IQ and ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4Q5_LEIBR

TriTrypDb:

LbrM.06.0900 , LBRM2903_060015800

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Q5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.511
CLV_NRD_NRD_1	141	143	PF00675	0.612
CLV_NRD_NRD_1	204	206	PF00675	0.429
CLV_NRD_NRD_1	447	449	PF00675	0.545
CLV_PCSK_SKI1_1	149	153	PF00082	0.527
CLV_PCSK_SKI1_1	4	8	PF00082	0.481
DEG_APCC_DBOX_1	37	45	PF00400	0.459
DEG_APCC_DBOX_1	407	415	PF00400	0.661
DEG_SPOP_SBC_1	354	358	PF00917	0.561
DEG_SPOP_SBC_1	377	381	PF00917	0.543
DOC_CYCLIN_RxL_1	1	9	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	455	461	PF00134	0.521
DOC_MAPK_gen_1	104	111	PF00069	0.464
DOC_MAPK_MEF2A_6	104	113	PF00069	0.462
DOC_MAPK_MEF2A_6	226	234	PF00069	0.450
DOC_PP2B_LxvP_1	170	173	PF13499	0.600
DOC_PP2B_LxvP_1	196	199	PF13499	0.426
DOC_PP2B_LxvP_1	374	377	PF13499	0.686
DOC_USP7_MATH_1	184	188	PF00917	0.421
DOC_USP7_MATH_1	296	300	PF00917	0.726
DOC_USP7_MATH_1	347	351	PF00917	0.702
DOC_USP7_MATH_1	354	358	PF00917	0.627
DOC_USP7_MATH_1	377	381	PF00917	0.547
DOC_USP7_MATH_1	437	441	PF00917	0.649
DOC_USP7_MATH_1	461	465	PF00917	0.518
DOC_USP7_UBL2_3	145	149	PF12436	0.574
DOC_WW_Pin1_4	258	263	PF00397	0.811
DOC_WW_Pin1_4	454	459	PF00397	0.524
LIG_14-3-3_CanoR_1	104	112	PF00244	0.597
LIG_14-3-3_CanoR_1	30	37	PF00244	0.587
LIG_14-3-3_CanoR_1	448	458	PF00244	0.673
LIG_AP2alpha_2	366	368	PF02296	0.706
LIG_APCC_ABBA_1	110	115	PF00400	0.582
LIG_CaM_IQ_9	213	228	PF13499	0.554
LIG_Clathr_ClatBox_1	110	114	PF01394	0.467
LIG_FHA_1	104	110	PF00498	0.540
LIG_FHA_1	127	133	PF00498	0.588
LIG_FHA_1	135	141	PF00498	0.581
LIG_FHA_1	155	161	PF00498	0.252
LIG_FHA_1	213	219	PF00498	0.466
LIG_FHA_1	450	456	PF00498	0.536
LIG_FHA_1	91	97	PF00498	0.551
LIG_LIR_Gen_1	150	159	PF02991	0.382
LIG_LIR_Gen_1	365	376	PF02991	0.707
LIG_LIR_Gen_1	97	107	PF02991	0.331
LIG_LIR_Nem_3	157	161	PF02991	0.336
LIG_LIR_Nem_3	219	225	PF02991	0.567
LIG_LIR_Nem_3	365	371	PF02991	0.701
LIG_LIR_Nem_3	49	55	PF02991	0.458
LIG_LIR_Nem_3	97	103	PF02991	0.331
LIG_MYND_1	258	262	PF01753	0.827
LIG_NRBOX	40	46	PF00104	0.562
LIG_SH2_CRK	100	104	PF00017	0.342
LIG_SH2_CRK	222	226	PF00017	0.633
LIG_SH2_CRK	332	336	PF00017	0.754
LIG_SH2_CRK	48	52	PF00017	0.456
LIG_SH2_NCK_1	168	172	PF00017	0.531
LIG_SH2_NCK_1	332	336	PF00017	0.754
LIG_SH2_NCK_1	48	52	PF00017	0.490
LIG_SH2_PTP2	158	161	PF00017	0.295
LIG_SH2_STAP1	168	172	PF00017	0.565
LIG_SH2_STAP1	48	52	PF00017	0.524
LIG_SH2_STAP1	80	84	PF00017	0.572
LIG_SH2_STAT3	308	311	PF00017	0.545
LIG_SH2_STAT5	131	134	PF00017	0.584
LIG_SH2_STAT5	158	161	PF00017	0.428
LIG_SH2_STAT5	168	171	PF00017	0.535
LIG_SH2_STAT5	55	58	PF00017	0.416
LIG_SH2_STAT5	64	67	PF00017	0.482
LIG_SH2_STAT5	95	98	PF00017	0.331
LIG_SH3_3	178	184	PF00018	0.526
LIG_SH3_3	300	306	PF00018	0.704
LIG_SH3_3	316	322	PF00018	0.675
LIG_SH3_3	337	343	PF00018	0.717
LIG_SH3_3	391	397	PF00018	0.587
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.583
LIG_SUMO_SIM_anti_2	157	163	PF11976	0.526
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.461
LIG_TRAF2_1	112	115	PF00917	0.347
LIG_TRAF2_1	239	242	PF00917	0.393
LIG_TYR_ITIM	220	225	PF00017	0.624
LIG_WW_3	182	186	PF00397	0.401
MOD_CK1_1	32	38	PF00069	0.583
MOD_CK1_1	350	356	PF00069	0.727
MOD_CK1_1	357	363	PF00069	0.665
MOD_CK1_1	438	444	PF00069	0.782
MOD_CK1_1	451	457	PF00069	0.506
MOD_CK2_1	138	144	PF00069	0.598
MOD_CK2_1	184	190	PF00069	0.638
MOD_GlcNHglycan	186	189	PF01048	0.639
MOD_GlcNHglycan	222	225	PF01048	0.576
MOD_GlcNHglycan	245	248	PF01048	0.725
MOD_GlcNHglycan	298	301	PF01048	0.827
MOD_GlcNHglycan	349	352	PF01048	0.727
MOD_GlcNHglycan	357	360	PF01048	0.785
MOD_GlcNHglycan	362	365	PF01048	0.758
MOD_GlcNHglycan	417	420	PF01048	0.505
MOD_GlcNHglycan	463	466	PF01048	0.516
MOD_GlcNHglycan	76	79	PF01048	0.486
MOD_GSK3_1	134	141	PF00069	0.539
MOD_GSK3_1	184	191	PF00069	0.421
MOD_GSK3_1	334	341	PF00069	0.773
MOD_GSK3_1	350	357	PF00069	0.770
MOD_GSK3_1	450	457	PF00069	0.623
MOD_GSK3_1	70	77	PF00069	0.585
MOD_GSK3_1	78	85	PF00069	0.574
MOD_GSK3_1	90	97	PF00069	0.592
MOD_LATS_1	446	452	PF00433	0.543
MOD_N-GLC_1	296	301	PF02516	0.783
MOD_N-GLC_1	82	87	PF02516	0.566
MOD_NEK2_1	154	159	PF00069	0.555
MOD_NEK2_1	189	194	PF00069	0.559
MOD_NEK2_1	29	34	PF00069	0.647
MOD_NEK2_1	420	425	PF00069	0.514
MOD_NEK2_1	70	75	PF00069	0.507
MOD_NEK2_2	126	131	PF00069	0.623
MOD_PKA_1	448	454	PF00069	0.544
MOD_PKA_2	103	109	PF00069	0.520
MOD_PKA_2	184	190	PF00069	0.638
MOD_PKA_2	220	226	PF00069	0.510
MOD_PKA_2	29	35	PF00069	0.629
MOD_PKA_2	461	467	PF00069	0.587
MOD_PKA_2	65	71	PF00069	0.486
MOD_Plk_1	126	132	PF00069	0.606
MOD_Plk_1	149	155	PF00069	0.543
MOD_Plk_1	166	172	PF00069	0.553
MOD_Plk_1	189	195	PF00069	0.642
MOD_Plk_1	211	217	PF00069	0.491
MOD_Plk_4	126	132	PF00069	0.595
MOD_Plk_4	154	160	PF00069	0.456
MOD_Plk_4	177	183	PF00069	0.513
MOD_Plk_4	387	393	PF00069	0.760
MOD_ProDKin_1	258	264	PF00069	0.810
MOD_ProDKin_1	454	460	PF00069	0.524
MOD_SUMO_rev_2	174	180	PF00179	0.589
MOD_SUMO_rev_2	190	199	PF00179	0.575
MOD_SUMO_rev_2	271	277	PF00179	0.583
TRG_DiLeu_BaEn_1	114	119	PF01217	0.511
TRG_DiLeu_BaEn_1	40	45	PF01217	0.476
TRG_DiLeu_BaEn_1	9	14	PF01217	0.453
TRG_DiLeu_BaEn_4	127	133	PF01217	0.373
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.561
TRG_DiLeu_LyEn_5	40	45	PF01217	0.558
TRG_ENDOCYTIC_2	100	103	PF00928	0.334
TRG_ENDOCYTIC_2	158	161	PF00928	0.324
TRG_ENDOCYTIC_2	222	225	PF00928	0.632
TRG_ENDOCYTIC_2	48	51	PF00928	0.455
TRG_ER_diArg_1	408	411	PF00400	0.661
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKD5	Leptomonas seymouri	61%	100%
A0A3R7KW02	Trypanosoma rangeli	33%	100%
A0A3S5H5T3	Leishmania donovani	73%	100%
A4HSY4	Leishmania infantum	73%	100%
E9AKX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QIY5	Leishmania major	73%	100%
V5BXU6	Trypanosoma cruzi	31%	100%