LeishMANIAdb
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DUF89 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DUF89 domain-containing protein
Gene product:
Putative Phosphatase/Protein of unknown function DUF89, putative
Species:
Leishmania braziliensis
UniProt:
A4H4M8_LEIBR
TriTrypDb:
LbrM.06.0630 , LBRM2903_060012000 *
Length:
1014

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4M8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4M8

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 4
GO:0016787 hydrolase activity 2 12
GO:0016788 hydrolase activity, acting on ester bonds 3 12
GO:0016791 phosphatase activity 5 12
GO:0016829 lyase activity 2 1
GO:0016830 carbon-carbon lyase activity 3 1
GO:0016832 aldehyde-lyase activity 4 1
GO:0042578 phosphoric ester hydrolase activity 4 12
GO:0043167 ion binding 2 4
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 113 117 PF00656 0.575
CLV_C14_Caspase3-7 532 536 PF00656 0.598
CLV_MEL_PAP_1 146 152 PF00089 0.351
CLV_MEL_PAP_1 421 427 PF00089 0.649
CLV_NRD_NRD_1 202 204 PF00675 0.473
CLV_NRD_NRD_1 274 276 PF00675 0.339
CLV_NRD_NRD_1 34 36 PF00675 0.400
CLV_NRD_NRD_1 423 425 PF00675 0.589
CLV_NRD_NRD_1 895 897 PF00675 0.287
CLV_NRD_NRD_1 921 923 PF00675 0.777
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PDC9 Leptomonas seymouri 66% 100%
A0A0S4J9G5 Bodo saltans 35% 100%
A0A1X0NKN4 Trypanosomatidae 41% 100%
A0A3R7MAF3 Trypanosoma rangeli 39% 100%
A0A3S5H5R3 Leishmania donovani 83% 100%
A4HSV3 Leishmania infantum 83% 100%
C9ZTG3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9AKU1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4QJ16 Leishmania major 83% 100%
V5BT19 Trypanosoma cruzi 40% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS