Putative arginine N-methyltransferase, type III

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein arginine n-methyltransferase 7

Species:

Leishmania braziliensis

UniProt:

A4H4P9_LEIBR

TriTrypDb:

LbrM.06.0840 , LBRM2903_060015200

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4P9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4P9

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008213	protein alkylation	5	12
GO:0009987	cellular process	1	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018195	peptidyl-arginine modification	6	12
GO:0018216	peptidyl-arginine methylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0032259	methylation	2	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0034969	histone arginine methylation	6	1
GO:0035246	peptidyl-arginine N-methylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016273	arginine N-methyltransferase activity	6	12
GO:0016274	protein-arginine N-methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0035241	protein-arginine omega-N monomethyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	307	309	PF00675	0.450
CLV_NRD_NRD_1	87	89	PF00675	0.494
CLV_PCSK_FUR_1	85	89	PF00082	0.439
CLV_PCSK_KEX2_1	307	309	PF00082	0.418
CLV_PCSK_KEX2_1	87	89	PF00082	0.444
CLV_PCSK_SKI1_1	312	316	PF00082	0.509
DEG_Kelch_Keap1_1	380	385	PF01344	0.342
DOC_CYCLIN_RxL_1	175	186	PF00134	0.356
DOC_CYCLIN_yCln2_LP_2	292	298	PF00134	0.290
DOC_MAPK_DCC_7	291	301	PF00069	0.435
DOC_MAPK_DCC_7	85	94	PF00069	0.251
DOC_MAPK_gen_1	312	319	PF00069	0.468
DOC_MAPK_gen_1	85	94	PF00069	0.362
DOC_MAPK_MEF2A_6	85	94	PF00069	0.251
DOC_PP2B_PxIxI_1	195	201	PF00149	0.454
DOC_PP4_FxxP_1	34	37	PF00568	0.529
DOC_PP4_FxxP_1	81	84	PF00568	0.356
DOC_USP7_MATH_1	124	128	PF00917	0.523
DOC_USP7_MATH_1	18	22	PF00917	0.655
DOC_USP7_MATH_1	253	257	PF00917	0.473
DOC_USP7_MATH_1	321	325	PF00917	0.316
DOC_USP7_MATH_1	392	396	PF00917	0.458
DOC_USP7_UBL2_3	145	149	PF12436	0.478
DOC_WW_Pin1_4	185	190	PF00397	0.484
DOC_WW_Pin1_4	43	48	PF00397	0.653
LIG_14-3-3_CanoR_1	283	288	PF00244	0.313
LIG_14-3-3_CanoR_1	307	312	PF00244	0.495
LIG_14-3-3_CanoR_1	397	403	PF00244	0.373
LIG_Actin_WH2_2	210	228	PF00022	0.240
LIG_Actin_WH2_2	73	89	PF00022	0.389
LIG_BRCT_BRCA1_1	200	204	PF00533	0.422
LIG_BRCT_BRCA1_1	272	276	PF00533	0.308
LIG_BRCT_BRCA1_1	285	289	PF00533	0.310
LIG_BRCT_BRCA1_1	385	389	PF00533	0.339
LIG_BRCT_BRCA1_2	272	278	PF00533	0.303
LIG_Clathr_ClatBox_1	298	302	PF01394	0.280
LIG_EVH1_1	192	196	PF00568	0.478
LIG_FHA_1	204	210	PF00498	0.289
LIG_FHA_1	226	232	PF00498	0.337
LIG_FHA_1	269	275	PF00498	0.323
LIG_FHA_2	186	192	PF00498	0.500
LIG_FHA_2	335	341	PF00498	0.366
LIG_FHA_2	343	349	PF00498	0.350
LIG_GBD_Chelix_1	199	207	PF00786	0.254
LIG_LIR_Gen_1	112	123	PF02991	0.394
LIG_LIR_Gen_1	286	297	PF02991	0.223
LIG_LIR_Gen_1	99	109	PF02991	0.342
LIG_LIR_Nem_3	112	118	PF02991	0.396
LIG_LIR_Nem_3	201	207	PF02991	0.492
LIG_LIR_Nem_3	255	260	PF02991	0.342
LIG_LIR_Nem_3	286	292	PF02991	0.300
LIG_LIR_Nem_3	310	314	PF02991	0.441
LIG_Pex14_2	311	315	PF04695	0.483
LIG_Pex14_2	72	76	PF04695	0.391
LIG_SH2_CRK	115	119	PF00017	0.451
LIG_SH2_CRK	239	243	PF00017	0.266
LIG_SH2_GRB2like	114	117	PF00017	0.440
LIG_SH2_STAT3	235	238	PF00017	0.193
LIG_SH2_STAT5	216	219	PF00017	0.294
LIG_SH2_STAT5	404	407	PF00017	0.507
LIG_SH3_3	190	196	PF00018	0.439
LIG_SUMO_SIM_par_1	150	155	PF11976	0.411
LIG_SUMO_SIM_par_1	205	212	PF11976	0.340
LIG_SUMO_SIM_par_1	297	302	PF11976	0.296
LIG_SUMO_SIM_par_1	315	320	PF11976	0.281
LIG_UBA3_1	138	145	PF00899	0.478
LIG_WW_3	82	86	PF00397	0.441
MOD_CK1_1	3	9	PF00069	0.688
MOD_CK1_1	380	386	PF00069	0.477
MOD_CK1_1	43	49	PF00069	0.482
MOD_CK1_1	55	61	PF00069	0.471
MOD_CK2_1	334	340	PF00069	0.370
MOD_CK2_1	342	348	PF00069	0.396
MOD_CK2_1	379	385	PF00069	0.483
MOD_CK2_1	416	422	PF00069	0.550
MOD_GlcNHglycan	126	129	PF01048	0.260
MOD_GlcNHglycan	135	138	PF01048	0.223
MOD_GlcNHglycan	20	23	PF01048	0.566
MOD_GlcNHglycan	211	214	PF01048	0.283
MOD_GlcNHglycan	323	326	PF01048	0.314
MOD_GlcNHglycan	382	385	PF01048	0.506
MOD_GlcNHglycan	6	9	PF01048	0.662
MOD_GSK3_1	133	140	PF00069	0.425
MOD_GSK3_1	16	23	PF00069	0.690
MOD_GSK3_1	181	188	PF00069	0.432
MOD_GSK3_1	194	201	PF00069	0.475
MOD_GSK3_1	270	277	PF00069	0.390
MOD_GSK3_1	303	310	PF00069	0.397
MOD_GSK3_1	317	324	PF00069	0.373
MOD_GSK3_1	379	386	PF00069	0.505
MOD_GSK3_1	411	418	PF00069	0.615
MOD_GSK3_1	52	59	PF00069	0.716
MOD_LATS_1	52	58	PF00433	0.507
MOD_N-GLC_1	352	357	PF02516	0.480
MOD_N-GLC_1	55	60	PF02516	0.624
MOD_N-GLC_1	66	71	PF02516	0.329
MOD_N-GLC_2	48	50	PF02516	0.501
MOD_NEK2_1	163	168	PF00069	0.514
MOD_NEK2_1	209	214	PF00069	0.283
MOD_NEK2_1	268	273	PF00069	0.351
MOD_NEK2_1	303	308	PF00069	0.349
MOD_NEK2_1	379	384	PF00069	0.480
MOD_PIKK_1	246	252	PF00454	0.256
MOD_PIKK_1	56	62	PF00454	0.501
MOD_PK_1	283	289	PF00069	0.298
MOD_PKA_1	307	313	PF00069	0.492
MOD_PKA_2	225	231	PF00069	0.356
MOD_PKA_2	307	313	PF00069	0.492
MOD_Plk_1	260	266	PF00069	0.362
MOD_Plk_1	269	275	PF00069	0.323
MOD_Plk_1	347	353	PF00069	0.509
MOD_Plk_1	377	383	PF00069	0.345
MOD_Plk_4	137	143	PF00069	0.423
MOD_Plk_4	194	200	PF00069	0.471
MOD_Plk_4	203	209	PF00069	0.224
MOD_Plk_4	270	276	PF00069	0.341
MOD_ProDKin_1	185	191	PF00069	0.484
MOD_ProDKin_1	43	49	PF00069	0.658
MOD_SUMO_for_1	144	147	PF00179	0.356
MOD_SUMO_rev_2	170	177	PF00179	0.517
TRG_DiLeu_BaEn_2	76	82	PF01217	0.506
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.336
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.371
TRG_ENDOCYTIC_2	102	105	PF00928	0.356
TRG_ENDOCYTIC_2	114	117	PF00928	0.340
TRG_ER_diArg_1	221	224	PF00400	0.407
TRG_ER_diArg_1	84	87	PF00400	0.441
TRG_NLS_MonoExtN_4	11	16	PF00514	0.748

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL4	Leptomonas seymouri	75%	100%
A0A0S4IRB2	Bodo saltans	58%	95%
A0A1X0NKR3	Trypanosomatidae	58%	88%
A0A3S7WPK3	Leishmania donovani	83%	97%
A0A422NZF0	Trypanosoma rangeli	57%	100%
A4HSX9	Leishmania infantum	83%	97%
A8IEF3	Chlamydomonas reinhardtii	26%	100%
B0JYW5	Xenopus tropicalis	27%	100%
B0W3L6	Culex quinquefasciatus	25%	71%
C9ZTK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AKW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	97%
O60678	Homo sapiens	27%	80%
O70467	Rattus norvegicus	27%	81%
Q174R2	Aedes aegypti	26%	72%
Q4QIZ0	Leishmania major	82%	100%
Q582G4	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	57%	100%
Q5XK84	Xenopus laevis	26%	71%
Q68EZ3	Xenopus laevis	25%	100%
Q6DC04	Danio rerio	27%	72%
Q7Q2B7	Anopheles gambiae	25%	68%
Q86X55	Homo sapiens	26%	70%
Q9WVG6	Mus musculus	26%	70%
V5BT47	Trypanosoma cruzi	56%	97%