Putative ribonuclease H1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribonuclease H1, putative

Species:

Leishmania braziliensis

UniProt:

A4H4J5_LEIBR

TriTrypDb:

LbrM.06.0270 , LBRM2903_060008300

Length:

228

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4J5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043137	DNA replication, removal of RNA primer	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	8
GO:0003676	nucleic acid binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004518	nuclease activity	4	8
GO:0004519	endonuclease activity	5	8
GO:0004521	RNA endonuclease activity	5	8
GO:0004523	RNA-DNA hybrid ribonuclease activity	7	8
GO:0004540	RNA nuclease activity	4	8
GO:0005488	binding	1	8
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	8
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0097159	organic cyclic compound binding	2	8
GO:0140098	catalytic activity, acting on RNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.451
CLV_NRD_NRD_1	224	226	PF00675	0.459
CLV_PCSK_KEX2_1	224	226	PF00082	0.459
CLV_PCSK_SKI1_1	118	122	PF00082	0.334
CLV_PCSK_SKI1_1	98	102	PF00082	0.306
CLV_Separin_Metazoa	181	185	PF03568	0.574
DEG_APCC_DBOX_1	55	63	PF00400	0.323
DEG_APCC_DBOX_1	97	105	PF00400	0.187
DOC_CYCLIN_yCln2_LP_2	179	185	PF00134	0.572
DOC_MAPK_MEF2A_6	98	105	PF00069	0.327
DOC_PP4_FxxP_1	96	99	PF00568	0.187
LIG_14-3-3_CanoR_1	151	156	PF00244	0.402
LIG_14-3-3_CanoR_1	40	48	PF00244	0.270
LIG_14-3-3_CterR_2	224	228	PF00244	0.519
LIG_APCC_ABBA_1	103	108	PF00400	0.313
LIG_APCC_ABBA_1	9	14	PF00400	0.212
LIG_BRCT_BRCA1_1	4	8	PF00533	0.341
LIG_FHA_1	5	11	PF00498	0.350
LIG_FHA_1	81	87	PF00498	0.367
LIG_LIR_Apic_2	94	99	PF02991	0.187
LIG_LIR_Gen_1	150	157	PF02991	0.418
LIG_LIR_Gen_1	5	16	PF02991	0.271
LIG_LIR_Nem_3	140	145	PF02991	0.337
LIG_LIR_Nem_3	150	155	PF02991	0.366
LIG_LIR_Nem_3	5	11	PF02991	0.338
LIG_SH2_CRK	152	156	PF00017	0.434
LIG_SH2_CRK	33	37	PF00017	0.187
LIG_SH2_SRC	12	15	PF00017	0.300
LIG_SH2_STAT3	156	159	PF00017	0.442
LIG_SH2_STAT3	161	164	PF00017	0.449
LIG_SH2_STAT5	106	109	PF00017	0.288
LIG_SH2_STAT5	111	114	PF00017	0.243
LIG_SH2_STAT5	12	15	PF00017	0.313
LIG_SUMO_SIM_anti_2	195	202	PF11976	0.451
LIG_TRAF2_2	135	140	PF00917	0.327
MOD_CK1_1	94	100	PF00069	0.316
MOD_GlcNHglycan	220	223	PF01048	0.393
MOD_GlcNHglycan	4	7	PF01048	0.419
MOD_GlcNHglycan	87	91	PF01048	0.327
MOD_GSK3_1	15	22	PF00069	0.327
MOD_GSK3_1	183	190	PF00069	0.594
MOD_GSK3_1	214	221	PF00069	0.294
MOD_GSK3_1	46	53	PF00069	0.423
MOD_LATS_1	202	208	PF00433	0.481
MOD_N-GLC_1	19	24	PF02516	0.413
MOD_N-GLC_1	192	197	PF02516	0.374
MOD_N-GLC_1	40	45	PF02516	0.275
MOD_NEK2_1	128	133	PF00069	0.311
MOD_NEK2_1	183	188	PF00069	0.475
MOD_NEK2_1	214	219	PF00069	0.543
MOD_NEK2_1	48	53	PF00069	0.467
MOD_NEK2_1	80	85	PF00069	0.327
MOD_PIKK_1	163	169	PF00454	0.441
MOD_PIKK_1	20	26	PF00454	0.215
MOD_PIKK_1	48	54	PF00454	0.327
MOD_PKA_2	183	189	PF00069	0.585
MOD_PKB_1	149	157	PF00069	0.399
MOD_Plk_4	151	157	PF00069	0.562
MOD_Plk_4	4	10	PF00069	0.399
TRG_DiLeu_BaEn_1	196	201	PF01217	0.446
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.187
TRG_ENDOCYTIC_2	152	155	PF00928	0.432
TRG_ENDOCYTIC_2	33	36	PF00928	0.343
TRG_ER_diArg_1	146	149	PF00400	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IX23	Bodo saltans	35%	75%
A0A3S7WPF2	Leishmania donovani	83%	91%
A0R3Q8	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	27%	100%
A4HSS0	Leishmania infantum	83%	91%
A5CEP5	Orientia tsutsugamushi (strain Boryong)	28%	100%
A6U6V5	Sinorhizobium medicae (strain WSM419)	31%	100%
A8LLC1	Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)	32%	100%
B2S2V0	Treponema pallidum subsp. pallidum (strain SS14)	30%	100%
B8HPS9	Cyanothece sp. (strain PCC 7425 / ATCC 29141)	29%	100%
C9ZTC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	76%
E9AKQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	91%
O60930	Homo sapiens	29%	80%
O69014	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	33%	100%
O70338	Mus musculus	27%	80%
O83372	Treponema pallidum (strain Nichols)	30%	100%
Q07705	Mycolicibacterium smegmatis	27%	100%
Q0AE34	Nitrosomonas eutropha (strain DSM 101675 / C91 / Nm57)	27%	100%
Q1GDG1	Ruegeria sp. (strain TM1040)	29%	100%
Q1QW64	Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)	26%	100%
Q28V43	Jannaschia sp. (strain CCS1)	33%	100%
Q4QJ50	Leishmania major	82%	100%
Q55801	Synechocystis sp. (strain PCC 6803 / Kazusa)	29%	100%
Q5BK46	Rattus norvegicus	28%	80%
Q7VDY9	Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)	30%	100%
Q82XV8	Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)	32%	100%
Q92RG0	Rhizobium meliloti (strain 1021)	29%	100%
Q9UST8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	86%
V5BEV1	Trypanosoma cruzi	36%	71%