Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4N4_LEIBR

TriTrypDb:

LbrM.06.0690 , LBRM2903_060012600

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0031390	Ctf18 RFC-like complex	3	5
GO:0032991	protein-containing complex	1	5
GO:0140513	nuclear protein-containing complex	2	5

Expansion

Sequence features

A4H4N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4N4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	5
GO:0007062	sister chromatid cohesion	3	5
GO:0007064	mitotic sister chromatid cohesion	4	5
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0022402	cell cycle process	2	5
GO:0051276	chromosome organization	5	5
GO:0071840	cellular component organization or biogenesis	2	5
GO:1903047	mitotic cell cycle process	3	5

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.630
CLV_NRD_NRD_1	153	155	PF00675	0.574
CLV_NRD_NRD_1	206	208	PF00675	0.660
CLV_NRD_NRD_1	210	212	PF00675	0.508
CLV_NRD_NRD_1	39	41	PF00675	0.557
CLV_NRD_NRD_1	43	45	PF00675	0.602
CLV_NRD_NRD_1	47	49	PF00675	0.629
CLV_PCSK_KEX2_1	112	114	PF00082	0.607
CLV_PCSK_KEX2_1	153	155	PF00082	0.574
CLV_PCSK_KEX2_1	210	212	PF00082	0.415
CLV_PCSK_KEX2_1	322	324	PF00082	0.703
CLV_PCSK_KEX2_1	38	40	PF00082	0.564
CLV_PCSK_KEX2_1	43	45	PF00082	0.602
CLV_PCSK_KEX2_1	47	49	PF00082	0.629
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.703
CLV_PCSK_PC7_1	39	45	PF00082	0.675
CLV_PCSK_SKI1_1	153	157	PF00082	0.479
CLV_PCSK_SKI1_1	226	230	PF00082	0.615
CLV_PCSK_SKI1_1	3	7	PF00082	0.441
CLV_PCSK_SKI1_1	319	323	PF00082	0.538
CLV_PCSK_SKI1_1	33	37	PF00082	0.501
DEG_Nend_Nbox_1	1	3	PF02207	0.500
DEG_SPOP_SBC_1	130	134	PF00917	0.596
DEG_SPOP_SBC_1	248	252	PF00917	0.540
DEG_SPOP_SBC_1	345	349	PF00917	0.495
DOC_CYCLIN_RxL_1	220	230	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	120	126	PF00134	0.520
DOC_MAPK_gen_1	153	160	PF00069	0.559
DOC_MAPK_MEF2A_6	153	162	PF00069	0.613
DOC_PP4_FxxP_1	191	194	PF00568	0.518
DOC_USP7_MATH_1	101	105	PF00917	0.529
DOC_USP7_MATH_1	116	120	PF00917	0.627
DOC_USP7_MATH_1	248	252	PF00917	0.569
DOC_USP7_MATH_1	346	350	PF00917	0.606
DOC_USP7_MATH_1	46	50	PF00917	0.665
DOC_USP7_MATH_1	51	55	PF00917	0.691
DOC_WW_Pin1_4	134	139	PF00397	0.718
DOC_WW_Pin1_4	199	204	PF00397	0.445
DOC_WW_Pin1_4	311	316	PF00397	0.571
DOC_WW_Pin1_4	341	346	PF00397	0.582
LIG_14-3-3_CanoR_1	128	138	PF00244	0.677
LIG_14-3-3_CanoR_1	144	150	PF00244	0.507
LIG_14-3-3_CanoR_1	153	158	PF00244	0.450
LIG_14-3-3_CanoR_1	174	178	PF00244	0.381
LIG_14-3-3_CanoR_1	188	192	PF00244	0.441
LIG_14-3-3_CanoR_1	338	345	PF00244	0.511
LIG_AP2alpha_1	279	283	PF02296	0.629
LIG_FHA_1	174	180	PF00498	0.417
LIG_FHA_1	214	220	PF00498	0.518
LIG_FHA_1	300	306	PF00498	0.533
LIG_FHA_1	346	352	PF00498	0.498
LIG_FHA_1	4	10	PF00498	0.415
LIG_FHA_2	154	160	PF00498	0.453
LIG_FHA_2	331	337	PF00498	0.627
LIG_FHA_2	85	91	PF00498	0.681
LIG_FXI_DFP_1	280	284	PF00024	0.473
LIG_LIR_Apic_2	190	194	PF02991	0.439
LIG_LIR_Nem_3	356	361	PF02991	0.478
LIG_PCNA_PIPBox_1	272	281	PF02747	0.449
LIG_PCNA_yPIPBox_3	359	367	PF02747	0.313
LIG_Pex14_2	191	195	PF04695	0.520
LIG_Pex14_2	279	283	PF04695	0.629
LIG_REV1ctd_RIR_1	147	158	PF16727	0.491
LIG_SH2_NCK_1	361	365	PF00017	0.418
LIG_SH2_SRC	361	364	PF00017	0.308
LIG_SH3_3	135	141	PF00018	0.666
LIG_SH3_3	155	161	PF00018	0.486
LIG_SH3_3	238	244	PF00018	0.697
LIG_SUMO_SIM_par_1	271	277	PF11976	0.440
LIG_SUMO_SIM_par_1	68	74	PF11976	0.507
LIG_TRAF2_1	88	91	PF00917	0.489
LIG_UBA3_1	15	21	PF00899	0.550
MOD_CDK_SPK_2	311	316	PF00069	0.525
MOD_CDK_SPxK_1	199	205	PF00069	0.441
MOD_CK1_1	131	137	PF00069	0.662
MOD_CK1_1	187	193	PF00069	0.582
MOD_CK1_1	250	256	PF00069	0.615
MOD_CK1_1	274	280	PF00069	0.688
MOD_CK1_1	308	314	PF00069	0.701
MOD_CK1_1	339	345	PF00069	0.597
MOD_CK1_1	349	355	PF00069	0.523
MOD_CK1_1	49	55	PF00069	0.614
MOD_CK1_1	71	77	PF00069	0.676
MOD_CK1_1	78	84	PF00069	0.574
MOD_CK2_1	153	159	PF00069	0.462
MOD_CK2_1	372	378	PF00069	0.362
MOD_CK2_1	39	45	PF00069	0.647
MOD_CK2_1	84	90	PF00069	0.548
MOD_GlcNHglycan	103	106	PF01048	0.560
MOD_GlcNHglycan	124	127	PF01048	0.605
MOD_GlcNHglycan	29	32	PF01048	0.460
MOD_GlcNHglycan	307	310	PF01048	0.640
MOD_GlcNHglycan	352	355	PF01048	0.617
MOD_GlcNHglycan	368	371	PF01048	0.411
MOD_GlcNHglycan	48	51	PF01048	0.638
MOD_GlcNHglycan	53	56	PF01048	0.648
MOD_GlcNHglycan	62	65	PF01048	0.573
MOD_GlcNHglycan	75	78	PF01048	0.756
MOD_GlcNHglycan	94	98	PF01048	0.574
MOD_GSK3_1	130	137	PF00069	0.746
MOD_GSK3_1	145	152	PF00069	0.594
MOD_GSK3_1	256	263	PF00069	0.617
MOD_GSK3_1	299	306	PF00069	0.636
MOD_GSK3_1	307	314	PF00069	0.675
MOD_GSK3_1	341	348	PF00069	0.570
MOD_GSK3_1	349	356	PF00069	0.591
MOD_GSK3_1	49	56	PF00069	0.773
MOD_GSK3_1	71	78	PF00069	0.600
MOD_GSK3_1	81	88	PF00069	0.642
MOD_GSK3_1	93	100	PF00069	0.623
MOD_N-GLC_1	349	354	PF02516	0.494
MOD_NEK2_1	149	154	PF00069	0.524
MOD_NEK2_1	213	218	PF00069	0.543
MOD_NEK2_1	372	377	PF00069	0.463
MOD_NEK2_1	5	10	PF00069	0.411
MOD_NEK2_1	70	75	PF00069	0.603
MOD_NEK2_2	178	183	PF00069	0.422
MOD_PIKK_1	213	219	PF00454	0.599
MOD_PKA_1	153	159	PF00069	0.468
MOD_PKA_1	39	45	PF00069	0.612
MOD_PKA_2	153	159	PF00069	0.468
MOD_PKA_2	173	179	PF00069	0.367
MOD_PKA_2	187	193	PF00069	0.446
MOD_PKA_2	39	45	PF00069	0.677
MOD_PKA_2	46	52	PF00069	0.674
MOD_PKB_1	292	300	PF00069	0.537
MOD_Plk_1	256	262	PF00069	0.614
MOD_Plk_1	330	336	PF00069	0.524
MOD_Plk_2-3	85	91	PF00069	0.500
MOD_Plk_4	145	151	PF00069	0.530
MOD_Plk_4	153	159	PF00069	0.446
MOD_Plk_4	256	262	PF00069	0.570
MOD_Plk_4	274	280	PF00069	0.681
MOD_Plk_4	353	359	PF00069	0.616
MOD_Plk_4	5	11	PF00069	0.407
MOD_ProDKin_1	134	140	PF00069	0.714
MOD_ProDKin_1	199	205	PF00069	0.441
MOD_ProDKin_1	311	317	PF00069	0.572
MOD_ProDKin_1	341	347	PF00069	0.581
TRG_ENDOCYTIC_2	361	364	PF00928	0.391
TRG_ER_diArg_1	111	113	PF00400	0.536
TRG_ER_diArg_1	209	211	PF00400	0.468
TRG_ER_diArg_1	38	40	PF00400	0.656
TRG_ER_diArg_1	46	48	PF00400	0.616
TRG_NES_CRM1_1	271	284	PF08389	0.454
TRG_NLS_MonoExtC_3	206	211	PF00514	0.544
TRG_NLS_MonoExtN_4	205	211	PF00514	0.538
TRG_Pf-PMV_PEXEL_1	207	212	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I714	Leptomonas seymouri	41%	100%
A0A3S7WPI0	Leishmania donovani	61%	94%
A4HSW0	Leishmania infantum	63%	95%
E9AKU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	94%
Q4QJ09	Leishmania major	62%	100%