Putative 60S ribosomal protein L23a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L23a, putative

Species:

Leishmania braziliensis

UniProt:

A4H4M3_LEIBR

TriTrypDb:

LbrM.06.0580 , LBRM2903_060011600

Length:

157

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	14
GO:0032991	protein-containing complex	1	15
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	15
GO:1990904	ribonucleoprotein complex	2	15
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

A4H4M3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4M3

PDB structure(s): 6az3_V

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	15
GO:0006518	peptide metabolic process	4	15
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0009058	biosynthetic process	2	15
GO:0009059	macromolecule biosynthetic process	4	15
GO:0009987	cellular process	1	15
GO:0019538	protein metabolic process	3	15
GO:0034641	cellular nitrogen compound metabolic process	3	15
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	15
GO:0043043	peptide biosynthetic process	5	15
GO:0043170	macromolecule metabolic process	3	15
GO:0043603	amide metabolic process	3	15
GO:0043604	amide biosynthetic process	4	15
GO:0044237	cellular metabolic process	2	15
GO:0044238	primary metabolic process	2	15
GO:0044249	cellular biosynthetic process	3	15
GO:0044260	obsolete cellular macromolecule metabolic process	3	15
GO:0044271	cellular nitrogen compound biosynthetic process	4	15
GO:0071704	organic substance metabolic process	2	15
GO:1901564	organonitrogen compound metabolic process	3	15
GO:1901566	organonitrogen compound biosynthetic process	4	15
GO:1901576	organic substance biosynthetic process	3	15
GO:0000027	ribosomal large subunit assembly	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	15
GO:0003723	RNA binding	4	15
GO:0003735	structural constituent of ribosome	2	15
GO:0005198	structural molecule activity	1	15
GO:0005488	binding	1	15
GO:0019843	rRNA binding	5	15
GO:0097159	organic cyclic compound binding	2	15
GO:1901363	heterocyclic compound binding	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.292
CLV_NRD_NRD_1	38	40	PF00675	0.486
CLV_NRD_NRD_1	48	50	PF00675	0.457
CLV_NRD_NRD_1	54	56	PF00675	0.461
CLV_PCSK_KEX2_1	48	50	PF00082	0.479
CLV_PCSK_KEX2_1	54	56	PF00082	0.498
CLV_PCSK_PC7_1	44	50	PF00082	0.461
CLV_PCSK_SKI1_1	121	125	PF00082	0.292
CLV_PCSK_SKI1_1	18	22	PF00082	0.607
CLV_PCSK_SKI1_1	26	30	PF00082	0.604
CLV_PCSK_SKI1_1	32	36	PF00082	0.527
CLV_PCSK_SKI1_1	70	74	PF00082	0.480
CLV_PCSK_SKI1_1	86	90	PF00082	0.287
DOC_CYCLIN_yClb1_LxF_4	94	100	PF00134	0.292
DOC_MAPK_gen_1	135	141	PF00069	0.346
DOC_MAPK_gen_1	26	36	PF00069	0.648
DOC_PP4_FxxP_1	47	50	PF00568	0.458
DOC_USP7_MATH_1	59	63	PF00917	0.545
DOC_USP7_UBL2_3	107	111	PF12436	0.292
DOC_USP7_UBL2_3	112	116	PF12436	0.292
DOC_USP7_UBL2_3	18	22	PF12436	0.596
DOC_USP7_UBL2_3	86	90	PF12436	0.305
LIG_14-3-3_CanoR_1	140	148	PF00244	0.392
LIG_14-3-3_CanoR_1	39	43	PF00244	0.529
LIG_14-3-3_CanoR_1	48	54	PF00244	0.410
LIG_14-3-3_CanoR_1	64	68	PF00244	0.449
LIG_14-3-3_CanoR_1	79	88	PF00244	0.217
LIG_Actin_WH2_2	121	137	PF00022	0.292
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BIR_III_1	1	5	PF00653	0.425
LIG_BIR_III_3	1	5	PF00653	0.425
LIG_FHA_1	29	35	PF00498	0.610
LIG_FHA_1	3	9	PF00498	0.686
LIG_FHA_1	96	102	PF00498	0.294
LIG_LIR_Apic_2	41	45	PF02991	0.543
LIG_LIR_Apic_2	52	56	PF02991	0.397
LIG_LIR_Gen_1	73	82	PF02991	0.352
LIG_LIR_Nem_3	73	78	PF02991	0.358
LIG_SH2_CRK	42	46	PF00017	0.467
LIG_SH2_CRK	53	57	PF00017	0.464
LIG_SH2_NCK_1	42	46	PF00017	0.467
LIG_SH2_PTP2	138	141	PF00017	0.361
LIG_SH2_STAT5	138	141	PF00017	0.361
LIG_SH2_STAT5	42	45	PF00017	0.472
LIG_UBA3_1	9	18	PF00899	0.462
MOD_GlcNHglycan	141	144	PF01048	0.400
MOD_GSK3_1	34	41	PF00069	0.584
MOD_GSK3_1	59	66	PF00069	0.501
MOD_N-GLC_1	105	110	PF02516	0.292
MOD_N-GLC_1	93	98	PF02516	0.292
MOD_NEK2_1	9	14	PF00069	0.462
MOD_PKA_2	139	145	PF00069	0.390
MOD_PKA_2	38	44	PF00069	0.566
MOD_PKA_2	63	69	PF00069	0.601
MOD_Plk_1	70	76	PF00069	0.381
MOD_Plk_1	93	99	PF00069	0.292
MOD_Plk_4	124	130	PF00069	0.316
MOD_Plk_4	95	101	PF00069	0.308
MOD_SUMO_rev_2	62	72	PF00179	0.606
TRG_DiLeu_BaEn_4	92	98	PF01217	0.292
TRG_ENDOCYTIC_2	138	141	PF00928	0.361
TRG_ER_diArg_1	47	49	PF00400	0.461
TRG_ER_diArg_1	53	55	PF00400	0.462
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4X7	Leptomonas seymouri	91%	100%
A0A0S4J345	Bodo saltans	74%	95%
A0A1D8PPS1	Candida albicans (strain SC5314 / ATCC MYA-2876)	46%	100%
A0A1X0NMB1	Trypanosomatidae	78%	96%
A0A1X0NMD0	Trypanosomatidae	81%	100%
A0A3S5IQT9	Trypanosoma rangeli	77%	100%
A0A3S7WPH7	Leishmania donovani	95%	100%
A4H4M4	Leishmania braziliensis	99%	100%
A4HSU9	Leishmania infantum	95%	100%
C9ZTF9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	96%
C9ZTG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	71%
E9AG68	Leishmania infantum	95%	100%
E9AKT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O22644	Fritillaria agrestis	51%	100%
O74391	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	100%
P04456	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	100%
P08792	Cyberlindnera jadinii	45%	100%
P0DJ57	Tetrahymena thermophila (strain SB210)	46%	100%
P41165	Trypanosoma brucei brucei	82%	96%
P48045	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	44%	100%
P48162	Caenorhabditis elegans	47%	100%
P51997	Puccinia graminis	50%	99%
P62750	Homo sapiens	53%	100%
P62751	Mus musculus	53%	100%
P62752	Rattus norvegicus	53%	100%
Q07761	Nicotiana tabacum	47%	100%
Q10330	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	100%
Q20647	Caenorhabditis elegans	53%	100%
Q24JY1	Bos taurus	53%	100%
Q4QJ20	Leishmania major	95%	100%
Q54BQ3	Dictyostelium discoideum	46%	93%
Q8LD46	Arabidopsis thaliana	53%	100%
Q9AT35	Daucus carota	48%	100%
Q9M3C3	Arabidopsis thaliana	50%	100%