FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4J4_LEIBR

TriTrypDb:

LbrM.06.0260 , LBRM2903_060008200

Length:

854

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0030870	Mre11 complex	3	9
GO:0032991	protein-containing complex	1	9
GO:0140513	nuclear protein-containing complex	2	9
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4J4

Function

Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	9
GO:0000077	DNA damage checkpoint signaling	5	9
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006259	DNA metabolic process	4	9
GO:0006281	DNA repair	5	9
GO:0006302	double-strand break repair	6	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0006950	response to stress	2	9
GO:0006974	DNA damage response	4	9
GO:0007093	mitotic cell cycle checkpoint signaling	4	9
GO:0007095	mitotic G2 DNA damage checkpoint signaling	6	9
GO:0007165	signal transduction	2	9
GO:0007346	regulation of mitotic cell cycle	5	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0010389	regulation of G2/M transition of mitotic cell cycle	7	9
GO:0010564	regulation of cell cycle process	5	9
GO:0010948	negative regulation of cell cycle process	6	9
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	8	9
GO:0022402	cell cycle process	2	9
GO:0031570	DNA integrity checkpoint signaling	5	9
GO:0033554	cellular response to stress	3	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0035556	intracellular signal transduction	3	9
GO:0042770	signal transduction in response to DNA damage	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0044773	mitotic DNA damage checkpoint signaling	6	9
GO:0044774	mitotic DNA integrity checkpoint signaling	5	9
GO:0044818	mitotic G2/M transition checkpoint	5	9
GO:0045786	negative regulation of cell cycle	5	9
GO:0045930	negative regulation of mitotic cell cycle	6	9
GO:0046483	heterocycle metabolic process	3	9
GO:0048519	negative regulation of biological process	3	9
GO:0048523	negative regulation of cellular process	4	9
GO:0050789	regulation of biological process	2	9
GO:0050794	regulation of cellular process	3	9
GO:0050896	response to stimulus	1	9
GO:0051716	cellular response to stimulus	2	9
GO:0051726	regulation of cell cycle	4	9
GO:0065007	biological regulation	1	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9
GO:1901987	regulation of cell cycle phase transition	6	9
GO:1901988	negative regulation of cell cycle phase transition	7	9
GO:1901990	regulation of mitotic cell cycle phase transition	6	9
GO:1901991	negative regulation of mitotic cell cycle phase transition	7	9
GO:1902749	regulation of cell cycle G2/M phase transition	7	9
GO:1902750	negative regulation of cell cycle G2/M phase transition	8	9
GO:1903047	mitotic cell cycle process	3	9
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0032392	DNA geometric change	7	1
GO:0032508	DNA duplex unwinding	8	1
GO:0051276	chromosome organization	5	1
GO:0071103	DNA conformation change	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003684	damaged DNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	507	511	PF00656	0.418
CLV_C14_Caspase3-7	620	624	PF00656	0.658
CLV_C14_Caspase3-7	66	70	PF00656	0.438
CLV_NRD_NRD_1	132	134	PF00675	0.608
CLV_NRD_NRD_1	405	407	PF00675	0.450
CLV_NRD_NRD_1	572	574	PF00675	0.653
CLV_NRD_NRD_1	615	617	PF00675	0.681
CLV_NRD_NRD_1	717	719	PF00675	0.628
CLV_NRD_NRD_1	775	777	PF00675	0.601
CLV_NRD_NRD_1	781	783	PF00675	0.586
CLV_PCSK_KEX2_1	134	136	PF00082	0.715
CLV_PCSK_KEX2_1	405	407	PF00082	0.449
CLV_PCSK_KEX2_1	572	574	PF00082	0.653
CLV_PCSK_KEX2_1	615	617	PF00082	0.610
CLV_PCSK_KEX2_1	717	719	PF00082	0.628
CLV_PCSK_KEX2_1	774	776	PF00082	0.618
CLV_PCSK_KEX2_1	781	783	PF00082	0.582
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.715
CLV_PCSK_SKI1_1	246	250	PF00082	0.402
CLV_PCSK_SKI1_1	406	410	PF00082	0.453
CLV_PCSK_SKI1_1	423	427	PF00082	0.286
CLV_PCSK_SKI1_1	473	477	PF00082	0.373
CLV_PCSK_SKI1_1	630	634	PF00082	0.761
CLV_PCSK_SKI1_1	693	697	PF00082	0.645
CLV_PCSK_SKI1_1	700	704	PF00082	0.628
DEG_APCC_DBOX_1	457	465	PF00400	0.461
DEG_COP1_1	723	732	PF00400	0.618
DEG_Nend_Nbox_1	1	3	PF02207	0.308
DEG_SCF_FBW7_1	249	256	PF00400	0.591
DOC_CDC14_PxL_1	332	340	PF14671	0.279
DOC_CKS1_1	250	255	PF01111	0.502
DOC_CKS1_1	309	314	PF01111	0.510
DOC_CKS1_1	7	12	PF01111	0.292
DOC_CYCLIN_RxL_1	403	413	PF00134	0.418
DOC_CYCLIN_RxL_1	513	521	PF00134	0.315
DOC_CYCLIN_yCln2_LP_2	254	260	PF00134	0.461
DOC_CYCLIN_yCln2_LP_2	328	334	PF00134	0.297
DOC_MAPK_gen_1	21	31	PF00069	0.405
DOC_MAPK_gen_1	470	478	PF00069	0.528
DOC_MAPK_MEF2A_6	145	152	PF00069	0.534
DOC_MAPK_MEF2A_6	182	190	PF00069	0.303
DOC_MAPK_MEF2A_6	321	328	PF00069	0.423
DOC_MAPK_MEF2A_6	39	48	PF00069	0.395
DOC_MAPK_MEF2A_6	717	724	PF00069	0.458
DOC_MAPK_NFAT4_5	145	153	PF00069	0.358
DOC_PP1_RVXF_1	180	186	PF00149	0.365
DOC_PP1_RVXF_1	433	439	PF00149	0.435
DOC_PP2B_LxvP_1	446	449	PF13499	0.497
DOC_PP2B_PxIxI_1	294	300	PF00149	0.241
DOC_PP4_FxxP_1	158	161	PF00568	0.329
DOC_PP4_FxxP_1	345	348	PF00568	0.481
DOC_PP4_FxxP_1	375	378	PF00568	0.501
DOC_PP4_FxxP_1	628	631	PF00568	0.701
DOC_USP7_MATH_1	273	277	PF00917	0.626
DOC_USP7_MATH_1	353	357	PF00917	0.603
DOC_USP7_MATH_1	358	362	PF00917	0.629
DOC_USP7_MATH_1	370	374	PF00917	0.510
DOC_USP7_MATH_1	391	395	PF00917	0.423
DOC_USP7_MATH_1	449	453	PF00917	0.589
DOC_USP7_MATH_1	679	683	PF00917	0.609
DOC_USP7_MATH_1	813	817	PF00917	0.609
DOC_USP7_UBL2_3	696	700	PF12436	0.579
DOC_WW_Pin1_4	106	111	PF00397	0.461
DOC_WW_Pin1_4	249	254	PF00397	0.618
DOC_WW_Pin1_4	308	313	PF00397	0.395
DOC_WW_Pin1_4	320	325	PF00397	0.411
DOC_WW_Pin1_4	336	341	PF00397	0.270
DOC_WW_Pin1_4	374	379	PF00397	0.630
DOC_WW_Pin1_4	6	11	PF00397	0.436
DOC_WW_Pin1_4	89	94	PF00397	0.771
LIG_14-3-3_CanoR_1	145	151	PF00244	0.521
LIG_14-3-3_CanoR_1	164	168	PF00244	0.401
LIG_14-3-3_CanoR_1	495	501	PF00244	0.437
LIG_14-3-3_CanoR_1	572	580	PF00244	0.631
LIG_14-3-3_CanoR_1	630	635	PF00244	0.548
LIG_14-3-3_CanoR_1	802	807	PF00244	0.481
LIG_Actin_WH2_2	167	184	PF00022	0.451
LIG_APCC_ABBA_1	475	480	PF00400	0.438
LIG_BIR_III_2	575	579	PF00653	0.686
LIG_BIR_III_4	362	366	PF00653	0.498
LIG_BIR_III_4	733	737	PF00653	0.493
LIG_BRCT_BRCA1_1	757	761	PF00533	0.548
LIG_Clathr_ClatBox_1	183	187	PF01394	0.424
LIG_Clathr_ClatBox_1	709	713	PF01394	0.644
LIG_CtBP_PxDLS_1	240	246	PF00389	0.453
LIG_deltaCOP1_diTrp_1	623	628	PF00928	0.647
LIG_EVH1_1	665	669	PF00568	0.644
LIG_FHA_1	147	153	PF00498	0.456
LIG_FHA_1	169	175	PF00498	0.439
LIG_FHA_1	214	220	PF00498	0.480
LIG_FHA_1	288	294	PF00498	0.316
LIG_FHA_1	41	47	PF00498	0.379
LIG_FHA_1	411	417	PF00498	0.399
LIG_FHA_1	479	485	PF00498	0.535
LIG_FHA_1	542	548	PF00498	0.469
LIG_FHA_1	561	567	PF00498	0.496
LIG_FHA_1	653	659	PF00498	0.688
LIG_FHA_1	724	730	PF00498	0.574
LIG_FHA_1	73	79	PF00498	0.416
LIG_FHA_1	758	764	PF00498	0.476
LIG_FHA_2	505	511	PF00498	0.440
LIG_FHA_2	530	536	PF00498	0.529
LIG_LIR_Apic_2	155	161	PF02991	0.383
LIG_LIR_Apic_2	344	348	PF02991	0.562
LIG_LIR_Apic_2	373	378	PF02991	0.503
LIG_LIR_Apic_2	611	617	PF02991	0.527
LIG_LIR_Apic_2	627	631	PF02991	0.686
LIG_LIR_Gen_1	165	174	PF02991	0.542
LIG_LIR_Gen_1	339	350	PF02991	0.311
LIG_LIR_Gen_1	413	422	PF02991	0.437
LIG_LIR_Gen_1	623	632	PF02991	0.672
LIG_LIR_Gen_1	758	768	PF02991	0.579
LIG_LIR_Gen_1	842	853	PF02991	0.654
LIG_LIR_Nem_3	165	170	PF02991	0.446
LIG_LIR_Nem_3	339	345	PF02991	0.395
LIG_LIR_Nem_3	413	417	PF02991	0.385
LIG_LIR_Nem_3	420	425	PF02991	0.419
LIG_LIR_Nem_3	502	508	PF02991	0.404
LIG_LIR_Nem_3	623	628	PF02991	0.676
LIG_LIR_Nem_3	758	764	PF02991	0.579
LIG_LIR_Nem_3	842	848	PF02991	0.669
LIG_LIR_Nem_3	9	15	PF02991	0.430
LIG_MYND_1	336	340	PF01753	0.314
LIG_OCRL_FandH_1	466	478	PF00620	0.394
LIG_Pex14_1	2	6	PF04695	0.313
LIG_Pex14_1	341	345	PF04695	0.441
LIG_REV1ctd_RIR_1	465	474	PF16727	0.469
LIG_SH2_CRK	282	286	PF00017	0.423
LIG_SH2_CRK	505	509	PF00017	0.360
LIG_SH2_CRK	614	618	PF00017	0.500
LIG_SH2_CRK	663	667	PF00017	0.645
LIG_SH2_NCK_1	121	125	PF00017	0.546
LIG_SH2_NCK_1	282	286	PF00017	0.452
LIG_SH2_NCK_1	663	667	PF00017	0.645
LIG_SH2_SRC	121	124	PF00017	0.575
LIG_SH2_SRC	334	337	PF00017	0.406
LIG_SH2_SRC	428	431	PF00017	0.355
LIG_SH2_STAT5	334	337	PF00017	0.435
LIG_SH2_STAT5	398	401	PF00017	0.408
LIG_SH2_STAT5	428	431	PF00017	0.379
LIG_SH3_1	321	327	PF00018	0.417
LIG_SH3_1	334	340	PF00018	0.376
LIG_SH3_1	663	669	PF00018	0.646
LIG_SH3_3	321	327	PF00018	0.386
LIG_SH3_3	334	340	PF00018	0.332
LIG_SH3_3	345	351	PF00018	0.426
LIG_SH3_3	480	486	PF00018	0.487
LIG_SH3_3	575	581	PF00018	0.682
LIG_SH3_3	591	597	PF00018	0.685
LIG_SH3_3	663	669	PF00018	0.556
LIG_SH3_3	791	797	PF00018	0.559
LIG_SH3_4	696	703	PF00018	0.468
LIG_SUMO_SIM_anti_2	187	194	PF11976	0.309
LIG_SUMO_SIM_anti_2	296	301	PF11976	0.235
LIG_SUMO_SIM_par_1	63	72	PF11976	0.390
LIG_SUMO_SIM_par_1	707	713	PF11976	0.556
LIG_SUMO_SIM_par_1	821	830	PF11976	0.654
LIG_TRAF2_1	532	535	PF00917	0.503
LIG_TRAF2_1	557	560	PF00917	0.603
LIG_TRFH_1	663	667	PF08558	0.645
LIG_TYR_ITIM	503	508	PF00017	0.330
LIG_TYR_ITIM	603	608	PF00017	0.500
MOD_CK1_1	108	114	PF00069	0.610
MOD_CK1_1	239	245	PF00069	0.541
MOD_CK1_1	373	379	PF00069	0.574
MOD_CK1_1	380	386	PF00069	0.579
MOD_CK1_1	410	416	PF00069	0.405
MOD_CK1_1	452	458	PF00069	0.635
MOD_CK1_1	499	505	PF00069	0.510
MOD_CK1_1	550	556	PF00069	0.561
MOD_CK1_1	590	596	PF00069	0.516
MOD_CK1_1	642	648	PF00069	0.557
MOD_CK1_1	723	729	PF00069	0.616
MOD_CK1_1	748	754	PF00069	0.481
MOD_CK1_1	816	822	PF00069	0.619
MOD_CK2_1	222	228	PF00069	0.648
MOD_CK2_1	349	355	PF00069	0.631
MOD_CK2_1	358	364	PF00069	0.747
MOD_CK2_1	454	460	PF00069	0.369
MOD_CK2_1	529	535	PF00069	0.541
MOD_Cter_Amidation	22	25	PF01082	0.280
MOD_Cter_Amidation	570	573	PF01082	0.659
MOD_GlcNHglycan	102	105	PF01048	0.496
MOD_GlcNHglycan	137	140	PF01048	0.692
MOD_GlcNHglycan	141	144	PF01048	0.726
MOD_GlcNHglycan	224	227	PF01048	0.607
MOD_GlcNHglycan	231	234	PF01048	0.660
MOD_GlcNHglycan	238	241	PF01048	0.620
MOD_GlcNHglycan	275	278	PF01048	0.563
MOD_GlcNHglycan	351	354	PF01048	0.703
MOD_GlcNHglycan	368	371	PF01048	0.587
MOD_GlcNHglycan	409	412	PF01048	0.425
MOD_GlcNHglycan	446	449	PF01048	0.530
MOD_GlcNHglycan	520	523	PF01048	0.577
MOD_GlcNHglycan	590	593	PF01048	0.614
MOD_GlcNHglycan	680	684	PF01048	0.563
MOD_GlcNHglycan	757	760	PF01048	0.639
MOD_GlcNHglycan	789	792	PF01048	0.619
MOD_GlcNHglycan	815	818	PF01048	0.563
MOD_GlcNHglycan	94	97	PF01048	0.536
MOD_GSK3_1	135	142	PF00069	0.692
MOD_GSK3_1	146	153	PF00069	0.519
MOD_GSK3_1	218	225	PF00069	0.635
MOD_GSK3_1	249	256	PF00069	0.695
MOD_GSK3_1	269	276	PF00069	0.422
MOD_GSK3_1	289	296	PF00069	0.307
MOD_GSK3_1	33	40	PF00069	0.471
MOD_GSK3_1	349	356	PF00069	0.580
MOD_GSK3_1	366	373	PF00069	0.632
MOD_GSK3_1	374	381	PF00069	0.545
MOD_GSK3_1	449	456	PF00069	0.554
MOD_GSK3_1	541	548	PF00069	0.522
MOD_GSK3_1	63	70	PF00069	0.426
MOD_GSK3_1	744	751	PF00069	0.563
MOD_GSK3_1	827	834	PF00069	0.693
MOD_GSK3_1	92	99	PF00069	0.745
MOD_N-GLC_1	478	483	PF02516	0.454
MOD_N-GLC_1	802	807	PF02516	0.481
MOD_NEK2_1	186	191	PF00069	0.525
MOD_NEK2_1	241	246	PF00069	0.526
MOD_NEK2_1	287	292	PF00069	0.397
MOD_NEK2_1	417	422	PF00069	0.411
MOD_NEK2_1	42	47	PF00069	0.413
MOD_NEK2_1	429	434	PF00069	0.435
MOD_NEK2_1	450	455	PF00069	0.589
MOD_NEK2_1	48	53	PF00069	0.503
MOD_NEK2_1	546	551	PF00069	0.446
MOD_NEK2_1	67	72	PF00069	0.383
MOD_NEK2_1	720	725	PF00069	0.623
MOD_NEK2_1	744	749	PF00069	0.539
MOD_NEK2_2	511	516	PF00069	0.406
MOD_PIKK_1	218	224	PF00454	0.620
MOD_PIKK_1	226	232	PF00454	0.565
MOD_PIKK_1	241	247	PF00454	0.508
MOD_PIKK_1	560	566	PF00454	0.738
MOD_PKA_1	775	781	PF00069	0.630
MOD_PKA_2	163	169	PF00069	0.450
MOD_PKA_2	571	577	PF00069	0.605
MOD_PKA_2	775	781	PF00069	0.630
MOD_PKB_1	133	141	PF00069	0.682
MOD_PKB_1	800	808	PF00069	0.477
MOD_Plk_1	186	192	PF00069	0.409
MOD_Plk_1	33	39	PF00069	0.378
MOD_Plk_1	609	615	PF00069	0.768
MOD_Plk_1	68	74	PF00069	0.453
MOD_Plk_1	802	808	PF00069	0.479
MOD_Plk_2-3	504	510	PF00069	0.374
MOD_Plk_4	186	192	PF00069	0.301
MOD_Plk_4	410	416	PF00069	0.350
MOD_Plk_4	504	510	PF00069	0.428
MOD_Plk_4	547	553	PF00069	0.407
MOD_Plk_4	590	596	PF00069	0.516
MOD_Plk_4	609	615	PF00069	0.461
MOD_Plk_4	720	726	PF00069	0.633
MOD_Plk_4	73	79	PF00069	0.325
MOD_ProDKin_1	106	112	PF00069	0.456
MOD_ProDKin_1	249	255	PF00069	0.619
MOD_ProDKin_1	308	314	PF00069	0.393
MOD_ProDKin_1	320	326	PF00069	0.414
MOD_ProDKin_1	336	342	PF00069	0.266
MOD_ProDKin_1	374	380	PF00069	0.630
MOD_ProDKin_1	6	12	PF00069	0.430
MOD_ProDKin_1	89	95	PF00069	0.773
TRG_DiLeu_BaEn_1	504	509	PF01217	0.364
TRG_DiLeu_LyEn_5	480	485	PF01217	0.523
TRG_ENDOCYTIC_2	282	285	PF00928	0.456
TRG_ENDOCYTIC_2	422	425	PF00928	0.406
TRG_ENDOCYTIC_2	505	508	PF00928	0.378
TRG_ENDOCYTIC_2	605	608	PF00928	0.502
TRG_ENDOCYTIC_2	668	671	PF00928	0.550
TRG_ER_diArg_1	614	616	PF00400	0.681
TRG_ER_diArg_1	774	776	PF00400	0.606
TRG_ER_diArg_1	810	813	PF00400	0.555
TRG_NES_CRM1_1	460	472	PF08389	0.297
TRG_NLS_MonoExtC_3	132	137	PF00514	0.614
TRG_NLS_MonoExtN_4	133	138	PF00514	0.612
TRG_Pf-PMV_PEXEL_1	419	424	PF00026	0.279

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6V8	Leptomonas seymouri	46%	95%
A0A0S4JDA4	Bodo saltans	28%	100%
A0A3S5H5P2	Leishmania donovani	73%	100%
A4HSR9	Leishmania infantum	73%	100%
E9AKQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QJ51	Leishmania major	73%	98%
V5B5S6	Trypanosoma cruzi	29%	100%