DUF3453 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4K1_LEIBR

TriTrypDb:

LbrM.06.0340 , LBRM2903_060009100

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4K1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4K1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.579
CLV_NRD_NRD_1	396	398	PF00675	0.570
CLV_NRD_NRD_1	402	404	PF00675	0.558
CLV_PCSK_KEX2_1	103	105	PF00082	0.559
CLV_PCSK_KEX2_1	395	397	PF00082	0.581
CLV_PCSK_KEX2_1	404	406	PF00082	0.545
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.545
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.587
CLV_PCSK_SKI1_1	151	155	PF00082	0.558
CLV_PCSK_SKI1_1	175	179	PF00082	0.351
CLV_PCSK_SKI1_1	217	221	PF00082	0.550
CLV_PCSK_SKI1_1	334	338	PF00082	0.635
CLV_PCSK_SKI1_1	397	401	PF00082	0.550
CLV_PCSK_SKI1_1	77	81	PF00082	0.461
DEG_APCC_DBOX_1	174	182	PF00400	0.296
DEG_SPOP_SBC_1	169	173	PF00917	0.455
DOC_CYCLIN_yClb5_NLxxxL_5	239	245	PF00134	0.558
DOC_MAPK_gen_1	196	204	PF00069	0.633
DOC_MAPK_gen_1	395	401	PF00069	0.688
DOC_PP1_RVXF_1	395	402	PF00149	0.500
DOC_PP2B_LxvP_1	233	236	PF13499	0.586
DOC_PP2B_LxvP_1	379	382	PF13499	0.680
DOC_USP7_MATH_1	134	138	PF00917	0.655
DOC_USP7_MATH_1	169	173	PF00917	0.487
DOC_USP7_MATH_1	286	290	PF00917	0.606
DOC_USP7_MATH_1	361	365	PF00917	0.552
DOC_USP7_MATH_1	409	413	PF00917	0.635
DOC_USP7_MATH_1	419	423	PF00917	0.592
DOC_USP7_MATH_1	60	64	PF00917	0.532
DOC_USP7_MATH_1	79	83	PF00917	0.628
DOC_WW_Pin1_4	205	210	PF00397	0.599
DOC_WW_Pin1_4	266	271	PF00397	0.565
LIG_14-3-3_CanoR_1	239	244	PF00244	0.463
LIG_14-3-3_CanoR_1	249	257	PF00244	0.424
LIG_14-3-3_CanoR_1	284	294	PF00244	0.711
LIG_14-3-3_CanoR_1	33	39	PF00244	0.614
LIG_14-3-3_CanoR_1	407	417	PF00244	0.719
LIG_Actin_WH2_2	139	156	PF00022	0.570
LIG_BIR_II_1	1	5	PF00653	0.603
LIG_Clathr_ClatBox_1	254	258	PF01394	0.597
LIG_Clathr_ClatBox_1	436	440	PF01394	0.700
LIG_deltaCOP1_diTrp_1	212	219	PF00928	0.605
LIG_eIF4E_1	238	244	PF01652	0.308
LIG_eIF4E_1	343	349	PF01652	0.423
LIG_FHA_1	169	175	PF00498	0.448
LIG_FHA_1	228	234	PF00498	0.321
LIG_FHA_1	25	31	PF00498	0.418
LIG_FHA_1	250	256	PF00498	0.496
LIG_FHA_1	290	296	PF00498	0.665
LIG_FHA_1	382	388	PF00498	0.556
LIG_FHA_1	423	429	PF00498	0.658
LIG_FHA_1	431	437	PF00498	0.701
LIG_FHA_2	8	14	PF00498	0.603
LIG_GBD_Chelix_1	88	96	PF00786	0.666
LIG_LIR_Gen_1	222	232	PF02991	0.497
LIG_LIR_Gen_1	263	272	PF02991	0.440
LIG_LIR_Gen_1	29	38	PF02991	0.615
LIG_LIR_Gen_1	367	374	PF02991	0.617
LIG_LIR_Nem_3	222	227	PF02991	0.469
LIG_LIR_Nem_3	230	235	PF02991	0.508
LIG_LIR_Nem_3	237	241	PF02991	0.457
LIG_LIR_Nem_3	263	267	PF02991	0.419
LIG_LIR_Nem_3	29	34	PF02991	0.545
LIG_LIR_Nem_3	35	41	PF02991	0.495
LIG_LIR_Nem_3	367	371	PF02991	0.623
LIG_NRBOX	222	228	PF00104	0.521
LIG_PCNA_TLS_4	313	322	PF02747	0.482
LIG_PDZ_Class_3	446	451	PF00595	0.689
LIG_PTB_Apo_2	279	286	PF02174	0.406
LIG_SH2_CRK	107	111	PF00017	0.580
LIG_SH2_CRK	238	242	PF00017	0.310
LIG_SH2_CRK	31	35	PF00017	0.405
LIG_SH2_GRB2like	343	346	PF00017	0.577
LIG_SH2_STAP1	264	268	PF00017	0.431
LIG_SH2_STAT5	145	148	PF00017	0.451
LIG_SH2_STAT5	161	164	PF00017	0.561
LIG_SH2_STAT5	319	322	PF00017	0.487
LIG_SH2_STAT5	343	346	PF00017	0.548
LIG_SH2_STAT5	373	376	PF00017	0.617
LIG_SH3_3	185	191	PF00018	0.325
LIG_SUMO_SIM_par_1	225	231	PF11976	0.422
LIG_SUMO_SIM_par_1	251	258	PF11976	0.576
LIG_SUMO_SIM_par_1	269	276	PF11976	0.300
LIG_SUMO_SIM_par_1	432	440	PF11976	0.699
LIG_TYR_ITIM	262	267	PF00017	0.432
LIG_UBA3_1	178	184	PF00899	0.300
LIG_UBA3_1	70	77	PF00899	0.411
LIG_UBA3_1	92	101	PF00899	0.550
LIG_WRC_WIRS_1	174	179	PF05994	0.520
MOD_CK1_1	21	27	PF00069	0.615
MOD_CK1_1	248	254	PF00069	0.469
MOD_CK1_1	260	266	PF00069	0.487
MOD_CK1_1	289	295	PF00069	0.605
MOD_CK1_1	389	395	PF00069	0.649
MOD_CK1_1	422	428	PF00069	0.602
MOD_CK2_1	134	140	PF00069	0.680
MOD_CK2_1	23	29	PF00069	0.612
MOD_CK2_1	260	266	PF00069	0.579
MOD_Cter_Amidation	331	334	PF01082	0.749
MOD_GlcNHglycan	214	217	PF01048	0.566
MOD_GlcNHglycan	34	37	PF01048	0.610
MOD_GlcNHglycan	388	391	PF01048	0.640
MOD_GlcNHglycan	421	424	PF01048	0.740
MOD_GlcNHglycan	56	59	PF01048	0.620
MOD_GlcNHglycan	81	84	PF01048	0.627
MOD_GSK3_1	108	115	PF00069	0.714
MOD_GSK3_1	169	176	PF00069	0.496
MOD_GSK3_1	19	26	PF00069	0.579
MOD_GSK3_1	244	251	PF00069	0.434
MOD_GSK3_1	262	269	PF00069	0.327
MOD_GSK3_1	273	280	PF00069	0.467
MOD_GSK3_1	285	292	PF00069	0.537
MOD_GSK3_1	54	61	PF00069	0.624
MOD_N-GLC_1	159	164	PF02516	0.657
MOD_N-GLC_1	239	244	PF02516	0.542
MOD_N-GLC_1	304	309	PF02516	0.616
MOD_N-GLC_1	430	435	PF02516	0.554
MOD_NEK2_1	153	158	PF00069	0.487
MOD_NEK2_1	19	24	PF00069	0.557
MOD_NEK2_1	219	224	PF00069	0.447
MOD_NEK2_1	244	249	PF00069	0.454
MOD_NEK2_1	257	262	PF00069	0.454
MOD_NEK2_1	277	282	PF00069	0.573
MOD_NEK2_1	285	290	PF00069	0.614
MOD_NEK2_1	34	39	PF00069	0.600
MOD_NEK2_1	359	364	PF00069	0.561
MOD_NEK2_1	73	78	PF00069	0.511
MOD_NEK2_1	92	97	PF00069	0.537
MOD_NEK2_2	361	366	PF00069	0.554
MOD_OFUCOSY	105	112	PF10250	0.706
MOD_PIKK_1	114	120	PF00454	0.740
MOD_PKA_2	248	254	PF00069	0.450
MOD_PKA_2	32	38	PF00069	0.632
MOD_PKA_2	326	332	PF00069	0.625
MOD_Plk_1	239	245	PF00069	0.492
MOD_Plk_2-3	326	332	PF00069	0.498
MOD_Plk_4	183	189	PF00069	0.512
MOD_Plk_4	219	225	PF00069	0.460
MOD_Plk_4	239	245	PF00069	0.227
MOD_Plk_4	383	389	PF00069	0.646
MOD_Plk_4	92	98	PF00069	0.556
MOD_ProDKin_1	205	211	PF00069	0.609
MOD_ProDKin_1	266	272	PF00069	0.563
MOD_SUMO_rev_2	326	335	PF00179	0.713
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.588
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.621
TRG_ENDOCYTIC_2	238	241	PF00928	0.488
TRG_ENDOCYTIC_2	264	267	PF00928	0.421
TRG_ENDOCYTIC_2	31	34	PF00928	0.525
TRG_ENDOCYTIC_2	38	41	PF00928	0.466
TRG_ER_diArg_1	403	406	PF00400	0.640
TRG_NLS_MonoExtC_3	402	407	PF00514	0.635
TRG_NLS_MonoExtN_4	403	408	PF00514	0.705
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ7	Leptomonas seymouri	46%	100%
A0A1X0NL47	Trypanosomatidae	32%	98%
A0A3S5H5P7	Leishmania donovani	78%	100%
A0A3S5IR10	Trypanosoma rangeli	29%	97%
A4HSS7	Leishmania infantum	78%	100%
C9ZTC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	98%
E9AKR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QJ43	Leishmania major	78%	100%
V5BA95	Trypanosoma cruzi	31%	98%