Aminoacyl-tRNA hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-tRNA hydrolase, putative

Species:

Leishmania braziliensis

UniProt:

A4H4Q4_LEIBR

TriTrypDb:

LbrM.06.0890 , LBRM2903_060015700

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	9
GO:0005739	mitochondrion	5	2
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4H4Q4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Q4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004045	aminoacyl-tRNA hydrolase activity	5	14
GO:0016787	hydrolase activity	2	14
GO:0016788	hydrolase activity, acting on ester bonds	3	14
GO:0052689	carboxylic ester hydrolase activity	4	14
GO:0140098	catalytic activity, acting on RNA	3	14
GO:0140101	catalytic activity, acting on a tRNA	4	14
GO:0140640	catalytic activity, acting on a nucleic acid	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	94	96	PF00675	0.247
CLV_PCSK_SKI1_1	156	160	PF00082	0.246
CLV_PCSK_SKI1_1	20	24	PF00082	0.521
CLV_PCSK_SKI1_1	215	219	PF00082	0.201
CLV_PCSK_SKI1_1	89	93	PF00082	0.317
CLV_PCSK_SKI1_1	96	100	PF00082	0.274
DEG_Nend_UBRbox_2	1	3	PF02207	0.424
DOC_PP4_FxxP_1	68	71	PF00568	0.597
DOC_USP7_MATH_1	122	126	PF00917	0.579
DOC_USP7_MATH_1	151	155	PF00917	0.417
DOC_USP7_MATH_1	193	197	PF00917	0.495
DOC_USP7_MATH_1	53	57	PF00917	0.218
DOC_WW_Pin1_4	127	132	PF00397	0.502
DOC_WW_Pin1_4	9	14	PF00397	0.448
LIG_14-3-3_CanoR_1	76	82	PF00244	0.649
LIG_14-3-3_CanoR_1	9	13	PF00244	0.399
LIG_FHA_1	138	144	PF00498	0.537
LIG_FHA_1	212	218	PF00498	0.564
LIG_LIR_Apic_2	66	71	PF02991	0.596
LIG_LIR_Gen_1	14	23	PF02991	0.397
LIG_LIR_Nem_3	14	19	PF02991	0.389
LIG_MYND_1	133	137	PF01753	0.401
LIG_Pex14_1	142	146	PF04695	0.503
LIG_Pex14_2	42	46	PF04695	0.248
LIG_Pex14_2	50	54	PF04695	0.279
LIG_SH2_NCK_1	3	7	PF00017	0.347
LIG_SH2_STAP1	3	7	PF00017	0.428
LIG_SH2_STAT5	182	185	PF00017	0.481
LIG_SH3_3	174	180	PF00018	0.469
LIG_SH3_3	35	41	PF00018	0.416
LIG_SUMO_SIM_anti_2	56	61	PF11976	0.267
LIG_UBA3_1	167	172	PF00899	0.487
LIG_UBA3_1	57	61	PF00899	0.301
MOD_CK1_1	11	17	PF00069	0.394
MOD_CK1_1	152	158	PF00069	0.495
MOD_CK1_1	24	30	PF00069	0.449
MOD_CK2_1	24	30	PF00069	0.383
MOD_CMANNOS	142	145	PF00535	0.287
MOD_GlcNHglycan	124	127	PF01048	0.407
MOD_GlcNHglycan	151	154	PF01048	0.224
MOD_GlcNHglycan	23	26	PF01048	0.618
MOD_GSK3_1	122	129	PF00069	0.497
MOD_GSK3_1	5	12	PF00069	0.335
MOD_GSK3_1	77	84	PF00069	0.664
MOD_NEK2_1	63	68	PF00069	0.658
MOD_PIKK_1	187	193	PF00454	0.448
MOD_PKA_2	8	14	PF00069	0.390
MOD_Plk_4	11	17	PF00069	0.410
MOD_Plk_4	195	201	PF00069	0.446
MOD_Plk_4	53	59	PF00069	0.488
MOD_Plk_4	63	69	PF00069	0.631
MOD_ProDKin_1	127	133	PF00069	0.502
MOD_ProDKin_1	9	15	PF00069	0.444
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.201

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P574	Leptomonas seymouri	63%	100%
A0A1X0NKN2	Trypanosomatidae	50%	100%
A0A3Q8IED2	Leishmania donovani	29%	100%
A0A3R7N0D9	Trypanosoma rangeli	48%	100%
A0A3S7WPI5	Leishmania donovani	78%	100%
A4HIH3	Leishmania braziliensis	29%	100%
A4I5S0	Leishmania infantum	29%	100%
C9ZTL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AKW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
E9B115	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4Q751	Leishmania major	28%	100%
Q4QIY6	Leishmania major	76%	100%