_LEIBR

TriTrypDb:

LbrM.06.0910 , LBRM2903_060016000

Length:

734

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A4H4Q6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Q6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	16
GO:0005488	binding	1	16
GO:0010181	FMN binding	4	16
GO:0016491	oxidoreductase activity	2	16
GO:0032553	ribonucleotide binding	3	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:0008670	2,4-dienoyl-CoA reductase (NADPH) activity	5	3
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	3
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.560
CLV_C14_Caspase3-7	705	709	PF00656	0.373
CLV_NRD_NRD_1	135	137	PF00675	0.235
CLV_NRD_NRD_1	219	221	PF00675	0.278
CLV_NRD_NRD_1	410	412	PF00675	0.411
CLV_NRD_NRD_1	432	434	PF00675	0.274
CLV_NRD_NRD_1	510	512	PF00675	0.256
CLV_NRD_NRD_1	541	543	PF00675	0.275
CLV_NRD_NRD_1	654	656	PF00675	0.274
CLV_PCSK_KEX2_1	137	139	PF00082	0.219
CLV_PCSK_KEX2_1	219	221	PF00082	0.258
CLV_PCSK_KEX2_1	432	434	PF00082	0.274
CLV_PCSK_KEX2_1	454	456	PF00082	0.372
CLV_PCSK_KEX2_1	510	512	PF00082	0.256
CLV_PCSK_KEX2_1	541	543	PF00082	0.275
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.273
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.372
CLV_PCSK_PC7_1	133	139	PF00082	0.217
CLV_PCSK_SKI1_1	25	29	PF00082	0.332
CLV_PCSK_SKI1_1	350	354	PF00082	0.247
CLV_PCSK_SKI1_1	406	410	PF00082	0.536
CLV_PCSK_SKI1_1	598	602	PF00082	0.313
CLV_PCSK_SKI1_1	655	659	PF00082	0.288
CLV_PCSK_SKI1_1	96	100	PF00082	0.299
DEG_APCC_DBOX_1	245	253	PF00400	0.484
DEG_APCC_KENBOX_2	458	462	PF00400	0.453
DEG_SPOP_SBC_1	12	16	PF00917	0.377
DOC_CKS1_1	26	31	PF01111	0.448
DOC_CYCLIN_RxL_1	347	355	PF00134	0.446
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.392
DOC_MAPK_gen_1	219	227	PF00069	0.486
DOC_MAPK_gen_1	406	416	PF00069	0.315
DOC_MAPK_gen_1	432	439	PF00069	0.274
DOC_MAPK_gen_1	471	480	PF00069	0.332
DOC_MAPK_gen_1	564	573	PF00069	0.256
DOC_MAPK_gen_1	592	602	PF00069	0.260
DOC_MAPK_gen_1	93	101	PF00069	0.510
DOC_MAPK_MEF2A_6	219	227	PF00069	0.451
DOC_MAPK_MEF2A_6	240	249	PF00069	0.409
DOC_MAPK_MEF2A_6	474	482	PF00069	0.325
DOC_MAPK_MEF2A_6	564	573	PF00069	0.256
DOC_PP2B_LxvP_1	525	528	PF13499	0.299
DOC_PP2B_LxvP_1	657	660	PF13499	0.153
DOC_SPAK_OSR1_1	240	244	PF12202	0.355
DOC_USP7_MATH_1	13	17	PF00917	0.430
DOC_USP7_MATH_1	21	25	PF00917	0.380
DOC_USP7_MATH_1	364	368	PF00917	0.510
DOC_USP7_MATH_1	518	522	PF00917	0.277
DOC_USP7_MATH_1	563	567	PF00917	0.304
DOC_USP7_UBL2_3	621	625	PF12436	0.361
DOC_USP7_UBL2_3	685	689	PF12436	0.394
DOC_WW_Pin1_4	143	148	PF00397	0.440
DOC_WW_Pin1_4	25	30	PF00397	0.261
DOC_WW_Pin1_4	284	289	PF00397	0.417
DOC_WW_Pin1_4	4	9	PF00397	0.613
DOC_WW_Pin1_4	585	590	PF00397	0.367
LIG_14-3-3_CanoR_1	115	125	PF00244	0.565
LIG_14-3-3_CanoR_1	138	147	PF00244	0.442
LIG_14-3-3_CanoR_1	154	158	PF00244	0.423
LIG_14-3-3_CanoR_1	240	246	PF00244	0.414
LIG_14-3-3_CanoR_1	311	318	PF00244	0.394
LIG_14-3-3_CanoR_1	388	396	PF00244	0.288
LIG_14-3-3_CanoR_1	411	415	PF00244	0.245
LIG_14-3-3_CanoR_1	474	482	PF00244	0.312
LIG_14-3-3_CanoR_1	510	518	PF00244	0.297
LIG_Actin_WH2_2	238	255	PF00022	0.430
LIG_APCC_ABBA_1	569	574	PF00400	0.256
LIG_BIR_III_4	211	215	PF00653	0.418
LIG_BIR_III_4	641	645	PF00653	0.386
LIG_BRCT_BRCA1_1	23	27	PF00533	0.361
LIG_BRCT_BRCA1_1	513	517	PF00533	0.304
LIG_FHA_1	112	118	PF00498	0.447
LIG_FHA_1	12	18	PF00498	0.370
LIG_FHA_1	222	228	PF00498	0.497
LIG_FHA_1	260	266	PF00498	0.436
LIG_FHA_1	328	334	PF00498	0.461
LIG_FHA_1	388	394	PF00498	0.302
LIG_FHA_1	423	429	PF00498	0.297
LIG_FHA_1	468	474	PF00498	0.275
LIG_FHA_1	617	623	PF00498	0.257
LIG_FHA_1	86	92	PF00498	0.418
LIG_FHA_2	206	212	PF00498	0.482
LIG_FHA_2	395	401	PF00498	0.201
LIG_FHA_2	436	442	PF00498	0.278
LIG_FHA_2	485	491	PF00498	0.302
LIG_HOMEOBOX	681	684	PF00046	0.377
LIG_LIR_Apic_2	156	162	PF02991	0.512
LIG_LIR_Gen_1	171	180	PF02991	0.458
LIG_LIR_Gen_1	460	468	PF02991	0.246
LIG_LIR_Gen_1	678	688	PF02991	0.349
LIG_LIR_LC3C_4	522	527	PF02991	0.214
LIG_LIR_Nem_3	171	176	PF02991	0.467
LIG_LIR_Nem_3	182	188	PF02991	0.406
LIG_LIR_Nem_3	24	30	PF02991	0.284
LIG_LIR_Nem_3	460	465	PF02991	0.205
LIG_LIR_Nem_3	697	701	PF02991	0.346
LIG_PCNA_PIPBox_1	63	72	PF02747	0.430
LIG_PCNA_yPIPBox_3	377	388	PF02747	0.321
LIG_PDZ_Class_2	729	734	PF00595	0.330
LIG_PTB_Apo_2	37	44	PF02174	0.510
LIG_PTB_Apo_2	670	677	PF02174	0.389
LIG_PTB_Phospho_1	37	43	PF10480	0.510
LIG_PTB_Phospho_1	670	676	PF10480	0.354
LIG_REV1ctd_RIR_1	67	77	PF16727	0.473
LIG_SH2_CRK	159	163	PF00017	0.418
LIG_SH2_CRK	43	47	PF00017	0.418
LIG_SH2_CRK	462	466	PF00017	0.193
LIG_SH2_GRB2like	48	51	PF00017	0.417
LIG_SH2_SRC	295	298	PF00017	0.510
LIG_SH2_SRC	728	731	PF00017	0.333
LIG_SH2_STAP1	173	177	PF00017	0.473
LIG_SH2_STAT3	384	387	PF00017	0.355
LIG_SH2_STAT3	399	402	PF00017	0.347
LIG_SH2_STAT5	123	126	PF00017	0.525
LIG_SH2_STAT5	168	171	PF00017	0.425
LIG_SH2_STAT5	295	298	PF00017	0.449
LIG_SH2_STAT5	358	361	PF00017	0.506
LIG_SH2_STAT5	48	51	PF00017	0.417
LIG_SH2_STAT5	572	575	PF00017	0.272
LIG_SH2_STAT5	701	704	PF00017	0.349
LIG_SH2_STAT5	710	713	PF00017	0.554
LIG_SH3_2	149	154	PF14604	0.440
LIG_SH3_3	146	152	PF00018	0.418
LIG_SH3_3	185	191	PF00018	0.510
LIG_SH3_3	315	321	PF00018	0.405
LIG_SH3_3	345	351	PF00018	0.516
LIG_SUMO_SIM_anti_2	413	418	PF11976	0.299
LIG_TRAF2_1	487	490	PF00917	0.372
LIG_WRC_WIRS_1	101	106	PF05994	0.510
LIG_WRC_WIRS_1	555	560	PF05994	0.386
MOD_CDK_SPxK_1	25	31	PF00069	0.386
MOD_CDK_SPxxK_3	585	592	PF00069	0.256
MOD_CK1_1	111	117	PF00069	0.461
MOD_CK1_1	142	148	PF00069	0.429
MOD_CK1_1	193	199	PF00069	0.490
MOD_CK1_1	367	373	PF00069	0.403
MOD_CK1_1	699	705	PF00069	0.397
MOD_CK1_1	7	13	PF00069	0.691
MOD_CK2_1	168	174	PF00069	0.448
MOD_CK2_1	255	261	PF00069	0.404
MOD_CK2_1	333	339	PF00069	0.344
MOD_CK2_1	394	400	PF00069	0.311
MOD_CK2_1	435	441	PF00069	0.277
MOD_CK2_1	484	490	PF00069	0.341
MOD_CK2_1	581	587	PF00069	0.256
MOD_Cter_Amidation	539	542	PF01082	0.275
MOD_GlcNHglycan	141	144	PF01048	0.268
MOD_GlcNHglycan	203	206	PF01048	0.273
MOD_GlcNHglycan	271	274	PF01048	0.268
MOD_GlcNHglycan	292	295	PF01048	0.306
MOD_GSK3_1	139	146	PF00069	0.420
MOD_GSK3_1	17	24	PF00069	0.374
MOD_GSK3_1	201	208	PF00069	0.512
MOD_GSK3_1	227	234	PF00069	0.470
MOD_GSK3_1	255	262	PF00069	0.394
MOD_GSK3_1	284	291	PF00069	0.428
MOD_GSK3_1	327	334	PF00069	0.501
MOD_GSK3_1	422	429	PF00069	0.305
MOD_GSK3_1	563	570	PF00069	0.409
MOD_GSK3_1	581	588	PF00069	0.319
MOD_GSK3_1	7	14	PF00069	0.607
MOD_GSK3_1	702	709	PF00069	0.355
MOD_N-GLC_1	278	283	PF02516	0.269
MOD_N-GLC_1	672	677	PF02516	0.255
MOD_N-GLC_2	377	379	PF02516	0.297
MOD_NEK2_1	1	6	PF00069	0.514
MOD_NEK2_1	11	16	PF00069	0.415
MOD_NEK2_1	201	206	PF00069	0.448
MOD_NEK2_1	221	226	PF00069	0.321
MOD_NEK2_1	241	246	PF00069	0.415
MOD_NEK2_1	259	264	PF00069	0.498
MOD_NEK2_1	269	274	PF00069	0.406
MOD_NEK2_1	277	282	PF00069	0.380
MOD_NEK2_1	301	306	PF00069	0.438
MOD_NEK2_1	333	338	PF00069	0.344
MOD_NEK2_1	473	478	PF00069	0.269
MOD_NEK2_1	533	538	PF00069	0.255
MOD_NEK2_1	86	91	PF00069	0.420
MOD_NEK2_2	696	701	PF00069	0.504
MOD_PIKK_1	616	622	PF00454	0.221
MOD_PK_1	474	480	PF00069	0.386
MOD_PKA_1	510	516	PF00069	0.256
MOD_PKA_2	111	117	PF00069	0.453
MOD_PKA_2	153	159	PF00069	0.553
MOD_PKA_2	310	316	PF00069	0.469
MOD_PKA_2	387	393	PF00069	0.290
MOD_PKA_2	410	416	PF00069	0.386
MOD_PKA_2	473	479	PF00069	0.283
MOD_PKA_2	510	516	PF00069	0.256
MOD_PKA_2	563	569	PF00069	0.255
MOD_PKA_2	706	712	PF00069	0.457
MOD_Plk_1	221	227	PF00069	0.512
MOD_Plk_1	278	284	PF00069	0.509
MOD_Plk_1	367	373	PF00069	0.428
MOD_Plk_1	435	441	PF00069	0.253
MOD_Plk_1	567	573	PF00069	0.438
MOD_Plk_1	627	633	PF00069	0.169
MOD_Plk_1	672	678	PF00069	0.284
MOD_Plk_1	696	702	PF00069	0.396
MOD_Plk_2-3	581	587	PF00069	0.196
MOD_Plk_4	193	199	PF00069	0.521
MOD_Plk_4	333	339	PF00069	0.344
MOD_Plk_4	426	432	PF00069	0.276
MOD_Plk_4	435	441	PF00069	0.278
MOD_Plk_4	554	560	PF00069	0.249
MOD_Plk_4	581	587	PF00069	0.386
MOD_Plk_4	598	604	PF00069	0.326
MOD_Plk_4	627	633	PF00069	0.253
MOD_Plk_4	660	666	PF00069	0.312
MOD_Plk_4	675	681	PF00069	0.349
MOD_Plk_4	7	13	PF00069	0.507
MOD_ProDKin_1	143	149	PF00069	0.440
MOD_ProDKin_1	25	31	PF00069	0.261
MOD_ProDKin_1	284	290	PF00069	0.417
MOD_ProDKin_1	4	10	PF00069	0.611
MOD_ProDKin_1	585	591	PF00069	0.367
TRG_DiLeu_BaEn_1	581	586	PF01217	0.386
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.427
TRG_ENDOCYTIC_2	173	176	PF00928	0.473
TRG_ENDOCYTIC_2	462	465	PF00928	0.245
TRG_ENDOCYTIC_2	48	51	PF00928	0.417
TRG_ENDOCYTIC_2	681	684	PF00928	0.398
TRG_ER_diArg_1	219	221	PF00400	0.457
TRG_ER_diArg_1	431	433	PF00400	0.274
TRG_ER_diArg_1	509	511	PF00400	0.256
TRG_ER_diArg_1	541	543	PF00400	0.275
TRG_NLS_MonoExtN_4	133	140	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	350	355	PF00026	0.250
TRG_Pf-PMV_PEXEL_1	471	475	PF00026	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P302	Leptomonas seymouri	32%	100%
A0A0N0P5L6	Leptomonas seymouri	84%	100%
A0A0S4JCH5	Bodo saltans	54%	100%
A0A0S4JST7	Bodo saltans	29%	100%
A0A1X0NKW1	Trypanosomatidae	67%	100%
A0A1X0NU55	Trypanosomatidae	32%	100%
A0A3S5H5T4	Leishmania donovani	91%	100%
A0A3S7X6G9	Leishmania donovani	31%	100%
A4HLD7	Leishmania braziliensis	31%	100%
A4HSY5	Leishmania infantum	91%	100%
A4I8U6	Leishmania infantum	32%	100%
A4J778	Desulforamulus reducens (strain ATCC BAA-1160 / DSM 100696 / MI-1)	28%	100%
C9ZTL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9AKX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B3R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
G9F1Y9	Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679)	28%	100%
O87278	Rhizobium meliloti (strain 1021)	26%	100%
P16099	Methylophilus methylotrophus	25%	100%
P19410	Clostridium scindens (strain JCM 10418 / VPI 12708)	28%	100%
P32370	Clostridium scindens (strain JCM 10418 / VPI 12708)	28%	100%
P32382	Thermoanaerobacter brockii	28%	100%
P42593	Escherichia coli (strain K12)	32%	100%
Q4Q4A9	Leishmania major	32%	100%
Q4QIY4	Leishmania major	92%	100%
V5AR23	Trypanosoma cruzi	32%	100%
V5BNI9	Trypanosoma cruzi	69%	100%