Putative 60S ribosomal protein L19

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L19, putative

Species:

Leishmania braziliensis

UniProt:

A4H4K7_LEIBR

TriTrypDb:

LbrM.06.0390

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	12
GO:0022625	cytosolic large ribosomal subunit	5	12
GO:0032991	protein-containing complex	1	12
GO:0044391	ribosomal subunit	3	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H4K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4K7

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.298
CLV_NRD_NRD_1	106	108	PF00675	0.299
CLV_NRD_NRD_1	173	175	PF00675	0.519
CLV_NRD_NRD_1	189	191	PF00675	0.571
CLV_NRD_NRD_1	37	39	PF00675	0.298
CLV_NRD_NRD_1	41	43	PF00675	0.299
CLV_NRD_NRD_1	51	53	PF00675	0.298
CLV_NRD_NRD_1	63	65	PF00675	0.269
CLV_NRD_NRD_1	80	82	PF00675	0.226
CLV_NRD_NRD_1	97	99	PF00675	0.298
CLV_PCSK_FUR_1	133	137	PF00082	0.298
CLV_PCSK_FUR_1	187	191	PF00082	0.504
CLV_PCSK_KEX2_1	103	105	PF00082	0.298
CLV_PCSK_KEX2_1	135	137	PF00082	0.334
CLV_PCSK_KEX2_1	180	182	PF00082	0.665
CLV_PCSK_KEX2_1	189	191	PF00082	0.514
CLV_PCSK_KEX2_1	80	82	PF00082	0.325
CLV_PCSK_KEX2_1	97	99	PF00082	0.298
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.313
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.665
CLV_PCSK_PC7_1	185	191	PF00082	0.503
CLV_PCSK_SKI1_1	103	107	PF00082	0.298
CLV_PCSK_SKI1_1	43	47	PF00082	0.298
CLV_PCSK_SKI1_1	53	57	PF00082	0.298
CLV_PCSK_SKI1_1	64	68	PF00082	0.298
DOC_USP7_MATH_1	205	209	PF00917	0.625
DOC_USP7_MATH_1	216	220	PF00917	0.675
DOC_USP7_MATH_1	224	228	PF00917	0.773
DOC_USP7_MATH_1	232	236	PF00917	0.566
DOC_USP7_MATH_1	266	270	PF00917	0.481
DOC_USP7_UBL2_3	146	150	PF12436	0.454
DOC_USP7_UBL2_3	175	179	PF12436	0.467
DOC_USP7_UBL2_3	267	271	PF12436	0.646
DOC_USP7_UBL2_3	39	43	PF12436	0.298
LIG_14-3-3_CanoR_1	38	42	PF00244	0.298
LIG_NRBOX	101	107	PF00104	0.298
LIG_SH2_STAT5	124	127	PF00017	0.276
LIG_SH3_2	249	254	PF14604	0.498
LIG_SH3_3	246	252	PF00018	0.586
LIG_UBA3_1	101	108	PF00899	0.298
LIG_UBA3_1	138	146	PF00899	0.222
MOD_CK1_1	37	43	PF00069	0.309
MOD_Cter_Amidation	78	81	PF01082	0.298
MOD_GlcNHglycan	207	210	PF01048	0.641
MOD_GlcNHglycan	218	221	PF01048	0.671
MOD_GlcNHglycan	226	229	PF01048	0.636
MOD_GlcNHglycan	75	78	PF01048	0.263
MOD_NEK2_1	10	15	PF00069	0.392
MOD_PKA_2	37	43	PF00069	0.298
MOD_PKA_2	73	79	PF00069	0.263
MOD_Plk_4	10	16	PF00069	0.367
MOD_SUMO_for_1	145	148	PF00179	0.444
TRG_DiLeu_BaLyEn_6	101	106	PF01217	0.298
TRG_ENDOCYTIC_2	120	123	PF00928	0.298
TRG_ER_diArg_1	102	104	PF00400	0.298
TRG_ER_diArg_1	187	190	PF00400	0.535
TRG_ER_diArg_1	19	22	PF00400	0.298
TRG_ER_diArg_1	60	63	PF00400	0.298
TRG_ER_diArg_1	96	98	PF00400	0.298
TRG_ER_diLys_1	267	271	PF00400	0.678
TRG_NLS_Bipartite_1	97	111	PF00514	0.392
TRG_NLS_MonoExtC_3	106	112	PF00514	0.392
TRG_NLS_MonoExtC_3	266	271	PF00514	0.677
TRG_NLS_MonoExtN_4	104	111	PF00514	0.392
TRG_NLS_MonoExtN_4	265	271	PF00514	0.669
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.298
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.298

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTS2	Leptomonas seymouri	94%	100%
A0A1X0NL07	Trypanosomatidae	85%	100%
A0A3R7MF58	Trypanosoma rangeli	87%	91%
A0A3S5H5Q3	Leishmania donovani	97%	100%
A4H4K5	Leishmania braziliensis	100%	100%
A4HST1	Leishmania infantum	97%	100%
A4HST3	Leishmania infantum	97%	100%
D0VWQ5	Canis lupus familiaris	56%	100%
E9AKR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O02639	Caenorhabditis elegans	55%	100%
P84098	Homo sapiens	56%	100%
P84099	Mus musculus	56%	100%
P84100	Rattus norvegicus	56%	100%
Q3T0W9	Bos taurus	56%	100%
Q4QJ37	Leishmania major	97%	100%
Q4QJ39	Leishmania major	97%	100%
Q5RB99	Pongo abelii	56%	100%
Q7ZYS1	Xenopus laevis	55%	100%
Q8HXN9	Macaca fascicularis	56%	100%