Exosome-associated protein 3

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4P6_LEIBR

TriTrypDb:

LbrM.06.0810 , LBRM2903_060014900

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4P6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.618
CLV_PCSK_KEX2_1	158	160	PF00082	0.605
CLV_PCSK_KEX2_1	16	18	PF00082	0.581
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.605
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.558
CLV_PCSK_SKI1_1	136	140	PF00082	0.635
CLV_PCSK_SKI1_1	175	179	PF00082	0.569
CLV_PCSK_SKI1_1	222	226	PF00082	0.574
CLV_PCSK_SKI1_1	8	12	PF00082	0.354
DEG_Nend_UBRbox_2	1	3	PF02207	0.552
DOC_USP7_MATH_1	162	166	PF00917	0.703
DOC_USP7_MATH_1	188	192	PF00917	0.501
DOC_USP7_MATH_1	73	77	PF00917	0.626
DOC_USP7_MATH_1	91	95	PF00917	0.727
DOC_USP7_UBL2_3	175	179	PF12436	0.496
DOC_WW_Pin1_4	97	102	PF00397	0.554
LIG_14-3-3_CanoR_1	117	125	PF00244	0.489
LIG_14-3-3_CanoR_1	48	57	PF00244	0.468
LIG_BRCT_BRCA1_1	51	55	PF00533	0.564
LIG_FHA_1	117	123	PF00498	0.524
LIG_FHA_1	145	151	PF00498	0.598
LIG_FHA_1	214	220	PF00498	0.606
LIG_FHA_1	54	60	PF00498	0.520
LIG_FHA_2	103	109	PF00498	0.441
LIG_FHA_2	169	175	PF00498	0.727
LIG_FHA_2	40	46	PF00498	0.499
LIG_SH2_STAT5	121	124	PF00017	0.421
LIG_SH2_STAT5	41	44	PF00017	0.555
LIG_SH2_STAT5	50	53	PF00017	0.534
LIG_SH3_3	170	176	PF00018	0.485
LIG_SH3_4	175	182	PF00018	0.500
LIG_SUMO_SIM_par_1	55	60	PF11976	0.429
LIG_UBA3_1	10	16	PF00899	0.541
LIG_Vh1_VBS_1	205	223	PF01044	0.625
MOD_CK1_1	207	213	PF00069	0.666
MOD_CK1_1	229	235	PF00069	0.606
MOD_CK1_1	39	45	PF00069	0.547
MOD_CK1_1	60	66	PF00069	0.585
MOD_CK1_1	99	105	PF00069	0.738
MOD_CK2_1	157	163	PF00069	0.629
MOD_CK2_1	168	174	PF00069	0.647
MOD_CK2_1	232	238	PF00069	0.704
MOD_CK2_1	39	45	PF00069	0.551
MOD_Cter_Amidation	156	159	PF01082	0.609
MOD_GlcNHglycan	163	167	PF01048	0.708
MOD_GlcNHglycan	186	189	PF01048	0.619
MOD_GlcNHglycan	231	234	PF01048	0.716
MOD_GlcNHglycan	51	54	PF01048	0.508
MOD_GlcNHglycan	75	78	PF01048	0.647
MOD_GlcNHglycan	84	87	PF01048	0.546
MOD_GlcNHglycan	93	96	PF01048	0.420
MOD_GSK3_1	139	146	PF00069	0.632
MOD_GSK3_1	162	169	PF00069	0.685
MOD_GSK3_1	184	191	PF00069	0.523
MOD_GSK3_1	224	231	PF00069	0.548
MOD_GSK3_1	49	56	PF00069	0.546
MOD_GSK3_1	80	87	PF00069	0.695
MOD_GSK3_1	96	103	PF00069	0.679
MOD_NEK2_1	224	229	PF00069	0.575
MOD_NEK2_1	49	54	PF00069	0.545
MOD_NEK2_1	55	60	PF00069	0.549
MOD_NEK2_1	82	87	PF00069	0.523
MOD_NEK2_1	96	101	PF00069	0.536
MOD_PKA_2	116	122	PF00069	0.440
MOD_PKA_2	80	86	PF00069	0.645
MOD_Plk_1	188	194	PF00069	0.505
MOD_Plk_1	33	39	PF00069	0.558
MOD_Plk_2-3	127	133	PF00069	0.492
MOD_Plk_4	215	221	PF00069	0.585
MOD_Plk_4	33	39	PF00069	0.636
MOD_Plk_4	57	63	PF00069	0.557
MOD_ProDKin_1	97	103	PF00069	0.553
MOD_SUMO_for_1	113	116	PF00179	0.485
MOD_SUMO_rev_2	2	10	PF00179	0.548
TRG_DiLeu_BaEn_1	215	220	PF01217	0.635
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.519
TRG_DiLeu_LyEn_5	6	11	PF01217	0.632
TRG_ER_FFAT_2	34	45	PF00635	0.404
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3M9	Leptomonas seymouri	56%	99%
A0A1X0NKL8	Trypanosomatidae	25%	100%
A0A3R7KNC7	Trypanosoma rangeli	31%	100%
A0A3S5H5S8	Leishmania donovani	67%	100%
A4HSX6	Leishmania infantum	66%	100%
C9ZTK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AKW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	97%
Q4QIZ3	Leishmania major	67%	95%
V5BNH6	Trypanosoma cruzi	31%	100%