SpoU_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SpoU rRNA Methylase family, putative

Species:

Leishmania braziliensis

UniProt:

A4H4L6_LEIBR

TriTrypDb:

LbrM.06.0510 , LBRM2903_060010900

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4L6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000154	rRNA modification	6	1
GO:0006364	rRNA processing	8	1
GO:0009451	RNA modification	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043412	macromolecule modification	4	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008168	methyltransferase activity	4	11
GO:0008173	RNA methyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0008649	rRNA methyltransferase activity	5	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016435	rRNA (guanine) methyltransferase activity	6	1
GO:0140102	catalytic activity, acting on a rRNA	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.727
CLV_NRD_NRD_1	167	169	PF00675	0.695
CLV_NRD_NRD_1	208	210	PF00675	0.486
CLV_NRD_NRD_1	372	374	PF00675	0.316
CLV_NRD_NRD_1	511	513	PF00675	0.618
CLV_NRD_NRD_1	57	59	PF00675	0.404
CLV_PCSK_FUR_1	162	166	PF00082	0.665
CLV_PCSK_KEX2_1	164	166	PF00082	0.707
CLV_PCSK_KEX2_1	208	210	PF00082	0.486
CLV_PCSK_KEX2_1	372	374	PF00082	0.318
CLV_PCSK_KEX2_1	511	513	PF00082	0.618
CLV_PCSK_KEX2_1	57	59	PF00082	0.404
CLV_PCSK_SKI1_1	126	130	PF00082	0.637
CLV_PCSK_SKI1_1	14	18	PF00082	0.697
CLV_PCSK_SKI1_1	180	184	PF00082	0.512
CLV_PCSK_SKI1_1	187	191	PF00082	0.503
CLV_PCSK_SKI1_1	287	291	PF00082	0.290
CLV_PCSK_SKI1_1	419	423	PF00082	0.295
DEG_APCC_DBOX_1	106	114	PF00400	0.444
DEG_APCC_DBOX_1	197	205	PF00400	0.425
DEG_SPOP_SBC_1	238	242	PF00917	0.666
DEG_SPOP_SBC_1	244	248	PF00917	0.610
DEG_SPOP_SBC_1	326	330	PF00917	0.565
DOC_CKS1_1	561	566	PF01111	0.495
DOC_CYCLIN_RxL_1	416	427	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	189	195	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	558	564	PF00134	0.447
DOC_MAPK_gen_1	187	195	PF00069	0.338
DOC_MAPK_gen_1	208	215	PF00069	0.449
DOC_MAPK_gen_1	515	523	PF00069	0.660
DOC_MAPK_MEF2A_6	187	195	PF00069	0.430
DOC_MAPK_MEF2A_6	517	525	PF00069	0.523
DOC_MAPK_MEF2A_6	80	87	PF00069	0.543
DOC_PP1_SILK_1	283	288	PF00149	0.562
DOC_PP2B_LxvP_1	150	153	PF13499	0.537
DOC_PP2B_LxvP_1	189	192	PF13499	0.524
DOC_USP7_MATH_1	250	254	PF00917	0.776
DOC_USP7_MATH_1	308	312	PF00917	0.501
DOC_USP7_MATH_1	326	330	PF00917	0.461
DOC_USP7_MATH_1	363	367	PF00917	0.530
DOC_USP7_MATH_1	493	497	PF00917	0.660
DOC_USP7_MATH_1	572	576	PF00917	0.531
DOC_WW_Pin1_4	25	30	PF00397	0.593
DOC_WW_Pin1_4	443	448	PF00397	0.646
DOC_WW_Pin1_4	557	562	PF00397	0.413
DOC_WW_Pin1_4	568	573	PF00397	0.484
DOC_WW_Pin1_4	79	84	PF00397	0.733
LIG_14-3-3_CanoR_1	175	182	PF00244	0.518
LIG_14-3-3_CanoR_1	301	310	PF00244	0.516
LIG_14-3-3_CanoR_1	312	318	PF00244	0.425
LIG_14-3-3_CanoR_1	325	334	PF00244	0.475
LIG_14-3-3_CanoR_1	335	343	PF00244	0.566
LIG_14-3-3_CanoR_1	344	354	PF00244	0.591
LIG_14-3-3_CanoR_1	372	382	PF00244	0.509
LIG_14-3-3_CanoR_1	4	10	PF00244	0.693
LIG_14-3-3_CanoR_1	453	463	PF00244	0.710
LIG_Actin_WH2_2	37	54	PF00022	0.533
LIG_Actin_WH2_2	437	455	PF00022	0.686
LIG_APCC_ABBA_1	63	68	PF00400	0.505
LIG_BRCT_BRCA1_1	313	317	PF00533	0.513
LIG_BRCT_BRCA1_1	329	333	PF00533	0.513
LIG_CSL_BTD_1	561	564	PF09270	0.490
LIG_FHA_1	11	17	PF00498	0.701
LIG_FHA_1	145	151	PF00498	0.639
LIG_FHA_1	239	245	PF00498	0.527
LIG_FHA_1	246	252	PF00498	0.765
LIG_FHA_1	305	311	PF00498	0.490
LIG_FHA_1	313	319	PF00498	0.491
LIG_FHA_1	48	54	PF00498	0.444
LIG_FHA_1	527	533	PF00498	0.344
LIG_FHA_1	80	86	PF00498	0.543
LIG_FHA_1	93	99	PF00498	0.470
LIG_FHA_2	247	253	PF00498	0.659
LIG_FHA_2	485	491	PF00498	0.648
LIG_LIR_Nem_3	288	294	PF02991	0.482
LIG_LIR_Nem_3	560	565	PF02991	0.585
LIG_MYND_1	101	105	PF01753	0.547
LIG_MYND_1	566	570	PF01753	0.520
LIG_SH2_CRK	176	180	PF00017	0.534
LIG_SH2_CRK	38	42	PF00017	0.537
LIG_SH2_STAP1	38	42	PF00017	0.537
LIG_SH2_STAT3	220	223	PF00017	0.574
LIG_SH2_STAT5	114	117	PF00017	0.469
LIG_SH2_STAT5	176	179	PF00017	0.490
LIG_SH3_2	102	107	PF14604	0.395
LIG_SH3_3	150	156	PF00018	0.721
LIG_SH3_3	168	174	PF00018	0.319
LIG_SH3_3	28	34	PF00018	0.515
LIG_SH3_3	362	368	PF00018	0.502
LIG_SH3_3	377	383	PF00018	0.525
LIG_SH3_3	410	416	PF00018	0.496
LIG_SH3_3	441	447	PF00018	0.408
LIG_SH3_3	536	542	PF00018	0.525
LIG_SH3_3	558	564	PF00018	0.480
LIG_SH3_3	93	99	PF00018	0.544
LIG_SUMO_SIM_anti_2	355	362	PF11976	0.585
LIG_SUMO_SIM_par_1	145	154	PF11976	0.677
LIG_SxIP_EBH_1	23	32	PF03271	0.585
LIG_TRAF2_1	119	122	PF00917	0.593
LIG_TRAF2_1	336	339	PF00917	0.408
LIG_WW_1	173	176	PF00397	0.398
LIG_WW_1	35	38	PF00397	0.596
LIG_WW_3	172	176	PF00397	0.331
MOD_CDK_SPK_2	443	448	PF00069	0.676
MOD_CDK_SPxxK_3	25	32	PF00069	0.635
MOD_CK1_1	239	245	PF00069	0.659
MOD_CK1_1	246	252	PF00069	0.608
MOD_CK1_1	311	317	PF00069	0.513
MOD_CK1_1	327	333	PF00069	0.461
MOD_CK1_1	347	353	PF00069	0.577
MOD_CK1_1	366	372	PF00069	0.424
MOD_CK1_1	384	390	PF00069	0.557
MOD_CK1_1	393	399	PF00069	0.573
MOD_CK1_1	485	491	PF00069	0.708
MOD_CK1_1	496	502	PF00069	0.709
MOD_CK1_1	560	566	PF00069	0.612
MOD_CK1_1	571	577	PF00069	0.643
MOD_CK2_1	116	122	PF00069	0.525
MOD_CK2_1	246	252	PF00069	0.663
MOD_CK2_1	352	358	PF00069	0.597
MOD_GlcNHglycan	21	24	PF01048	0.614
MOD_GlcNHglycan	252	256	PF01048	0.768
MOD_GlcNHglycan	329	332	PF01048	0.351
MOD_GlcNHglycan	347	350	PF01048	0.286
MOD_GlcNHglycan	354	357	PF01048	0.319
MOD_GlcNHglycan	361	364	PF01048	0.196
MOD_GlcNHglycan	389	392	PF01048	0.373
MOD_GlcNHglycan	490	493	PF01048	0.690
MOD_GlcNHglycan	495	498	PF01048	0.738
MOD_GlcNHglycan	5	8	PF01048	0.706
MOD_GlcNHglycan	533	536	PF01048	0.435
MOD_GlcNHglycan	76	79	PF01048	0.783
MOD_GSK3_1	144	151	PF00069	0.778
MOD_GSK3_1	181	188	PF00069	0.306
MOD_GSK3_1	239	246	PF00069	0.785
MOD_GSK3_1	304	311	PF00069	0.493
MOD_GSK3_1	343	350	PF00069	0.568
MOD_GSK3_1	359	366	PF00069	0.430
MOD_GSK3_1	381	388	PF00069	0.513
MOD_GSK3_1	43	50	PF00069	0.455
MOD_GSK3_1	452	459	PF00069	0.634
MOD_GSK3_1	479	486	PF00069	0.698
MOD_GSK3_1	568	575	PF00069	0.528
MOD_GSK3_1	69	76	PF00069	0.770
MOD_LATS_1	454	460	PF00433	0.522
MOD_N-GLC_1	19	24	PF02516	0.575
MOD_NEK2_1	10	15	PF00069	0.667
MOD_NEK2_1	185	190	PF00069	0.557
MOD_NEK2_1	215	220	PF00069	0.452
MOD_NEK2_1	343	348	PF00069	0.491
MOD_NEK2_1	452	457	PF00069	0.685
MOD_NEK2_1	484	489	PF00069	0.708
MOD_NEK2_1	73	78	PF00069	0.734
MOD_PIKK_1	334	340	PF00454	0.511
MOD_PIKK_1	456	462	PF00454	0.531
MOD_PIKK_1	479	485	PF00454	0.524
MOD_PIKK_1	545	551	PF00454	0.412
MOD_PKA_2	10	16	PF00069	0.596
MOD_PKA_2	174	180	PF00069	0.529
MOD_PKA_2	3	9	PF00069	0.642
MOD_PKA_2	311	317	PF00069	0.487
MOD_PKA_2	324	330	PF00069	0.496
MOD_PKA_2	334	340	PF00069	0.577
MOD_PKA_2	343	349	PF00069	0.594
MOD_PKA_2	452	458	PF00069	0.669
MOD_Plk_1	116	122	PF00069	0.599
MOD_Plk_1	215	221	PF00069	0.461
MOD_Plk_1	393	399	PF00069	0.585
MOD_Plk_1	519	525	PF00069	0.528
MOD_Plk_4	266	272	PF00069	0.524
MOD_Plk_4	43	49	PF00069	0.404
MOD_ProDKin_1	25	31	PF00069	0.589
MOD_ProDKin_1	443	449	PF00069	0.650
MOD_ProDKin_1	557	563	PF00069	0.423
MOD_ProDKin_1	568	574	PF00069	0.483
MOD_ProDKin_1	79	85	PF00069	0.733
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.695
TRG_ENDOCYTIC_2	176	179	PF00928	0.417
TRG_ENDOCYTIC_2	38	41	PF00928	0.538
TRG_ER_diArg_1	510	512	PF00400	0.598
TRG_NLS_MonoExtN_4	165	172	PF00514	0.675
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3C1	Leptomonas seymouri	48%	100%
A0A1X0NKH6	Trypanosomatidae	30%	100%
A0A3R7KE58	Trypanosoma rangeli	33%	100%
A0A3S5H5Q8	Leishmania donovani	73%	100%
A4HSU2	Leishmania infantum	73%	100%
C9ZTF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AKS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QJ28	Leishmania major	72%	97%
V5BT12	Trypanosoma cruzi	29%	100%