C3H1-type domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 35

Species:

Leishmania braziliensis

UniProt:

A4H4K3_LEIBR

TriTrypDb:

LbrM.06.0360 , LBRM2903_060009300

Length:

375

Annotations

LeishMANIAdb annotations

A Zn-finger protein with a TM segment on the C-terminus (2 paralogous lineages in Kinetoplastids: A4HSS9_LEIINvs. A4I356_LEIIN). Unlikely to be GPI-anchored due to reverse topology. Weakly similar to NLRC3/NOD3 intracellular immune receptor.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0005929	cilium	4	12
GO:0016020	membrane	2	4
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12

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Expansion

Sequence features

A4H4K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4K3

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0003729	mRNA binding	5	10
GO:0005488	binding	1	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.555
CLV_C14_Caspase3-7	75	79	PF00656	0.444
CLV_NRD_NRD_1	200	202	PF00675	0.597
CLV_PCSK_KEX2_1	13	15	PF00082	0.666
CLV_PCSK_KEX2_1	200	202	PF00082	0.710
CLV_PCSK_KEX2_1	231	233	PF00082	0.745
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.649
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.726
CLV_PCSK_SKI1_1	156	160	PF00082	0.467
CLV_PCSK_SKI1_1	231	235	PF00082	0.694

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NM91	Trypanosomatidae	53%	91%
A0A3R7KZS1	Trypanosoma rangeli	53%	92%
A0A3S5H5P9	Leishmania donovani	86%	94%
A0A3S7X0C2	Leishmania donovani	21%	100%
A4HSS9	Leishmania infantum	86%	94%
A4I356	Leishmania infantum	21%	100%
C9ZTD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	95%
E9AKR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QJ41	Leishmania major	86%	100%
V5BXP3	Trypanosoma cruzi	58%	92%

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