U-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U-box domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H4L7_LEIBR

TriTrypDb:

LbrM.06.0520 , LBRM2903_060011000

Length:

760

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H4L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4L7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	383	387	PF00656	0.624
CLV_C14_Caspase3-7	463	467	PF00656	0.671
CLV_NRD_NRD_1	166	168	PF00675	0.492
CLV_NRD_NRD_1	248	250	PF00675	0.372
CLV_NRD_NRD_1	335	337	PF00675	0.606
CLV_NRD_NRD_1	47	49	PF00675	0.598
CLV_NRD_NRD_1	589	591	PF00675	0.499
CLV_NRD_NRD_1	596	598	PF00675	0.451
CLV_PCSK_FUR_1	164	168	PF00082	0.603
CLV_PCSK_FUR_1	587	591	PF00082	0.370
CLV_PCSK_KEX2_1	164	166	PF00082	0.492
CLV_PCSK_KEX2_1	248	250	PF00082	0.372
CLV_PCSK_KEX2_1	335	337	PF00082	0.606
CLV_PCSK_KEX2_1	38	40	PF00082	0.590
CLV_PCSK_KEX2_1	47	49	PF00082	0.579
CLV_PCSK_KEX2_1	589	591	PF00082	0.515
CLV_PCSK_KEX2_1	596	598	PF00082	0.429
CLV_PCSK_KEX2_1	691	693	PF00082	0.346
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.590
CLV_PCSK_PC1ET2_1	691	693	PF00082	0.346
CLV_PCSK_PC7_1	34	40	PF00082	0.586
CLV_PCSK_SKI1_1	159	163	PF00082	0.586
CLV_PCSK_SKI1_1	287	291	PF00082	0.473
CLV_PCSK_SKI1_1	345	349	PF00082	0.498
CLV_PCSK_SKI1_1	448	452	PF00082	0.467
CLV_PCSK_SKI1_1	629	633	PF00082	0.308
CLV_PCSK_SKI1_1	95	99	PF00082	0.593
DEG_APCC_DBOX_1	447	455	PF00400	0.664
DEG_APCC_DBOX_1	588	596	PF00400	0.595
DEG_Nend_Nbox_1	1	3	PF02207	0.406
DEG_ODPH_VHL_1	139	151	PF01847	0.611
DEG_ODPH_VHL_1	560	573	PF01847	0.509
DEG_SCF_FBW7_1	198	205	PF00400	0.730
DEG_SCF_TRCP1_1	466	472	PF00400	0.670
DEG_SPOP_SBC_1	178	182	PF00917	0.616
DEG_SPOP_SBC_1	203	207	PF00917	0.810
DEG_SPOP_SBC_1	77	81	PF00917	0.391
DOC_CDC14_PxL_1	647	655	PF14671	0.639
DOC_CKS1_1	260	265	PF01111	0.568
DOC_CKS1_1	470	475	PF01111	0.645
DOC_CYCLIN_yCln2_LP_2	607	613	PF00134	0.767
DOC_MAPK_gen_1	248	256	PF00069	0.569
DOC_MAPK_gen_1	587	594	PF00069	0.589
DOC_MAPK_gen_1	741	749	PF00069	0.438
DOC_MAPK_MEF2A_6	138	147	PF00069	0.411
DOC_MAPK_MEF2A_6	278	286	PF00069	0.590
DOC_MAPK_MEF2A_6	414	422	PF00069	0.603
DOC_MAPK_MEF2A_6	52	61	PF00069	0.373
DOC_MAPK_RevD_3	152	166	PF00069	0.760
DOC_PP1_RVXF_1	157	164	PF00149	0.787
DOC_PP1_RVXF_1	393	399	PF00149	0.596
DOC_PP2B_LxvP_1	611	614	PF13499	0.672
DOC_PP2B_LxvP_1	616	619	PF13499	0.641
DOC_PP4_FxxP_1	609	612	PF00568	0.768
DOC_USP7_MATH_1	107	111	PF00917	0.462
DOC_USP7_MATH_1	173	177	PF00917	0.805
DOC_USP7_MATH_1	203	207	PF00917	0.740
DOC_USP7_MATH_1	443	447	PF00917	0.763
DOC_USP7_MATH_1	548	552	PF00917	0.571
DOC_USP7_MATH_1	562	566	PF00917	0.373
DOC_USP7_MATH_1	640	644	PF00917	0.512
DOC_USP7_MATH_1	664	668	PF00917	0.726
DOC_WW_Pin1_4	198	203	PF00397	0.725
DOC_WW_Pin1_4	259	264	PF00397	0.563
DOC_WW_Pin1_4	386	391	PF00397	0.651
DOC_WW_Pin1_4	438	443	PF00397	0.730
DOC_WW_Pin1_4	469	474	PF00397	0.720
DOC_WW_Pin1_4	623	628	PF00397	0.706
LIG_14-3-3_CanoR_1	146	152	PF00244	0.751
LIG_14-3-3_CanoR_1	226	230	PF00244	0.727
LIG_14-3-3_CanoR_1	248	254	PF00244	0.725
LIG_14-3-3_CanoR_1	287	293	PF00244	0.662
LIG_14-3-3_CanoR_1	335	341	PF00244	0.614
LIG_14-3-3_CanoR_1	39	44	PF00244	0.388
LIG_14-3-3_CanoR_1	437	442	PF00244	0.664
LIG_14-3-3_CanoR_1	47	51	PF00244	0.379
LIG_14-3-3_CanoR_1	52	56	PF00244	0.351
LIG_14-3-3_CanoR_1	534	540	PF00244	0.520
LIG_14-3-3_CanoR_1	717	723	PF00244	0.500
LIG_14-3-3_CanoR_1	95	103	PF00244	0.438
LIG_Actin_WH2_2	130	148	PF00022	0.298
LIG_APCC_ABBA_1	632	637	PF00400	0.704
LIG_BRCT_BRCA1_1	13	17	PF00533	0.397
LIG_BRCT_BRCA1_1	147	151	PF00533	0.631
LIG_BRCT_BRCA1_1	388	392	PF00533	0.787
LIG_BRCT_BRCA1_1	59	63	PF00533	0.367
LIG_BRCT_BRCA1_1	79	83	PF00533	0.352
LIG_eIF4E_1	2	8	PF01652	0.401
LIG_EVH1_1	609	613	PF00568	0.694
LIG_FHA_1	250	256	PF00498	0.676
LIG_FHA_1	361	367	PF00498	0.684
LIG_FHA_1	512	518	PF00498	0.484
LIG_FHA_1	719	725	PF00498	0.523
LIG_FHA_2	381	387	PF00498	0.769
LIG_FHA_2	660	666	PF00498	0.752
LIG_Integrin_isoDGR_2	532	534	PF01839	0.723
LIG_LIR_Apic_2	606	612	PF02991	0.591
LIG_LIR_Gen_1	14	23	PF02991	0.393
LIG_LIR_Gen_1	228	237	PF02991	0.761
LIG_LIR_Gen_1	96	106	PF02991	0.394
LIG_LIR_Nem_3	122	128	PF02991	0.326
LIG_LIR_Nem_3	14	20	PF02991	0.395
LIG_LIR_Nem_3	148	154	PF02991	0.638
LIG_LIR_Nem_3	228	232	PF02991	0.767
LIG_LIR_Nem_3	252	256	PF02991	0.664
LIG_LIR_Nem_3	341	347	PF02991	0.689
LIG_LIR_Nem_3	54	58	PF02991	0.375
LIG_LIR_Nem_3	685	690	PF02991	0.549
LIG_NRBOX	57	63	PF00104	0.369
LIG_PCNA_PIPBox_1	30	39	PF02747	0.382
LIG_PCNA_yPIPBox_3	30	39	PF02747	0.382
LIG_Pex14_1	130	134	PF04695	0.411
LIG_Pex14_1	229	233	PF04695	0.768
LIG_Pex14_2	292	296	PF04695	0.668
LIG_Pex14_2	88	92	PF04695	0.398
LIG_SH2_CRK	337	341	PF00017	0.608
LIG_SH2_CRK	439	443	PF00017	0.833
LIG_SH2_NCK_1	439	443	PF00017	0.749
LIG_SH2_STAP1	221	225	PF00017	0.770
LIG_SH2_STAP1	246	250	PF00017	0.574
LIG_SH2_STAP1	751	755	PF00017	0.675
LIG_SH2_STAT5	2	5	PF00017	0.400
LIG_SH2_STAT5	253	256	PF00017	0.673
LIG_SH2_STAT5	311	314	PF00017	0.683
LIG_SH2_STAT5	480	483	PF00017	0.492
LIG_SH2_STAT5	50	53	PF00017	0.388
LIG_SH2_STAT5	728	731	PF00017	0.438
LIG_SH2_STAT5	751	754	PF00017	0.603
LIG_SH3_1	439	445	PF00018	0.829
LIG_SH3_1	456	462	PF00018	0.632
LIG_SH3_2	473	478	PF14604	0.634
LIG_SH3_2	612	617	PF14604	0.660
LIG_SH3_3	439	445	PF00018	0.819
LIG_SH3_3	456	462	PF00018	0.709
LIG_SH3_3	470	476	PF00018	0.595
LIG_SH3_3	541	547	PF00018	0.526
LIG_SH3_3	556	562	PF00018	0.354
LIG_SH3_3	607	613	PF00018	0.703
LIG_SH3_3	669	675	PF00018	0.668
LIG_SUMO_SIM_anti_2	236	242	PF11976	0.725
LIG_SUMO_SIM_anti_2	514	521	PF11976	0.543
LIG_SUMO_SIM_par_1	238	245	PF11976	0.755
LIG_SUMO_SIM_par_1	54	60	PF11976	0.371
LIG_SUMO_SIM_par_1	630	637	PF11976	0.516
LIG_TRAF2_1	432	435	PF00917	0.671
LIG_TRAF2_1	621	624	PF00917	0.642
LIG_TRAF2_2	698	703	PF00917	0.546
LIG_TRFH_1	609	613	PF08558	0.761
LIG_UBA3_1	686	691	PF00899	0.546
LIG_WRC_WIRS_1	289	294	PF05994	0.662
MOD_CDC14_SPxK_1	626	629	PF00782	0.532
MOD_CDK_SPxK_1	259	265	PF00069	0.568
MOD_CDK_SPxK_1	623	629	PF00069	0.532
MOD_CDK_SPxxK_3	441	448	PF00069	0.649
MOD_CK1_1	213	219	PF00069	0.754
MOD_CK1_1	242	248	PF00069	0.684
MOD_CK1_1	259	265	PF00069	0.676
MOD_CK1_1	291	297	PF00069	0.667
MOD_CK1_1	318	324	PF00069	0.724
MOD_CK1_1	338	344	PF00069	0.663
MOD_CK1_1	351	357	PF00069	0.725
MOD_CK1_1	401	407	PF00069	0.699
MOD_CK1_1	408	414	PF00069	0.689
MOD_CK1_1	441	447	PF00069	0.776
MOD_CK1_1	464	470	PF00069	0.823
MOD_CK1_1	550	556	PF00069	0.605
MOD_CK1_1	79	85	PF00069	0.395
MOD_CK2_1	388	394	PF00069	0.604
MOD_CK2_1	428	434	PF00069	0.844
MOD_Cter_Amidation	333	336	PF01082	0.610
MOD_GlcNHglycan	168	172	PF01048	0.482
MOD_GlcNHglycan	175	178	PF01048	0.530
MOD_GlcNHglycan	183	186	PF01048	0.550
MOD_GlcNHglycan	212	215	PF01048	0.562
MOD_GlcNHglycan	217	220	PF01048	0.586
MOD_GlcNHglycan	299	302	PF01048	0.540
MOD_GlcNHglycan	320	323	PF01048	0.527
MOD_GlcNHglycan	332	335	PF01048	0.541
MOD_GlcNHglycan	400	403	PF01048	0.573
MOD_GlcNHglycan	430	433	PF01048	0.464
MOD_GlcNHglycan	445	448	PF01048	0.408
MOD_GlcNHglycan	466	469	PF01048	0.587
MOD_GlcNHglycan	491	494	PF01048	0.411
MOD_GlcNHglycan	641	645	PF01048	0.461
MOD_GlcNHglycan	667	670	PF01048	0.597
MOD_GlcNHglycan	730	733	PF01048	0.238
MOD_GlcNHglycan	744	747	PF01048	0.453
MOD_GlcNHglycan	98	101	PF01048	0.609
MOD_GSK3_1	167	174	PF00069	0.727
MOD_GSK3_1	177	184	PF00069	0.766
MOD_GSK3_1	198	205	PF00069	0.730
MOD_GSK3_1	210	217	PF00069	0.743
MOD_GSK3_1	221	228	PF00069	0.575
MOD_GSK3_1	287	294	PF00069	0.662
MOD_GSK3_1	307	314	PF00069	0.518
MOD_GSK3_1	348	355	PF00069	0.738
MOD_GSK3_1	386	393	PF00069	0.792
MOD_GSK3_1	401	408	PF00069	0.595
MOD_GSK3_1	423	430	PF00069	0.728
MOD_GSK3_1	437	444	PF00069	0.752
MOD_GSK3_1	460	467	PF00069	0.670
MOD_GSK3_1	503	510	PF00069	0.543
MOD_GSK3_1	547	554	PF00069	0.596
MOD_GSK3_1	7	14	PF00069	0.399
MOD_GSK3_1	718	725	PF00069	0.483
MOD_GSK3_1	77	84	PF00069	0.393
MOD_NEK2_1	1	6	PF00069	0.402
MOD_NEK2_1	13	18	PF00069	0.372
MOD_NEK2_1	145	150	PF00069	0.707
MOD_NEK2_1	225	230	PF00069	0.739
MOD_NEK2_1	256	261	PF00069	0.650
MOD_NEK2_1	288	293	PF00069	0.662
MOD_NEK2_1	304	309	PF00069	0.678
MOD_NEK2_1	348	353	PF00069	0.759
MOD_NEK2_1	380	385	PF00069	0.797
MOD_NEK2_1	398	403	PF00069	0.563
MOD_NEK2_1	489	494	PF00069	0.372
MOD_NEK2_1	57	62	PF00069	0.368
MOD_NEK2_1	7	12	PF00069	0.388
MOD_NEK2_1	749	754	PF00069	0.683
MOD_NEK2_1	93	98	PF00069	0.515
MOD_NEK2_2	221	226	PF00069	0.589
MOD_NEK2_2	32	37	PF00069	0.378
MOD_PIKK_1	256	262	PF00454	0.675
MOD_PIKK_1	471	477	PF00454	0.807
MOD_PKA_1	335	341	PF00069	0.766
MOD_PKA_2	107	113	PF00069	0.430
MOD_PKA_2	145	151	PF00069	0.632
MOD_PKA_2	210	216	PF00069	0.649
MOD_PKA_2	225	231	PF00069	0.719
MOD_PKA_2	335	341	PF00069	0.729
MOD_PKA_2	428	434	PF00069	0.664
MOD_PKA_2	46	52	PF00069	0.396
MOD_PKA_2	533	539	PF00069	0.510
MOD_PKB_1	165	173	PF00069	0.623
MOD_Plk_1	21	27	PF00069	0.385
MOD_Plk_1	221	227	PF00069	0.585
MOD_Plk_2-3	703	709	PF00069	0.546
MOD_Plk_4	239	245	PF00069	0.716
MOD_Plk_4	292	298	PF00069	0.675
MOD_Plk_4	304	310	PF00069	0.686
MOD_Plk_4	360	366	PF00069	0.682
MOD_Plk_4	39	45	PF00069	0.388
MOD_Plk_4	408	414	PF00069	0.608
MOD_Plk_4	57	63	PF00069	0.331
MOD_ProDKin_1	198	204	PF00069	0.729
MOD_ProDKin_1	259	265	PF00069	0.568
MOD_ProDKin_1	386	392	PF00069	0.651
MOD_ProDKin_1	438	444	PF00069	0.730
MOD_ProDKin_1	469	475	PF00069	0.716
MOD_ProDKin_1	623	629	PF00069	0.708
TRG_DiLeu_BaEn_1	628	633	PF01217	0.623
TRG_DiLeu_BaEn_2	393	399	PF01217	0.596
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.782
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.374
TRG_DiLeu_BaLyEn_6	596	601	PF01217	0.758
TRG_ENDOCYTIC_2	2	5	PF00928	0.400
TRG_ENDOCYTIC_2	253	256	PF00928	0.673
TRG_ENDOCYTIC_2	337	340	PF00928	0.613
TRG_ER_diArg_1	163	166	PF00400	0.690
TRG_ER_diArg_1	248	250	PF00400	0.572
TRG_ER_diArg_1	335	337	PF00400	0.688
TRG_ER_diArg_1	595	597	PF00400	0.665
TRG_ER_FFAT_2	501	510	PF00635	0.445
TRG_NES_CRM1_1	410	423	PF08389	0.699
TRG_Pf-PMV_PEXEL_1	692	697	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIV8	Leptomonas seymouri	51%	100%
A0A3S5H5Q9	Leishmania donovani	78%	100%
A4HSU3	Leishmania infantum	78%	100%
E9AKT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QJ27	Leishmania major	78%	99%