LeishMANIAdb
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Basic immunoglobulin-like variable motif-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Basic immunoglobulin-like variable motif-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H4M0_LEIBR
TriTrypDb:
LbrM.06.0550 , LBRM2903_060011300 *
Length:
849

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4M0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4M0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 198 202 PF00656 0.566
CLV_C14_Caspase3-7 36 40 PF00656 0.601
CLV_C14_Caspase3-7 58 62 PF00656 0.586
CLV_C14_Caspase3-7 673 677 PF00656 0.589
CLV_NRD_NRD_1 217 219 PF00675 0.654
CLV_NRD_NRD_1 234 236 PF00675 0.532
CLV_NRD_NRD_1 477 479 PF00675 0.519
CLV_NRD_NRD_1 506 508 PF00675 0.622
CLV_NRD_NRD_1 91 93 PF00675 0.567
CLV_PCSK_FUR_1 232 236 PF00082 0.538
CLV_PCSK_KEX2_1 213 215 PF00082 0.552
CLV_PCSK_KEX2_1 229 231 PF00082 0.478
CLV_PCSK_KEX2_1 234 236 PF00082 0.541
CLV_PCSK_KEX2_1 506 508 PF00082 0.622
CLV_PCSK_KEX2_1 560 562 PF00082 0.624
CLV_PCSK_KEX2_1 91 93 PF00082 0.567
CLV_PCSK_PC1ET2_1 213 215 PF00082 0.552
CLV_PCSK_PC1ET2_1 229 231 PF00082 0.478
CLV_PCSK_PC1ET2_1 560 562 PF00082 0.624
CLV_PCSK_PC7_1 230 236 PF00082 0.534
CLV_PCSK_SKI1_1 218 222 PF00082 0.777
CLV_PCSK_SKI1_1 276 280 PF00082 0.527
CLV_PCSK_SKI1_1 294 298 PF00082 0.388
CLV_PCSK_SKI1_1 414 418 PF00082 0.472
DEG_APCC_DBOX_1 275 283 PF00400 0.450
DEG_APCC_DBOX_1 792 800 PF00400 0.427
DEG_Nend_UBRbox_2 1 3 PF02207 0.575
DEG_SPOP_SBC_1 750 754 PF00917 0.729
DOC_CKS1_1 25 30 PF01111 0.558
DOC_CYCLIN_yCln2_LP_2 644 650 PF00134 0.726
DOC_MAPK_DCC_7 276 284 PF00069 0.446
DOC_MAPK_MEF2A_6 276 284 PF00069 0.455
DOC_PP2B_LxvP_1 297 300 PF13499 0.507
DOC_PP4_FxxP_1 352 355 PF00568 0.504
DOC_PP4_FxxP_1 448 451 PF00568 0.533
DOC_USP7_MATH_1 108 112 PF00917 0.675
DOC_USP7_MATH_1 197 201 PF00917 0.581
DOC_USP7_MATH_1 360 364 PF00917 0.409
DOC_USP7_MATH_1 38 42 PF00917 0.599
DOC_USP7_MATH_1 454 458 PF00917 0.388
DOC_USP7_MATH_1 574 578 PF00917 0.629
DOC_USP7_MATH_1 638 642 PF00917 0.691
DOC_USP7_MATH_1 649 653 PF00917 0.576
DOC_USP7_MATH_1 655 659 PF00917 0.678
DOC_USP7_MATH_1 68 72 PF00917 0.600
DOC_USP7_MATH_1 699 703 PF00917 0.629
DOC_USP7_MATH_1 712 716 PF00917 0.701
DOC_USP7_MATH_1 732 736 PF00917 0.545
DOC_USP7_MATH_1 739 743 PF00917 0.659
DOC_USP7_MATH_1 750 754 PF00917 0.571
DOC_USP7_MATH_1 774 778 PF00917 0.716
DOC_USP7_MATH_1 829 833 PF00917 0.649
DOC_USP7_UBL2_3 219 223 PF12436 0.631
DOC_USP7_UBL2_3 225 229 PF12436 0.560
DOC_USP7_UBL2_3 511 515 PF12436 0.715
DOC_WW_Pin1_4 148 153 PF00397 0.574
DOC_WW_Pin1_4 24 29 PF00397 0.578
DOC_WW_Pin1_4 259 264 PF00397 0.673
DOC_WW_Pin1_4 39 44 PF00397 0.646
DOC_WW_Pin1_4 488 493 PF00397 0.520
DOC_WW_Pin1_4 627 632 PF00397 0.717
DOC_WW_Pin1_4 651 656 PF00397 0.631
DOC_WW_Pin1_4 667 672 PF00397 0.563
DOC_WW_Pin1_4 716 721 PF00397 0.655
DOC_WW_Pin1_4 744 749 PF00397 0.706
DOC_WW_Pin1_4 780 785 PF00397 0.717
DOC_WW_Pin1_4 825 830 PF00397 0.584
LIG_14-3-3_CanoR_1 234 239 PF00244 0.631
LIG_14-3-3_CanoR_1 338 347 PF00244 0.531
LIG_14-3-3_CanoR_1 478 487 PF00244 0.484
LIG_14-3-3_CanoR_1 591 597 PF00244 0.591
LIG_14-3-3_CanoR_1 598 605 PF00244 0.590
LIG_14-3-3_CanoR_1 705 710 PF00244 0.661
LIG_14-3-3_CanoR_1 778 784 PF00244 0.621
LIG_14-3-3_CanoR_1 830 834 PF00244 0.719
LIG_Actin_WH2_2 582 600 PF00022 0.582
LIG_BIR_III_4 550 554 PF00653 0.612
LIG_BRCT_BRCA1_1 490 494 PF00533 0.527
LIG_deltaCOP1_diTrp_1 358 364 PF00928 0.528
LIG_FHA_1 254 260 PF00498 0.644
LIG_FHA_1 269 275 PF00498 0.559
LIG_FHA_1 397 403 PF00498 0.525
LIG_FHA_1 405 411 PF00498 0.435
LIG_FHA_1 459 465 PF00498 0.380
LIG_FHA_1 535 541 PF00498 0.611
LIG_FHA_1 578 584 PF00498 0.671
LIG_FHA_1 619 625 PF00498 0.647
LIG_FHA_1 630 636 PF00498 0.693
LIG_FHA_1 88 94 PF00498 0.777
LIG_FHA_1 99 105 PF00498 0.654
LIG_FHA_2 12 18 PF00498 0.606
LIG_FHA_2 153 159 PF00498 0.577
LIG_FHA_2 193 199 PF00498 0.609
LIG_FHA_2 219 225 PF00498 0.626
LIG_FHA_2 285 291 PF00498 0.527
LIG_FHA_2 450 456 PF00498 0.426
LIG_FHA_2 615 621 PF00498 0.701
LIG_IRF3_LxIS_1 145 151 PF10401 0.573
LIG_LIR_Apic_2 447 451 PF02991 0.518
LIG_LIR_Gen_1 319 329 PF02991 0.538
LIG_LIR_Nem_3 319 325 PF02991 0.525
LIG_LIR_Nem_3 353 359 PF02991 0.500
LIG_LIR_Nem_3 491 497 PF02991 0.509
LIG_MLH1_MIPbox_1 490 494 PF16413 0.527
LIG_MYND_1 633 637 PF01753 0.592
LIG_PALB2_WD40_1 369 377 PF16756 0.452
LIG_PCNA_yPIPBox_3 367 379 PF02747 0.459
LIG_Pex14_1 205 209 PF04695 0.657
LIG_Pex14_2 352 356 PF04695 0.495
LIG_PTB_Apo_2 320 327 PF02174 0.434
LIG_PTB_Phospho_1 320 326 PF10480 0.434
LIG_REV1ctd_RIR_1 492 499 PF16727 0.506
LIG_SH2_CRK 322 326 PF00017 0.509
LIG_SH2_CRK 432 436 PF00017 0.443
LIG_SH2_SRC 117 120 PF00017 0.682
LIG_SH2_SRC 324 327 PF00017 0.454
LIG_SH2_SRC 438 441 PF00017 0.472
LIG_SH2_STAP1 125 129 PF00017 0.640
LIG_SH2_STAP1 132 136 PF00017 0.676
LIG_SH2_STAP1 476 480 PF00017 0.504
LIG_SH2_STAP1 814 818 PF00017 0.530
LIG_SH2_STAT3 172 175 PF00017 0.587
LIG_SH2_STAT5 117 120 PF00017 0.671
LIG_SH2_STAT5 324 327 PF00017 0.474
LIG_SH2_STAT5 388 391 PF00017 0.465
LIG_SH3_2 786 791 PF14604 0.598
LIG_SH3_3 115 121 PF00018 0.628
LIG_SH3_3 22 28 PF00018 0.556
LIG_SH3_3 580 586 PF00018 0.603
LIG_SH3_3 628 634 PF00018 0.712
LIG_SH3_3 693 699 PF00018 0.587
LIG_SH3_3 714 720 PF00018 0.618
LIG_SH3_3 783 789 PF00018 0.608
LIG_SH3_CIN85_PxpxPR_1 586 591 PF14604 0.559
LIG_SUMO_SIM_anti_2 26 33 PF11976 0.623
LIG_SUMO_SIM_anti_2 617 626 PF11976 0.622
LIG_SUMO_SIM_par_1 270 275 PF11976 0.532
LIG_SUMO_SIM_par_1 30 36 PF11976 0.589
LIG_TRAF2_1 162 165 PF00917 0.627
LIG_TRAF2_1 167 170 PF00917 0.618
LIG_TRAF2_1 342 345 PF00917 0.512
LIG_TRAF2_1 44 47 PF00917 0.702
LIG_TYR_ITIM 436 441 PF00017 0.463
LIG_WW_2 633 636 PF00397 0.597
MOD_CDK_SPK_2 825 830 PF00069 0.584
MOD_CK1_1 253 259 PF00069 0.628
MOD_CK1_1 317 323 PF00069 0.433
MOD_CK1_1 396 402 PF00069 0.534
MOD_CK1_1 457 463 PF00069 0.352
MOD_CK1_1 577 583 PF00069 0.622
MOD_CK1_1 592 598 PF00069 0.688
MOD_CK1_1 615 621 PF00069 0.673
MOD_CK1_1 679 685 PF00069 0.628
MOD_CK1_1 708 714 PF00069 0.650
MOD_CK1_1 752 758 PF00069 0.594
MOD_CK1_1 782 788 PF00069 0.659
MOD_CK1_1 828 834 PF00069 0.683
MOD_CK1_1 841 847 PF00069 0.646
MOD_CK1_1 87 93 PF00069 0.667
MOD_CK2_1 11 17 PF00069 0.613
MOD_CK2_1 148 154 PF00069 0.678
MOD_CK2_1 192 198 PF00069 0.724
MOD_CK2_1 218 224 PF00069 0.631
MOD_CK2_1 339 345 PF00069 0.492
MOD_CK2_1 449 455 PF00069 0.423
MOD_CK2_1 48 54 PF00069 0.647
MOD_CK2_1 573 579 PF00069 0.592
MOD_CK2_1 732 738 PF00069 0.706
MOD_CK2_1 74 80 PF00069 0.583
MOD_CK2_1 769 775 PF00069 0.597
MOD_CK2_1 840 846 PF00069 0.597
MOD_GlcNHglycan 104 107 PF01048 0.547
MOD_GlcNHglycan 110 113 PF01048 0.645
MOD_GlcNHglycan 134 137 PF01048 0.802
MOD_GlcNHglycan 22 25 PF01048 0.692
MOD_GlcNHglycan 251 255 PF01048 0.703
MOD_GlcNHglycan 331 334 PF01048 0.517
MOD_GlcNHglycan 395 398 PF01048 0.528
MOD_GlcNHglycan 50 53 PF01048 0.648
MOD_GlcNHglycan 576 579 PF01048 0.691
MOD_GlcNHglycan 591 594 PF01048 0.556
MOD_GlcNHglycan 710 713 PF01048 0.700
MOD_GlcNHglycan 714 717 PF01048 0.654
MOD_GlcNHglycan 720 723 PF01048 0.604
MOD_GlcNHglycan 76 79 PF01048 0.602
MOD_GlcNHglycan 771 774 PF01048 0.593
MOD_GlcNHglycan 86 89 PF01048 0.630
MOD_GSK3_1 148 155 PF00069 0.702
MOD_GSK3_1 20 27 PF00069 0.695
MOD_GSK3_1 214 221 PF00069 0.665
MOD_GSK3_1 239 246 PF00069 0.686
MOD_GSK3_1 253 260 PF00069 0.607
MOD_GSK3_1 329 336 PF00069 0.383
MOD_GSK3_1 362 369 PF00069 0.508
MOD_GSK3_1 393 400 PF00069 0.381
MOD_GSK3_1 449 456 PF00069 0.511
MOD_GSK3_1 529 536 PF00069 0.684
MOD_GSK3_1 569 576 PF00069 0.732
MOD_GSK3_1 612 619 PF00069 0.672
MOD_GSK3_1 651 658 PF00069 0.653
MOD_GSK3_1 708 715 PF00069 0.693
MOD_GSK3_1 739 746 PF00069 0.632
MOD_GSK3_1 821 828 PF00069 0.652
MOD_GSK3_1 98 105 PF00069 0.575
MOD_LATS_1 703 709 PF00433 0.598
MOD_N-GLC_1 366 371 PF02516 0.463
MOD_N-GLC_1 404 409 PF02516 0.521
MOD_N-GLC_1 569 574 PF02516 0.648
MOD_N-GLC_1 615 620 PF02516 0.570
MOD_N-GLC_1 705 710 PF02516 0.604
MOD_N-GLC_1 98 103 PF02516 0.672
MOD_NEK2_1 255 260 PF00069 0.561
MOD_NEK2_1 284 289 PF00069 0.414
MOD_NEK2_1 329 334 PF00069 0.574
MOD_NEK2_1 74 79 PF00069 0.576
MOD_NEK2_1 84 89 PF00069 0.596
MOD_NEK2_1 98 103 PF00069 0.606
MOD_NEK2_2 458 463 PF00069 0.478
MOD_NEK2_2 522 527 PF00069 0.603
MOD_NEK2_2 68 73 PF00069 0.568
MOD_PIKK_1 130 136 PF00454 0.598
MOD_PIKK_1 165 171 PF00454 0.726
MOD_PIKK_1 199 205 PF00454 0.713
MOD_PIKK_1 339 345 PF00454 0.492
MOD_PIKK_1 478 484 PF00454 0.491
MOD_PK_1 705 711 PF00069 0.605
MOD_PKA_1 218 224 PF00069 0.631
MOD_PKA_1 234 240 PF00069 0.537
MOD_PKA_1 478 484 PF00069 0.491
MOD_PKA_1 511 517 PF00069 0.655
MOD_PKA_2 234 240 PF00069 0.659
MOD_PKA_2 829 835 PF00069 0.615
MOD_PKB_1 232 240 PF00069 0.670
MOD_Plk_1 250 256 PF00069 0.574
MOD_Plk_1 366 372 PF00069 0.465
MOD_Plk_1 458 464 PF00069 0.477
MOD_Plk_1 522 528 PF00069 0.583
MOD_Plk_1 68 74 PF00069 0.566
MOD_Plk_1 705 711 PF00069 0.605
MOD_Plk_1 774 780 PF00069 0.610
MOD_Plk_1 814 820 PF00069 0.544
MOD_Plk_1 98 104 PF00069 0.614
MOD_Plk_2-3 55 61 PF00069 0.591
MOD_Plk_4 243 249 PF00069 0.688
MOD_Plk_4 317 323 PF00069 0.433
MOD_Plk_4 324 330 PF00069 0.399
MOD_Plk_4 345 351 PF00069 0.500
MOD_Plk_4 366 372 PF00069 0.465
MOD_Plk_4 458 464 PF00069 0.477
MOD_Plk_4 577 583 PF00069 0.718
MOD_Plk_4 592 598 PF00069 0.592
MOD_Plk_4 639 645 PF00069 0.612
MOD_Plk_4 679 685 PF00069 0.620
MOD_Plk_4 68 74 PF00069 0.566
MOD_Plk_4 99 105 PF00069 0.568
MOD_ProDKin_1 148 154 PF00069 0.573
MOD_ProDKin_1 24 30 PF00069 0.580
MOD_ProDKin_1 259 265 PF00069 0.674
MOD_ProDKin_1 39 45 PF00069 0.649
MOD_ProDKin_1 488 494 PF00069 0.516
MOD_ProDKin_1 627 633 PF00069 0.714
MOD_ProDKin_1 651 657 PF00069 0.631
MOD_ProDKin_1 667 673 PF00069 0.563
MOD_ProDKin_1 716 722 PF00069 0.656
MOD_ProDKin_1 744 750 PF00069 0.703
MOD_ProDKin_1 780 786 PF00069 0.717
MOD_ProDKin_1 825 831 PF00069 0.584
MOD_SUMO_for_1 789 792 PF00179 0.580
MOD_SUMO_rev_2 486 492 PF00179 0.497
TRG_DiLeu_BaEn_2 68 74 PF01217 0.566
TRG_DiLeu_BaEn_3 344 350 PF01217 0.498
TRG_DiLeu_BaLyEn_6 298 303 PF01217 0.497
TRG_ENDOCYTIC_2 322 325 PF00928 0.532
TRG_ENDOCYTIC_2 326 329 PF00928 0.503
TRG_ENDOCYTIC_2 438 441 PF00928 0.472
TRG_ENDOCYTIC_2 767 770 PF00928 0.607
TRG_ER_diArg_1 230 233 PF00400 0.641
TRG_ER_diArg_1 383 386 PF00400 0.479
TRG_ER_diArg_1 91 93 PF00400 0.567
TRG_NLS_Bipartite_1 213 233 PF00514 0.513
TRG_NLS_MonoExtN_4 507 514 PF00514 0.627
TRG_Pf-PMV_PEXEL_1 598 602 PF00026 0.589

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WPG2 Leishmania donovani 61% 98%
E9AG67 Leishmania infantum 61% 87%
E9AKT3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 100%
Q4QJ24 Leishmania major 60% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS