Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4N8_LEIBR

TriTrypDb:

LbrM.06.0730 , LBRM2903_060013400 , LBRM2903_060013500

Length:

946

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4N8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.523
CLV_C14_Caspase3-7	265	269	PF00656	0.486
CLV_C14_Caspase3-7	336	340	PF00656	0.482
CLV_C14_Caspase3-7	416	420	PF00656	0.522
CLV_C14_Caspase3-7	914	918	PF00656	0.488
CLV_NRD_NRD_1	218	220	PF00675	0.653
CLV_NRD_NRD_1	230	232	PF00675	0.589
CLV_NRD_NRD_1	280	282	PF00675	0.573
CLV_NRD_NRD_1	283	285	PF00675	0.588
CLV_NRD_NRD_1	302	304	PF00675	0.733
CLV_NRD_NRD_1	361	363	PF00675	0.586
CLV_NRD_NRD_1	408	410	PF00675	0.539
CLV_NRD_NRD_1	469	471	PF00675	0.599
CLV_NRD_NRD_1	488	490	PF00675	0.489
CLV_NRD_NRD_1	694	696	PF00675	0.542
CLV_NRD_NRD_1	926	928	PF00675	0.512
CLV_PCSK_FUR_1	281	285	PF00082	0.558
CLV_PCSK_FUR_1	359	363	PF00082	0.511
CLV_PCSK_KEX2_1	217	219	PF00082	0.655
CLV_PCSK_KEX2_1	230	232	PF00082	0.580
CLV_PCSK_KEX2_1	280	282	PF00082	0.573
CLV_PCSK_KEX2_1	283	285	PF00082	0.581
CLV_PCSK_KEX2_1	302	304	PF00082	0.586
CLV_PCSK_KEX2_1	361	363	PF00082	0.586
CLV_PCSK_KEX2_1	407	409	PF00082	0.536
CLV_PCSK_KEX2_1	469	471	PF00082	0.467
CLV_PCSK_KEX2_1	488	490	PF00082	0.489
CLV_PCSK_KEX2_1	694	696	PF00082	0.542
CLV_PCSK_KEX2_1	926	928	PF00082	0.512
CLV_PCSK_SKI1_1	423	427	PF00082	0.569
CLV_PCSK_SKI1_1	741	745	PF00082	0.434
CLV_PCSK_SKI1_1	794	798	PF00082	0.357
DEG_APCC_DBOX_1	705	713	PF00400	0.556
DEG_SPOP_SBC_1	184	188	PF00917	0.538
DEG_SPOP_SBC_1	896	900	PF00917	0.648
DOC_ANK_TNKS_1	230	237	PF00023	0.638
DOC_CDC14_PxL_1	474	482	PF14671	0.469
DOC_CKS1_1	294	299	PF01111	0.556
DOC_CYCLIN_yCln2_LP_2	73	79	PF00134	0.549
DOC_MAPK_DCC_7	648	656	PF00069	0.536
DOC_MAPK_gen_1	427	437	PF00069	0.581
DOC_MAPK_gen_1	589	598	PF00069	0.379
DOC_MAPK_HePTP_8	588	600	PF00069	0.379
DOC_MAPK_MEF2A_6	430	439	PF00069	0.500
DOC_MAPK_MEF2A_6	591	600	PF00069	0.380
DOC_MAPK_MEF2A_6	648	656	PF00069	0.536
DOC_MAPK_NFAT4_5	593	601	PF00069	0.379
DOC_PP2B_LxvP_1	73	76	PF13499	0.561
DOC_PP2B_LxvP_1	832	835	PF13499	0.575
DOC_PP2B_LxvP_1	86	89	PF13499	0.534
DOC_PP2B_LxvP_1	920	923	PF13499	0.450
DOC_USP7_MATH_1	148	152	PF00917	0.590
DOC_USP7_MATH_1	184	188	PF00917	0.538
DOC_USP7_MATH_1	238	242	PF00917	0.560
DOC_USP7_MATH_1	243	247	PF00917	0.540
DOC_USP7_MATH_1	305	309	PF00917	0.517
DOC_USP7_MATH_1	519	523	PF00917	0.571
DOC_USP7_MATH_1	716	720	PF00917	0.371
DOC_USP7_MATH_1	788	792	PF00917	0.508
DOC_USP7_MATH_1	89	93	PF00917	0.624
DOC_USP7_MATH_1	896	900	PF00917	0.648
DOC_WW_Pin1_4	144	149	PF00397	0.555
DOC_WW_Pin1_4	194	199	PF00397	0.654
DOC_WW_Pin1_4	263	268	PF00397	0.483
DOC_WW_Pin1_4	293	298	PF00397	0.555
DOC_WW_Pin1_4	327	332	PF00397	0.812
DOC_WW_Pin1_4	629	634	PF00397	0.649
DOC_WW_Pin1_4	643	648	PF00397	0.559
DOC_WW_Pin1_4	93	98	PF00397	0.651
LIG_14-3-3_CanoR_1	13	22	PF00244	0.556
LIG_14-3-3_CanoR_1	283	290	PF00244	0.617
LIG_14-3-3_CanoR_1	430	438	PF00244	0.535
LIG_14-3-3_CanoR_1	440	449	PF00244	0.565
LIG_14-3-3_CanoR_1	739	744	PF00244	0.506
LIG_14-3-3_CanoR_1	842	851	PF00244	0.511
LIG_14-3-3_CanoR_1	90	97	PF00244	0.546
LIG_BIR_III_2	304	308	PF00653	0.523
LIG_BIR_III_4	483	487	PF00653	0.646
LIG_BRCT_BRCA1_1	354	358	PF00533	0.482
LIG_Clathr_ClatBox_1	687	691	PF01394	0.516
LIG_CtBP_PxDLS_1	203	207	PF00389	0.532
LIG_FHA_1	150	156	PF00498	0.547
LIG_FHA_1	178	184	PF00498	0.540
LIG_FHA_1	240	246	PF00498	0.524
LIG_FHA_1	327	333	PF00498	0.808
LIG_FHA_1	494	500	PF00498	0.564
LIG_FHA_1	509	515	PF00498	0.652
LIG_FHA_1	590	596	PF00498	0.388
LIG_FHA_1	666	672	PF00498	0.577
LIG_FHA_1	834	840	PF00498	0.613
LIG_FHA_1	902	908	PF00498	0.518
LIG_FHA_2	173	179	PF00498	0.556
LIG_FHA_2	187	193	PF00498	0.604
LIG_FHA_2	414	420	PF00498	0.525
LIG_FHA_2	458	464	PF00498	0.498
LIG_FHA_2	836	842	PF00498	0.629
LIG_Integrin_RGD_1	427	429	PF01839	0.522
LIG_LIR_Gen_1	772	778	PF02991	0.348
LIG_LIR_Nem_3	314	319	PF02991	0.504
LIG_LIR_Nem_3	538	542	PF02991	0.436
LIG_LIR_Nem_3	772	777	PF02991	0.351
LIG_SH2_CRK	492	496	PF00017	0.531
LIG_SH2_NCK_1	864	868	PF00017	0.646
LIG_SH2_SRC	862	865	PF00017	0.586
LIG_SH2_STAT3	602	605	PF00017	0.383
LIG_SH2_STAT5	319	322	PF00017	0.609
LIG_SH3_1	226	232	PF00018	0.658
LIG_SH3_1	55	61	PF00018	0.616
LIG_SH3_2	76	81	PF14604	0.551
LIG_SH3_3	226	232	PF00018	0.658
LIG_SH3_3	23	29	PF00018	0.657
LIG_SH3_3	291	297	PF00018	0.562
LIG_SH3_3	496	502	PF00018	0.523
LIG_SH3_3	547	553	PF00018	0.591
LIG_SH3_3	55	61	PF00018	0.674
LIG_SH3_3	649	655	PF00018	0.648
LIG_SH3_3	66	72	PF00018	0.600
LIG_SH3_3	710	716	PF00018	0.474
LIG_SH3_3	73	79	PF00018	0.576
LIG_SH3_3	85	91	PF00018	0.569
LIG_Sin3_3	477	484	PF02671	0.480
LIG_SUMO_SIM_anti_2	668	673	PF11976	0.568
LIG_SUMO_SIM_anti_2	836	841	PF11976	0.626
LIG_SUMO_SIM_par_1	202	209	PF11976	0.532
LIG_SUMO_SIM_par_1	835	841	PF11976	0.623
LIG_TRAF2_1	758	761	PF00917	0.440
LIG_TRAF2_1	784	787	PF00917	0.359
LIG_TRAF2_1	931	934	PF00917	0.574
LIG_WRC_WIRS_1	393	398	PF05994	0.484
LIG_WRC_WIRS_1	559	564	PF05994	0.515
LIG_WRC_WIRS_1	774	779	PF05994	0.346
MOD_CDK_SPK_2	194	199	PF00069	0.587
MOD_CDK_SPK_2	643	648	PF00069	0.538
MOD_CDK_SPK_2	98	103	PF00069	0.533
MOD_CK1_1	16	22	PF00069	0.581
MOD_CK1_1	164	170	PF00069	0.557
MOD_CK1_1	172	178	PF00069	0.624
MOD_CK1_1	188	194	PF00069	0.565
MOD_CK1_1	248	254	PF00069	0.635
MOD_CK1_1	321	327	PF00069	0.658
MOD_CK1_1	342	348	PF00069	0.470
MOD_CK1_1	373	379	PF00069	0.674
MOD_CK1_1	384	390	PF00069	0.589
MOD_CK1_1	392	398	PF00069	0.490
MOD_CK1_1	4	10	PF00069	0.685
MOD_CK1_1	444	450	PF00069	0.616
MOD_CK1_1	508	514	PF00069	0.680
MOD_CK1_1	665	671	PF00069	0.572
MOD_CK1_1	802	808	PF00069	0.482
MOD_CK1_1	843	849	PF00069	0.568
MOD_CK1_1	93	99	PF00069	0.583
MOD_CK2_1	354	360	PF00069	0.483
MOD_CK2_1	376	382	PF00069	0.634
MOD_CK2_1	457	463	PF00069	0.528
MOD_CK2_1	519	525	PF00069	0.550
MOD_CK2_1	629	635	PF00069	0.528
MOD_CK2_1	802	808	PF00069	0.482
MOD_DYRK1A_RPxSP_1	194	198	PF00069	0.654
MOD_DYRK1A_RPxSP_1	263	267	PF00069	0.479
MOD_GlcNHglycan	10	13	PF01048	0.613
MOD_GlcNHglycan	129	132	PF01048	0.707
MOD_GlcNHglycan	194	197	PF01048	0.572
MOD_GlcNHglycan	274	277	PF01048	0.568
MOD_GlcNHglycan	386	389	PF01048	0.637
MOD_GlcNHglycan	431	434	PF01048	0.539
MOD_GlcNHglycan	443	446	PF01048	0.613
MOD_GlcNHglycan	453	456	PF01048	0.566
MOD_GlcNHglycan	507	510	PF01048	0.537
MOD_GlcNHglycan	841	845	PF01048	0.639
MOD_GlcNHglycan	913	916	PF01048	0.551
MOD_GSK3_1	1	8	PF00069	0.663
MOD_GSK3_1	144	151	PF00069	0.590
MOD_GSK3_1	157	164	PF00069	0.563
MOD_GSK3_1	16	23	PF00069	0.555
MOD_GSK3_1	169	176	PF00069	0.617
MOD_GSK3_1	182	189	PF00069	0.576
MOD_GSK3_1	239	246	PF00069	0.646
MOD_GSK3_1	311	318	PF00069	0.591
MOD_GSK3_1	322	329	PF00069	0.613
MOD_GSK3_1	333	340	PF00069	0.520
MOD_GSK3_1	366	373	PF00069	0.674
MOD_GSK3_1	374	381	PF00069	0.716
MOD_GSK3_1	440	447	PF00069	0.644
MOD_GSK3_1	508	515	PF00069	0.643
MOD_GSK3_1	517	524	PF00069	0.575
MOD_GSK3_1	629	636	PF00069	0.656
MOD_GSK3_1	674	681	PF00069	0.488
MOD_GSK3_1	760	767	PF00069	0.380
MOD_GSK3_1	798	805	PF00069	0.348
MOD_GSK3_1	840	847	PF00069	0.491
MOD_GSK3_1	881	888	PF00069	0.566
MOD_GSK3_1	89	96	PF00069	0.650
MOD_GSK3_1	897	904	PF00069	0.623
MOD_GSK3_1	936	943	PF00069	0.450
MOD_NEK2_1	1	6	PF00069	0.666
MOD_NEK2_1	142	147	PF00069	0.560
MOD_NEK2_1	183	188	PF00069	0.686
MOD_NEK2_1	249	254	PF00069	0.634
MOD_NEK2_1	343	348	PF00069	0.617
MOD_NEK2_1	439	444	PF00069	0.648
MOD_NEK2_1	451	456	PF00069	0.531
MOD_NEK2_1	634	639	PF00069	0.562
MOD_NEK2_1	880	885	PF00069	0.520
MOD_NEK2_1	936	941	PF00069	0.591
MOD_NEK2_2	354	359	PF00069	0.520
MOD_OFUCOSY	254	260	PF10250	0.503
MOD_PIKK_1	16	22	PF00454	0.547
MOD_PIKK_1	243	249	PF00454	0.508
MOD_PIKK_1	311	317	PF00454	0.493
MOD_PIKK_1	34	40	PF00454	0.491
MOD_PIKK_1	519	525	PF00454	0.534
MOD_PIKK_1	609	615	PF00454	0.419
MOD_PIKK_1	659	665	PF00454	0.646
MOD_PIKK_1	716	722	PF00454	0.369
MOD_PIKK_1	788	794	PF00454	0.506
MOD_PIKK_1	881	887	PF00454	0.585
MOD_PKA_1	283	289	PF00069	0.569
MOD_PKA_1	408	414	PF00069	0.538
MOD_PKA_1	694	700	PF00069	0.395
MOD_PKA_2	14	20	PF00069	0.550
MOD_PKA_2	283	289	PF00069	0.569
MOD_PKA_2	311	317	PF00069	0.537
MOD_PKA_2	384	390	PF00069	0.512
MOD_PKA_2	408	414	PF00069	0.538
MOD_PKA_2	429	435	PF00069	0.604
MOD_PKA_2	439	445	PF00069	0.605
MOD_PKA_2	503	509	PF00069	0.654
MOD_PKA_2	694	700	PF00069	0.395
MOD_PKA_2	89	95	PF00069	0.550
MOD_PKA_2	936	942	PF00069	0.594
MOD_PKB_1	281	289	PF00069	0.652
MOD_Plk_1	208	214	PF00069	0.665
MOD_Plk_1	352	358	PF00069	0.501
MOD_Plk_1	389	395	PF00069	0.493
MOD_Plk_1	764	770	PF00069	0.500
MOD_Plk_1	798	804	PF00069	0.348
MOD_Plk_1	840	846	PF00069	0.515
MOD_Plk_2-3	558	564	PF00069	0.514
MOD_Plk_4	161	167	PF00069	0.620
MOD_Plk_4	46	52	PF00069	0.685
MOD_Plk_4	678	684	PF00069	0.593
MOD_Plk_4	835	841	PF00069	0.623
MOD_Plk_4	908	914	PF00069	0.499
MOD_ProDKin_1	144	150	PF00069	0.550
MOD_ProDKin_1	194	200	PF00069	0.652
MOD_ProDKin_1	263	269	PF00069	0.487
MOD_ProDKin_1	293	299	PF00069	0.555
MOD_ProDKin_1	327	333	PF00069	0.815
MOD_ProDKin_1	629	635	PF00069	0.653
MOD_ProDKin_1	643	649	PF00069	0.560
MOD_ProDKin_1	93	99	PF00069	0.651
MOD_SUMO_for_1	796	799	PF00179	0.355
MOD_SUMO_rev_2	533	542	PF00179	0.454
TRG_AP2beta_CARGO_1	772	781	PF09066	0.351
TRG_DiLeu_BaEn_1	434	439	PF01217	0.497
TRG_DiLeu_BaLyEn_6	433	438	PF01217	0.638
TRG_DiLeu_BaLyEn_6	550	555	PF01217	0.580
TRG_DiLeu_BaLyEn_6	705	710	PF01217	0.556
TRG_ENDOCYTIC_2	492	495	PF00928	0.531
TRG_ER_diArg_1	216	219	PF00400	0.660
TRG_ER_diArg_1	229	231	PF00400	0.575
TRG_ER_diArg_1	280	283	PF00400	0.677
TRG_ER_diArg_1	406	409	PF00400	0.528
TRG_ER_diArg_1	469	471	PF00400	0.599
TRG_ER_diArg_1	588	591	PF00400	0.527
TRG_ER_diArg_1	738	741	PF00400	0.602
TRG_ER_diArg_1	926	928	PF00400	0.512
TRG_NES_CRM1_1	798	813	PF08389	0.509
TRG_Pf-PMV_PEXEL_1	593	597	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	604	608	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	822	827	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPI2	Leishmania donovani	62%	89%
A4HSW6	Leishmania infantum	62%	100%
E9AKV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	99%
Q4QJ03	Leishmania major	61%	100%