LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

DUF547 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF547 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H4K4_LEIBR
TriTrypDb:
LbrM.06.0370 , LBRM2903_060009400
Length:
910

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4K4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4K4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 115 119 PF00656 0.427
CLV_C14_Caspase3-7 534 538 PF00656 0.427
CLV_NRD_NRD_1 11 13 PF00675 0.514
CLV_NRD_NRD_1 392 394 PF00675 0.618
CLV_NRD_NRD_1 400 402 PF00675 0.622
CLV_NRD_NRD_1 48 50 PF00675 0.410
CLV_NRD_NRD_1 644 646 PF00675 0.557
CLV_NRD_NRD_1 840 842 PF00675 0.495
CLV_PCSK_KEX2_1 11 13 PF00082 0.604
CLV_PCSK_KEX2_1 221 223 PF00082 0.396
CLV_PCSK_KEX2_1 392 394 PF00082 0.610
CLV_PCSK_KEX2_1 402 404 PF00082 0.629
CLV_PCSK_KEX2_1 840 842 PF00082 0.495
CLV_PCSK_PC1ET2_1 221 223 PF00082 0.455
CLV_PCSK_PC1ET2_1 402 404 PF00082 0.640
CLV_PCSK_PC7_1 836 842 PF00082 0.483
CLV_PCSK_SKI1_1 142 146 PF00082 0.450
CLV_PCSK_SKI1_1 356 360 PF00082 0.446
CLV_PCSK_SKI1_1 383 387 PF00082 0.610
CLV_PCSK_SKI1_1 441 445 PF00082 0.404
CLV_PCSK_SKI1_1 728 732 PF00082 0.446
CLV_PCSK_SKI1_1 841 845 PF00082 0.514
CLV_PCSK_SKI1_1 862 866 PF00082 0.636
CLV_PCSK_SKI1_1 93 97 PF00082 0.432
DEG_APCC_DBOX_1 355 363 PF00400 0.389
DEG_APCC_DBOX_1 522 530 PF00400 0.438
DEG_SPOP_SBC_1 531 535 PF00917 0.378
DEG_SPOP_SBC_1 736 740 PF00917 0.467
DOC_CKS1_1 227 232 PF01111 0.460
DOC_CKS1_1 692 697 PF01111 0.578
DOC_CYCLIN_RxL_1 139 148 PF00134 0.457
DOC_CYCLIN_RxL_1 353 360 PF00134 0.508
DOC_CYCLIN_yCln2_LP_2 210 216 PF00134 0.567
DOC_CYCLIN_yCln2_LP_2 635 641 PF00134 0.558
DOC_CYCLIN_yCln2_LP_2 69 75 PF00134 0.449
DOC_MAPK_gen_1 221 227 PF00069 0.365
DOC_MAPK_gen_1 520 528 PF00069 0.376
DOC_MAPK_JIP1_4 749 755 PF00069 0.548
DOC_MAPK_MEF2A_6 520 528 PF00069 0.376
DOC_MAPK_MEF2A_6 549 557 PF00069 0.447
DOC_MAPK_MEF2A_6 899 907 PF00069 0.560
DOC_PP2B_LxvP_1 311 314 PF13499 0.502
DOC_PP2B_LxvP_1 69 72 PF13499 0.422
DOC_SPAK_OSR1_1 347 351 PF12202 0.547
DOC_USP7_MATH_1 251 255 PF00917 0.516
DOC_USP7_MATH_1 354 358 PF00917 0.459
DOC_USP7_MATH_1 36 40 PF00917 0.463
DOC_USP7_MATH_1 361 365 PF00917 0.347
DOC_USP7_MATH_1 559 563 PF00917 0.446
DOC_USP7_MATH_1 644 648 PF00917 0.556
DOC_USP7_MATH_1 702 706 PF00917 0.640
DOC_USP7_MATH_1 736 740 PF00917 0.573
DOC_USP7_MATH_1 75 79 PF00917 0.512
DOC_USP7_UBL2_3 677 681 PF12436 0.503
DOC_WW_Pin1_4 226 231 PF00397 0.433
DOC_WW_Pin1_4 315 320 PF00397 0.628
DOC_WW_Pin1_4 424 429 PF00397 0.501
DOC_WW_Pin1_4 484 489 PF00397 0.724
DOC_WW_Pin1_4 490 495 PF00397 0.775
DOC_WW_Pin1_4 532 537 PF00397 0.462
DOC_WW_Pin1_4 557 562 PF00397 0.431
DOC_WW_Pin1_4 605 610 PF00397 0.524
DOC_WW_Pin1_4 691 696 PF00397 0.600
DOC_WW_Pin1_4 700 705 PF00397 0.681
DOC_WW_Pin1_4 851 856 PF00397 0.449
LIG_14-3-3_CanoR_1 280 285 PF00244 0.438
LIG_14-3-3_CanoR_1 441 450 PF00244 0.481
LIG_14-3-3_CanoR_1 508 518 PF00244 0.467
LIG_14-3-3_CanoR_1 570 574 PF00244 0.491
LIG_14-3-3_CanoR_1 602 608 PF00244 0.566
LIG_14-3-3_CanoR_1 764 769 PF00244 0.525
LIG_APCC_ABBA_1 61 66 PF00400 0.494
LIG_APCC_ABBAyCdc20_2 93 99 PF00400 0.434
LIG_BIR_II_1 1 5 PF00653 0.513
LIG_BRCT_BRCA1_1 15 19 PF00533 0.567
LIG_BRCT_BRCA1_1 514 518 PF00533 0.498
LIG_BRCT_BRCA1_1 559 563 PF00533 0.424
LIG_BRCT_BRCA1_1 57 61 PF00533 0.366
LIG_BRCT_BRCA1_1 838 842 PF00533 0.536
LIG_Clathr_ClatBox_1 261 265 PF01394 0.647
LIG_Clathr_ClatBox_1 290 294 PF01394 0.300
LIG_CtBP_PxDLS_1 564 568 PF00389 0.364
LIG_deltaCOP1_diTrp_1 15 23 PF00928 0.532
LIG_FHA_1 227 233 PF00498 0.352
LIG_FHA_1 241 247 PF00498 0.515
LIG_FHA_1 271 277 PF00498 0.613
LIG_FHA_1 308 314 PF00498 0.520
LIG_FHA_1 372 378 PF00498 0.590
LIG_FHA_1 455 461 PF00498 0.468
LIG_FHA_1 509 515 PF00498 0.420
LIG_FHA_1 663 669 PF00498 0.670
LIG_FHA_1 715 721 PF00498 0.619
LIG_FHA_1 774 780 PF00498 0.671
LIG_FHA_1 816 822 PF00498 0.526
LIG_FHA_2 532 538 PF00498 0.411
LIG_FHA_2 541 547 PF00498 0.635
LIG_FHA_2 613 619 PF00498 0.734
LIG_FHA_2 775 781 PF00498 0.608
LIG_FHA_2 800 806 PF00498 0.633
LIG_FHA_2 866 872 PF00498 0.667
LIG_IRF3_LxIS_1 900 906 PF10401 0.556
LIG_LIR_Gen_1 452 460 PF02991 0.419
LIG_LIR_Gen_1 468 478 PF02991 0.359
LIG_LIR_Gen_1 572 582 PF02991 0.523
LIG_LIR_Gen_1 820 830 PF02991 0.462
LIG_LIR_LC3C_4 716 721 PF02991 0.579
LIG_LIR_Nem_3 277 282 PF02991 0.424
LIG_LIR_Nem_3 452 456 PF02991 0.356
LIG_LIR_Nem_3 468 474 PF02991 0.335
LIG_LIR_Nem_3 572 578 PF02991 0.520
LIG_LIR_Nem_3 58 64 PF02991 0.365
LIG_LIR_Nem_3 767 771 PF02991 0.405
LIG_LIR_Nem_3 820 825 PF02991 0.437
LIG_LIR_Nem_3 868 873 PF02991 0.474
LIG_LIR_Nem_3 897 903 PF02991 0.561
LIG_LYPXL_yS_3 214 217 PF13949 0.397
LIG_NRBOX 256 262 PF00104 0.620
LIG_Pex14_2 19 23 PF04695 0.476
LIG_Pex14_2 470 474 PF04695 0.389
LIG_Pex14_2 838 842 PF04695 0.387
LIG_PTB_Apo_2 863 870 PF02174 0.446
LIG_PTB_Phospho_1 863 869 PF10480 0.442
LIG_SH2_CRK 762 766 PF00017 0.417
LIG_SH2_NCK_1 340 344 PF00017 0.388
LIG_SH2_NCK_1 771 775 PF00017 0.393
LIG_SH2_STAP1 155 159 PF00017 0.410
LIG_SH2_STAP1 242 246 PF00017 0.437
LIG_SH2_STAT3 548 551 PF00017 0.480
LIG_SH2_STAT5 242 245 PF00017 0.432
LIG_SH2_STAT5 3 6 PF00017 0.581
LIG_SH2_STAT5 685 688 PF00017 0.394
LIG_SH2_STAT5 754 757 PF00017 0.451
LIG_SH3_1 126 132 PF00018 0.374
LIG_SH3_1 558 564 PF00018 0.337
LIG_SH3_3 126 132 PF00018 0.374
LIG_SH3_3 210 216 PF00018 0.412
LIG_SH3_3 224 230 PF00018 0.355
LIG_SH3_3 311 317 PF00018 0.588
LIG_SH3_3 558 564 PF00018 0.504
LIG_SH3_3 701 707 PF00018 0.532
LIG_SH3_3 739 745 PF00018 0.478
LIG_SUMO_SIM_anti_2 525 530 PF11976 0.493
LIG_SUMO_SIM_anti_2 568 575 PF11976 0.574
LIG_SUMO_SIM_anti_2 664 670 PF11976 0.555
LIG_SUMO_SIM_anti_2 716 722 PF11976 0.631
LIG_SUMO_SIM_par_1 664 670 PF11976 0.555
LIG_TRFH_1 605 609 PF08558 0.572
LIG_TYR_ITSM 866 873 PF00017 0.574
LIG_UBA3_1 640 646 PF00899 0.470
LIG_WRPW_2 279 282 PF00400 0.419
LIG_WRPW_2 61 64 PF00400 0.413
LIG_WW_1 271 274 PF00397 0.658
MOD_CDK_SPK_2 424 429 PF00069 0.501
MOD_CDK_SPxK_1 851 857 PF00069 0.445
MOD_CK1_1 108 114 PF00069 0.496
MOD_CK1_1 249 255 PF00069 0.658
MOD_CK1_1 442 448 PF00069 0.479
MOD_CK1_1 473 479 PF00069 0.492
MOD_CK1_1 484 490 PF00069 0.639
MOD_CK1_1 493 499 PF00069 0.468
MOD_CK1_1 512 518 PF00069 0.338
MOD_CK1_1 532 538 PF00069 0.367
MOD_CK1_1 540 546 PF00069 0.469
MOD_CK1_1 569 575 PF00069 0.411
MOD_CK1_1 693 699 PF00069 0.621
MOD_CK1_1 705 711 PF00069 0.669
MOD_CK1_1 713 719 PF00069 0.569
MOD_CK1_1 851 857 PF00069 0.445
MOD_CK1_1 889 895 PF00069 0.765
MOD_CK2_1 108 114 PF00069 0.359
MOD_CK2_1 249 255 PF00069 0.680
MOD_CK2_1 354 360 PF00069 0.448
MOD_CK2_1 540 546 PF00069 0.666
MOD_CK2_1 612 618 PF00069 0.554
MOD_CK2_1 644 650 PF00069 0.637
MOD_CK2_1 664 670 PF00069 0.577
MOD_CK2_1 788 794 PF00069 0.625
MOD_CK2_1 799 805 PF00069 0.564
MOD_CK2_1 865 871 PF00069 0.529
MOD_Cter_Amidation 390 393 PF01082 0.497
MOD_GlcNHglycan 107 110 PF01048 0.501
MOD_GlcNHglycan 147 150 PF01048 0.484
MOD_GlcNHglycan 410 413 PF01048 0.765
MOD_GlcNHglycan 441 444 PF01048 0.420
MOD_GlcNHglycan 465 470 PF01048 0.466
MOD_GlcNHglycan 475 478 PF01048 0.536
MOD_GlcNHglycan 488 491 PF01048 0.585
MOD_GlcNHglycan 511 514 PF01048 0.617
MOD_GlcNHglycan 612 615 PF01048 0.611
MOD_GlcNHglycan 646 649 PF01048 0.676
MOD_GlcNHglycan 826 829 PF01048 0.569
MOD_GlcNHglycan 888 891 PF01048 0.645
MOD_GSK3_1 247 254 PF00069 0.459
MOD_GSK3_1 270 277 PF00069 0.561
MOD_GSK3_1 371 378 PF00069 0.586
MOD_GSK3_1 454 461 PF00069 0.457
MOD_GSK3_1 486 493 PF00069 0.544
MOD_GSK3_1 508 515 PF00069 0.611
MOD_GSK3_1 531 538 PF00069 0.421
MOD_GSK3_1 565 572 PF00069 0.457
MOD_GSK3_1 608 615 PF00069 0.579
MOD_GSK3_1 702 709 PF00069 0.716
MOD_GSK3_1 710 717 PF00069 0.757
MOD_GSK3_1 770 777 PF00069 0.564
MOD_LATS_1 245 251 PF00433 0.583
MOD_N-GLC_1 565 570 PF02516 0.562
MOD_N-GLC_1 865 870 PF02516 0.680
MOD_N-GLC_2 74 76 PF02516 0.428
MOD_NEK2_1 105 110 PF00069 0.269
MOD_NEK2_1 145 150 PF00069 0.336
MOD_NEK2_1 157 162 PF00069 0.238
MOD_NEK2_1 199 204 PF00069 0.552
MOD_NEK2_1 232 237 PF00069 0.374
MOD_NEK2_1 307 312 PF00069 0.393
MOD_NEK2_1 324 329 PF00069 0.624
MOD_NEK2_1 439 444 PF00069 0.373
MOD_NEK2_1 56 61 PF00069 0.397
MOD_NEK2_1 587 592 PF00069 0.428
MOD_NEK2_1 610 615 PF00069 0.481
MOD_NEK2_1 88 93 PF00069 0.384
MOD_NEK2_1 903 908 PF00069 0.588
MOD_PIKK_1 134 140 PF00454 0.630
MOD_PIKK_1 249 255 PF00454 0.658
MOD_PIKK_1 535 541 PF00454 0.524
MOD_PIKK_1 737 743 PF00454 0.617
MOD_PIKK_1 876 882 PF00454 0.521
MOD_PKA_2 246 252 PF00069 0.641
MOD_PKA_2 569 575 PF00069 0.492
MOD_PKA_2 644 650 PF00069 0.611
MOD_PKB_1 278 286 PF00069 0.382
MOD_PKB_1 860 868 PF00069 0.508
MOD_Plk_1 113 119 PF00069 0.360
MOD_Plk_1 274 280 PF00069 0.599
MOD_Plk_1 375 381 PF00069 0.520
MOD_Plk_1 451 457 PF00069 0.428
MOD_Plk_1 465 471 PF00069 0.386
MOD_Plk_1 679 685 PF00069 0.569
MOD_Plk_1 713 719 PF00069 0.675
MOD_Plk_1 865 871 PF00069 0.586
MOD_Plk_1 895 901 PF00069 0.689
MOD_Plk_2-3 664 670 PF00069 0.577
MOD_Plk_4 232 238 PF00069 0.349
MOD_Plk_4 514 520 PF00069 0.502
MOD_Plk_4 569 575 PF00069 0.471
MOD_Plk_4 587 593 PF00069 0.362
MOD_Plk_4 664 670 PF00069 0.692
MOD_Plk_4 714 720 PF00069 0.629
MOD_Plk_4 764 770 PF00069 0.473
MOD_Plk_4 774 780 PF00069 0.649
MOD_Plk_4 817 823 PF00069 0.524
MOD_ProDKin_1 226 232 PF00069 0.437
MOD_ProDKin_1 315 321 PF00069 0.629
MOD_ProDKin_1 424 430 PF00069 0.497
MOD_ProDKin_1 484 490 PF00069 0.727
MOD_ProDKin_1 532 538 PF00069 0.465
MOD_ProDKin_1 557 563 PF00069 0.428
MOD_ProDKin_1 605 611 PF00069 0.531
MOD_ProDKin_1 691 697 PF00069 0.608
MOD_ProDKin_1 700 706 PF00069 0.684
MOD_ProDKin_1 851 857 PF00069 0.445
MOD_SUMO_for_1 149 152 PF00179 0.360
MOD_SUMO_for_1 19 22 PF00179 0.480
MOD_SUMO_for_1 262 265 PF00179 0.599
TRG_DiLeu_BaEn_1 52 57 PF01217 0.468
TRG_DiLeu_BaEn_1 618 623 PF01217 0.543
TRG_DiLeu_BaLyEn_6 166 171 PF01217 0.493
TRG_DiLeu_BaLyEn_6 302 307 PF01217 0.383
TRG_DiLeu_BaLyEn_6 445 450 PF01217 0.416
TRG_ENDOCYTIC_2 214 217 PF00928 0.397
TRG_ENDOCYTIC_2 762 765 PF00928 0.412
TRG_ENDOCYTIC_2 870 873 PF00928 0.478
TRG_ER_diArg_1 10 12 PF00400 0.617
TRG_ER_diArg_1 123 126 PF00400 0.444
TRG_ER_diArg_1 400 403 PF00400 0.662
TRG_ER_diArg_1 840 842 PF00400 0.630
TRG_ER_diArg_1 859 862 PF00400 0.584
TRG_NES_CRM1_1 833 848 PF08389 0.357
TRG_NLS_Bipartite_1 392 406 PF00514 0.512
TRG_NLS_MonoExtC_3 400 405 PF00514 0.661
TRG_NLS_MonoExtN_4 401 406 PF00514 0.711
TRG_Pf-PMV_PEXEL_1 11 15 PF00026 0.488
TRG_Pf-PMV_PEXEL_1 356 360 PF00026 0.432
TRG_Pf-PMV_PEXEL_1 448 452 PF00026 0.449

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6G5 Leptomonas seymouri 44% 100%
A0A1X0NMA5 Trypanosomatidae 31% 100%
A0A3S5H5Q0 Leishmania donovani 80% 100%
A0A422NGV5 Trypanosoma rangeli 31% 100%
A4HST0 Leishmania infantum 81% 100%
C9ZTD6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9AKR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
Q4QJ40 Leishmania major 81% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS