C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4K6_LEIBR

TriTrypDb:

LbrM.06.0400 , LBRM2903_060009800

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4K6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.627
CLV_NRD_NRD_1	156	158	PF00675	0.602
CLV_NRD_NRD_1	29	31	PF00675	0.538
CLV_PCSK_FUR_1	154	158	PF00082	0.569
CLV_PCSK_KEX2_1	149	151	PF00082	0.581
CLV_PCSK_KEX2_1	156	158	PF00082	0.576
CLV_PCSK_KEX2_1	29	31	PF00082	0.482
CLV_PCSK_KEX2_1	41	43	PF00082	0.507
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.647
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.536
CLV_PCSK_SKI1_1	180	184	PF00082	0.507
CLV_PCSK_SKI1_1	22	26	PF00082	0.502
CLV_PCSK_SKI1_1	57	61	PF00082	0.557
DEG_SPOP_SBC_1	112	116	PF00917	0.625
DEG_SPOP_SBC_1	70	74	PF00917	0.793
DEG_SPOP_SBC_1	85	89	PF00917	0.726
DOC_MAPK_gen_1	179	186	PF00069	0.510
DOC_USP7_MATH_1	112	116	PF00917	0.730
DOC_USP7_MATH_1	70	74	PF00917	0.695
LIG_14-3-3_CanoR_1	154	160	PF00244	0.414
LIG_APCC_ABBA_1	18	23	PF00400	0.501
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BIR_III_4	107	111	PF00653	0.639
LIG_FHA_1	3	9	PF00498	0.595
LIG_FHA_1	54	60	PF00498	0.572
LIG_FHA_1	85	91	PF00498	0.766
LIG_FHA_2	156	162	PF00498	0.411
LIG_NRBOX	170	176	PF00104	0.401
LIG_SH2_STAT5	10	13	PF00017	0.496
LIG_SH2_STAT5	19	22	PF00017	0.497
MOD_CK1_1	123	129	PF00069	0.734
MOD_CK1_1	2	8	PF00069	0.608
MOD_CK1_1	74	80	PF00069	0.729
MOD_GlcNHglycan	115	118	PF01048	0.771
MOD_GlcNHglycan	130	133	PF01048	0.537
MOD_GlcNHglycan	138	141	PF01048	0.530
MOD_GlcNHglycan	76	79	PF01048	0.585
MOD_GSK3_1	119	126	PF00069	0.759
MOD_GSK3_1	136	143	PF00069	0.470
MOD_GSK3_1	169	176	PF00069	0.522
MOD_GSK3_1	70	77	PF00069	0.699
MOD_NEK2_1	120	125	PF00069	0.653
MOD_NEK2_1	35	40	PF00069	0.686
MOD_NEK2_1	68	73	PF00069	0.637
MOD_PIKK_1	35	41	PF00454	0.680
MOD_PKA_2	155	161	PF00069	0.411
MOD_PKA_2	53	59	PF00069	0.676
MOD_PKA_2	68	74	PF00069	0.634
MOD_Plk_1	102	108	PF00069	0.644
MOD_Plk_4	169	175	PF00069	0.614
MOD_SUMO_rev_2	172	182	PF00179	0.515
TRG_DiLeu_BaEn_1	55	60	PF01217	0.574
TRG_ER_diArg_1	154	157	PF00400	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II80	Leptomonas seymouri	53%	92%
A0A3S5H5Q2	Leishmania donovani	80%	100%
A4HST2	Leishmania infantum	80%	100%
E9AKR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QJ38	Leishmania major	80%	100%