L-ornithine N(5)-oxygenase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4L5_LEIBR

TriTrypDb:

LbrM.06.0500 , LBRM2903_060010800

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4L5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	413	417	PF00656	0.576
CLV_C14_Caspase3-7	5	9	PF00656	0.617
CLV_C14_Caspase3-7	504	508	PF00656	0.566
CLV_NRD_NRD_1	106	108	PF00675	0.597
CLV_NRD_NRD_1	11	13	PF00675	0.573
CLV_NRD_NRD_1	146	148	PF00675	0.630
CLV_NRD_NRD_1	534	536	PF00675	0.518
CLV_NRD_NRD_1	571	573	PF00675	0.544
CLV_NRD_NRD_1	63	65	PF00675	0.636
CLV_PCSK_KEX2_1	106	108	PF00082	0.574
CLV_PCSK_KEX2_1	11	13	PF00082	0.573
CLV_PCSK_KEX2_1	146	148	PF00082	0.645
CLV_PCSK_KEX2_1	375	377	PF00082	0.575
CLV_PCSK_KEX2_1	534	536	PF00082	0.518
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.575
CLV_PCSK_SKI1_1	107	111	PF00082	0.574
CLV_PCSK_SKI1_1	137	141	PF00082	0.747
CLV_PCSK_SKI1_1	232	236	PF00082	0.517
CLV_PCSK_SKI1_1	375	379	PF00082	0.563
CLV_PCSK_SKI1_1	391	395	PF00082	0.551
CLV_PCSK_SKI1_1	453	457	PF00082	0.625
CLV_PCSK_SKI1_1	487	491	PF00082	0.605
CLV_PCSK_SKI1_1	534	538	PF00082	0.404
CLV_PCSK_SKI1_1	579	583	PF00082	0.538
DEG_APCC_DBOX_1	471	479	PF00400	0.528
DEG_SCF_FBW7_1	206	213	PF00400	0.487
DEG_SCF_FBW7_2	45	51	PF00400	0.557
DEG_SPOP_SBC_1	32	36	PF00917	0.613
DEG_SPOP_SBC_1	94	98	PF00917	0.637
DOC_CKS1_1	207	212	PF01111	0.491
DOC_CKS1_1	387	392	PF01111	0.558
DOC_CKS1_1	45	50	PF01111	0.557
DOC_CKS1_1	471	476	PF01111	0.549
DOC_CYCLIN_RxL_1	102	113	PF00134	0.610
DOC_CYCLIN_RxL_1	229	237	PF00134	0.508
DOC_CYCLIN_RxL_1	531	541	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	174	180	PF00134	0.518
DOC_MAPK_DCC_7	324	334	PF00069	0.512
DOC_MAPK_gen_1	355	364	PF00069	0.527
DOC_MAPK_MEF2A_6	355	364	PF00069	0.564
DOC_MAPK_MEF2A_6	405	414	PF00069	0.558
DOC_PP1_RVXF_1	230	237	PF00149	0.509
DOC_PP1_RVXF_1	303	309	PF00149	0.446
DOC_PP1_RVXF_1	353	360	PF00149	0.543
DOC_PP1_RVXF_1	427	433	PF00149	0.660
DOC_PP2B_LxvP_1	174	177	PF13499	0.516
DOC_PP2B_LxvP_1	362	365	PF13499	0.603
DOC_PP2B_LxvP_1	412	415	PF13499	0.700
DOC_PP4_FxxP_1	476	479	PF00568	0.519
DOC_USP7_MATH_1	130	134	PF00917	0.758
DOC_USP7_MATH_1	145	149	PF00917	0.735
DOC_USP7_MATH_1	225	229	PF00917	0.503
DOC_USP7_MATH_1	271	275	PF00917	0.513
DOC_USP7_MATH_1	32	36	PF00917	0.761
DOC_USP7_MATH_1	495	499	PF00917	0.692
DOC_USP7_MATH_1	60	64	PF00917	0.726
DOC_USP7_MATH_1	85	89	PF00917	0.686
DOC_USP7_MATH_1	94	98	PF00917	0.590
DOC_USP7_UBL2_3	569	573	PF12436	0.612
DOC_WW_Pin1_4	206	211	PF00397	0.494
DOC_WW_Pin1_4	254	259	PF00397	0.509
DOC_WW_Pin1_4	375	380	PF00397	0.565
DOC_WW_Pin1_4	386	391	PF00397	0.547
DOC_WW_Pin1_4	44	49	PF00397	0.574
DOC_WW_Pin1_4	470	475	PF00397	0.539
DOC_WW_Pin1_4	63	68	PF00397	0.635
DOC_WW_Pin1_4	86	91	PF00397	0.649
LIG_14-3-3_CanoR_1	232	237	PF00244	0.516
LIG_14-3-3_CanoR_1	350	354	PF00244	0.649
LIG_14-3-3_CanoR_1	422	432	PF00244	0.572
LIG_14-3-3_CanoR_1	453	463	PF00244	0.555
LIG_14-3-3_CanoR_1	547	551	PF00244	0.678
LIG_AP2alpha_1	511	515	PF02296	0.529
LIG_BIR_III_4	507	511	PF00653	0.507
LIG_BRCT_BRCA1_1	256	260	PF00533	0.493
LIG_Clathr_ClatBox_1	536	540	PF01394	0.414
LIG_FHA_1	203	209	PF00498	0.515
LIG_FHA_1	409	415	PF00498	0.599
LIG_FHA_1	438	444	PF00498	0.544
LIG_FHA_2	333	339	PF00498	0.556
LIG_FHA_2	387	393	PF00498	0.574
LIG_FHA_2	411	417	PF00498	0.588
LIG_LIR_Apic_2	473	479	PF02991	0.525
LIG_LIR_Gen_1	235	243	PF02991	0.535
LIG_LIR_Gen_1	356	367	PF02991	0.647
LIG_LIR_Gen_1	498	508	PF02991	0.642
LIG_LIR_Nem_3	235	239	PF02991	0.531
LIG_LIR_Nem_3	315	319	PF02991	0.443
LIG_LIR_Nem_3	356	362	PF02991	0.650
LIG_LIR_Nem_3	404	410	PF02991	0.566
LIG_LIR_Nem_3	498	503	PF02991	0.623
LIG_LIR_Nem_3	549	553	PF02991	0.672
LIG_LIR_Nem_3	577	581	PF02991	0.596
LIG_Pex14_2	373	377	PF04695	0.596
LIG_Pex14_2	452	456	PF04695	0.624
LIG_Pex14_2	511	515	PF04695	0.529
LIG_SH2_CRK	471	475	PF00017	0.534
LIG_SH2_PTP2	585	588	PF00017	0.586
LIG_SH2_STAT5	154	157	PF00017	0.580
LIG_SH2_STAT5	167	170	PF00017	0.334
LIG_SH2_STAT5	316	319	PF00017	0.443
LIG_SH2_STAT5	446	449	PF00017	0.545
LIG_SH2_STAT5	585	588	PF00017	0.586
LIG_SH3_3	204	210	PF00018	0.497
LIG_SH3_3	219	225	PF00018	0.503
LIG_SH3_3	362	368	PF00018	0.537
LIG_SUMO_SIM_anti_2	383	389	PF11976	0.533
LIG_SUMO_SIM_par_1	204	209	PF11976	0.499
LIG_SUMO_SIM_par_1	383	389	PF11976	0.533
LIG_SUMO_SIM_par_1	410	416	PF11976	0.608
LIG_TRAF2_1	335	338	PF00917	0.567
LIG_TYR_ITIM	548	553	PF00017	0.689
LIG_WRC_WIRS_1	233	238	PF05994	0.522
LIG_WW_2	365	368	PF00397	0.536
MOD_CDK_SPK_2	386	391	PF00069	0.547
MOD_CK1_1	13	19	PF00069	0.685
MOD_CK1_1	223	229	PF00069	0.520
MOD_CK1_1	33	39	PF00069	0.628
MOD_CK1_1	351	357	PF00069	0.565
MOD_CK1_1	425	431	PF00069	0.605
MOD_CK1_1	546	552	PF00069	0.673
MOD_CK1_1	577	583	PF00069	0.521
MOD_CK1_1	63	69	PF00069	0.660
MOD_CK1_1	89	95	PF00069	0.661
MOD_CK1_1	96	102	PF00069	0.612
MOD_CK2_1	13	19	PF00069	0.744
MOD_CK2_1	332	338	PF00069	0.552
MOD_Cter_Amidation	119	122	PF01082	0.765
MOD_GlcNHglycan	132	135	PF01048	0.754
MOD_GlcNHglycan	147	150	PF01048	0.570
MOD_GlcNHglycan	15	18	PF01048	0.690
MOD_GlcNHglycan	225	228	PF01048	0.504
MOD_GlcNHglycan	269	272	PF01048	0.503
MOD_GlcNHglycan	309	312	PF01048	0.478
MOD_GlcNHglycan	37	40	PF01048	0.656
MOD_GlcNHglycan	440	443	PF01048	0.585
MOD_GlcNHglycan	466	469	PF01048	0.599
MOD_GlcNHglycan	98	101	PF01048	0.729
MOD_GSK3_1	202	209	PF00069	0.507
MOD_GSK3_1	267	274	PF00069	0.526
MOD_GSK3_1	30	37	PF00069	0.717
MOD_GSK3_1	349	356	PF00069	0.659
MOD_GSK3_1	393	400	PF00069	0.569
MOD_GSK3_1	40	47	PF00069	0.656
MOD_GSK3_1	509	516	PF00069	0.600
MOD_GSK3_1	52	59	PF00069	0.637
MOD_GSK3_1	6	13	PF00069	0.747
MOD_GSK3_1	76	83	PF00069	0.606
MOD_GSK3_1	85	92	PF00069	0.605
MOD_N-GLC_1	220	225	PF02516	0.513
MOD_N-GLC_1	408	413	PF02516	0.602
MOD_N-GLC_1	461	466	PF02516	0.681
MOD_N-GLC_1	79	84	PF02516	0.688
MOD_NEK2_1	110	115	PF00069	0.576
MOD_NEK2_1	220	225	PF00069	0.520
MOD_NEK2_1	353	358	PF00069	0.686
MOD_NEK2_1	401	406	PF00069	0.575
MOD_NEK2_1	423	428	PF00069	0.580
MOD_NEK2_1	437	442	PF00069	0.541
MOD_NEK2_1	463	468	PF00069	0.574
MOD_NEK2_1	517	522	PF00069	0.556
MOD_NEK2_1	76	81	PF00069	0.640
MOD_NEK2_2	393	398	PF00069	0.570
MOD_NEK2_2	495	500	PF00069	0.692
MOD_OFUCOSY	276	283	PF10250	0.459
MOD_PIKK_1	160	166	PF00454	0.545
MOD_PIKK_1	194	200	PF00454	0.604
MOD_PIKK_1	210	216	PF00454	0.362
MOD_PIKK_1	378	384	PF00454	0.547
MOD_PIKK_1	6	12	PF00454	0.611
MOD_PKA_2	10	16	PF00069	0.770
MOD_PKA_2	145	151	PF00069	0.583
MOD_PKA_2	202	208	PF00069	0.509
MOD_PKA_2	349	355	PF00069	0.699
MOD_PKA_2	397	403	PF00069	0.572
MOD_PKA_2	546	552	PF00069	0.673
MOD_PKB_1	305	313	PF00069	0.451
MOD_Plk_1	220	226	PF00069	0.523
MOD_Plk_1	330	336	PF00069	0.549
MOD_Plk_1	408	414	PF00069	0.601
MOD_Plk_1	79	85	PF00069	0.756
MOD_Plk_4	150	156	PF00069	0.515
MOD_Plk_4	202	208	PF00069	0.509
MOD_Plk_4	225	231	PF00069	0.499
MOD_Plk_4	256	262	PF00069	0.487
MOD_Plk_4	281	287	PF00069	0.436
MOD_Plk_4	397	403	PF00069	0.572
MOD_Plk_4	447	453	PF00069	0.547
MOD_Plk_4	546	552	PF00069	0.643
MOD_ProDKin_1	206	212	PF00069	0.489
MOD_ProDKin_1	254	260	PF00069	0.503
MOD_ProDKin_1	375	381	PF00069	0.566
MOD_ProDKin_1	386	392	PF00069	0.552
MOD_ProDKin_1	44	50	PF00069	0.574
MOD_ProDKin_1	470	476	PF00069	0.535
MOD_ProDKin_1	63	69	PF00069	0.629
MOD_ProDKin_1	86	92	PF00069	0.648
MOD_SUMO_for_1	266	269	PF00179	0.436
MOD_SUMO_rev_2	386	396	PF00179	0.576
TRG_DiLeu_BaEn_1	533	538	PF01217	0.405
TRG_DiLeu_BaLyEn_6	532	537	PF01217	0.412
TRG_ENDOCYTIC_2	167	170	PF00928	0.410
TRG_ENDOCYTIC_2	316	319	PF00928	0.449
TRG_ENDOCYTIC_2	550	553	PF00928	0.691
TRG_ENDOCYTIC_2	585	588	PF00928	0.586
TRG_ER_diArg_1	105	107	PF00400	0.582
TRG_ER_diArg_1	11	14	PF00400	0.574
TRG_ER_diArg_1	304	307	PF00400	0.462
TRG_ER_diArg_1	534	536	PF00400	0.518
TRG_NLS_MonoExtC_3	571	576	PF00514	0.615
TRG_NLS_MonoExtN_4	569	576	PF00514	0.613
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	535	540	PF00026	0.667
TRG_Pf-PMV_PEXEL_1	579	583	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I218	Leptomonas seymouri	85%	100%
A0A0S4KH91	Bodo saltans	71%	100%
A0A1X0NLE5	Trypanosomatidae	66%	98%
A0A3S5IR64	Trypanosoma rangeli	76%	100%
A0A3S7WPF9	Leishmania donovani	94%	100%
A4HSU1	Leishmania infantum	94%	100%
C9ZTF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9AKS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QJ29	Leishmania major	95%	100%