Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H4L1_LEIBR

TriTrypDb:

LbrM.06.0460 , LBRM2903_060010400

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4L1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4L1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.517
CLV_C14_Caspase3-7	130	134	PF00656	0.489
CLV_C14_Caspase3-7	268	272	PF00656	0.524
CLV_C14_Caspase3-7	322	326	PF00656	0.653
CLV_C14_Caspase3-7	44	48	PF00656	0.751
CLV_C14_Caspase3-7	52	56	PF00656	0.709
CLV_NRD_NRD_1	131	133	PF00675	0.561
CLV_NRD_NRD_1	189	191	PF00675	0.542
CLV_NRD_NRD_1	255	257	PF00675	0.621
CLV_NRD_NRD_1	314	316	PF00675	0.545
CLV_NRD_NRD_1	346	348	PF00675	0.659
CLV_NRD_NRD_1	365	367	PF00675	0.560
CLV_PCSK_FUR_1	187	191	PF00082	0.541
CLV_PCSK_FUR_1	256	260	PF00082	0.523
CLV_PCSK_KEX2_1	131	133	PF00082	0.561
CLV_PCSK_KEX2_1	189	191	PF00082	0.604
CLV_PCSK_KEX2_1	258	260	PF00082	0.517
CLV_PCSK_KEX2_1	314	316	PF00082	0.545
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.518
CLV_PCSK_SKI1_1	264	268	PF00082	0.512
CLV_PCSK_SKI1_1	406	410	PF00082	0.539
DEG_APCC_DBOX_1	263	271	PF00400	0.508
DEG_APCC_DBOX_1	405	413	PF00400	0.521
DEG_SPOP_SBC_1	502	506	PF00917	0.481
DEG_SPOP_SBC_1	73	77	PF00917	0.576
DEG_SPOP_SBC_1	79	83	PF00917	0.535
DEG_SPOP_SBC_1	85	89	PF00917	0.633
DEG_SPOP_SBC_1	95	99	PF00917	0.584
DOC_CKS1_1	243	248	PF01111	0.512
DOC_MAPK_DCC_7	383	392	PF00069	0.587
DOC_MAPK_DCC_7	490	500	PF00069	0.523
DOC_MAPK_gen_1	257	269	PF00069	0.514
DOC_MAPK_gen_1	442	451	PF00069	0.601
DOC_MAPK_MEF2A_6	262	269	PF00069	0.669
DOC_MAPK_MEF2A_6	383	392	PF00069	0.587
DOC_MAPK_MEF2A_6	444	453	PF00069	0.515
DOC_MAPK_NFAT4_5	262	270	PF00069	0.668
DOC_USP7_MATH_1	211	215	PF00917	0.642
DOC_USP7_MATH_1	297	301	PF00917	0.511
DOC_USP7_MATH_1	468	472	PF00917	0.686
DOC_USP7_MATH_1	502	506	PF00917	0.481
DOC_USP7_UBL2_3	363	367	PF12436	0.580
DOC_USP7_UBL2_3	433	437	PF12436	0.659
DOC_USP7_UBL2_3	7	11	PF12436	0.492
DOC_WW_Pin1_4	105	110	PF00397	0.537
DOC_WW_Pin1_4	192	197	PF00397	0.696
DOC_WW_Pin1_4	219	224	PF00397	0.576
DOC_WW_Pin1_4	228	233	PF00397	0.516
DOC_WW_Pin1_4	242	247	PF00397	0.511
DOC_WW_Pin1_4	306	311	PF00397	0.635
DOC_WW_Pin1_4	34	39	PF00397	0.524
DOC_WW_Pin1_4	397	402	PF00397	0.592
LIG_14-3-3_CanoR_1	162	169	PF00244	0.786
LIG_14-3-3_CanoR_1	264	270	PF00244	0.509
LIG_14-3-3_CanoR_1	314	320	PF00244	0.637
LIG_14-3-3_CanoR_1	347	352	PF00244	0.582
LIG_14-3-3_CanoR_1	366	374	PF00244	0.630
LIG_14-3-3_CanoR_1	375	382	PF00244	0.589
LIG_14-3-3_CanoR_1	444	450	PF00244	0.515
LIG_14-3-3_CanoR_1	490	494	PF00244	0.562
LIG_14-3-3_CanoR_1	68	74	PF00244	0.646
LIG_14-3-3_CterR_2	501	506	PF00244	0.482
LIG_BIR_III_4	133	137	PF00653	0.507
LIG_BRCT_BRCA1_1	352	356	PF00533	0.489
LIG_BRCT_BRCA1_1	60	64	PF00533	0.488
LIG_CSL_BTD_1	243	246	PF09270	0.535
LIG_FHA_1	166	172	PF00498	0.628
LIG_FHA_1	180	186	PF00498	0.586
LIG_FHA_1	273	279	PF00498	0.556
LIG_FHA_1	347	353	PF00498	0.493
LIG_FHA_1	444	450	PF00498	0.525
LIG_FHA_1	79	85	PF00498	0.505
LIG_FHA_2	108	114	PF00498	0.587
LIG_FHA_2	243	249	PF00498	0.630
LIG_FHA_2	392	398	PF00498	0.610
LIG_LIR_Gen_1	89	96	PF02991	0.559
LIG_LIR_Nem_3	113	118	PF02991	0.636
LIG_LIR_Nem_3	172	177	PF02991	0.508
LIG_LIR_Nem_3	415	421	PF02991	0.523
LIG_LIR_Nem_3	481	485	PF02991	0.480
LIG_LIR_Nem_3	54	60	PF02991	0.506
LIG_LIR_Nem_3	61	67	PF02991	0.480
LIG_LIR_Nem_3	89	95	PF02991	0.558
LIG_LYPXL_yS_3	115	118	PF13949	0.512
LIG_SH3_3	113	119	PF00018	0.579
LIG_SH3_3	278	284	PF00018	0.593
LIG_SUMO_SIM_par_1	217	222	PF11976	0.570
LIG_TRAF2_1	411	414	PF00917	0.589
LIG_TRFH_1	115	119	PF08558	0.509
LIG_TYR_ITIM	416	421	PF00017	0.503
LIG_WRC_WIRS_1	171	176	PF05994	0.558
LIG_WW_3	280	284	PF00397	0.516
MOD_CDC14_SPxK_1	311	314	PF00782	0.690
MOD_CDK_SPxK_1	308	314	PF00069	0.689
MOD_CDK_SPxxK_3	308	315	PF00069	0.535
MOD_CK1_1	111	117	PF00069	0.632
MOD_CK1_1	127	133	PF00069	0.542
MOD_CK1_1	197	203	PF00069	0.566
MOD_CK1_1	214	220	PF00069	0.649
MOD_CK1_1	222	228	PF00069	0.598
MOD_CK1_1	23	29	PF00069	0.592
MOD_CK1_1	272	278	PF00069	0.505
MOD_CK1_1	306	312	PF00069	0.594
MOD_CK1_1	32	38	PF00069	0.656
MOD_CK1_1	350	356	PF00069	0.573
MOD_CK1_1	43	49	PF00069	0.634
MOD_CK1_1	51	57	PF00069	0.619
MOD_CK1_1	58	64	PF00069	0.710
MOD_CK1_1	66	72	PF00069	0.696
MOD_CK1_1	90	96	PF00069	0.649
MOD_CK1_1	97	103	PF00069	0.603
MOD_CK2_1	232	238	PF00069	0.591
MOD_CK2_1	391	397	PF00069	0.755
MOD_CK2_1	408	414	PF00069	0.556
MOD_DYRK1A_RPxSP_1	192	196	PF00069	0.586
MOD_GlcNHglycan	126	129	PF01048	0.604
MOD_GlcNHglycan	143	146	PF01048	0.685
MOD_GlcNHglycan	165	168	PF01048	0.541
MOD_GlcNHglycan	192	195	PF01048	0.627
MOD_GlcNHglycan	199	202	PF01048	0.565
MOD_GlcNHglycan	22	25	PF01048	0.503
MOD_GlcNHglycan	259	262	PF01048	0.517
MOD_GlcNHglycan	305	308	PF01048	0.788
MOD_GlcNHglycan	317	320	PF01048	0.647
MOD_GlcNHglycan	38	41	PF01048	0.586
MOD_GlcNHglycan	470	473	PF01048	0.612
MOD_GlcNHglycan	51	54	PF01048	0.578
MOD_GlcNHglycan	68	71	PF01048	0.599
MOD_GlcNHglycan	92	95	PF01048	0.580
MOD_GSK3_1	101	108	PF00069	0.640
MOD_GSK3_1	118	125	PF00069	0.527
MOD_GSK3_1	161	168	PF00069	0.624
MOD_GSK3_1	188	195	PF00069	0.710
MOD_GSK3_1	228	235	PF00069	0.594
MOD_GSK3_1	265	272	PF00069	0.697
MOD_GSK3_1	29	36	PF00069	0.649
MOD_GSK3_1	346	353	PF00069	0.523
MOD_GSK3_1	408	415	PF00069	0.723
MOD_GSK3_1	424	431	PF00069	0.503
MOD_GSK3_1	43	50	PF00069	0.620
MOD_GSK3_1	51	58	PF00069	0.601
MOD_GSK3_1	68	75	PF00069	0.649
MOD_GSK3_1	80	87	PF00069	0.674
MOD_GSK3_1	90	97	PF00069	0.578
MOD_LATS_1	345	351	PF00433	0.499
MOD_NEK2_1	14	19	PF00069	0.509
MOD_NEK2_1	169	174	PF00069	0.603
MOD_NEK2_1	185	190	PF00069	0.514
MOD_NEK2_1	199	204	PF00069	0.495
MOD_NEK2_1	265	270	PF00069	0.602
MOD_NEK2_1	303	308	PF00069	0.594
MOD_NEK2_1	451	456	PF00069	0.674
MOD_NEK2_1	74	79	PF00069	0.553
MOD_PKA_1	257	263	PF00069	0.517
MOD_PKA_1	347	353	PF00069	0.539
MOD_PKA_2	161	167	PF00069	0.615
MOD_PKA_2	179	185	PF00069	0.572
MOD_PKA_2	188	194	PF00069	0.606
MOD_PKA_2	313	319	PF00069	0.659
MOD_PKA_2	346	352	PF00069	0.653
MOD_PKA_2	365	371	PF00069	0.572
MOD_PKA_2	443	449	PF00069	0.513
MOD_PKA_2	489	495	PF00069	0.518
MOD_PKB_1	442	450	PF00069	0.541
MOD_Plk_1	292	298	PF00069	0.523
MOD_Plk_1	412	418	PF00069	0.597
MOD_Plk_1	428	434	PF00069	0.458
MOD_Plk_4	214	220	PF00069	0.543
MOD_Plk_4	265	271	PF00069	0.602
MOD_Plk_4	347	353	PF00069	0.585
MOD_Plk_4	478	484	PF00069	0.476
MOD_Plk_4	55	61	PF00069	0.575
MOD_Plk_4	69	75	PF00069	0.646
MOD_ProDKin_1	105	111	PF00069	0.537
MOD_ProDKin_1	192	198	PF00069	0.691
MOD_ProDKin_1	219	225	PF00069	0.573
MOD_ProDKin_1	228	234	PF00069	0.516
MOD_ProDKin_1	242	248	PF00069	0.513
MOD_ProDKin_1	306	312	PF00069	0.635
MOD_ProDKin_1	34	40	PF00069	0.527
MOD_ProDKin_1	397	403	PF00069	0.594
TRG_ENDOCYTIC_2	115	118	PF00928	0.512
TRG_ENDOCYTIC_2	418	421	PF00928	0.641
TRG_ER_diArg_1	186	189	PF00400	0.537
TRG_ER_diArg_1	262	265	PF00400	0.517
TRG_ER_diArg_1	313	315	PF00400	0.543
TRG_ER_diArg_1	374	377	PF00400	0.740
TRG_NLS_MonoCore_2	255	260	PF00514	0.510
TRG_NLS_MonoExtN_4	256	261	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T5	Leptomonas seymouri	36%	100%
A0A3S5H5Q5	Leishmania donovani	53%	100%
A4HST7	Leishmania infantum	53%	100%
E9AKS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
Q4QJ33	Leishmania major	50%	100%