TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4L0_LEIBR

TriTrypDb:

LbrM.06.0450 , LBRM2903_060010200

Length:

958

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H4L0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4L0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.658
CLV_C14_Caspase3-7	317	321	PF00656	0.588
CLV_C14_Caspase3-7	341	345	PF00656	0.397
CLV_C14_Caspase3-7	477	481	PF00656	0.665
CLV_C14_Caspase3-7	889	893	PF00656	0.693
CLV_NRD_NRD_1	294	296	PF00675	0.628
CLV_NRD_NRD_1	297	299	PF00675	0.608
CLV_NRD_NRD_1	407	409	PF00675	0.670
CLV_NRD_NRD_1	410	412	PF00675	0.561
CLV_NRD_NRD_1	516	518	PF00675	0.642
CLV_NRD_NRD_1	622	624	PF00675	0.733
CLV_PCSK_FUR_1	295	299	PF00082	0.646
CLV_PCSK_KEX2_1	293	295	PF00082	0.609
CLV_PCSK_KEX2_1	297	299	PF00082	0.591
CLV_PCSK_KEX2_1	407	409	PF00082	0.670
CLV_PCSK_KEX2_1	516	518	PF00082	0.642
CLV_PCSK_KEX2_1	611	613	PF00082	0.663
CLV_PCSK_KEX2_1	622	624	PF00082	0.822
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.663
CLV_PCSK_PC7_1	293	299	PF00082	0.641
CLV_PCSK_SKI1_1	235	239	PF00082	0.536
CLV_PCSK_SKI1_1	297	301	PF00082	0.500
CLV_PCSK_SKI1_1	407	411	PF00082	0.628
CLV_PCSK_SKI1_1	420	424	PF00082	0.752
CLV_PCSK_SKI1_1	581	585	PF00082	0.573
CLV_PCSK_SKI1_1	767	771	PF00082	0.709
CLV_Separin_Metazoa	188	192	PF03568	0.618
DEG_APCC_DBOX_1	423	431	PF00400	0.785
DEG_Nend_Nbox_1	1	3	PF02207	0.802
DEG_SCF_FBW7_1	770	777	PF00400	0.562
DEG_SCF_FBW7_1	813	818	PF00400	0.563
DEG_SCF_FBW7_2	134	140	PF00400	0.520
DEG_SPOP_SBC_1	540	544	PF00917	0.711
DEG_SPOP_SBC_1	637	641	PF00917	0.577
DEG_SPOP_SBC_1	780	784	PF00917	0.754
DEG_SPOP_SBC_1	938	942	PF00917	0.747
DOC_CKS1_1	134	139	PF01111	0.579
DOC_CKS1_1	771	776	PF01111	0.659
DOC_CYCLIN_RxL_1	762	775	PF00134	0.689
DOC_CYCLIN_yCln2_LP_2	423	429	PF00134	0.794
DOC_MAPK_MEF2A_6	458	465	PF00069	0.559
DOC_MAPK_MEF2A_6	668	675	PF00069	0.812
DOC_PP2B_LxvP_1	423	426	PF13499	0.683
DOC_PP2B_LxvP_1	75	78	PF13499	0.788
DOC_PP2B_LxvP_1	792	795	PF13499	0.811
DOC_PP4_FxxP_1	705	708	PF00568	0.535
DOC_PP4_FxxP_1	852	855	PF00568	0.780
DOC_USP7_MATH_1	183	187	PF00917	0.438
DOC_USP7_MATH_1	254	258	PF00917	0.460
DOC_USP7_MATH_1	303	307	PF00917	0.493
DOC_USP7_MATH_1	362	366	PF00917	0.588
DOC_USP7_MATH_1	37	41	PF00917	0.759
DOC_USP7_MATH_1	512	516	PF00917	0.803
DOC_USP7_MATH_1	540	544	PF00917	0.695
DOC_USP7_MATH_1	592	596	PF00917	0.684
DOC_USP7_MATH_1	638	642	PF00917	0.805
DOC_USP7_MATH_1	653	657	PF00917	0.512
DOC_USP7_MATH_1	730	734	PF00917	0.681
DOC_USP7_MATH_1	741	745	PF00917	0.787
DOC_USP7_MATH_1	772	776	PF00917	0.700
DOC_USP7_MATH_1	78	82	PF00917	0.726
DOC_USP7_MATH_1	938	942	PF00917	0.763
DOC_USP7_MATH_1	95	99	PF00917	0.621
DOC_USP7_MATH_1	951	955	PF00917	0.587
DOC_USP7_MATH_2	791	797	PF00917	0.788
DOC_WW_Pin1_4	133	138	PF00397	0.607
DOC_WW_Pin1_4	252	257	PF00397	0.508
DOC_WW_Pin1_4	33	38	PF00397	0.731
DOC_WW_Pin1_4	39	44	PF00397	0.680
DOC_WW_Pin1_4	479	484	PF00397	0.658
DOC_WW_Pin1_4	558	563	PF00397	0.757
DOC_WW_Pin1_4	654	659	PF00397	0.600
DOC_WW_Pin1_4	719	724	PF00397	0.570
DOC_WW_Pin1_4	745	750	PF00397	0.762
DOC_WW_Pin1_4	770	775	PF00397	0.657
DOC_WW_Pin1_4	811	816	PF00397	0.793
DOC_WW_Pin1_4	85	90	PF00397	0.827
DOC_WW_Pin1_4	891	896	PF00397	0.527
LIG_14-3-3_CanoR_1	297	305	PF00244	0.643
LIG_14-3-3_CanoR_1	383	391	PF00244	0.545
LIG_14-3-3_CanoR_1	516	526	PF00244	0.602
LIG_14-3-3_CanoR_1	57	66	PF00244	0.767
LIG_14-3-3_CanoR_1	612	618	PF00244	0.584
LIG_14-3-3_CanoR_1	70	76	PF00244	0.611
LIG_14-3-3_CanoR_1	743	749	PF00244	0.584
LIG_14-3-3_CanoR_1	931	935	PF00244	0.740
LIG_14-3-3_CterR_2	955	958	PF00244	0.795
LIG_Actin_WH2_2	201	219	PF00022	0.384
LIG_BIR_III_2	10	14	PF00653	0.533
LIG_BRCT_BRCA1_1	712	716	PF00533	0.655
LIG_deltaCOP1_diTrp_1	344	351	PF00928	0.588
LIG_FHA_1	216	222	PF00498	0.587
LIG_FHA_1	323	329	PF00498	0.604
LIG_FHA_1	370	376	PF00498	0.577
LIG_FHA_1	383	389	PF00498	0.443
LIG_FHA_1	530	536	PF00498	0.558
LIG_FHA_1	542	548	PF00498	0.406
LIG_FHA_1	707	713	PF00498	0.553
LIG_FHA_1	72	78	PF00498	0.714
LIG_FHA_1	745	751	PF00498	0.579
LIG_FHA_1	758	764	PF00498	0.810
LIG_FHA_1	808	814	PF00498	0.828
LIG_FHA_1	827	833	PF00498	0.667
LIG_FHA_1	861	867	PF00498	0.767
LIG_FHA_1	945	951	PF00498	0.538
LIG_FHA_2	614	620	PF00498	0.601
LIG_FHA_2	816	822	PF00498	0.611
LIG_FHA_2	860	866	PF00498	0.502
LIG_FHA_2	887	893	PF00498	0.793
LIG_HCF-1_HBM_1	119	122	PF13415	0.563
LIG_LIR_Apic_2	549	555	PF02991	0.728
LIG_LIR_Apic_2	921	926	PF02991	0.549
LIG_LIR_Gen_1	155	163	PF02991	0.543
LIG_LIR_Gen_1	195	205	PF02991	0.528
LIG_LIR_Nem_3	155	161	PF02991	0.631
LIG_LIR_Nem_3	195	200	PF02991	0.499
LIG_LIR_Nem_3	402	406	PF02991	0.545
LIG_LIR_Nem_3	786	792	PF02991	0.819
LIG_Pex14_2	833	837	PF04695	0.603
LIG_SH2_CRK	158	162	PF00017	0.643
LIG_SH2_CRK	266	270	PF00017	0.498
LIG_SH2_CRK	552	556	PF00017	0.640
LIG_SH2_CRK	560	564	PF00017	0.721
LIG_SH2_CRK	587	591	PF00017	0.588
LIG_SH2_GRB2like	371	374	PF00017	0.630
LIG_SH2_NCK_1	158	162	PF00017	0.546
LIG_SH2_NCK_1	560	564	PF00017	0.718
LIG_SH2_NCK_1	858	862	PF00017	0.724
LIG_SH2_NCK_1	9	13	PF00017	0.745
LIG_SH2_NCK_1	923	927	PF00017	0.544
LIG_SH2_STAP1	158	162	PF00017	0.546
LIG_SH2_STAP1	371	375	PF00017	0.627
LIG_SH2_STAT3	492	495	PF00017	0.837
LIG_SH2_STAT5	371	374	PF00017	0.560
LIG_SH2_STAT5	644	647	PF00017	0.575
LIG_SH2_STAT5	65	68	PF00017	0.524
LIG_SH2_STAT5	844	847	PF00017	0.766
LIG_SH2_STAT5	858	861	PF00017	0.533
LIG_SH3_2	658	663	PF14604	0.576
LIG_SH3_3	131	137	PF00018	0.725
LIG_SH3_3	423	429	PF00018	0.692
LIG_SH3_3	485	491	PF00018	0.491
LIG_SH3_3	655	661	PF00018	0.726
LIG_SH3_3	810	816	PF00018	0.581
LIG_SH3_3	83	89	PF00018	0.722
LIG_SH3_3	894	900	PF00018	0.778
LIG_SH3_3	99	105	PF00018	0.702
LIG_Sin3_3	167	174	PF02671	0.509
LIG_SUMO_SIM_par_1	542	549	PF11976	0.442
LIG_SUMO_SIM_par_1	766	773	PF11976	0.655
LIG_SUMO_SIM_par_1	790	796	PF11976	0.791
LIG_SUMO_SIM_par_1	862	869	PF11976	0.528
LIG_TRAF2_1	185	188	PF00917	0.669
LIG_TRAF2_1	384	387	PF00917	0.527
LIG_TRFH_1	133	137	PF08558	0.458
LIG_UBA3_1	212	217	PF00899	0.604
LIG_WRC_WIRS_1	400	405	PF05994	0.649
MOD_CDC14_SPxK_1	42	45	PF00782	0.549
MOD_CDK_SPK_2	85	90	PF00069	0.574
MOD_CDK_SPxK_1	39	45	PF00069	0.553
MOD_CK1_1	178	184	PF00069	0.537
MOD_CK1_1	30	36	PF00069	0.641
MOD_CK1_1	365	371	PF00069	0.578
MOD_CK1_1	543	549	PF00069	0.520
MOD_CK1_1	596	602	PF00069	0.798
MOD_CK1_1	61	67	PF00069	0.516
MOD_CK1_1	621	627	PF00069	0.673
MOD_CK1_1	640	646	PF00069	0.587
MOD_CK1_1	648	654	PF00069	0.744
MOD_CK1_1	676	682	PF00069	0.543
MOD_CK1_1	710	716	PF00069	0.707
MOD_CK1_1	744	750	PF00069	0.649
MOD_CK1_1	81	87	PF00069	0.825
MOD_CK1_1	826	832	PF00069	0.779
MOD_CK1_1	906	912	PF00069	0.807
MOD_CK1_1	933	939	PF00069	0.794
MOD_CK1_1	941	947	PF00069	0.663
MOD_CK2_1	236	242	PF00069	0.526
MOD_CK2_1	904	910	PF00069	0.809
MOD_GlcNHglycan	177	180	PF01048	0.564
MOD_GlcNHglycan	316	319	PF01048	0.747
MOD_GlcNHglycan	32	35	PF01048	0.601
MOD_GlcNHglycan	502	505	PF01048	0.852
MOD_GlcNHglycan	548	551	PF01048	0.551
MOD_GlcNHglycan	564	567	PF01048	0.787
MOD_GlcNHglycan	570	573	PF01048	0.708
MOD_GlcNHglycan	61	64	PF01048	0.738
MOD_GlcNHglycan	625	628	PF01048	0.592
MOD_GlcNHglycan	647	650	PF01048	0.669
MOD_GlcNHglycan	675	678	PF01048	0.568
MOD_GlcNHglycan	717	720	PF01048	0.588
MOD_GlcNHglycan	738	741	PF01048	0.837
MOD_GlcNHglycan	754	757	PF01048	0.553
MOD_GlcNHglycan	795	798	PF01048	0.736
MOD_GlcNHglycan	801	804	PF01048	0.802
MOD_GlcNHglycan	824	828	PF01048	0.777
MOD_GlcNHglycan	871	874	PF01048	0.677
MOD_GlcNHglycan	875	878	PF01048	0.629
MOD_GlcNHglycan	906	909	PF01048	0.696
MOD_GlcNHglycan	96	100	PF01048	0.724
MOD_GSK3_1	120	127	PF00069	0.619
MOD_GSK3_1	175	182	PF00069	0.690
MOD_GSK3_1	26	33	PF00069	0.578
MOD_GSK3_1	358	365	PF00069	0.481
MOD_GSK3_1	369	376	PF00069	0.470
MOD_GSK3_1	446	453	PF00069	0.638
MOD_GSK3_1	500	507	PF00069	0.595
MOD_GSK3_1	525	532	PF00069	0.749
MOD_GSK3_1	539	546	PF00069	0.601
MOD_GSK3_1	558	565	PF00069	0.806
MOD_GSK3_1	57	64	PF00069	0.571
MOD_GSK3_1	592	599	PF00069	0.621
MOD_GSK3_1	621	628	PF00069	0.587
MOD_GSK3_1	633	640	PF00069	0.681
MOD_GSK3_1	706	713	PF00069	0.699
MOD_GSK3_1	715	722	PF00069	0.766
MOD_GSK3_1	731	738	PF00069	0.620
MOD_GSK3_1	741	748	PF00069	0.713
MOD_GSK3_1	770	777	PF00069	0.789
MOD_GSK3_1	778	785	PF00069	0.762
MOD_GSK3_1	795	802	PF00069	0.512
MOD_GSK3_1	807	814	PF00069	0.781
MOD_GSK3_1	81	88	PF00069	0.825
MOD_GSK3_1	815	822	PF00069	0.539
MOD_GSK3_1	856	863	PF00069	0.730
MOD_GSK3_1	869	876	PF00069	0.777
MOD_GSK3_1	882	889	PF00069	0.663
MOD_GSK3_1	898	905	PF00069	0.576
MOD_GSK3_1	929	936	PF00069	0.790
MOD_GSK3_1	937	944	PF00069	0.673
MOD_GSK3_1	950	957	PF00069	0.581
MOD_LATS_1	448	454	PF00433	0.609
MOD_N-GLC_2	261	263	PF02516	0.458
MOD_NEK2_1	124	129	PF00069	0.561
MOD_NEK2_1	216	221	PF00069	0.485
MOD_NEK2_1	27	32	PF00069	0.625
MOD_NEK2_1	461	466	PF00069	0.470
MOD_NEK2_1	498	503	PF00069	0.848
MOD_NEK2_1	541	546	PF00069	0.539
MOD_NEK2_1	59	64	PF00069	0.721
MOD_NEK2_1	633	638	PF00069	0.767
MOD_NEK2_1	736	741	PF00069	0.595
MOD_NEK2_1	763	768	PF00069	0.552
MOD_NEK2_1	808	813	PF00069	0.673
MOD_NEK2_1	902	907	PF00069	0.744
MOD_NEK2_1	950	955	PF00069	0.792
MOD_PIKK_1	338	344	PF00454	0.610
MOD_PIKK_1	382	388	PF00454	0.527
MOD_PIKK_1	525	531	PF00454	0.765
MOD_PIKK_1	631	637	PF00454	0.628
MOD_PIKK_1	731	737	PF00454	0.708
MOD_PK_1	939	945	PF00069	0.536
MOD_PKA_1	297	303	PF00069	0.416
MOD_PKA_2	297	303	PF00069	0.416
MOD_PKA_2	362	368	PF00069	0.581
MOD_PKA_2	382	388	PF00069	0.299
MOD_PKA_2	504	510	PF00069	0.633
MOD_PKA_2	518	524	PF00069	0.613
MOD_PKA_2	568	574	PF00069	0.756
MOD_PKA_2	621	627	PF00069	0.725
MOD_PKA_2	69	75	PF00069	0.628
MOD_PKA_2	731	737	PF00069	0.594
MOD_PKA_2	742	748	PF00069	0.658
MOD_PKA_2	930	936	PF00069	0.564
MOD_PKB_1	295	303	PF00069	0.407
MOD_Plk_1	120	126	PF00069	0.776
MOD_Plk_1	200	206	PF00069	0.523
MOD_Plk_1	321	327	PF00069	0.556
MOD_Plk_1	577	583	PF00069	0.559
MOD_Plk_1	911	917	PF00069	0.564
MOD_Plk_1	951	957	PF00069	0.789
MOD_Plk_2-3	322	328	PF00069	0.453
MOD_Plk_4	373	379	PF00069	0.613
MOD_Plk_4	450	456	PF00069	0.448
MOD_Plk_4	61	67	PF00069	0.516
MOD_Plk_4	707	713	PF00069	0.758
MOD_Plk_4	785	791	PF00069	0.766
MOD_Plk_4	815	821	PF00069	0.565
MOD_ProDKin_1	133	139	PF00069	0.593
MOD_ProDKin_1	252	258	PF00069	0.503
MOD_ProDKin_1	33	39	PF00069	0.736
MOD_ProDKin_1	479	485	PF00069	0.659
MOD_ProDKin_1	558	564	PF00069	0.762
MOD_ProDKin_1	654	660	PF00069	0.604
MOD_ProDKin_1	719	725	PF00069	0.575
MOD_ProDKin_1	745	751	PF00069	0.757
MOD_ProDKin_1	770	776	PF00069	0.658
MOD_ProDKin_1	811	817	PF00069	0.792
MOD_ProDKin_1	85	91	PF00069	0.824
MOD_ProDKin_1	891	897	PF00069	0.523
MOD_SUMO_rev_2	214	219	PF00179	0.600
MOD_SUMO_rev_2	933	941	PF00179	0.539
TRG_DiLeu_BaEn_3	187	193	PF01217	0.517
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.629
TRG_DiLeu_BaLyEn_6	554	559	PF01217	0.613
TRG_ENDOCYTIC_2	158	161	PF00928	0.639
TRG_ENDOCYTIC_2	197	200	PF00928	0.501
TRG_ENDOCYTIC_2	266	269	PF00928	0.485
TRG_ENDOCYTIC_2	413	416	PF00928	0.451
TRG_ENDOCYTIC_2	617	620	PF00928	0.582
TRG_ENDOCYTIC_2	789	792	PF00928	0.814
TRG_ENDOCYTIC_2	857	860	PF00928	0.714
TRG_ER_diArg_1	293	295	PF00400	0.623
TRG_ER_diArg_1	297	299	PF00400	0.591
TRG_ER_diArg_1	406	408	PF00400	0.657
TRG_ER_diArg_1	516	519	PF00400	0.674
TRG_NES_CRM1_1	145	155	PF08389	0.599
TRG_NES_CRM1_1	281	292	PF08389	0.492
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	287	292	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7KMM4	Trypanosoma rangeli	36%	100%
A0A3S7WPE9	Leishmania donovani	68%	96%
A4HST6	Leishmania infantum	69%	97%
E9AKS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	96%
Q4QJ34	Leishmania major	67%	99%