Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4L9_LEIBR

TriTrypDb:

LbrM.06.0540 , LBRM2903_060011200

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4L9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	223	225	PF00675	0.584
CLV_PCSK_KEX2_1	223	225	PF00082	0.566
CLV_PCSK_KEX2_1	96	98	PF00082	0.466
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.466
CLV_PCSK_SKI1_1	168	172	PF00082	0.631
CLV_PCSK_SKI1_1	93	97	PF00082	0.535
DOC_CKS1_1	164	169	PF01111	0.396
DOC_CKS1_1	249	254	PF01111	0.417
DOC_CYCLIN_RxL_1	255	264	PF00134	0.587
DOC_MAPK_gen_1	171	180	PF00069	0.385
DOC_PP1_RVXF_1	256	263	PF00149	0.381
DOC_PP2B_LxvP_1	35	38	PF13499	0.495
DOC_USP7_MATH_1	12	16	PF00917	0.640
DOC_USP7_MATH_1	193	197	PF00917	0.697
DOC_USP7_MATH_1	199	203	PF00917	0.664
DOC_USP7_MATH_1	5	9	PF00917	0.683
DOC_USP7_MATH_1	57	61	PF00917	0.568
DOC_USP7_MATH_1	76	80	PF00917	0.460
DOC_USP7_UBL2_3	197	201	PF12436	0.463
DOC_WW_Pin1_4	141	146	PF00397	0.699
DOC_WW_Pin1_4	163	168	PF00397	0.680
DOC_WW_Pin1_4	248	253	PF00397	0.417
DOC_WW_Pin1_4	281	286	PF00397	0.430
DOC_WW_Pin1_4	43	48	PF00397	0.626
LIG_14-3-3_CanoR_1	161	165	PF00244	0.595
LIG_14-3-3_CanoR_1	174	180	PF00244	0.417
LIG_14-3-3_CanoR_1	83	91	PF00244	0.595
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BIR_III_4	192	196	PF00653	0.660
LIG_BRCT_BRCA1_1	2	6	PF00533	0.562
LIG_BRCT_BRCA1_1	306	310	PF00533	0.616
LIG_CSL_BTD_1	236	239	PF09270	0.399
LIG_CSL_BTD_1	249	252	PF09270	0.421
LIG_deltaCOP1_diTrp_1	253	262	PF00928	0.390
LIG_FHA_1	120	126	PF00498	0.538
LIG_FHA_1	173	179	PF00498	0.538
LIG_FHA_1	249	255	PF00498	0.417
LIG_HCF-1_HBM_1	264	267	PF13415	0.450
LIG_LIR_Gen_1	264	274	PF02991	0.368
LIG_LIR_Nem_3	228	232	PF02991	0.625
LIG_LIR_Nem_3	264	270	PF02991	0.389
LIG_REV1ctd_RIR_1	88	97	PF16727	0.493
LIG_SH2_NCK_1	69	73	PF00017	0.466
LIG_SH2_SRC	69	72	PF00017	0.526
LIG_SH2_STAP1	288	292	PF00017	0.394
LIG_SH2_STAT5	158	161	PF00017	0.567
LIG_SH2_STAT5	261	264	PF00017	0.456
LIG_SH3_3	41	47	PF00018	0.638
LIG_SUMO_SIM_anti_2	245	251	PF11976	0.536
LIG_SUMO_SIM_par_1	245	251	PF11976	0.437
LIG_TRAF2_1	112	115	PF00917	0.539
LIG_TRAF2_1	144	147	PF00917	0.620
LIG_UBA3_1	34	39	PF00899	0.525
MOD_CAAXbox	308	311	PF01239	0.630
MOD_CDK_SPK_2	163	168	PF00069	0.647
MOD_CK1_1	119	125	PF00069	0.679
MOD_CK1_1	184	190	PF00069	0.545
MOD_CK1_1	301	307	PF00069	0.584
MOD_CK1_1	7	13	PF00069	0.665
MOD_CK2_1	141	147	PF00069	0.624
MOD_CMANNOS	237	240	PF00535	0.510
MOD_GlcNHglycan	135	138	PF01048	0.774
MOD_GlcNHglycan	15	18	PF01048	0.617
MOD_GlcNHglycan	175	178	PF01048	0.495
MOD_GlcNHglycan	192	196	PF01048	0.564
MOD_GlcNHglycan	201	204	PF01048	0.514
MOD_GlcNHglycan	303	306	PF01048	0.505
MOD_GlcNHglycan	7	10	PF01048	0.660
MOD_GlcNHglycan	85	88	PF01048	0.621
MOD_GSK3_1	113	120	PF00069	0.584
MOD_GSK3_1	193	200	PF00069	0.689
MOD_N-GLC_1	12	17	PF02516	0.735
MOD_NEK2_1	270	275	PF00069	0.433
MOD_PIKK_1	181	187	PF00454	0.377
MOD_PKA_2	160	166	PF00069	0.522
MOD_PKA_2	173	179	PF00069	0.419
MOD_PKA_2	270	276	PF00069	0.397
MOD_PKA_2	298	304	PF00069	0.544
MOD_Plk_4	216	222	PF00069	0.522
MOD_Plk_4	225	231	PF00069	0.505
MOD_Plk_4	242	248	PF00069	0.517
MOD_ProDKin_1	141	147	PF00069	0.694
MOD_ProDKin_1	163	169	PF00069	0.680
MOD_ProDKin_1	248	254	PF00069	0.417
MOD_ProDKin_1	281	287	PF00069	0.431
MOD_ProDKin_1	43	49	PF00069	0.620
MOD_SUMO_for_1	170	173	PF00179	0.626
MOD_SUMO_rev_2	173	183	PF00179	0.386
TRG_ENDOCYTIC_2	267	270	PF00928	0.367
TRG_ER_diArg_1	222	224	PF00400	0.619
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6B6	Leptomonas seymouri	65%	100%
A0A1X0NKM4	Trypanosomatidae	41%	100%
A0A3S7WPG5	Leishmania donovani	81%	100%
A0A422NGX7	Trypanosoma rangeli	41%	100%
A4HSU5	Leishmania infantum	81%	100%
C9ZTF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AKT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QJ25	Leishmania major	78%	95%
V5B7V6	Trypanosoma cruzi	41%	100%