Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 34

Species:

Leishmania braziliensis

UniProt:

A4H4J0_LEIBR

TriTrypDb:

LbrM.06.0220 , LBRM2903_060007800

Length:

988

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	3
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4H4J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4J0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	477	481	PF00656	0.500
CLV_C14_Caspase3-7	527	531	PF00656	0.627
CLV_C14_Caspase3-7	700	704	PF00656	0.503
CLV_C14_Caspase3-7	838	842	PF00656	0.541
CLV_NRD_NRD_1	416	418	PF00675	0.416
CLV_NRD_NRD_1	48	50	PF00675	0.449
CLV_NRD_NRD_1	738	740	PF00675	0.615
CLV_NRD_NRD_1	742	744	PF00675	0.530
CLV_NRD_NRD_1	897	899	PF00675	0.665
CLV_PCSK_KEX2_1	152	154	PF00082	0.497
CLV_PCSK_KEX2_1	271	273	PF00082	0.443
CLV_PCSK_KEX2_1	416	418	PF00082	0.416
CLV_PCSK_KEX2_1	48	50	PF00082	0.490
CLV_PCSK_KEX2_1	62	64	PF00082	0.567
CLV_PCSK_KEX2_1	738	740	PF00082	0.613
CLV_PCSK_KEX2_1	742	744	PF00082	0.528
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.497
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.374
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.585
CLV_PCSK_PC7_1	738	744	PF00082	0.506
CLV_PCSK_SKI1_1	11	15	PF00082	0.459
CLV_PCSK_SKI1_1	344	348	PF00082	0.666
CLV_PCSK_SKI1_1	44	48	PF00082	0.582
CLV_PCSK_SKI1_1	71	75	PF00082	0.525
CLV_PCSK_SKI1_1	840	844	PF00082	0.604
CLV_PCSK_SKI1_1	898	902	PF00082	0.507
DEG_APCC_DBOX_1	754	762	PF00400	0.412
DEG_SCF_TRCP1_1	103	109	PF00400	0.515
DEG_SPOP_SBC_1	810	814	PF00917	0.513
DEG_SPOP_SBC_1	82	86	PF00917	0.511
DOC_CKS1_1	302	307	PF01111	0.506
DOC_CKS1_1	723	728	PF01111	0.768
DOC_CYCLIN_RxL_1	295	306	PF00134	0.501
DOC_CYCLIN_RxL_1	467	477	PF00134	0.513
DOC_CYCLIN_RxL_1	8	17	PF00134	0.460
DOC_CYCLIN_yCln2_LP_2	504	510	PF00134	0.519
DOC_CYCLIN_yCln2_LP_2	668	674	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	939	945	PF00134	0.590
DOC_MAPK_gen_1	271	277	PF00069	0.502
DOC_MAPK_gen_1	467	476	PF00069	0.471
DOC_MAPK_MEF2A_6	184	193	PF00069	0.406
DOC_MAPK_MEF2A_6	467	476	PF00069	0.506
DOC_MAPK_MEF2A_6	683	690	PF00069	0.502
DOC_PP1_RVXF_1	296	303	PF00149	0.422
DOC_PP1_RVXF_1	780	786	PF00149	0.445
DOC_PP2B_LxvP_1	653	656	PF13499	0.537
DOC_PP2B_PxIxI_1	778	784	PF00149	0.368
DOC_PP4_FxxP_1	302	305	PF00568	0.469
DOC_PP4_FxxP_1	346	349	PF00568	0.475
DOC_PP4_FxxP_1	489	492	PF00568	0.566
DOC_PP4_FxxP_1	591	594	PF00568	0.442
DOC_PP4_FxxP_1	858	861	PF00568	0.662
DOC_PP4_FxxP_1	924	927	PF00568	0.621
DOC_USP7_MATH_1	114	118	PF00917	0.664
DOC_USP7_MATH_1	307	311	PF00917	0.473
DOC_USP7_MATH_1	559	563	PF00917	0.530
DOC_USP7_MATH_1	598	602	PF00917	0.388
DOC_USP7_MATH_1	718	722	PF00917	0.571
DOC_USP7_MATH_1	724	728	PF00917	0.585
DOC_USP7_MATH_1	73	77	PF00917	0.774
DOC_USP7_MATH_1	811	815	PF00917	0.722
DOC_USP7_MATH_1	82	86	PF00917	0.489
DOC_USP7_MATH_1	878	882	PF00917	0.667
DOC_USP7_MATH_1	905	909	PF00917	0.703
DOC_USP7_MATH_1	911	915	PF00917	0.653
DOC_USP7_MATH_1	93	97	PF00917	0.463
DOC_USP7_MATH_1	960	964	PF00917	0.642
DOC_USP7_UBL2_3	67	71	PF12436	0.643
DOC_WW_Pin1_4	127	132	PF00397	0.645
DOC_WW_Pin1_4	170	175	PF00397	0.378
DOC_WW_Pin1_4	301	306	PF00397	0.442
DOC_WW_Pin1_4	345	350	PF00397	0.571
DOC_WW_Pin1_4	357	362	PF00397	0.505
DOC_WW_Pin1_4	722	727	PF00397	0.748
DOC_WW_Pin1_4	876	881	PF00397	0.779
DOC_WW_Pin1_4	979	984	PF00397	0.391
LIG_14-3-3_CanoR_1	140	146	PF00244	0.544
LIG_14-3-3_CanoR_1	272	278	PF00244	0.375
LIG_14-3-3_CanoR_1	284	289	PF00244	0.485
LIG_14-3-3_CanoR_1	298	303	PF00244	0.435
LIG_14-3-3_CanoR_1	344	349	PF00244	0.478
LIG_14-3-3_CanoR_1	387	392	PF00244	0.572
LIG_14-3-3_CanoR_1	610	619	PF00244	0.416
LIG_14-3-3_CanoR_1	742	748	PF00244	0.421
LIG_14-3-3_CanoR_1	755	765	PF00244	0.475
LIG_Actin_WH2_2	884	900	PF00022	0.509
LIG_APCC_ABBA_1	538	543	PF00400	0.476
LIG_BIR_III_2	17	21	PF00653	0.580
LIG_BRCT_BRCA1_1	172	176	PF00533	0.449
LIG_BRCT_BRCA1_1	260	264	PF00533	0.257
LIG_BRCT_BRCA1_1	600	604	PF00533	0.354
LIG_BRCT_BRCA1_1	612	616	PF00533	0.422
LIG_BRCT_BRCA1_1	920	924	PF00533	0.642
LIG_Clathr_ClatBox_1	13	17	PF01394	0.460
LIG_EH_1	851	855	PF12763	0.498
LIG_EVH1_1	858	862	PF00568	0.631
LIG_FHA_1	236	242	PF00498	0.459
LIG_FHA_1	500	506	PF00498	0.471
LIG_FHA_1	595	601	PF00498	0.423
LIG_FHA_1	612	618	PF00498	0.443
LIG_FHA_1	676	682	PF00498	0.541
LIG_FHA_1	685	691	PF00498	0.434
LIG_FHA_1	8	14	PF00498	0.524
LIG_FHA_1	811	817	PF00498	0.494
LIG_FHA_1	883	889	PF00498	0.569
LIG_FHA_2	193	199	PF00498	0.512
LIG_FHA_2	204	210	PF00498	0.397
LIG_FHA_2	290	296	PF00498	0.277
LIG_FHA_2	420	426	PF00498	0.404
LIG_FHA_2	642	648	PF00498	0.390
LIG_FHA_2	660	666	PF00498	0.524
LIG_FHA_2	815	821	PF00498	0.629
LIG_FHA_2	913	919	PF00498	0.664
LIG_Integrin_RGD_1	928	930	PF01839	0.668
LIG_IRF3_LxIS_1	309	315	PF10401	0.411
LIG_LIR_Apic_2	276	282	PF02991	0.448
LIG_LIR_Apic_2	301	305	PF02991	0.440
LIG_LIR_Apic_2	343	349	PF02991	0.751
LIG_LIR_Apic_2	401	406	PF02991	0.592
LIG_LIR_Apic_2	589	594	PF02991	0.434
LIG_LIR_Apic_2	921	927	PF02991	0.680
LIG_LIR_Gen_1	250	256	PF02991	0.380
LIG_LIR_Gen_1	261	270	PF02991	0.334
LIG_LIR_Gen_1	291	302	PF02991	0.381
LIG_LIR_Gen_1	308	319	PF02991	0.355
LIG_LIR_Gen_1	38	46	PF02991	0.448
LIG_LIR_Gen_1	536	546	PF02991	0.461
LIG_LIR_Gen_1	550	560	PF02991	0.467
LIG_LIR_Gen_1	601	609	PF02991	0.454
LIG_LIR_Gen_1	613	624	PF02991	0.376
LIG_LIR_Gen_1	833	844	PF02991	0.462
LIG_LIR_Nem_3	173	179	PF02991	0.384
LIG_LIR_Nem_3	192	196	PF02991	0.332
LIG_LIR_Nem_3	250	254	PF02991	0.427
LIG_LIR_Nem_3	261	267	PF02991	0.388
LIG_LIR_Nem_3	291	297	PF02991	0.352
LIG_LIR_Nem_3	308	314	PF02991	0.421
LIG_LIR_Nem_3	38	42	PF02991	0.442
LIG_LIR_Nem_3	536	541	PF02991	0.449
LIG_LIR_Nem_3	550	555	PF02991	0.414
LIG_LIR_Nem_3	589	595	PF02991	0.355
LIG_LIR_Nem_3	601	605	PF02991	0.449
LIG_LIR_Nem_3	613	619	PF02991	0.385
LIG_LIR_Nem_3	745	750	PF02991	0.503
LIG_LIR_Nem_3	817	822	PF02991	0.480
LIG_LIR_Nem_3	833	839	PF02991	0.432
LIG_MYND_1	135	139	PF01753	0.646
LIG_PAM2_1	849	861	PF00658	0.640
LIG_PCNA_yPIPBox_3	152	162	PF02747	0.518
LIG_Pex14_1	403	407	PF04695	0.576
LIG_Pex14_1	588	592	PF04695	0.460
LIG_Pex14_2	172	176	PF04695	0.449
LIG_Pex14_2	785	789	PF04695	0.533
LIG_Pex14_2	854	858	PF04695	0.546
LIG_REV1ctd_RIR_1	174	184	PF16727	0.385
LIG_SH2_CRK	270	274	PF00017	0.412
LIG_SH2_CRK	294	298	PF00017	0.545
LIG_SH2_CRK	323	327	PF00017	0.497
LIG_SH2_CRK	39	43	PF00017	0.403
LIG_SH2_GRB2like	39	42	PF00017	0.442
LIG_SH2_NCK_1	219	223	PF00017	0.285
LIG_SH2_PTP2	279	282	PF00017	0.426
LIG_SH2_PTP2	592	595	PF00017	0.456
LIG_SH2_SRC	294	297	PF00017	0.431
LIG_SH2_SRC	592	595	PF00017	0.456
LIG_SH2_STAP1	162	166	PF00017	0.601
LIG_SH2_STAP1	407	411	PF00017	0.509
LIG_SH2_STAT3	162	165	PF00017	0.452
LIG_SH2_STAT3	211	214	PF00017	0.525
LIG_SH2_STAT3	460	463	PF00017	0.491
LIG_SH2_STAT3	757	760	PF00017	0.440
LIG_SH2_STAT5	142	145	PF00017	0.485
LIG_SH2_STAT5	251	254	PF00017	0.362
LIG_SH2_STAT5	279	282	PF00017	0.370
LIG_SH2_STAT5	311	314	PF00017	0.404
LIG_SH2_STAT5	382	385	PF00017	0.526
LIG_SH2_STAT5	391	394	PF00017	0.560
LIG_SH2_STAT5	460	463	PF00017	0.504
LIG_SH2_STAT5	552	555	PF00017	0.510
LIG_SH2_STAT5	592	595	PF00017	0.394
LIG_SH2_STAT5	641	644	PF00017	0.414
LIG_SH2_STAT5	757	760	PF00017	0.415
LIG_SH2_STAT5	857	860	PF00017	0.633
LIG_SH2_STAT5	867	870	PF00017	0.629
LIG_SH2_STAT5	965	968	PF00017	0.572
LIG_SH3_1	132	138	PF00018	0.545
LIG_SH3_1	728	734	PF00018	0.688
LIG_SH3_1	857	863	PF00018	0.630
LIG_SH3_2	135	140	PF14604	0.672
LIG_SH3_2	723	728	PF14604	0.709
LIG_SH3_3	108	114	PF00018	0.764
LIG_SH3_3	132	138	PF00018	0.663
LIG_SH3_3	168	174	PF00018	0.424
LIG_SH3_3	193	199	PF00018	0.477
LIG_SH3_3	495	501	PF00018	0.419
LIG_SH3_3	660	666	PF00018	0.459
LIG_SH3_3	720	726	PF00018	0.698
LIG_SH3_3	728	734	PF00018	0.723
LIG_SH3_3	856	862	PF00018	0.616
LIG_SUMO_SIM_anti_2	526	536	PF11976	0.551
LIG_SUMO_SIM_anti_2	636	641	PF11976	0.512
LIG_SUMO_SIM_par_1	186	192	PF11976	0.607
LIG_SUMO_SIM_par_1	3	10	PF11976	0.470
LIG_SUMO_SIM_par_1	501	506	PF11976	0.517
LIG_SxIP_EBH_1	977	986	PF03271	0.395
LIG_TRAF2_1	206	209	PF00917	0.445
LIG_TRAF2_1	52	55	PF00917	0.670
LIG_TRAF2_1	662	665	PF00917	0.519
LIG_TYR_ITIM	268	273	PF00017	0.277
LIG_TYR_ITSM	290	297	PF00017	0.273
LIG_WRC_WIRS_1	190	195	PF05994	0.458
LIG_WRC_WIRS_1	299	304	PF05994	0.328
LIG_WRC_WIRS_1	616	621	PF05994	0.369
LIG_WRPW_2	457	460	PF00400	0.341
LIG_WW_3	137	141	PF00397	0.621
MOD_CDK_SPK_2	127	132	PF00069	0.511
MOD_CDK_SPxK_1	722	728	PF00069	0.701
MOD_CDK_SPxxK_3	127	134	PF00069	0.547
MOD_CDK_SPxxK_3	979	986	PF00069	0.413
MOD_CK1_1	104	110	PF00069	0.488
MOD_CK1_1	116	122	PF00069	0.531
MOD_CK1_1	220	226	PF00069	0.338
MOD_CK1_1	24	30	PF00069	0.562
MOD_CK1_1	301	307	PF00069	0.443
MOD_CK1_1	360	366	PF00069	0.779
MOD_CK1_1	499	505	PF00069	0.588
MOD_CK1_1	696	702	PF00069	0.646
MOD_CK1_1	814	820	PF00069	0.682
MOD_CK1_1	830	836	PF00069	0.466
MOD_CK1_1	85	91	PF00069	0.632
MOD_CK1_1	879	885	PF00069	0.821
MOD_CK1_1	932	938	PF00069	0.644
MOD_CK1_1	963	969	PF00069	0.557
MOD_CK2_1	192	198	PF00069	0.504
MOD_CK2_1	203	209	PF00069	0.390
MOD_CK2_1	419	425	PF00069	0.379
MOD_CK2_1	659	665	PF00069	0.545
MOD_CK2_1	932	938	PF00069	0.623
MOD_CK2_1	958	964	PF00069	0.533
MOD_Cter_Amidation	414	417	PF01082	0.579
MOD_GlcNHglycan	103	106	PF01048	0.489
MOD_GlcNHglycan	116	119	PF01048	0.541
MOD_GlcNHglycan	394	397	PF01048	0.590
MOD_GlcNHglycan	399	403	PF01048	0.504
MOD_GlcNHglycan	518	521	PF01048	0.660
MOD_GlcNHglycan	549	552	PF01048	0.620
MOD_GlcNHglycan	561	564	PF01048	0.544
MOD_GlcNHglycan	588	591	PF01048	0.338
MOD_GlcNHglycan	606	609	PF01048	0.429
MOD_GlcNHglycan	699	702	PF01048	0.645
MOD_GlcNHglycan	705	708	PF01048	0.691
MOD_GlcNHglycan	75	78	PF01048	0.665
MOD_GlcNHglycan	805	808	PF01048	0.760
MOD_GlcNHglycan	85	88	PF01048	0.517
MOD_GlcNHglycan	881	884	PF01048	0.734
MOD_GlcNHglycan	90	93	PF01048	0.476
MOD_GlcNHglycan	907	910	PF01048	0.679
MOD_GlcNHglycan	960	963	PF01048	0.539
MOD_GSK3_1	141	148	PF00069	0.467
MOD_GSK3_1	236	243	PF00069	0.405
MOD_GSK3_1	258	265	PF00069	0.288
MOD_GSK3_1	284	291	PF00069	0.473
MOD_GSK3_1	301	308	PF00069	0.437
MOD_GSK3_1	345	352	PF00069	0.602
MOD_GSK3_1	420	427	PF00069	0.531
MOD_GSK3_1	428	435	PF00069	0.677
MOD_GSK3_1	547	554	PF00069	0.470
MOD_GSK3_1	576	583	PF00069	0.510
MOD_GSK3_1	594	601	PF00069	0.464
MOD_GSK3_1	611	618	PF00069	0.428
MOD_GSK3_1	619	626	PF00069	0.525
MOD_GSK3_1	651	658	PF00069	0.503
MOD_GSK3_1	67	74	PF00069	0.636
MOD_GSK3_1	692	699	PF00069	0.585
MOD_GSK3_1	718	725	PF00069	0.506
MOD_GSK3_1	766	773	PF00069	0.470
MOD_GSK3_1	799	806	PF00069	0.731
MOD_GSK3_1	81	88	PF00069	0.487
MOD_GSK3_1	810	817	PF00069	0.650
MOD_GSK3_1	826	833	PF00069	0.622
MOD_GSK3_1	878	885	PF00069	0.694
MOD_GSK3_1	886	893	PF00069	0.644
MOD_GSK3_1	963	970	PF00069	0.526
MOD_N-GLC_1	516	521	PF02516	0.666
MOD_N-GLC_2	481	483	PF02516	0.413
MOD_NEK2_1	234	239	PF00069	0.369
MOD_NEK2_1	273	278	PF00069	0.345
MOD_NEK2_1	604	609	PF00069	0.366
MOD_NEK2_1	619	624	PF00069	0.457
MOD_NEK2_1	651	656	PF00069	0.517
MOD_NEK2_1	693	698	PF00069	0.560
MOD_NEK2_1	958	963	PF00069	0.466
MOD_NEK2_1	967	972	PF00069	0.464
MOD_NEK2_2	262	267	PF00069	0.375
MOD_NEK2_2	598	603	PF00069	0.422
MOD_PIKK_1	718	724	PF00454	0.507
MOD_PIKK_1	756	762	PF00454	0.521
MOD_PIKK_1	796	802	PF00454	0.517
MOD_PIKK_1	929	935	PF00454	0.700
MOD_PK_1	284	290	PF00069	0.477
MOD_PKA_1	742	748	PF00069	0.525
MOD_PKA_1	898	904	PF00069	0.535
MOD_PKA_2	145	151	PF00069	0.498
MOD_PKA_2	386	392	PF00069	0.657
MOD_PKA_2	499	505	PF00069	0.501
MOD_PKA_2	742	748	PF00069	0.488
MOD_PKA_2	771	777	PF00069	0.550
MOD_Plk_1	220	226	PF00069	0.431
MOD_Plk_1	770	776	PF00069	0.540
MOD_Plk_1	963	969	PF00069	0.480
MOD_Plk_4	1	7	PF00069	0.634
MOD_Plk_4	289	295	PF00069	0.380
MOD_Plk_4	307	313	PF00069	0.415
MOD_Plk_4	35	41	PF00069	0.461
MOD_Plk_4	387	393	PF00069	0.559
MOD_Plk_4	499	505	PF00069	0.484
MOD_Plk_4	551	557	PF00069	0.524
MOD_Plk_4	619	625	PF00069	0.449
MOD_Plk_4	635	641	PF00069	0.393
MOD_Plk_4	863	869	PF00069	0.645
MOD_Plk_4	887	893	PF00069	0.508
MOD_ProDKin_1	127	133	PF00069	0.645
MOD_ProDKin_1	170	176	PF00069	0.381
MOD_ProDKin_1	301	307	PF00069	0.451
MOD_ProDKin_1	345	351	PF00069	0.568
MOD_ProDKin_1	357	363	PF00069	0.505
MOD_ProDKin_1	722	728	PF00069	0.753
MOD_ProDKin_1	876	882	PF00069	0.781
MOD_ProDKin_1	979	985	PF00069	0.403
MOD_SUMO_for_1	179	182	PF00179	0.491
MOD_SUMO_rev_2	103	112	PF00179	0.517
TRG_DiLeu_BaEn_2	951	957	PF01217	0.412
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.452
TRG_ENDOCYTIC_2	142	145	PF00928	0.439
TRG_ENDOCYTIC_2	251	254	PF00928	0.362
TRG_ENDOCYTIC_2	270	273	PF00928	0.377
TRG_ENDOCYTIC_2	294	297	PF00928	0.547
TRG_ENDOCYTIC_2	311	314	PF00928	0.366
TRG_ENDOCYTIC_2	39	42	PF00928	0.442
TRG_ENDOCYTIC_2	552	555	PF00928	0.510
TRG_ENDOCYTIC_2	592	595	PF00928	0.394
TRG_ER_diArg_1	131	134	PF00400	0.496
TRG_ER_diArg_1	416	418	PF00400	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6D8	Leptomonas seymouri	54%	98%
A0A3S5H5N9	Leishmania donovani	81%	100%
A0A422MY92	Trypanosoma rangeli	30%	100%
A4HSR5	Leishmania infantum	81%	100%
C9ZTB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AKQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QJ55	Leishmania major	82%	100%
V5BEV7	Trypanosoma cruzi	29%	100%