LeishMANIAdb
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C3H1-type domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
C3H1-type domain-containing protein
Gene product:
Present in the outer mitochondrial membrane proteome 35
Species:
Leishmania braziliensis
UniProt:
A4H4K3_LEIBR
TriTrypDb:
LbrM.06.0360 , LBRM2903_060009300 *
Length:
375

Annotations

LeishMANIAdb annotations

A Zn-finger protein with a TM segment on the C-terminus (2 paralogous lineages in Kinetoplastids: A4HSS9_LEIINvs. A4I356_LEIIN). Unlikely to be GPI-anchored due to reverse topology. Weakly similar to NLRC3/NOD3 intracellular immune receptor.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005929 cilium 4 12
GO:0042995 cell projection 2 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0110165 cellular anatomical entity 1 12
GO:0120025 plasma membrane bounded cell projection 3 12
GO:0005737 cytoplasm 2 1
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 4
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1

Expansion

Sequence features

A4H4K3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4K3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 10
GO:0003723 RNA binding 4 10
GO:0003729 mRNA binding 5 10
GO:0005488 binding 1 12
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0097159 organic cyclic compound binding 2 10
GO:1901363 heterocyclic compound binding 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 29 33 PF00656 0.555
CLV_C14_Caspase3-7 75 79 PF00656 0.444
CLV_NRD_NRD_1 200 202 PF00675 0.597
CLV_PCSK_KEX2_1 13 15 PF00082 0.666
CLV_PCSK_KEX2_1 200 202 PF00082 0.710
CLV_PCSK_KEX2_1 231 233 PF00082 0.745
CLV_PCSK_PC1ET2_1 13 15 PF00082 0.649
CLV_PCSK_PC1ET2_1 231 233 PF00082 0.726
CLV_PCSK_SKI1_1 156 160 PF00082 0.467
CLV_PCSK_SKI1_1 231 235 PF00082 0.694
DEG_SPOP_SBC_1 300 304 PF00917 0.484
DOC_CYCLIN_yCln2_LP_2 315 321 PF00134 0.477
DOC_PP1_RVXF_1 154 160 PF00149 0.243
DOC_PP2B_LxvP_1 315 318 PF13499 0.476
DOC_PP4_FxxP_1 349 352 PF00568 0.389
DOC_USP7_MATH_1 241 245 PF00917 0.543
DOC_USP7_MATH_1 260 264 PF00917 0.343
DOC_USP7_UBL2_3 231 235 PF12436 0.483
DOC_WW_Pin1_4 226 231 PF00397 0.444
DOC_WW_Pin1_4 338 343 PF00397 0.551
LIG_14-3-3_CanoR_1 180 185 PF00244 0.496
LIG_14-3-3_CanoR_1 232 238 PF00244 0.499
LIG_APCC_ABBAyCdc20_2 19 25 PF00400 0.440
LIG_EH_1 191 195 PF12763 0.385
LIG_eIF4E_1 291 297 PF01652 0.387
LIG_FHA_1 271 277 PF00498 0.394
LIG_FHA_2 80 86 PF00498 0.278
LIG_LIR_Apic_2 346 352 PF02991 0.397
LIG_LIR_Gen_1 179 189 PF02991 0.368
LIG_LIR_Gen_1 78 88 PF02991 0.373
LIG_LIR_Nem_3 21 26 PF02991 0.462
LIG_LIR_Nem_3 78 83 PF02991 0.422
LIG_PDZ_Class_1 370 375 PF00595 0.374
LIG_SH2_PTP2 267 270 PF00017 0.261
LIG_SH2_SRC 108 111 PF00017 0.311
LIG_SH2_SRC 267 270 PF00017 0.271
LIG_SH2_STAP1 23 27 PF00017 0.420
LIG_SH2_STAT5 108 111 PF00017 0.311
LIG_SH2_STAT5 26 29 PF00017 0.431
LIG_SH2_STAT5 267 270 PF00017 0.268
LIG_SH2_STAT5 51 54 PF00017 0.471
LIG_SH3_4 7 14 PF00018 0.387
LIG_SUMO_SIM_anti_2 112 118 PF11976 0.341
LIG_SUMO_SIM_anti_2 361 366 PF11976 0.376
LIG_SUMO_SIM_par_1 368 373 PF11976 0.246
LIG_TRAF2_1 38 41 PF00917 0.492
LIG_TYR_ITIM 106 111 PF00017 0.363
LIG_WRC_WIRS_1 80 85 PF05994 0.325
MOD_CDC14_SPxK_1 229 232 PF00782 0.477
MOD_CDK_SPK_2 226 231 PF00069 0.467
MOD_CDK_SPxK_1 226 232 PF00069 0.470
MOD_CK1_1 100 106 PF00069 0.356
MOD_CK1_1 112 118 PF00069 0.352
MOD_CK1_1 30 36 PF00069 0.628
MOD_CK1_1 338 344 PF00069 0.645
MOD_Cter_Amidation 11 14 PF01082 0.559
MOD_GlcNHglycan 133 137 PF01048 0.371
MOD_GlcNHglycan 202 205 PF01048 0.593
MOD_GlcNHglycan 29 32 PF01048 0.603
MOD_GSK3_1 176 183 PF00069 0.575
MOD_GSK3_1 233 240 PF00069 0.706
MOD_GSK3_1 295 302 PF00069 0.561
MOD_GSK3_1 331 338 PF00069 0.526
MOD_GSK3_1 96 103 PF00069 0.391
MOD_N-GLC_1 224 229 PF02516 0.514
MOD_N-GLC_1 285 290 PF02516 0.522
MOD_N-GLC_1 97 102 PF02516 0.419
MOD_NEK2_1 132 137 PF00069 0.413
MOD_NEK2_1 150 155 PF00069 0.368
MOD_NEK2_1 162 167 PF00069 0.415
MOD_NEK2_1 233 238 PF00069 0.717
MOD_NEK2_1 296 301 PF00069 0.575
MOD_NEK2_1 353 358 PF00069 0.480
MOD_NEK2_1 360 365 PF00069 0.295
MOD_PIKK_1 7 13 PF00454 0.455
MOD_PKA_1 18 24 PF00069 0.596
MOD_PKA_1 200 206 PF00069 0.569
MOD_PKA_2 200 206 PF00069 0.471
MOD_PKB_1 308 316 PF00069 0.627
MOD_Plk_1 112 118 PF00069 0.361
MOD_Plk_1 162 168 PF00069 0.460
MOD_Plk_1 270 276 PF00069 0.649
MOD_Plk_1 335 341 PF00069 0.792
MOD_Plk_1 345 351 PF00069 0.457
MOD_Plk_1 97 103 PF00069 0.419
MOD_Plk_4 112 118 PF00069 0.334
MOD_Plk_4 162 168 PF00069 0.475
MOD_Plk_4 18 24 PF00069 0.706
MOD_Plk_4 233 239 PF00069 0.624
MOD_Plk_4 280 286 PF00069 0.559
MOD_Plk_4 296 302 PF00069 0.495
MOD_Plk_4 353 359 PF00069 0.531
MOD_Plk_4 360 366 PF00069 0.263
MOD_Plk_4 97 103 PF00069 0.366
MOD_ProDKin_1 226 232 PF00069 0.560
MOD_ProDKin_1 338 344 PF00069 0.705
MOD_SUMO_rev_2 203 212 PF00179 0.505
TRG_ENDOCYTIC_2 108 111 PF00928 0.370
TRG_ENDOCYTIC_2 181 184 PF00928 0.443
TRG_ER_diArg_1 199 201 PF00400 0.663
TRG_ER_diArg_1 308 311 PF00400 0.631
TRG_ER_diArg_1 314 317 PF00400 0.563
TRG_NLS_MonoExtC_3 230 235 PF00514 0.633
TRG_NLS_MonoExtN_4 230 235 PF00514 0.542

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NM91 Trypanosomatidae 53% 91%
A0A3R7KZS1 Trypanosoma rangeli 53% 92%
A0A3S5H5P9 Leishmania donovani 86% 94%
A0A3S7X0C2 Leishmania donovani 21% 100%
A4HSS9 Leishmania infantum 86% 94%
A4I356 Leishmania infantum 21% 100%
C9ZTD5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 95%
E9AKR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4QJ41 Leishmania major 86% 100%
V5BXP3 Trypanosoma cruzi 58% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS