Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4Q1_LEIBR

TriTrypDb:

LbrM.06.0860 , LBRM2903_060015400

Length:

749

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Q1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	192	194	PF00675	0.467
CLV_NRD_NRD_1	208	210	PF00675	0.511
CLV_NRD_NRD_1	241	243	PF00675	0.539
CLV_NRD_NRD_1	276	278	PF00675	0.682
CLV_NRD_NRD_1	374	376	PF00675	0.613
CLV_NRD_NRD_1	44	46	PF00675	0.616
CLV_NRD_NRD_1	493	495	PF00675	0.579
CLV_NRD_NRD_1	507	509	PF00675	0.420
CLV_NRD_NRD_1	615	617	PF00675	0.587
CLV_PCSK_KEX2_1	192	194	PF00082	0.467
CLV_PCSK_KEX2_1	208	210	PF00082	0.511
CLV_PCSK_KEX2_1	241	243	PF00082	0.532
CLV_PCSK_KEX2_1	374	376	PF00082	0.613
CLV_PCSK_KEX2_1	44	46	PF00082	0.573
CLV_PCSK_KEX2_1	492	494	PF00082	0.482
CLV_PCSK_KEX2_1	507	509	PF00082	0.480
CLV_PCSK_KEX2_1	615	617	PF00082	0.587
CLV_PCSK_KEX2_1	684	686	PF00082	0.728
CLV_PCSK_KEX2_1	698	700	PF00082	0.657
CLV_PCSK_PC1ET2_1	684	686	PF00082	0.674
CLV_PCSK_PC1ET2_1	698	700	PF00082	0.535
CLV_PCSK_PC7_1	370	376	PF00082	0.607
CLV_PCSK_SKI1_1	11	15	PF00082	0.531
CLV_PCSK_SKI1_1	195	199	PF00082	0.564
CLV_PCSK_SKI1_1	219	223	PF00082	0.515
CLV_PCSK_SKI1_1	337	341	PF00082	0.448
CLV_PCSK_SKI1_1	427	431	PF00082	0.595
CLV_PCSK_SKI1_1	493	497	PF00082	0.485
CLV_PCSK_SKI1_1	508	512	PF00082	0.525
CLV_PCSK_SKI1_1	645	649	PF00082	0.572
CLV_PCSK_SKI1_1	675	679	PF00082	0.619
DEG_Nend_UBRbox_2	1	3	PF02207	0.577
DEG_SCF_FBW7_1	533	540	PF00400	0.522
DEG_SCF_FBW7_1	63	68	PF00400	0.535
DEG_SPOP_SBC_1	260	264	PF00917	0.546
DEG_SPOP_SBC_1	30	34	PF00917	0.564
DOC_ANK_TNKS_1	631	638	PF00023	0.554
DOC_CKS1_1	325	330	PF01111	0.475
DOC_CKS1_1	340	345	PF01111	0.556
DOC_CYCLIN_yCln2_LP_2	736	742	PF00134	0.443
DOC_MAPK_DCC_7	363	373	PF00069	0.507
DOC_MAPK_gen_1	374	380	PF00069	0.574
DOC_MAPK_gen_1	698	706	PF00069	0.496
DOC_PP1_RVXF_1	483	490	PF00149	0.478
DOC_PP2B_LxvP_1	151	154	PF13499	0.471
DOC_PP2B_LxvP_1	539	542	PF13499	0.520
DOC_PP2B_LxvP_1	567	570	PF13499	0.566
DOC_PP2B_LxvP_1	736	739	PF13499	0.443
DOC_PP4_FxxP_1	14	17	PF00568	0.517
DOC_USP7_MATH_1	29	33	PF00917	0.661
DOC_USP7_MATH_1	344	348	PF00917	0.509
DOC_USP7_MATH_1	422	426	PF00917	0.667
DOC_USP7_MATH_1	458	462	PF00917	0.639
DOC_USP7_MATH_1	47	51	PF00917	0.517
DOC_USP7_MATH_1	481	485	PF00917	0.411
DOC_USP7_MATH_1	527	531	PF00917	0.644
DOC_USP7_MATH_1	574	578	PF00917	0.641
DOC_USP7_MATH_1	65	69	PF00917	0.506
DOC_USP7_MATH_1	99	103	PF00917	0.561
DOC_WW_Pin1_4	305	310	PF00397	0.632
DOC_WW_Pin1_4	324	329	PF00397	0.421
DOC_WW_Pin1_4	339	344	PF00397	0.546
DOC_WW_Pin1_4	476	481	PF00397	0.513
DOC_WW_Pin1_4	523	528	PF00397	0.634
DOC_WW_Pin1_4	533	538	PF00397	0.578
DOC_WW_Pin1_4	61	66	PF00397	0.608
DOC_WW_Pin1_4	619	624	PF00397	0.647
DOC_WW_Pin1_4	74	79	PF00397	0.585
LIG_14-3-3_CanoR_1	117	122	PF00244	0.536
LIG_14-3-3_CanoR_1	177	184	PF00244	0.570
LIG_14-3-3_CanoR_1	261	266	PF00244	0.572
LIG_14-3-3_CanoR_1	275	281	PF00244	0.564
LIG_14-3-3_CanoR_1	302	306	PF00244	0.538
LIG_14-3-3_CanoR_1	374	379	PF00244	0.528
LIG_14-3-3_CanoR_1	45	53	PF00244	0.548
LIG_14-3-3_CanoR_1	507	517	PF00244	0.495
LIG_14-3-3_CanoR_1	522	527	PF00244	0.563
LIG_14-3-3_CanoR_1	556	564	PF00244	0.761
LIG_14-3-3_CanoR_1	615	623	PF00244	0.753
LIG_14-3-3_CanoR_1	69	78	PF00244	0.553
LIG_14-3-3_CanoR_1	718	727	PF00244	0.663
LIG_Actin_WH2_2	426	441	PF00022	0.506
LIG_APCC_ABBA_1	657	662	PF00400	0.523
LIG_BIR_III_2	477	481	PF00653	0.575
LIG_CtBP_PxDLS_1	564	568	PF00389	0.567
LIG_deltaCOP1_diTrp_1	387	391	PF00928	0.569
LIG_FHA_1	185	191	PF00498	0.467
LIG_FHA_1	260	266	PF00498	0.678
LIG_FHA_1	288	294	PF00498	0.685
LIG_FHA_1	302	308	PF00498	0.573
LIG_FHA_1	534	540	PF00498	0.529
LIG_FHA_1	58	64	PF00498	0.551
LIG_FHA_1	676	682	PF00498	0.525
LIG_FHA_1	701	707	PF00498	0.615
LIG_FHA_1	708	714	PF00498	0.497
LIG_FHA_1	733	739	PF00498	0.629
LIG_FHA_1	742	748	PF00498	0.534
LIG_FHA_2	50	56	PF00498	0.579
LIG_FHA_2	695	701	PF00498	0.519
LIG_Integrin_RGD_1	381	383	PF01839	0.536
LIG_LIR_Apic_2	160	166	PF02991	0.494
LIG_LIR_Gen_1	10	20	PF02991	0.444
LIG_LIR_Gen_1	327	338	PF02991	0.600
LIG_LIR_Gen_1	484	490	PF02991	0.440
LIG_LIR_Gen_1	88	99	PF02991	0.560
LIG_LIR_Nem_3	10	15	PF02991	0.490
LIG_LIR_Nem_3	25	30	PF02991	0.537
LIG_LIR_Nem_3	327	333	PF02991	0.545
LIG_LIR_Nem_3	387	392	PF02991	0.570
LIG_LIR_Nem_3	484	489	PF02991	0.444
LIG_LIR_Nem_3	88	94	PF02991	0.563
LIG_MYND_1	565	569	PF01753	0.572
LIG_NRBOX	514	520	PF00104	0.546
LIG_PDZ_Class_2	744	749	PF00595	0.577
LIG_Pex14_1	388	392	PF04695	0.497
LIG_Rb_pABgroove_1	14	22	PF01858	0.527
LIG_SH2_CRK	163	167	PF00017	0.613
LIG_SH2_CRK	244	248	PF00017	0.506
LIG_SH2_CRK	27	31	PF00017	0.547
LIG_SH2_CRK	91	95	PF00017	0.559
LIG_SH2_NCK_1	475	479	PF00017	0.594
LIG_SH2_SRC	20	23	PF00017	0.621
LIG_SH2_SRC	392	395	PF00017	0.422
LIG_SH2_SRC	475	478	PF00017	0.534
LIG_SH2_STAP1	244	248	PF00017	0.506
LIG_SH2_STAT5	392	395	PF00017	0.501
LIG_SH3_2	369	374	PF14604	0.490
LIG_SH3_3	118	124	PF00018	0.478
LIG_SH3_3	306	312	PF00018	0.721
LIG_SH3_3	322	328	PF00018	0.434
LIG_SH3_3	366	372	PF00018	0.552
LIG_SH3_3	567	573	PF00018	0.659
LIG_SH3_3	620	626	PF00018	0.720
LIG_SH3_3	75	81	PF00018	0.671
LIG_SUMO_SIM_anti_2	125	130	PF11976	0.396
LIG_SUMO_SIM_anti_2	223	236	PF11976	0.526
LIG_SUMO_SIM_par_1	223	237	PF11976	0.456
LIG_SUMO_SIM_par_1	303	308	PF11976	0.600
LIG_SUMO_SIM_par_1	702	707	PF11976	0.468
LIG_TRAF2_1	211	214	PF00917	0.507
LIG_TRAF2_1	35	38	PF00917	0.588
LIG_WRC_WIRS_1	501	506	PF05994	0.472
MOD_CDK_SPK_2	324	329	PF00069	0.536
MOD_CK1_1	108	114	PF00069	0.561
MOD_CK1_1	225	231	PF00069	0.442
MOD_CK1_1	276	282	PF00069	0.601
MOD_CK1_1	283	289	PF00069	0.598
MOD_CK1_1	32	38	PF00069	0.542
MOD_CK1_1	347	353	PF00069	0.574
MOD_CK1_1	49	55	PF00069	0.538
MOD_CK1_1	526	532	PF00069	0.600
MOD_CK1_1	631	637	PF00069	0.578
MOD_CK1_1	74	80	PF00069	0.565
MOD_CK1_1	98	104	PF00069	0.728
MOD_CK2_1	225	231	PF00069	0.475
MOD_CK2_1	31	37	PF00069	0.620
MOD_CK2_1	619	625	PF00069	0.581
MOD_CK2_1	694	700	PF00069	0.523
MOD_CMANNOS	388	391	PF00535	0.494
MOD_Cter_Amidation	42	45	PF01082	0.549
MOD_GlcNHglycan	101	104	PF01048	0.534
MOD_GlcNHglycan	172	175	PF01048	0.504
MOD_GlcNHglycan	244	247	PF01048	0.610
MOD_GlcNHglycan	344	347	PF01048	0.661
MOD_GlcNHglycan	412	415	PF01048	0.624
MOD_GlcNHglycan	418	421	PF01048	0.575
MOD_GlcNHglycan	424	427	PF01048	0.509
MOD_GlcNHglycan	49	52	PF01048	0.664
MOD_GlcNHglycan	533	536	PF01048	0.676
MOD_GlcNHglycan	581	584	PF01048	0.669
MOD_GlcNHglycan	589	593	PF01048	0.490
MOD_GlcNHglycan	633	636	PF01048	0.662
MOD_GlcNHglycan	649	652	PF01048	0.658
MOD_GlcNHglycan	694	697	PF01048	0.652
MOD_GlcNHglycan	74	77	PF01048	0.563
MOD_GlcNHglycan	97	100	PF01048	0.533
MOD_GSK3_1	103	110	PF00069	0.535
MOD_GSK3_1	140	147	PF00069	0.580
MOD_GSK3_1	176	183	PF00069	0.479
MOD_GSK3_1	276	283	PF00069	0.682
MOD_GSK3_1	301	308	PF00069	0.768
MOD_GSK3_1	311	318	PF00069	0.527
MOD_GSK3_1	410	417	PF00069	0.641
MOD_GSK3_1	464	471	PF00069	0.695
MOD_GSK3_1	521	528	PF00069	0.487
MOD_GSK3_1	533	540	PF00069	0.513
MOD_GSK3_1	554	561	PF00069	0.734
MOD_GSK3_1	57	64	PF00069	0.732
MOD_GSK3_1	575	582	PF00069	0.614
MOD_GSK3_1	610	617	PF00069	0.741
MOD_GSK3_1	643	650	PF00069	0.692
MOD_GSK3_1	70	77	PF00069	0.556
MOD_GSK3_1	95	102	PF00069	0.531
MOD_N-GLC_1	70	75	PF02516	0.540
MOD_NEK2_1	105	110	PF00069	0.454
MOD_NEK2_1	222	227	PF00069	0.549
MOD_NEK2_1	596	601	PF00069	0.538
MOD_NEK2_1	665	670	PF00069	0.630
MOD_NEK2_1	692	697	PF00069	0.536
MOD_NEK2_1	72	77	PF00069	0.593
MOD_NEK2_1	732	737	PF00069	0.359
MOD_NEK2_1	85	90	PF00069	0.620
MOD_NEK2_2	610	615	PF00069	0.631
MOD_PIKK_1	212	218	PF00454	0.429
MOD_PIKK_1	508	514	PF00454	0.518
MOD_PIKK_1	558	564	PF00454	0.557
MOD_PK_1	117	123	PF00069	0.466
MOD_PK_1	374	380	PF00069	0.597
MOD_PKA_1	374	380	PF00069	0.574
MOD_PKA_1	615	621	PF00069	0.581
MOD_PKA_2	139	145	PF00069	0.546
MOD_PKA_2	176	182	PF00069	0.392
MOD_PKA_2	260	266	PF00069	0.552
MOD_PKA_2	276	282	PF00069	0.554
MOD_PKA_2	301	307	PF00069	0.539
MOD_PKA_2	374	380	PF00069	0.513
MOD_PKA_2	521	527	PF00069	0.471
MOD_PKA_2	555	561	PF00069	0.758
MOD_PKA_2	614	620	PF00069	0.620
MOD_PKA_2	631	637	PF00069	0.759
MOD_PKA_2	653	659	PF00069	0.587
MOD_PKA_2	692	698	PF00069	0.613
MOD_Plk_1	212	218	PF00069	0.491
MOD_Plk_1	222	228	PF00069	0.530
MOD_Plk_1	300	306	PF00069	0.642
MOD_Plk_1	597	603	PF00069	0.557
MOD_Plk_1	673	679	PF00069	0.527
MOD_Plk_2-3	315	321	PF00069	0.463
MOD_Plk_2-3	37	43	PF00069	0.616
MOD_Plk_4	15	21	PF00069	0.529
MOD_Plk_4	158	164	PF00069	0.460
MOD_Plk_4	222	228	PF00069	0.428
MOD_Plk_4	4	10	PF00069	0.514
MOD_Plk_4	597	603	PF00069	0.513
MOD_Plk_4	655	661	PF00069	0.551
MOD_Plk_4	665	671	PF00069	0.604
MOD_Plk_4	732	738	PF00069	0.357
MOD_ProDKin_1	305	311	PF00069	0.628
MOD_ProDKin_1	324	330	PF00069	0.421
MOD_ProDKin_1	339	345	PF00069	0.553
MOD_ProDKin_1	476	482	PF00069	0.508
MOD_ProDKin_1	523	529	PF00069	0.639
MOD_ProDKin_1	533	539	PF00069	0.578
MOD_ProDKin_1	61	67	PF00069	0.608
MOD_ProDKin_1	619	625	PF00069	0.649
MOD_ProDKin_1	74	80	PF00069	0.580
MOD_SUMO_rev_2	576	582	PF00179	0.553
MOD_SUMO_rev_2	631	639	PF00179	0.550
TRG_DiLeu_BaEn_1	213	218	PF01217	0.510
TRG_DiLeu_BaEn_4	213	219	PF01217	0.426
TRG_DiLeu_BaLyEn_6	544	549	PF01217	0.658
TRG_ENDOCYTIC_2	244	247	PF00928	0.504
TRG_ENDOCYTIC_2	27	30	PF00928	0.545
TRG_ENDOCYTIC_2	392	395	PF00928	0.569
TRG_ENDOCYTIC_2	91	94	PF00928	0.559
TRG_ER_diArg_1	192	195	PF00400	0.472
TRG_ER_diArg_1	207	209	PF00400	0.513
TRG_ER_diArg_1	241	243	PF00400	0.530
TRG_ER_diArg_1	373	375	PF00400	0.610
TRG_ER_diArg_1	492	494	PF00400	0.580
TRG_ER_diArg_1	506	508	PF00400	0.419
TRG_ER_diArg_1	614	616	PF00400	0.582
TRG_Pf-PMV_PEXEL_1	291	296	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4D6	Leptomonas seymouri	33%	100%
A0A3S7WPJ7	Leishmania donovani	62%	96%
A4HSY1	Leishmania infantum	61%	96%
E9AKW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	99%
Q4QIY8	Leishmania major	60%	99%