DUF362 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4L4_LEIBR

TriTrypDb:

LbrM.06.0490 , LBRM2903_060010700

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4L4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.435
CLV_NRD_NRD_1	95	97	PF00675	0.397
CLV_PCSK_KEX2_1	17	19	PF00082	0.414
CLV_PCSK_KEX2_1	95	97	PF00082	0.400
CLV_PCSK_SKI1_1	168	172	PF00082	0.438
CLV_PCSK_SKI1_1	17	21	PF00082	0.419
CLV_PCSK_SKI1_1	33	37	PF00082	0.443
DOC_MAPK_gen_1	102	111	PF00069	0.408
DOC_MAPK_gen_1	135	144	PF00069	0.470
DOC_MAPK_gen_1	95	101	PF00069	0.383
DOC_MAPK_HePTP_8	99	111	PF00069	0.487
DOC_MAPK_MEF2A_6	102	111	PF00069	0.422
DOC_MAPK_MEF2A_6	135	144	PF00069	0.459
DOC_MAPK_NFAT4_5	104	112	PF00069	0.411
DOC_USP7_MATH_1	113	117	PF00917	0.327
DOC_USP7_MATH_1	170	174	PF00917	0.508
DOC_USP7_MATH_1	57	61	PF00917	0.524
DOC_WW_Pin1_4	174	179	PF00397	0.326
LIG_14-3-3_CanoR_1	139	145	PF00244	0.416
LIG_14-3-3_CanoR_1	274	282	PF00244	0.655
LIG_14-3-3_CterR_2	313	315	PF00244	0.512
LIG_BIR_II_1	1	5	PF00653	0.395
LIG_DLG_GKlike_1	102	109	PF00625	0.509
LIG_FHA_1	154	160	PF00498	0.363
LIG_FHA_1	253	259	PF00498	0.499
LIG_FHA_1	92	98	PF00498	0.494
LIG_FHA_2	122	128	PF00498	0.624
LIG_FHA_2	180	186	PF00498	0.386
LIG_HCF-1_HBM_1	231	234	PF13415	0.453
LIG_IBAR_NPY_1	245	247	PF08397	0.490
LIG_IRF3_LxIS_1	136	143	PF10401	0.546
LIG_LIR_Nem_3	205	209	PF02991	0.400
LIG_LIR_Nem_3	231	237	PF02991	0.483
LIG_PCNA_yPIPBox_3	17	30	PF02747	0.370
LIG_SH2_CRK	223	227	PF00017	0.559
LIG_SH2_STAP1	146	150	PF00017	0.475
LIG_SH2_STAP1	234	238	PF00017	0.457
LIG_SH2_STAT5	247	250	PF00017	0.491
LIG_SH2_STAT5	3	6	PF00017	0.434
LIG_SH2_STAT5	9	12	PF00017	0.389
LIG_SH3_3	197	203	PF00018	0.514
LIG_TYR_ITIM	204	209	PF00017	0.275
MOD_CK1_1	277	283	PF00069	0.653
MOD_CK2_1	179	185	PF00069	0.386
MOD_GlcNHglycan	191	195	PF01048	0.568
MOD_GlcNHglycan	276	279	PF01048	0.649
MOD_GlcNHglycan	59	62	PF01048	0.569
MOD_GSK3_1	170	177	PF00069	0.541
MOD_GSK3_1	270	277	PF00069	0.619
MOD_GSK3_1	307	314	PF00069	0.778
MOD_N-GLC_1	307	312	PF02516	0.727
MOD_NEK2_1	140	145	PF00069	0.410
MOD_NEK2_1	179	184	PF00069	0.560
MOD_NEK2_2	170	175	PF00069	0.342
MOD_PKA_2	140	146	PF00069	0.406
MOD_PKA_2	57	63	PF00069	0.626
MOD_Plk_1	102	108	PF00069	0.519
MOD_Plk_4	202	208	PF00069	0.431
MOD_Plk_4	286	292	PF00069	0.500
MOD_ProDKin_1	174	180	PF00069	0.324
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.404
TRG_ENDOCYTIC_2	206	209	PF00928	0.436
TRG_ENDOCYTIC_2	212	215	PF00928	0.508
TRG_ENDOCYTIC_2	223	226	PF00928	0.452
TRG_ENDOCYTIC_2	238	241	PF00928	0.374
TRG_ENDOCYTIC_2	9	12	PF00928	0.394
TRG_ER_diArg_1	134	137	PF00400	0.607
TRG_ER_diArg_1	139	142	PF00400	0.428
TRG_ER_diArg_1	16	18	PF00400	0.417
TRG_ER_diArg_1	95	97	PF00400	0.404
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVD6	Leptomonas seymouri	58%	96%
A0A0S4KF96	Bodo saltans	32%	100%
A0A1X0NKJ3	Trypanosomatidae	45%	100%
A0A3S5H5Q7	Leishmania donovani	84%	97%
A4HSU0	Leishmania infantum	84%	97%
C9ZTF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AKS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QJ30	Leishmania major	83%	100%
V5B7V1	Trypanosoma cruzi	46%	100%