Carbonic anhydrase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Carbonic anhydrase

Gene product:

carbonic anhydrase family protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H4M7_LEIBR

TriTrypDb:

LbrM.06.0620 , LBRM2903_060011900

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4M7

Function

Biological processes
Term	Name	Level	Count
GO:0009605	response to external stimulus	2	7
GO:0009991	response to extracellular stimulus	3	7
GO:0015976	carbon utilization	5	7
GO:0031667	response to nutrient levels	4	7
GO:0050896	response to stimulus	1	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004089	carbonate dehydratase activity	5	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0016829	lyase activity	2	7
GO:0016835	carbon-oxygen lyase activity	3	7
GO:0016836	hydro-lyase activity	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.502
CLV_NRD_NRD_1	282	284	PF00675	0.361
CLV_NRD_NRD_1	366	368	PF00675	0.369
CLV_PCSK_KEX2_1	17	19	PF00082	0.502
CLV_PCSK_KEX2_1	278	280	PF00082	0.280
CLV_PCSK_KEX2_1	282	284	PF00082	0.280
CLV_PCSK_KEX2_1	366	368	PF00082	0.369
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.280
CLV_PCSK_SKI1_1	282	286	PF00082	0.361
CLV_PCSK_SKI1_1	359	363	PF00082	0.386
CLV_Separin_Metazoa	110	114	PF03568	0.479
CLV_Separin_Metazoa	167	171	PF03568	0.295
DEG_APCC_DBOX_1	281	289	PF00400	0.332
DEG_APCC_DBOX_1	290	298	PF00400	0.236
DOC_ANK_TNKS_1	60	67	PF00023	0.435
DOC_CKS1_1	106	111	PF01111	0.464
DOC_CYCLIN_RxL_1	356	363	PF00134	0.355
DOC_MAPK_gen_1	337	346	PF00069	0.198
DOC_MAPK_JIP1_4	184	190	PF00069	0.361
DOC_PP2B_LxvP_1	98	101	PF13499	0.551
DOC_PP4_FxxP_1	4	7	PF00568	0.530
DOC_USP7_MATH_1	101	105	PF00917	0.515
DOC_USP7_MATH_1	149	153	PF00917	0.448
DOC_USP7_MATH_1	9	13	PF00917	0.686
DOC_USP7_UBL2_3	372	376	PF12436	0.288
DOC_WW_Pin1_4	105	110	PF00397	0.547
DOC_WW_Pin1_4	117	122	PF00397	0.616
DOC_WW_Pin1_4	65	70	PF00397	0.486
DOC_WW_Pin1_4	78	83	PF00397	0.426
LIG_14-3-3_CanoR_1	138	144	PF00244	0.515
LIG_14-3-3_CanoR_1	359	365	PF00244	0.370
LIG_14-3-3_CanoR_1	366	371	PF00244	0.398
LIG_14-3-3_CanoR_1	45	49	PF00244	0.426
LIG_eIF4E_1	106	112	PF01652	0.464
LIG_FHA_1	106	112	PF00498	0.510
LIG_FHA_1	253	259	PF00498	0.473
LIG_FHA_1	310	316	PF00498	0.280
LIG_FHA_1	45	51	PF00498	0.395
LIG_FHA_1	95	101	PF00498	0.623
LIG_FHA_2	105	111	PF00498	0.603
LIG_LIR_Apic_2	104	109	PF02991	0.461
LIG_LIR_Gen_1	174	180	PF02991	0.385
LIG_LIR_Nem_3	174	179	PF02991	0.401
LIG_LIR_Nem_3	379	385	PF02991	0.535
LIG_Pex14_2	4	8	PF04695	0.436
LIG_PTB_Apo_2	169	176	PF02174	0.383
LIG_PTB_Phospho_1	169	175	PF10480	0.383
LIG_SH2_NCK_1	106	110	PF00017	0.463
LIG_SH2_STAT5	106	109	PF00017	0.606
LIG_SH2_STAT5	175	178	PF00017	0.411
LIG_SH2_STAT5	187	190	PF00017	0.317
LIG_SH3_3	90	96	PF00018	0.543
LIG_SH3_5	156	160	PF00018	0.298
LIG_Sin3_3	227	234	PF02671	0.280
LIG_WW_3	147	151	PF00397	0.456
MOD_CK1_1	104	110	PF00069	0.413
MOD_CK1_1	120	126	PF00069	0.562
MOD_CK1_1	39	45	PF00069	0.711
MOD_CK1_1	68	74	PF00069	0.528
MOD_CK1_1	84	90	PF00069	0.593
MOD_CK2_1	104	110	PF00069	0.600
MOD_CK2_1	365	371	PF00069	0.372
MOD_GlcNHglycan	11	14	PF01048	0.658
MOD_GlcNHglycan	151	154	PF01048	0.433
MOD_GlcNHglycan	245	248	PF01048	0.313
MOD_GlcNHglycan	273	276	PF01048	0.280
MOD_GlcNHglycan	31	34	PF01048	0.618
MOD_GSK3_1	101	108	PF00069	0.553
MOD_GSK3_1	113	120	PF00069	0.586
MOD_GSK3_1	16	23	PF00069	0.565
MOD_GSK3_1	25	32	PF00069	0.505
MOD_GSK3_1	73	80	PF00069	0.477
MOD_NEK2_1	139	144	PF00069	0.536
MOD_NEK2_1	271	276	PF00069	0.280
MOD_NEK2_1	29	34	PF00069	0.476
MOD_NEK2_1	73	78	PF00069	0.468
MOD_NEK2_2	101	106	PF00069	0.469
MOD_PIKK_1	122	128	PF00454	0.440
MOD_PIKK_1	317	323	PF00454	0.231
MOD_PK_1	366	372	PF00069	0.298
MOD_PKA_1	366	372	PF00069	0.298
MOD_PKA_2	149	155	PF00069	0.440
MOD_PKA_2	16	22	PF00069	0.484
MOD_PKA_2	333	339	PF00069	0.290
MOD_PKA_2	365	371	PF00069	0.387
MOD_PKA_2	39	45	PF00069	0.507
MOD_PKA_2	94	100	PF00069	0.613
MOD_PKB_1	113	121	PF00069	0.493
MOD_Plk_1	113	119	PF00069	0.652
MOD_Plk_4	101	107	PF00069	0.615
MOD_Plk_4	130	136	PF00069	0.536
MOD_Plk_4	25	31	PF00069	0.481
MOD_ProDKin_1	105	111	PF00069	0.547
MOD_ProDKin_1	117	123	PF00069	0.609
MOD_ProDKin_1	65	71	PF00069	0.487
MOD_ProDKin_1	78	84	PF00069	0.423
MOD_SUMO_for_1	127	130	PF00179	0.435
MOD_SUMO_for_1	238	241	PF00179	0.270
TRG_DiLeu_BaEn_1	130	135	PF01217	0.448
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.408
TRG_DiLeu_BaLyEn_6	357	362	PF01217	0.350
TRG_ENDOCYTIC_2	187	190	PF00928	0.317
TRG_ENDOCYTIC_2	385	388	PF00928	0.397
TRG_ER_diArg_1	16	18	PF00400	0.488
TRG_ER_diArg_1	281	283	PF00400	0.393
TRG_ER_diArg_1	337	340	PF00400	0.198
TRG_ER_diArg_1	58	61	PF00400	0.644
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX68	Leptomonas seymouri	69%	99%
A0A3S5H5R2	Leishmania donovani	88%	100%
A4HSV2	Leishmania infantum	88%	100%
E9AKU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O94255	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q4QJ17	Leishmania major	87%	100%