Ammonium_transp domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4I9_LEIBR

TriTrypDb:

LbrM.06.0210 , LBRM2903_060007700

Length:

212

Annotations

LeishMANIAdb annotations

Although obviously looks like a transporter, only very weak homologies exist outside KInetoplastids

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4H4I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4I9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	93	97	PF00656	0.652
CLV_NRD_NRD_1	206	208	PF00675	0.339
CLV_NRD_NRD_1	28	30	PF00675	0.417
CLV_PCSK_SKI1_1	152	156	PF00082	0.401
CLV_PCSK_SKI1_1	208	212	PF00082	0.474
CLV_PCSK_SKI1_1	84	88	PF00082	0.361
DOC_MAPK_gen_1	29	36	PF00069	0.595
DOC_MAPK_HePTP_8	26	38	PF00069	0.621
DOC_MAPK_MEF2A_6	29	38	PF00069	0.543
DOC_MAPK_RevD_3	15	30	PF00069	0.507
DOC_PP4_FxxP_1	201	204	PF00568	0.595
LIG_14-3-3_CanoR_1	152	159	PF00244	0.620
LIG_BRCT_BRCA1_1	125	129	PF00533	0.417
LIG_FHA_1	154	160	PF00498	0.554
LIG_FHA_1	187	193	PF00498	0.380
LIG_FHA_2	77	83	PF00498	0.487
LIG_HP1_1	16	20	PF01393	0.342
LIG_LIR_Apic_2	199	204	PF02991	0.581
LIG_LIR_Gen_1	139	149	PF02991	0.387
LIG_LIR_Gen_1	72	80	PF02991	0.430
LIG_LIR_Nem_3	112	118	PF02991	0.418
LIG_LIR_Nem_3	139	144	PF02991	0.315
LIG_LIR_Nem_3	72	78	PF02991	0.428
LIG_Pex14_1	107	111	PF04695	0.407
LIG_Pex14_1	117	121	PF04695	0.409
LIG_SH2_CRK	111	115	PF00017	0.430
LIG_SH2_CRK	121	125	PF00017	0.360
LIG_SH2_STAP1	111	115	PF00017	0.469
LIG_SH2_STAT5	111	114	PF00017	0.462
LIG_SH2_STAT5	141	144	PF00017	0.469
LIG_SUMO_SIM_anti_2	32	38	PF11976	0.409
LIG_TYR_ITIM	109	114	PF00017	0.469
LIG_UBA3_1	13	22	PF00899	0.395
MOD_CK1_1	123	129	PF00069	0.474
MOD_CK1_1	153	159	PF00069	0.577
MOD_CK1_1	32	38	PF00069	0.417
MOD_CK2_1	133	139	PF00069	0.307
MOD_CMANNOS	117	120	PF00535	0.464
MOD_GlcNHglycan	135	138	PF01048	0.323
MOD_GlcNHglycan	196	199	PF01048	0.445
MOD_GSK3_1	153	160	PF00069	0.596
MOD_GSK3_1	76	83	PF00069	0.499
MOD_N-GLC_1	24	29	PF02516	0.351
MOD_N-GLC_1	5	10	PF02516	0.355
MOD_N-GLC_1	80	85	PF02516	0.335
MOD_NEK2_1	109	114	PF00069	0.430
MOD_NEK2_1	150	155	PF00069	0.470
MOD_NEK2_1	43	48	PF00069	0.359
MOD_NEK2_1	5	10	PF00069	0.358
MOD_NEK2_1	80	85	PF00069	0.510
MOD_NMyristoyl	1	7	PF02799	0.317
MOD_PKA_1	29	35	PF00069	0.533
MOD_Plk_1	24	30	PF00069	0.500
MOD_Plk_1	5	11	PF00069	0.334
MOD_Plk_4	102	108	PF00069	0.387
MOD_Plk_4	109	115	PF00069	0.387
MOD_Plk_4	140	146	PF00069	0.341
MOD_Plk_4	196	202	PF00069	0.416
MOD_Plk_4	32	38	PF00069	0.507
MOD_Plk_4	5	11	PF00069	0.356
MOD_Plk_4	69	75	PF00069	0.384
TRG_DiLeu_BaEn_1	130	135	PF01217	0.285
TRG_ENDOCYTIC_2	10	13	PF00928	0.307
TRG_ENDOCYTIC_2	111	114	PF00928	0.358
TRG_ENDOCYTIC_2	121	124	PF00928	0.327
TRG_ENDOCYTIC_2	141	144	PF00928	0.469
TRG_ER_diLys_1	208	212	PF00400	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZR4	Leptomonas seymouri	62%	100%
A0A1X0NL26	Trypanosomatidae	34%	85%
A0A3R7N0V5	Trypanosoma rangeli	33%	97%
A0A3S5H5N8	Leishmania donovani	78%	100%
A4HSR4	Leishmania infantum	78%	100%
C9ZTB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	93%