Haemolysin-III_related_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Haemolysin-III related, putative

Species:

Leishmania braziliensis

UniProt:

A4H4N9_LEIBR

TriTrypDb:

LbrM.06.0740 , LBRM2903_060013600 , LBRM2903_060013700

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4H4N9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4N9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0038023	signaling receptor activity	2	1
GO:0060089	molecular transducer activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	563	567	PF00656	0.497
CLV_MEL_PAP_1	58	64	PF00089	0.373
CLV_NRD_NRD_1	160	162	PF00675	0.543
CLV_NRD_NRD_1	178	180	PF00675	0.389
CLV_NRD_NRD_1	534	536	PF00675	0.371
CLV_NRD_NRD_1	541	543	PF00675	0.395
CLV_NRD_NRD_1	557	559	PF00675	0.422
CLV_NRD_NRD_1	70	72	PF00675	0.421
CLV_NRD_NRD_1	90	92	PF00675	0.334
CLV_NRD_NRD_1	98	100	PF00675	0.350
CLV_PCSK_KEX2_1	100	102	PF00082	0.348
CLV_PCSK_KEX2_1	160	162	PF00082	0.543
CLV_PCSK_KEX2_1	178	180	PF00082	0.389
CLV_PCSK_KEX2_1	534	536	PF00082	0.371
CLV_PCSK_KEX2_1	541	543	PF00082	0.395
CLV_PCSK_KEX2_1	557	559	PF00082	0.422
CLV_PCSK_KEX2_1	70	72	PF00082	0.421
CLV_PCSK_KEX2_1	90	92	PF00082	0.334
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.348
CLV_PCSK_PC7_1	174	180	PF00082	0.411
CLV_PCSK_PC7_1	96	102	PF00082	0.351
CLV_PCSK_SKI1_1	101	105	PF00082	0.387
CLV_PCSK_SKI1_1	179	183	PF00082	0.411
CLV_PCSK_SKI1_1	209	213	PF00082	0.468
CLV_PCSK_SKI1_1	387	391	PF00082	0.331
CLV_PCSK_SKI1_1	4	8	PF00082	0.431
DEG_APCC_DBOX_1	100	108	PF00400	0.592
DEG_APCC_DBOX_1	260	268	PF00400	0.225
DEG_SPOP_SBC_1	454	458	PF00917	0.610
DEG_SPOP_SBC_1	572	576	PF00917	0.637
DEG_SPOP_SBC_1	602	606	PF00917	0.633
DOC_CYCLIN_RxL_1	384	391	PF00134	0.380
DOC_MAPK_DCC_7	261	271	PF00069	0.331
DOC_MAPK_DCC_7	618	626	PF00069	0.643
DOC_MAPK_gen_1	467	475	PF00069	0.409
DOC_MAPK_gen_1	70	76	PF00069	0.538
DOC_MAPK_MEF2A_6	19	28	PF00069	0.618
DOC_MAPK_MEF2A_6	618	626	PF00069	0.643
DOC_PP2B_LxvP_1	133	136	PF13499	0.313
DOC_PP2B_LxvP_1	236	239	PF13499	0.211
DOC_PP2B_LxvP_1	251	254	PF13499	0.279
DOC_PP2B_LxvP_1	285	288	PF13499	0.411
DOC_PP2B_LxvP_1	390	393	PF13499	0.560
DOC_PP2B_LxvP_1	414	417	PF13499	0.669
DOC_PP2B_LxvP_1	619	622	PF13499	0.643
DOC_USP7_MATH_1	103	107	PF00917	0.523
DOC_USP7_MATH_1	220	224	PF00917	0.280
DOC_USP7_MATH_1	237	241	PF00917	0.375
DOC_USP7_MATH_1	326	330	PF00917	0.269
DOC_USP7_MATH_1	453	457	PF00917	0.660
DOC_USP7_MATH_1	51	55	PF00917	0.607
DOC_USP7_MATH_1	571	575	PF00917	0.687
DOC_USP7_MATH_1	603	607	PF00917	0.622
DOC_WW_Pin1_4	10	15	PF00397	0.631
DOC_WW_Pin1_4	179	184	PF00397	0.286
DOC_WW_Pin1_4	204	209	PF00397	0.259
DOC_WW_Pin1_4	218	223	PF00397	0.321
DOC_WW_Pin1_4	238	243	PF00397	0.194
DOC_WW_Pin1_4	289	294	PF00397	0.411
DOC_WW_Pin1_4	45	50	PF00397	0.715
LIG_14-3-3_CanoR_1	261	267	PF00244	0.296
LIG_14-3-3_CanoR_1	387	393	PF00244	0.541
LIG_14-3-3_CanoR_1	435	442	PF00244	0.666
LIG_14-3-3_CanoR_1	94	99	PF00244	0.485
LIG_APCC_ABBA_1	109	114	PF00400	0.408
LIG_APCC_ABBA_1	658	663	PF00400	0.494
LIG_BRCT_BRCA1_1	222	226	PF00533	0.331
LIG_CSL_BTD_1	133	136	PF09270	0.332
LIG_deltaCOP1_diTrp_1	80	85	PF00928	0.521
LIG_EVH1_1	251	255	PF00568	0.331
LIG_EVH1_1	414	418	PF00568	0.592
LIG_FHA_1	113	119	PF00498	0.531
LIG_FHA_1	274	280	PF00498	0.308
LIG_FHA_1	332	338	PF00498	0.306
LIG_FHA_1	339	345	PF00498	0.297
LIG_FHA_1	449	455	PF00498	0.678
LIG_FHA_1	538	544	PF00498	0.623
LIG_FHA_1	625	631	PF00498	0.636
LIG_FHA_1	71	77	PF00498	0.530
LIG_FHA_2	188	194	PF00498	0.274
LIG_FHA_2	455	461	PF00498	0.703
LIG_FHA_2	5	11	PF00498	0.627
LIG_FHA_2	561	567	PF00498	0.495
LIG_FHA_2	612	618	PF00498	0.657
LIG_GBD_Chelix_1	377	385	PF00786	0.390
LIG_HP1_1	268	272	PF01393	0.222
LIG_IBAR_NPY_1	86	88	PF08397	0.578
LIG_LIR_Gen_1	114	124	PF02991	0.510
LIG_LIR_Gen_1	280	288	PF02991	0.313
LIG_LIR_Gen_1	314	324	PF02991	0.390
LIG_LIR_Gen_1	509	519	PF02991	0.275
LIG_LIR_Gen_1	57	67	PF02991	0.569
LIG_LIR_Gen_1	614	624	PF02991	0.646
LIG_LIR_Gen_1	80	89	PF02991	0.519
LIG_LIR_Nem_3	114	119	PF02991	0.510
LIG_LIR_Nem_3	223	229	PF02991	0.312
LIG_LIR_Nem_3	280	286	PF02991	0.313
LIG_LIR_Nem_3	314	319	PF02991	0.390
LIG_LIR_Nem_3	509	515	PF02991	0.275
LIG_LIR_Nem_3	522	527	PF02991	0.311
LIG_LIR_Nem_3	57	62	PF02991	0.567
LIG_LIR_Nem_3	614	619	PF02991	0.595
LIG_LIR_Nem_3	666	670	PF02991	0.534
LIG_LIR_Nem_3	80	85	PF02991	0.528
LIG_NRBOX	126	132	PF00104	0.332
LIG_PCNA_yPIPBox_3	294	308	PF02747	0.476
LIG_Pex14_2	273	277	PF04695	0.299
LIG_Pex14_2	426	430	PF04695	0.527
LIG_PTB_Apo_2	110	117	PF02174	0.476
LIG_PTB_Apo_2	504	511	PF02174	0.326
LIG_PTB_Phospho_1	504	510	PF10480	0.323
LIG_SH2_CRK	296	300	PF00017	0.476
LIG_SH2_CRK	476	480	PF00017	0.313
LIG_SH2_CRK	667	671	PF00017	0.550
LIG_SH2_GRB2like	505	508	PF00017	0.320
LIG_SH2_NCK_1	667	671	PF00017	0.605
LIG_SH2_PTP2	198	201	PF00017	0.208
LIG_SH2_PTP2	347	350	PF00017	0.531
LIG_SH2_SRC	198	201	PF00017	0.240
LIG_SH2_STAP1	316	320	PF00017	0.222
LIG_SH2_STAP1	510	514	PF00017	0.222
LIG_SH2_STAP1	77	81	PF00017	0.463
LIG_SH2_STAT5	110	113	PF00017	0.479
LIG_SH2_STAT5	149	152	PF00017	0.285
LIG_SH2_STAT5	198	201	PF00017	0.240
LIG_SH2_STAT5	318	321	PF00017	0.313
LIG_SH2_STAT5	347	350	PF00017	0.439
LIG_SH2_STAT5	476	479	PF00017	0.313
LIG_SH2_STAT5	484	487	PF00017	0.313
LIG_SH2_STAT5	628	631	PF00017	0.575
LIG_SH2_STAT5	637	640	PF00017	0.520
LIG_SH2_STAT5	88	91	PF00017	0.585
LIG_SH3_1	412	418	PF00018	0.601
LIG_SH3_3	236	242	PF00018	0.332
LIG_SH3_3	249	255	PF00018	0.377
LIG_SH3_3	347	353	PF00018	0.476
LIG_SH3_3	390	396	PF00018	0.647
LIG_SH3_3	410	416	PF00018	0.734
LIG_SUMO_SIM_anti_2	263	268	PF11976	0.248
LIG_SUMO_SIM_anti_2	278	283	PF11976	0.199
LIG_SUMO_SIM_par_1	72	78	PF11976	0.524
LIG_SxIP_EBH_1	261	273	PF03271	0.229
LIG_WRC_WIRS_1	274	279	PF05994	0.313
LIG_WW_3	134	138	PF00397	0.331
MOD_CDK_SPK_2	10	15	PF00069	0.630
MOD_CDK_SPK_2	204	209	PF00069	0.253
MOD_CDK_SPK_2	289	294	PF00069	0.411
MOD_CK1_1	151	157	PF00069	0.217
MOD_CK1_1	257	263	PF00069	0.360
MOD_CK1_1	40	46	PF00069	0.738
MOD_CK1_1	444	450	PF00069	0.622
MOD_CK1_1	54	60	PF00069	0.654
MOD_CK1_1	580	586	PF00069	0.661
MOD_CK1_1	601	607	PF00069	0.659
MOD_CK1_1	631	637	PF00069	0.524
MOD_CK1_1	652	658	PF00069	0.516
MOD_CK2_1	151	157	PF00069	0.211
MOD_CK2_1	72	78	PF00069	0.579
MOD_DYRK1A_RPxSP_1	179	183	PF00069	0.211
MOD_GlcNHglycan	143	146	PF01048	0.476
MOD_GlcNHglycan	152	156	PF01048	0.410
MOD_GlcNHglycan	311	314	PF01048	0.354
MOD_GlcNHglycan	328	331	PF01048	0.448
MOD_GlcNHglycan	390	393	PF01048	0.481
MOD_GlcNHglycan	438	441	PF01048	0.470
MOD_GlcNHglycan	443	446	PF01048	0.429
MOD_GlcNHglycan	464	467	PF01048	0.390
MOD_GlcNHglycan	53	56	PF01048	0.484
MOD_GlcNHglycan	551	554	PF01048	0.307
MOD_GlcNHglycan	579	582	PF01048	0.517
MOD_GlcNHglycan	594	597	PF01048	0.392
MOD_GlcNHglycan	630	633	PF01048	0.342
MOD_GlcNHglycan	651	654	PF01048	0.301
MOD_GSK3_1	139	146	PF00069	0.315
MOD_GSK3_1	164	171	PF00069	0.263
MOD_GSK3_1	218	225	PF00069	0.251
MOD_GSK3_1	273	280	PF00069	0.297
MOD_GSK3_1	37	44	PF00069	0.747
MOD_GSK3_1	443	450	PF00069	0.638
MOD_GSK3_1	50	57	PF00069	0.570
MOD_GSK3_1	573	580	PF00069	0.683
MOD_GSK3_1	597	604	PF00069	0.702
MOD_GSK3_1	6	13	PF00069	0.629
MOD_GSK3_1	624	631	PF00069	0.645
MOD_LATS_1	162	168	PF00433	0.211
MOD_N-GLC_1	112	117	PF02516	0.276
MOD_N-GLC_1	506	511	PF02516	0.520
MOD_N-GLC_1	519	524	PF02516	0.313
MOD_NEK2_1	141	146	PF00069	0.252
MOD_NEK2_1	262	267	PF00069	0.276
MOD_NEK2_1	273	278	PF00069	0.313
MOD_NEK2_1	28	33	PF00069	0.626
MOD_NEK2_1	309	314	PF00069	0.297
MOD_NEK2_1	338	343	PF00069	0.230
MOD_NEK2_1	530	535	PF00069	0.554
MOD_NEK2_1	577	582	PF00069	0.606
MOD_NEK2_1	624	629	PF00069	0.646
MOD_NEK2_2	222	227	PF00069	0.211
MOD_NEK2_2	573	578	PF00069	0.535
MOD_NEK2_2	72	77	PF00069	0.523
MOD_PIKK_1	497	503	PF00454	0.408
MOD_PKA_1	70	76	PF00069	0.538
MOD_PKA_2	136	142	PF00069	0.331
MOD_PKA_2	260	266	PF00069	0.296
MOD_PKA_2	577	583	PF00069	0.688
MOD_PKA_2	70	76	PF00069	0.541
MOD_PKB_1	433	441	PF00069	0.555
MOD_Plk_1	112	118	PF00069	0.476
MOD_Plk_1	506	512	PF00069	0.321
MOD_Plk_1	519	525	PF00069	0.313
MOD_Plk_4	103	109	PF00069	0.537
MOD_Plk_4	168	174	PF00069	0.276
MOD_Plk_4	262	268	PF00069	0.295
MOD_Plk_4	277	283	PF00069	0.294
MOD_Plk_4	339	345	PF00069	0.313
MOD_Plk_4	54	60	PF00069	0.590
MOD_Plk_4	611	617	PF00069	0.586
MOD_Plk_4	624	630	PF00069	0.670
MOD_Plk_4	72	78	PF00069	0.459
MOD_ProDKin_1	10	16	PF00069	0.631
MOD_ProDKin_1	179	185	PF00069	0.286
MOD_ProDKin_1	204	210	PF00069	0.259
MOD_ProDKin_1	218	224	PF00069	0.321
MOD_ProDKin_1	238	244	PF00069	0.194
MOD_ProDKin_1	289	295	PF00069	0.411
MOD_ProDKin_1	45	51	PF00069	0.714
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.373
TRG_ENDOCYTIC_2	283	286	PF00928	0.476
TRG_ENDOCYTIC_2	296	299	PF00928	0.476
TRG_ENDOCYTIC_2	316	319	PF00928	0.390
TRG_ENDOCYTIC_2	347	350	PF00928	0.476
TRG_ENDOCYTIC_2	476	479	PF00928	0.313
TRG_ENDOCYTIC_2	484	487	PF00928	0.313
TRG_ENDOCYTIC_2	510	513	PF00928	0.343
TRG_ENDOCYTIC_2	662	665	PF00928	0.482
TRG_ENDOCYTIC_2	667	670	PF00928	0.541
TRG_ER_diArg_1	159	161	PF00400	0.229
TRG_ER_diArg_1	467	470	PF00400	0.508
TRG_ER_diArg_1	541	543	PF00400	0.576
TRG_ER_diArg_1	556	558	PF00400	0.598
TRG_ER_diArg_1	69	71	PF00400	0.616
TRG_ER_diArg_1	89	91	PF00400	0.532
TRG_ER_diArg_1	93	96	PF00400	0.532
TRG_ER_diArg_1	98	101	PF00400	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4X6	Leptomonas seymouri	41%	88%
A0A3S5H5S3	Leishmania donovani	73%	100%
A4HSW7	Leishmania infantum	73%	100%
E9AKV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QJ02	Leishmania major	73%	100%