Kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinesin

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4K9_LEIBR

TriTrypDb:

LbrM.06.0440 , LBRM2903_060010100

Length:

684

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4K9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4K9

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003774	cytoskeletal motor activity	1	2
GO:0003777	microtubule motor activity	2	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0005524	ATP binding	5	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140657	ATP-dependent activity	1	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.748
CLV_NRD_NRD_1	181	183	PF00675	0.683
CLV_NRD_NRD_1	274	276	PF00675	0.610
CLV_NRD_NRD_1	297	299	PF00675	0.431
CLV_NRD_NRD_1	417	419	PF00675	0.579
CLV_NRD_NRD_1	462	464	PF00675	0.576
CLV_NRD_NRD_1	510	512	PF00675	0.557
CLV_NRD_NRD_1	600	602	PF00675	0.527
CLV_NRD_NRD_1	630	632	PF00675	0.624
CLV_PCSK_FUR_1	179	183	PF00082	0.533
CLV_PCSK_FUR_1	415	419	PF00082	0.576
CLV_PCSK_FUR_1	628	632	PF00082	0.582
CLV_PCSK_KEX2_1	181	183	PF00082	0.683
CLV_PCSK_KEX2_1	297	299	PF00082	0.431
CLV_PCSK_KEX2_1	417	419	PF00082	0.579
CLV_PCSK_KEX2_1	510	512	PF00082	0.440
CLV_PCSK_KEX2_1	602	604	PF00082	0.533
CLV_PCSK_KEX2_1	630	632	PF00082	0.629
CLV_PCSK_PC1ET2_1	602	604	PF00082	0.542
CLV_PCSK_SKI1_1	268	272	PF00082	0.533
CLV_PCSK_SKI1_1	36	40	PF00082	0.585
CLV_PCSK_SKI1_1	402	406	PF00082	0.485
CLV_PCSK_SKI1_1	54	58	PF00082	0.477
DEG_APCC_KENBOX_2	189	193	PF00400	0.774
DEG_Nend_UBRbox_2	1	3	PF02207	0.613
DEG_SPOP_SBC_1	13	17	PF00917	0.825
DEG_SPOP_SBC_1	56	60	PF00917	0.685
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.414
DOC_MAPK_DCC_7	345	355	PF00069	0.482
DOC_MAPK_gen_1	297	305	PF00069	0.385
DOC_MAPK_gen_1	601	612	PF00069	0.563
DOC_MAPK_MEF2A_6	533	541	PF00069	0.458
DOC_PP4_FxxP_1	248	251	PF00568	0.491
DOC_USP7_MATH_1	120	124	PF00917	0.426
DOC_USP7_MATH_1	151	155	PF00917	0.600
DOC_USP7_MATH_1	237	241	PF00917	0.495
DOC_USP7_MATH_1	291	295	PF00917	0.419
DOC_USP7_MATH_1	330	334	PF00917	0.567
DOC_USP7_MATH_1	443	447	PF00917	0.644
DOC_USP7_MATH_1	448	452	PF00917	0.628
DOC_USP7_MATH_1	56	60	PF00917	0.682
DOC_USP7_MATH_1	675	679	PF00917	0.599
DOC_USP7_MATH_1	74	78	PF00917	0.749
DOC_USP7_MATH_1	86	90	PF00917	0.754
DOC_USP7_UBL2_3	36	40	PF12436	0.612
DOC_WW_Pin1_4	147	152	PF00397	0.482
DOC_WW_Pin1_4	15	20	PF00397	0.740
LIG_14-3-3_CanoR_1	106	114	PF00244	0.543
LIG_14-3-3_CanoR_1	143	148	PF00244	0.437
LIG_14-3-3_CanoR_1	169	177	PF00244	0.551
LIG_14-3-3_CanoR_1	297	301	PF00244	0.415
LIG_14-3-3_CanoR_1	533	541	PF00244	0.576
LIG_14-3-3_CanoR_1	54	64	PF00244	0.557
LIG_14-3-3_CanoR_1	6	11	PF00244	0.718
LIG_14-3-3_CanoR_1	619	626	PF00244	0.588
LIG_14-3-3_CanoR_1	636	644	PF00244	0.528
LIG_14-3-3_CanoR_1	652	658	PF00244	0.631
LIG_Actin_WH2_2	555	570	PF00022	0.562
LIG_BIR_III_4	186	190	PF00653	0.757
LIG_BIR_III_4	447	451	PF00653	0.376
LIG_BRCT_BRCA1_1	129	133	PF00533	0.402
LIG_BRCT_BRCA1_1	502	506	PF00533	0.571
LIG_BRCT_BRCA1_1	95	99	PF00533	0.485
LIG_deltaCOP1_diTrp_1	94	99	PF00928	0.401
LIG_DLG_GKlike_1	6	14	PF00625	0.570
LIG_EH1_1	389	397	PF00400	0.476
LIG_FHA_1	215	221	PF00498	0.606
LIG_FHA_1	278	284	PF00498	0.380
LIG_FHA_1	345	351	PF00498	0.355
LIG_FHA_1	457	463	PF00498	0.466
LIG_FHA_1	500	506	PF00498	0.536
LIG_FHA_1	581	587	PF00498	0.460
LIG_FHA_1	621	627	PF00498	0.607
LIG_FHA_2	186	192	PF00498	0.786
LIG_FHA_2	302	308	PF00498	0.355
LIG_FHA_2	346	352	PF00498	0.384
LIG_FHA_2	495	501	PF00498	0.599
LIG_FHA_2	606	612	PF00498	0.514
LIG_Integrin_isoDGR_2	206	208	PF01839	0.703
LIG_LIR_Apic_2	146	151	PF02991	0.448
LIG_LIR_Apic_2	247	251	PF02991	0.489
LIG_LIR_Apic_2	92	98	PF02991	0.411
LIG_LIR_Gen_1	111	122	PF02991	0.356
LIG_LIR_Gen_1	130	139	PF02991	0.446
LIG_LIR_Gen_1	302	311	PF02991	0.358
LIG_LIR_Gen_1	503	512	PF02991	0.562
LIG_LIR_Gen_1	58	69	PF02991	0.515
LIG_LIR_Nem_3	111	117	PF02991	0.355
LIG_LIR_Nem_3	130	134	PF02991	0.483
LIG_LIR_Nem_3	221	227	PF02991	0.500
LIG_LIR_Nem_3	302	308	PF02991	0.359
LIG_LIR_Nem_3	503	509	PF02991	0.564
LIG_LIR_Nem_3	58	64	PF02991	0.528
LIG_NRBOX	345	351	PF00104	0.355
LIG_Pex14_1	95	99	PF04695	0.484
LIG_SH2_CRK	148	152	PF00017	0.475
LIG_SH2_CRK	61	65	PF00017	0.507
LIG_SH2_NCK_1	10	14	PF00017	0.727
LIG_SH2_NCK_1	289	293	PF00017	0.470
LIG_SH2_PTP2	131	134	PF00017	0.512
LIG_SH2_PTP2	357	360	PF00017	0.393
LIG_SH2_SRC	114	117	PF00017	0.480
LIG_SH2_SRC	289	292	PF00017	0.465
LIG_SH2_STAP1	114	118	PF00017	0.545
LIG_SH2_STAT5	131	134	PF00017	0.394
LIG_SH2_STAT5	357	360	PF00017	0.393
LIG_SH2_STAT5	565	568	PF00017	0.521
LIG_SH2_STAT5	585	588	PF00017	0.317
LIG_SH2_STAT5	61	64	PF00017	0.550
LIG_SH3_3	114	120	PF00018	0.426
LIG_SH3_3	132	138	PF00018	0.309
LIG_SH3_3	16	22	PF00018	0.755
LIG_SH3_3	243	249	PF00018	0.461
LIG_SH3_3	252	258	PF00018	0.432
LIG_SH3_3	267	273	PF00018	0.338
LIG_SH3_3	285	291	PF00018	0.382
LIG_SH3_3	659	665	PF00018	0.686
LIG_SH3_3	674	680	PF00018	0.549
LIG_SUMO_SIM_par_1	359	365	PF11976	0.476
LIG_TYR_ITIM	355	360	PF00017	0.418
LIG_UBA3_1	166	175	PF00899	0.581
LIG_UBA3_1	596	604	PF00899	0.595
LIG_WW_3	20	24	PF00397	0.551
MOD_CK1_1	11	17	PF00069	0.741
MOD_CK1_1	123	129	PF00069	0.488
MOD_CK1_1	141	147	PF00069	0.311
MOD_CK1_1	200	206	PF00069	0.748
MOD_CK1_1	212	218	PF00069	0.634
MOD_CK1_1	299	305	PF00069	0.383
MOD_CK1_1	362	368	PF00069	0.388
MOD_CK1_1	375	381	PF00069	0.387
MOD_CK1_1	384	390	PF00069	0.529
MOD_CK1_1	41	47	PF00069	0.648
MOD_CK1_1	59	65	PF00069	0.392
MOD_CK1_1	632	638	PF00069	0.524
MOD_CK1_1	656	662	PF00069	0.669
MOD_CK1_1	78	84	PF00069	0.760
MOD_CK1_1	88	94	PF00069	0.735
MOD_CK2_1	185	191	PF00069	0.797
MOD_CK2_1	345	351	PF00069	0.371
MOD_CK2_1	47	53	PF00069	0.549
MOD_CK2_1	494	500	PF00069	0.538
MOD_CK2_1	539	545	PF00069	0.458
MOD_CK2_1	605	611	PF00069	0.445
MOD_CK2_1	88	94	PF00069	0.483
MOD_Cter_Amidation	295	298	PF01082	0.474
MOD_Cter_Amidation	599	602	PF01082	0.586
MOD_GlcNHglycan	126	129	PF01048	0.453
MOD_GlcNHglycan	135	138	PF01048	0.346
MOD_GlcNHglycan	140	143	PF01048	0.372
MOD_GlcNHglycan	202	205	PF01048	0.691
MOD_GlcNHglycan	334	337	PF01048	0.593
MOD_GlcNHglycan	366	369	PF01048	0.417
MOD_GlcNHglycan	49	52	PF01048	0.606
MOD_GlcNHglycan	637	640	PF01048	0.640
MOD_GSK3_1	11	18	PF00069	0.672
MOD_GSK3_1	120	127	PF00069	0.470
MOD_GSK3_1	143	150	PF00069	0.453
MOD_GSK3_1	195	202	PF00069	0.822
MOD_GSK3_1	2	9	PF00069	0.645
MOD_GSK3_1	214	221	PF00069	0.433
MOD_GSK3_1	292	299	PF00069	0.515
MOD_GSK3_1	341	348	PF00069	0.419
MOD_GSK3_1	52	59	PF00069	0.535
MOD_GSK3_1	523	530	PF00069	0.514
MOD_GSK3_1	586	593	PF00069	0.609
MOD_GSK3_1	643	650	PF00069	0.603
MOD_GSK3_1	652	659	PF00069	0.593
MOD_GSK3_1	74	81	PF00069	0.653
MOD_GSK3_1	85	92	PF00069	0.700
MOD_LATS_1	45	51	PF00433	0.559
MOD_N-GLC_1	123	128	PF02516	0.538
MOD_N-GLC_1	195	200	PF02516	0.696
MOD_N-GLC_1	384	389	PF02516	0.409
MOD_N-GLC_1	443	448	PF02516	0.591
MOD_N-GLC_1	99	104	PF02516	0.459
MOD_NEK2_1	133	138	PF00069	0.302
MOD_NEK2_1	214	219	PF00069	0.575
MOD_NEK2_1	341	346	PF00069	0.505
MOD_NEK2_1	372	377	PF00069	0.436
MOD_NEK2_1	4	9	PF00069	0.682
MOD_NEK2_1	456	461	PF00069	0.564
MOD_NEK2_1	528	533	PF00069	0.552
MOD_NEK2_1	539	544	PF00069	0.525
MOD_NEK2_1	647	652	PF00069	0.680
MOD_NEK2_1	670	675	PF00069	0.620
MOD_NEK2_1	99	104	PF00069	0.475
MOD_PIKK_1	141	147	PF00454	0.449
MOD_PIKK_1	195	201	PF00454	0.761
MOD_PIKK_1	521	527	PF00454	0.537
MOD_PIKK_1	528	534	PF00454	0.480
MOD_PIKK_1	580	586	PF00454	0.604
MOD_PIKK_1	660	666	PF00454	0.689
MOD_PIKK_1	8	14	PF00454	0.764
MOD_PIKK_1	80	86	PF00454	0.739
MOD_PIKK_1	93	99	PF00454	0.662
MOD_PKA_2	168	174	PF00069	0.417
MOD_PKA_2	296	302	PF00069	0.416
MOD_PKA_2	435	441	PF00069	0.556
MOD_PKA_2	532	538	PF00069	0.576
MOD_PKA_2	618	624	PF00069	0.562
MOD_PKA_2	629	635	PF00069	0.414
MOD_PKA_2	647	653	PF00069	0.515
MOD_PKB_1	603	611	PF00069	0.506
MOD_Plk_1	212	218	PF00069	0.466
MOD_Plk_1	278	284	PF00069	0.380
MOD_Plk_1	317	323	PF00069	0.485
MOD_Plk_1	384	390	PF00069	0.426
MOD_Plk_1	539	545	PF00069	0.458
MOD_Plk_1	580	586	PF00069	0.589
MOD_Plk_1	99	105	PF00069	0.458
MOD_Plk_2-3	540	546	PF00069	0.381
MOD_Plk_4	127	133	PF00069	0.458
MOD_Plk_4	143	149	PF00069	0.395
MOD_Plk_4	301	307	PF00069	0.405
MOD_Plk_4	345	351	PF00069	0.362
MOD_ProDKin_1	147	153	PF00069	0.486
MOD_ProDKin_1	15	21	PF00069	0.739
MOD_SUMO_rev_2	338	347	PF00179	0.472
MOD_SUMO_rev_2	540	548	PF00179	0.491
TRG_DiLeu_BaEn_1	318	323	PF01217	0.364
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.461
TRG_DiLeu_BaLyEn_6	451	456	PF01217	0.469
TRG_ENDOCYTIC_2	114	117	PF00928	0.435
TRG_ENDOCYTIC_2	131	134	PF00928	0.394
TRG_ENDOCYTIC_2	224	227	PF00928	0.493
TRG_ENDOCYTIC_2	289	292	PF00928	0.421
TRG_ENDOCYTIC_2	357	360	PF00928	0.393
TRG_ENDOCYTIC_2	61	64	PF00928	0.494
TRG_ER_diArg_1	178	181	PF00400	0.657
TRG_ER_diArg_1	258	261	PF00400	0.536
TRG_ER_diArg_1	414	417	PF00400	0.579
TRG_ER_diArg_1	509	511	PF00400	0.560
TRG_ER_diArg_1	603	606	PF00400	0.567
TRG_ER_diArg_1	630	633	PF00400	0.631
TRG_ER_diArg_1	64	67	PF00400	0.590
TRG_NLS_MonoCore_2	600	605	PF00514	0.608
TRG_NLS_MonoExtC_3	600	605	PF00514	0.565
TRG_NLS_MonoExtN_4	601	606	PF00514	0.559
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC06	Leptomonas seymouri	72%	98%
A0A0S4KIG4	Bodo saltans	29%	93%
A0A1X0NKL3	Trypanosomatidae	52%	100%
A0A3R7LWH4	Trypanosoma rangeli	50%	100%
A0A3S5H5Q4	Leishmania donovani	88%	99%
A4HST5	Leishmania infantum	89%	99%
C9ZTE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AKS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QJ35	Leishmania major	88%	100%
V5DPG4	Trypanosoma cruzi	52%	100%