DUF89 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative Phosphatase/Protein of unknown function DUF89, putative

Species:

Leishmania braziliensis

UniProt:

A4H4M8_LEIBR

TriTrypDb:

LbrM.06.0630 , LBRM2903_060012000

Length:

1014

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4M8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0005488	binding	1	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0016829	lyase activity	2	1
GO:0016830	carbon-carbon lyase activity	3	1
GO:0016832	aldehyde-lyase activity	4	1
GO:0097023	fructose 6-phosphate aldolase activity	5	1
GO:0103026	fructose-1-phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.575
CLV_C14_Caspase3-7	532	536	PF00656	0.598
CLV_MEL_PAP_1	146	152	PF00089	0.351
CLV_MEL_PAP_1	421	427	PF00089	0.649
CLV_NRD_NRD_1	202	204	PF00675	0.473
CLV_NRD_NRD_1	274	276	PF00675	0.339
CLV_NRD_NRD_1	34	36	PF00675	0.400
CLV_NRD_NRD_1	423	425	PF00675	0.589
CLV_NRD_NRD_1	895	897	PF00675	0.287
CLV_NRD_NRD_1	921	923	PF00675	0.777
CLV_PCSK_KEX2_1	274	276	PF00082	0.339
CLV_PCSK_KEX2_1	34	36	PF00082	0.400
CLV_PCSK_KEX2_1	351	353	PF00082	0.534
CLV_PCSK_KEX2_1	358	360	PF00082	0.539
CLV_PCSK_KEX2_1	423	425	PF00082	0.657
CLV_PCSK_KEX2_1	781	783	PF00082	0.371
CLV_PCSK_KEX2_1	895	897	PF00082	0.287
CLV_PCSK_KEX2_1	921	923	PF00082	0.700
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.530
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.529
CLV_PCSK_PC1ET2_1	781	783	PF00082	0.368
CLV_PCSK_SKI1_1	280	284	PF00082	0.288
CLV_PCSK_SKI1_1	316	320	PF00082	0.541
CLV_PCSK_SKI1_1	345	349	PF00082	0.420
CLV_PCSK_SKI1_1	40	44	PF00082	0.470
CLV_PCSK_SKI1_1	578	582	PF00082	0.303
CLV_PCSK_SKI1_1	618	622	PF00082	0.298
CLV_PCSK_SKI1_1	786	790	PF00082	0.358
CLV_PCSK_SKI1_1	802	806	PF00082	0.237
CLV_PCSK_SKI1_1	829	833	PF00082	0.442
CLV_PCSK_SKI1_1	97	101	PF00082	0.608
CLV_PCSK_SKI1_1	972	976	PF00082	0.367
CLV_Separin_Metazoa	380	384	PF03568	0.499
CLV_Separin_Metazoa	557	561	PF03568	0.607
DEG_APCC_DBOX_1	781	789	PF00400	0.589
DEG_Kelch_actinfilin_1	512	516	PF01344	0.471
DEG_Nend_UBRbox_1	1	4	PF02207	0.669
DOC_CKS1_1	940	945	PF01111	0.676
DOC_CKS1_1	98	103	PF01111	0.503
DOC_MAPK_gen_1	373	381	PF00069	0.569
DOC_MAPK_gen_1	583	592	PF00069	0.528
DOC_MAPK_gen_1	972	982	PF00069	0.395
DOC_MAPK_gen_1	987	996	PF00069	0.504
DOC_PP1_RVXF_1	204	210	PF00149	0.435
DOC_PP1_RVXF_1	539	545	PF00149	0.448
DOC_PP2B_LxvP_1	161	164	PF13499	0.527
DOC_PP2B_LxvP_1	435	438	PF13499	0.533
DOC_PP2B_LxvP_1	980	983	PF13499	0.603
DOC_USP7_MATH_1	148	152	PF00917	0.520
DOC_USP7_MATH_1	408	412	PF00917	0.641
DOC_USP7_MATH_1	643	647	PF00917	0.584
DOC_USP7_MATH_1	649	653	PF00917	0.429
DOC_USP7_MATH_1	734	738	PF00917	0.563
DOC_USP7_MATH_1	864	868	PF00917	0.793
DOC_USP7_MATH_1	967	971	PF00917	0.439
DOC_USP7_UBL2_3	63	67	PF12436	0.243
DOC_WW_Pin1_4	423	428	PF00397	0.639
DOC_WW_Pin1_4	508	513	PF00397	0.666
DOC_WW_Pin1_4	752	757	PF00397	0.500
DOC_WW_Pin1_4	939	944	PF00397	0.617
DOC_WW_Pin1_4	947	952	PF00397	0.671
DOC_WW_Pin1_4	97	102	PF00397	0.588
LIG_14-3-3_CanoR_1	110	115	PF00244	0.638
LIG_14-3-3_CanoR_1	149	157	PF00244	0.507
LIG_14-3-3_CanoR_1	206	210	PF00244	0.452
LIG_14-3-3_CanoR_1	236	246	PF00244	0.384
LIG_14-3-3_CanoR_1	502	508	PF00244	0.741
LIG_14-3-3_CanoR_1	6	10	PF00244	0.409
LIG_14-3-3_CanoR_1	782	786	PF00244	0.530
LIG_14-3-3_CanoR_1	829	839	PF00244	0.409
LIG_14-3-3_CanoR_1	972	982	PF00244	0.422
LIG_Actin_WH2_2	51	69	PF00022	0.400
LIG_BRCT_BRCA1_1	949	953	PF00533	0.430
LIG_Clathr_ClatBox_1	10	14	PF01394	0.324
LIG_Clathr_ClatBox_1	132	136	PF01394	0.459
LIG_CtBP_PxDLS_1	101	105	PF00389	0.495
LIG_deltaCOP1_diTrp_1	900	908	PF00928	0.487
LIG_EH1_1	276	284	PF00400	0.384
LIG_FHA_1	109	115	PF00498	0.457
LIG_FHA_1	22	28	PF00498	0.384
LIG_FHA_1	238	244	PF00498	0.385
LIG_FHA_1	481	487	PF00498	0.634
LIG_FHA_1	502	508	PF00498	0.621
LIG_FHA_1	696	702	PF00498	0.531
LIG_FHA_1	831	837	PF00498	0.461
LIG_FHA_1	904	910	PF00498	0.596
LIG_FHA_1	942	948	PF00498	0.588
LIG_FHA_1	961	967	PF00498	0.475
LIG_FHA_2	16	22	PF00498	0.339
LIG_FHA_2	358	364	PF00498	0.457
LIG_FHA_2	753	759	PF00498	0.487
LIG_FHA_2	950	956	PF00498	0.578
LIG_FHA_2	986	992	PF00498	0.346
LIG_GBD_Chelix_1	681	689	PF00786	0.229
LIG_IBAR_NPY_1	156	158	PF08397	0.505
LIG_LIR_Apic_2	208	212	PF02991	0.466
LIG_LIR_Apic_2	810	816	PF02991	0.487
LIG_LIR_Gen_1	360	367	PF02991	0.373
LIG_LIR_Gen_1	411	421	PF02991	0.640
LIG_LIR_Gen_1	483	492	PF02991	0.575
LIG_LIR_Gen_1	8	15	PF02991	0.339
LIG_LIR_Gen_1	950	960	PF02991	0.448
LIG_LIR_LC3C_4	8	12	PF02991	0.297
LIG_LIR_Nem_3	1001	1007	PF02991	0.419
LIG_LIR_Nem_3	140	146	PF02991	0.480
LIG_LIR_Nem_3	155	161	PF02991	0.413
LIG_LIR_Nem_3	173	178	PF02991	0.524
LIG_LIR_Nem_3	208	213	PF02991	0.362
LIG_LIR_Nem_3	257	261	PF02991	0.386
LIG_LIR_Nem_3	343	347	PF02991	0.433
LIG_LIR_Nem_3	360	364	PF02991	0.369
LIG_LIR_Nem_3	411	416	PF02991	0.637
LIG_LIR_Nem_3	449	455	PF02991	0.400
LIG_LIR_Nem_3	483	487	PF02991	0.594
LIG_LIR_Nem_3	572	577	PF02991	0.598
LIG_LIR_Nem_3	609	615	PF02991	0.482
LIG_LIR_Nem_3	8	12	PF02991	0.339
LIG_LIR_Nem_3	817	822	PF02991	0.519
LIG_LIR_Nem_3	82	87	PF02991	0.358
LIG_LIR_Nem_3	891	897	PF02991	0.514
LIG_LIR_Nem_3	950	956	PF02991	0.453
LIG_NRBOX	684	690	PF00104	0.589
LIG_PCNA_PIPBox_1	80	89	PF02747	0.339
LIG_Pex14_1	209	213	PF04695	0.451
LIG_Pex14_1	403	407	PF04695	0.416
LIG_Pex14_2	9	13	PF04695	0.329
LIG_PTB_Apo_2	153	160	PF02174	0.555
LIG_PTB_Apo_2	403	410	PF02174	0.557
LIG_PTB_Apo_2	491	498	PF02174	0.651
LIG_PTB_Apo_2	769	776	PF02174	0.429
LIG_PTB_Apo_2	825	832	PF02174	0.554
LIG_PTB_Phospho_1	153	159	PF10480	0.553
LIG_PTB_Phospho_1	403	409	PF10480	0.557
LIG_REV1ctd_RIR_1	829	838	PF16727	0.361
LIG_SH2_CRK	1004	1008	PF00017	0.385
LIG_SH2_CRK	258	262	PF00017	0.384
LIG_SH2_CRK	407	411	PF00017	0.480
LIG_SH2_CRK	413	417	PF00017	0.573
LIG_SH2_CRK	612	616	PF00017	0.589
LIG_SH2_CRK	894	898	PF00017	0.589
LIG_SH2_GRB2like	413	416	PF00017	0.647
LIG_SH2_GRB2like	722	725	PF00017	0.541
LIG_SH2_GRB2like	770	773	PF00017	0.429
LIG_SH2_NCK_1	413	417	PF00017	0.677
LIG_SH2_NCK_1	927	931	PF00017	0.537
LIG_SH2_SRC	407	410	PF00017	0.551
LIG_SH2_SRC	413	416	PF00017	0.655
LIG_SH2_STAP1	159	163	PF00017	0.509
LIG_SH2_STAP1	770	774	PF00017	0.524
LIG_SH2_STAT3	213	216	PF00017	0.328
LIG_SH2_STAT3	722	725	PF00017	0.589
LIG_SH2_STAT5	258	261	PF00017	0.363
LIG_SH2_STAT5	409	412	PF00017	0.580
LIG_SH2_STAT5	451	454	PF00017	0.378
LIG_SH2_STAT5	459	462	PF00017	0.395
LIG_SH2_STAT5	722	725	PF00017	0.589
LIG_SH2_STAT5	750	753	PF00017	0.515
LIG_SH2_STAT5	770	773	PF00017	0.579
LIG_SH2_STAT5	830	833	PF00017	0.457
LIG_SH2_STAT5	86	89	PF00017	0.481
LIG_SH3_3	175	181	PF00018	0.560
LIG_SH3_3	23	29	PF00018	0.243
LIG_SH3_3	261	267	PF00018	0.438
LIG_SH3_3	389	395	PF00018	0.484
LIG_SH3_3	489	495	PF00018	0.536
LIG_SH3_3	506	512	PF00018	0.676
LIG_SH3_3	524	530	PF00018	0.623
LIG_SH3_3	556	562	PF00018	0.696
LIG_SH3_3	563	569	PF00018	0.652
LIG_SH3_3	75	81	PF00018	0.467
LIG_SH3_3	785	791	PF00018	0.556
LIG_TRAF2_1	360	363	PF00917	0.552
LIG_TRAF2_1	469	472	PF00917	0.607
LIG_TRAF2_1	913	916	PF00917	0.579
LIG_TYR_ITIM	892	897	PF00017	0.589
LIG_UBA3_1	589	594	PF00899	0.541
LIG_WW_2	392	395	PF00397	0.518
LIG_WW_3	822	826	PF00397	0.554
MOD_CDK_SPK_2	752	757	PF00069	0.591
MOD_CK1_1	205	211	PF00069	0.383
MOD_CK1_1	365	371	PF00069	0.509
MOD_CK1_1	629	635	PF00069	0.509
MOD_CK1_1	752	758	PF00069	0.493
MOD_CK1_1	970	976	PF00069	0.464
MOD_CK2_1	205	211	PF00069	0.550
MOD_CK2_1	357	363	PF00069	0.479
MOD_CK2_1	925	931	PF00069	0.637
MOD_CK2_1	949	955	PF00069	0.591
MOD_CMANNOS	619	622	PF00535	0.298
MOD_Cter_Amidation	32	35	PF01082	0.400
MOD_GlcNHglycan	1000	1003	PF01048	0.449
MOD_GlcNHglycan	367	370	PF01048	0.669
MOD_GlcNHglycan	518	521	PF01048	0.653
MOD_GlcNHglycan	562	565	PF01048	0.697
MOD_GlcNHglycan	651	654	PF01048	0.284
MOD_GlcNHglycan	736	739	PF01048	0.376
MOD_GlcNHglycan	836	839	PF01048	0.662
MOD_GlcNHglycan	851	854	PF01048	0.575
MOD_GlcNHglycan	866	869	PF01048	0.575
MOD_GlcNHglycan	882	885	PF01048	0.228
MOD_GlcNHglycan	927	930	PF01048	0.606
MOD_GlcNHglycan	944	947	PF01048	0.553
MOD_GSK3_1	148	155	PF00069	0.444
MOD_GSK3_1	283	290	PF00069	0.565
MOD_GSK3_1	643	650	PF00069	0.575
MOD_GSK3_1	777	784	PF00069	0.455
MOD_GSK3_1	830	837	PF00069	0.494
MOD_GSK3_1	845	852	PF00069	0.620
MOD_GSK3_1	903	910	PF00069	0.509
MOD_GSK3_1	994	1001	PF00069	0.349
MOD_N-GLC_1	365	370	PF02516	0.538
MOD_N-GLC_1	695	700	PF02516	0.363
MOD_N-GLC_2	227	229	PF02516	0.339
MOD_NEK2_1	15	20	PF00069	0.338
MOD_NEK2_1	228	233	PF00069	0.371
MOD_NEK2_1	237	242	PF00069	0.378
MOD_NEK2_1	283	288	PF00069	0.417
MOD_NEK2_1	48	53	PF00069	0.375
MOD_NEK2_1	636	641	PF00069	0.522
MOD_NEK2_1	759	764	PF00069	0.589
MOD_NEK2_1	766	771	PF00069	0.589
MOD_NEK2_1	858	863	PF00069	0.685
MOD_NEK2_1	874	879	PF00069	0.539
MOD_NEK2_2	569	574	PF00069	0.599
MOD_NEK2_2	967	972	PF00069	0.390
MOD_PIKK_1	148	154	PF00454	0.453
MOD_PIKK_1	485	491	PF00454	0.665
MOD_PIKK_1	495	501	PF00454	0.640
MOD_PIKK_1	572	578	PF00454	0.539
MOD_PIKK_1	811	817	PF00454	0.522
MOD_PIKK_1	830	836	PF00454	0.407
MOD_PIKK_1	936	942	PF00454	0.602
MOD_PIKK_1	960	966	PF00454	0.467
MOD_PK_1	110	116	PF00069	0.736
MOD_PK_1	352	358	PF00069	0.560
MOD_PK_1	529	535	PF00069	0.607
MOD_PKA_1	781	787	PF00069	0.541
MOD_PKA_2	148	154	PF00069	0.438
MOD_PKA_2	202	208	PF00069	0.495
MOD_PKA_2	5	11	PF00069	0.412
MOD_PKA_2	501	507	PF00069	0.789
MOD_PKA_2	781	787	PF00069	0.631
MOD_PKA_2	998	1004	PF00069	0.401
MOD_Plk_1	15	21	PF00069	0.324
MOD_Plk_1	626	632	PF00069	0.505
MOD_Plk_1	759	765	PF00069	0.544
MOD_Plk_2-3	72	78	PF00069	0.400
MOD_Plk_2-3	949	955	PF00069	0.560
MOD_Plk_4	15	21	PF00069	0.324
MOD_Plk_4	205	211	PF00069	0.448
MOD_Plk_4	228	234	PF00069	0.428
MOD_Plk_4	239	245	PF00069	0.332
MOD_Plk_4	329	335	PF00069	0.512
MOD_Plk_4	352	358	PF00069	0.560
MOD_Plk_4	5	11	PF00069	0.397
MOD_Plk_4	53	59	PF00069	0.363
MOD_Plk_4	569	575	PF00069	0.694
MOD_Plk_4	626	632	PF00069	0.509
MOD_Plk_4	808	814	PF00069	0.546
MOD_ProDKin_1	423	429	PF00069	0.649
MOD_ProDKin_1	508	514	PF00069	0.632
MOD_ProDKin_1	752	758	PF00069	0.500
MOD_ProDKin_1	939	945	PF00069	0.621
MOD_ProDKin_1	947	953	PF00069	0.655
MOD_ProDKin_1	97	103	PF00069	0.592
MOD_SUMO_for_1	913	916	PF00179	0.541
MOD_SUMO_for_1	974	977	PF00179	0.381
MOD_SUMO_rev_2	64	69	PF00179	0.476
TRG_DiLeu_BaEn_4	915	921	PF01217	0.619
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.339
TRG_DiLeu_BaLyEn_6	684	689	PF01217	0.589
TRG_DiLeu_BaLyEn_6	893	898	PF01217	0.449
TRG_ENDOCYTIC_2	1004	1007	PF00928	0.418
TRG_ENDOCYTIC_2	158	161	PF00928	0.515
TRG_ENDOCYTIC_2	175	178	PF00928	0.597
TRG_ENDOCYTIC_2	258	261	PF00928	0.384
TRG_ENDOCYTIC_2	407	410	PF00928	0.467
TRG_ENDOCYTIC_2	413	416	PF00928	0.571
TRG_ENDOCYTIC_2	453	456	PF00928	0.403
TRG_ENDOCYTIC_2	459	462	PF00928	0.420
TRG_ENDOCYTIC_2	555	558	PF00928	0.538
TRG_ENDOCYTIC_2	577	580	PF00928	0.339
TRG_ENDOCYTIC_2	612	615	PF00928	0.589
TRG_ENDOCYTIC_2	819	822	PF00928	0.487
TRG_ENDOCYTIC_2	894	897	PF00928	0.589
TRG_ER_diArg_1	265	268	PF00400	0.324
TRG_ER_diArg_1	423	425	PF00400	0.589
TRG_ER_diArg_1	894	896	PF00400	0.487
TRG_ER_diArg_1	920	922	PF00400	0.490
TRG_NES_CRM1_1	116	129	PF08389	0.443
TRG_NES_CRM1_1	314	324	PF08389	0.555
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	687	692	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.271
TRG_Pf-PMV_PEXEL_1	895	900	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDC9	Leptomonas seymouri	66%	100%
A0A0S4J9G5	Bodo saltans	35%	100%
A0A1X0NKN4	Trypanosomatidae	41%	100%
A0A3R7MAF3	Trypanosoma rangeli	39%	100%
A0A3S5H5R3	Leishmania donovani	83%	100%
A4HSV3	Leishmania infantum	83%	100%
C9ZTG3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AKU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QJ16	Leishmania major	83%	100%
V5BT19	Trypanosoma cruzi	40%	100%