NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4N3_LEIBR

TriTrypDb:

LbrM.06.0680 , LBRM2903_060012500

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	8
GO:0005758	mitochondrial intermembrane space	6	8
GO:0016020	membrane	2	8
GO:0019866	organelle inner membrane	4	8
GO:0031090	organelle membrane	3	8
GO:0031966	mitochondrial membrane	4	8
GO:0031970	organelle envelope lumen	5	8
GO:0031974	membrane-enclosed lumen	2	8
GO:0043233	organelle lumen	3	8
GO:0070013	intracellular organelle lumen	4	8
GO:0070469	respirasome	2	8
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4H4N3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4N3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.443
CLV_NRD_NRD_1	65	67	PF00675	0.551
CLV_NRD_NRD_1	79	81	PF00675	0.590
CLV_PCSK_KEX2_1	145	147	PF00082	0.445
CLV_PCSK_KEX2_1	152	154	PF00082	0.426
CLV_PCSK_KEX2_1	30	32	PF00082	0.675
CLV_PCSK_KEX2_1	65	67	PF00082	0.566
CLV_PCSK_KEX2_1	78	80	PF00082	0.617
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.498
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.534
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.566
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.617
CLV_PCSK_SKI1_1	133	137	PF00082	0.438
DEG_SCF_FBW7_1	44	51	PF00400	0.696
DEG_SPOP_SBC_1	17	21	PF00917	0.780
DOC_CKS1_1	56	61	PF01111	0.621
DOC_MAPK_gen_1	204	211	PF00069	0.536
DOC_PP2B_LxvP_1	125	128	PF13499	0.616
DOC_USP7_MATH_1	3	7	PF00917	0.686
DOC_USP7_MATH_1	48	52	PF00917	0.651
DOC_USP7_MATH_1	81	85	PF00917	0.622
DOC_USP7_MATH_1	97	101	PF00917	0.737
DOC_WW_Pin1_4	44	49	PF00397	0.679
DOC_WW_Pin1_4	55	60	PF00397	0.617
DOC_WW_Pin1_4	71	76	PF00397	0.571
DOC_WW_Pin1_4	99	104	PF00397	0.465
LIG_deltaCOP1_diTrp_1	160	166	PF00928	0.461
LIG_deltaCOP1_diTrp_1	195	203	PF00928	0.596
LIG_FHA_1	45	51	PF00498	0.685
LIG_FHA_2	136	142	PF00498	0.549
LIG_FHA_2	19	25	PF00498	0.746
LIG_FHA_2	56	62	PF00498	0.615
LIG_LIR_Gen_1	114	124	PF02991	0.552
LIG_LIR_Gen_1	195	203	PF02991	0.585
LIG_LIR_Nem_3	114	119	PF02991	0.549
LIG_LIR_Nem_3	173	179	PF02991	0.497
LIG_LIR_Nem_3	51	56	PF02991	0.687
LIG_Pex14_1	227	231	PF04695	0.494
LIG_PTB_Apo_2	110	117	PF02174	0.636
LIG_SH2_CRK	53	57	PF00017	0.637
LIG_SH3_1	188	194	PF00018	0.686
LIG_SH3_3	188	194	PF00018	0.617
LIG_TRAF2_1	58	61	PF00917	0.587
LIG_TYR_ITSM	172	179	PF00017	0.581
LIG_WRC_WIRS_1	200	205	PF05994	0.577
MOD_CDK_SPxxK_3	71	78	PF00069	0.680
MOD_CK1_1	51	57	PF00069	0.607
MOD_CK1_1	6	12	PF00069	0.628
MOD_CK1_1	96	102	PF00069	0.561
MOD_CK2_1	18	24	PF00069	0.760
MOD_CK2_1	54	60	PF00069	0.606
MOD_CMANNOS	163	166	PF00535	0.453
MOD_GlcNHglycan	12	15	PF01048	0.674
MOD_GlcNHglycan	53	56	PF01048	0.486
MOD_GlcNHglycan	83	86	PF01048	0.595
MOD_GlcNHglycan	94	98	PF01048	0.694
MOD_GSK3_1	3	10	PF00069	0.657
MOD_GSK3_1	44	51	PF00069	0.674
MOD_GSK3_1	92	99	PF00069	0.628
MOD_N-GLC_1	37	42	PF02516	0.746
MOD_NEK2_1	135	140	PF00069	0.566
MOD_NEK2_1	16	21	PF00069	0.751
MOD_NEK2_1	162	167	PF00069	0.478
MOD_NEK2_1	199	204	PF00069	0.569
MOD_NEK2_2	48	53	PF00069	0.492
MOD_NMyristoyl	1	7	PF02799	0.635
MOD_PKA_2	171	177	PF00069	0.582
MOD_Plk_1	48	54	PF00069	0.710
MOD_Plk_2-3	115	121	PF00069	0.547
MOD_Plk_4	171	177	PF00069	0.582
MOD_Plk_4	48	54	PF00069	0.490
MOD_ProDKin_1	44	50	PF00069	0.680
MOD_ProDKin_1	55	61	PF00069	0.614
MOD_ProDKin_1	71	77	PF00069	0.570
MOD_ProDKin_1	99	105	PF00069	0.460
MOD_SUMO_for_1	85	88	PF00179	0.530
TRG_ENDOCYTIC_2	176	179	PF00928	0.560
TRG_ENDOCYTIC_2	53	56	PF00928	0.648
TRG_ENDOCYTIC_2	69	72	PF00928	0.537
TRG_ER_diArg_1	79	81	PF00400	0.647
TRG_NLS_Bipartite_1	65	82	PF00514	0.461
TRG_NLS_MonoExtN_4	75	82	PF00514	0.660
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5D1	Leptomonas seymouri	65%	100%
A0A0S4J9I1	Bodo saltans	49%	100%
A0A1X0NL39	Trypanosomatidae	56%	100%
A0A3R7LT07	Trypanosoma rangeli	50%	100%
A0A3S5H5R9	Leishmania donovani	80%	100%
A4HSV9	Leishmania infantum	80%	100%
C9ZTH2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AKU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QJ10	Leishmania major	79%	100%