Qb-SNARE_protein_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qb-SNARE protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H4P4_LEIBR

TriTrypDb:

LbrM.06.0790 , LBRM2903_060014700

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0012505	endomembrane system	2	1
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4H4P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4P4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.538
CLV_NRD_NRD_1	140	142	PF00675	0.383
CLV_NRD_NRD_1	145	147	PF00675	0.378
CLV_NRD_NRD_1	374	376	PF00675	0.390
CLV_NRD_NRD_1	377	379	PF00675	0.381
CLV_NRD_NRD_1	38	40	PF00675	0.473
CLV_PCSK_FUR_1	200	204	PF00082	0.298
CLV_PCSK_FUR_1	375	379	PF00082	0.405
CLV_PCSK_KEX2_1	117	119	PF00082	0.537
CLV_PCSK_KEX2_1	139	141	PF00082	0.431
CLV_PCSK_KEX2_1	145	147	PF00082	0.389
CLV_PCSK_KEX2_1	2	4	PF00082	0.497
CLV_PCSK_KEX2_1	202	204	PF00082	0.295
CLV_PCSK_KEX2_1	374	376	PF00082	0.402
CLV_PCSK_KEX2_1	377	379	PF00082	0.392
CLV_PCSK_KEX2_1	38	40	PF00082	0.466
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.497
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.308
CLV_PCSK_PC7_1	141	147	PF00082	0.419
CLV_PCSK_SKI1_1	206	210	PF00082	0.442
CLV_PCSK_SKI1_1	310	314	PF00082	0.445
CLV_PCSK_SKI1_1	70	74	PF00082	0.367
DEG_APCC_DBOX_1	69	77	PF00400	0.576
DEG_Nend_UBRbox_1	1	4	PF02207	0.705
DEG_SCF_FBW7_1	178	183	PF00400	0.560
DEG_SPOP_SBC_1	171	175	PF00917	0.679
DEG_SPOP_SBC_1	246	250	PF00917	0.561
DOC_CYCLIN_yCln2_LP_2	224	230	PF00134	0.703
DOC_MAPK_gen_1	2	13	PF00069	0.675
DOC_MAPK_gen_1	202	213	PF00069	0.557
DOC_MAPK_MEF2A_6	6	15	PF00069	0.594
DOC_PP4_FxxP_1	257	260	PF00568	0.583
DOC_USP7_MATH_1	171	175	PF00917	0.750
DOC_USP7_MATH_1	180	184	PF00917	0.738
DOC_USP7_MATH_1	20	24	PF00917	0.575
DOC_USP7_MATH_1	230	234	PF00917	0.727
DOC_USP7_MATH_1	246	250	PF00917	0.740
DOC_USP7_MATH_1	289	293	PF00917	0.744
DOC_USP7_MATH_1	358	362	PF00917	0.586
DOC_USP7_MATH_1	87	91	PF00917	0.660
DOC_WW_Pin1_4	176	181	PF00397	0.628
DOC_WW_Pin1_4	255	260	PF00397	0.662
DOC_WW_Pin1_4	292	297	PF00397	0.661
DOC_WW_Pin1_4	50	55	PF00397	0.613
LIG_14-3-3_CanoR_1	126	133	PF00244	0.521
LIG_14-3-3_CanoR_1	160	170	PF00244	0.609
LIG_14-3-3_CanoR_1	3	9	PF00244	0.636
LIG_14-3-3_CanoR_1	329	337	PF00244	0.575
LIG_Actin_WH2_2	1	16	PF00022	0.583
LIG_Actin_WH2_2	287	303	PF00022	0.552
LIG_Actin_WH2_2	59	76	PF00022	0.547
LIG_BIR_III_4	81	85	PF00653	0.522
LIG_CaM_IQ_9	367	383	PF13499	0.578
LIG_EH1_1	390	398	PF00400	0.410
LIG_eIF4E_1	391	397	PF01652	0.410
LIG_FHA_1	110	116	PF00498	0.634
LIG_FHA_1	128	134	PF00498	0.626
LIG_FHA_1	98	104	PF00498	0.614
LIG_GBD_Chelix_1	392	400	PF00786	0.355
LIG_LIR_Gen_1	311	321	PF02991	0.574
LIG_LIR_Gen_1	59	67	PF02991	0.460
LIG_LIR_Nem_3	306	312	PF02991	0.560
LIG_LIR_Nem_3	59	63	PF02991	0.531
LIG_NRBOX	394	400	PF00104	0.430
LIG_NRBOX	401	407	PF00104	0.402
LIG_Pex14_2	309	313	PF04695	0.589
LIG_SH2_STAT5	239	242	PF00017	0.650
LIG_SH2_STAT5	391	394	PF00017	0.322
LIG_SH2_STAT5	60	63	PF00017	0.487
LIG_SH3_3	224	230	PF00018	0.789
LIG_SH3_3	253	259	PF00018	0.584
LIG_TRAF2_1	275	278	PF00917	0.662
LIG_TRAF2_1	349	352	PF00917	0.597
LIG_TRAF2_1	94	97	PF00917	0.765
LIG_Vh1_VBS_1	390	408	PF01044	0.330
MOD_CDK_SPxK_1	50	56	PF00069	0.647
MOD_CK1_1	122	128	PF00069	0.628
MOD_CK1_1	233	239	PF00069	0.741
MOD_CK1_1	249	255	PF00069	0.718
MOD_CK1_1	258	264	PF00069	0.742
MOD_CK1_1	266	272	PF00069	0.755
MOD_CK1_1	292	298	PF00069	0.708
MOD_CK2_1	272	278	PF00069	0.663
MOD_CK2_1	299	305	PF00069	0.588
MOD_CK2_1	91	97	PF00069	0.758
MOD_GlcNHglycan	121	124	PF01048	0.390
MOD_GlcNHglycan	174	177	PF01048	0.568
MOD_GlcNHglycan	182	185	PF01048	0.511
MOD_GlcNHglycan	23	26	PF01048	0.419
MOD_GlcNHglycan	260	263	PF01048	0.540
MOD_GlcNHglycan	265	268	PF01048	0.573
MOD_GlcNHglycan	301	304	PF01048	0.523
MOD_GlcNHglycan	87	90	PF01048	0.517
MOD_GSK3_1	121	128	PF00069	0.666
MOD_GSK3_1	14	21	PF00069	0.722
MOD_GSK3_1	161	168	PF00069	0.565
MOD_GSK3_1	172	179	PF00069	0.708
MOD_GSK3_1	245	252	PF00069	0.610
MOD_GSK3_1	273	280	PF00069	0.610
MOD_GSK3_1	380	387	PF00069	0.608
MOD_GSK3_1	85	92	PF00069	0.669
MOD_NEK2_1	161	166	PF00069	0.589
MOD_NEK2_1	312	317	PF00069	0.573
MOD_PIKK_1	273	279	PF00454	0.594
MOD_PKA_2	125	131	PF00069	0.579
MOD_PKA_2	328	334	PF00069	0.547
MOD_PKA_2	380	386	PF00069	0.585
MOD_Plk_1	358	364	PF00069	0.543
MOD_Plk_1	383	389	PF00069	0.577
MOD_Plk_2-3	97	103	PF00069	0.702
MOD_ProDKin_1	176	182	PF00069	0.626
MOD_ProDKin_1	255	261	PF00069	0.662
MOD_ProDKin_1	292	298	PF00069	0.660
MOD_ProDKin_1	50	56	PF00069	0.609
MOD_SUMO_rev_2	90	100	PF00179	0.603
TRG_DiLeu_BaEn_1	110	115	PF01217	0.700
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.569
TRG_ENDOCYTIC_2	205	208	PF00928	0.594
TRG_ENDOCYTIC_2	60	63	PF00928	0.526
TRG_ER_diArg_1	139	141	PF00400	0.509
TRG_ER_diArg_1	374	377	PF00400	0.603
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P557	Leptomonas seymouri	44%	91%
A0A0S4JA95	Bodo saltans	24%	100%
A0A1X0NMF9	Trypanosomatidae	27%	100%
A0A3S7WPJ4	Leishmania donovani	76%	100%
A0A422NZG0	Trypanosoma rangeli	31%	100%
A4HSX4	Leishmania infantum	76%	100%
E9AKW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QIZ5	Leishmania major	72%	100%
V5BT43	Trypanosoma cruzi	31%	93%