EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4I8_LEIBR

TriTrypDb:

LbrM.06.0200 , LBRM2903_060007600

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4I8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.341
CLV_NRD_NRD_1	109	111	PF00675	0.314
CLV_NRD_NRD_1	118	120	PF00675	0.361
CLV_NRD_NRD_1	24	26	PF00675	0.463
CLV_PCSK_KEX2_1	109	111	PF00082	0.323
CLV_PCSK_SKI1_1	17	21	PF00082	0.404
CLV_PCSK_SKI1_1	271	275	PF00082	0.611
CLV_PCSK_SKI1_1	56	60	PF00082	0.359
DEG_APCC_DBOX_1	55	63	PF00400	0.378
DEG_Nend_UBRbox_1	1	4	PF02207	0.625
DEG_SPOP_SBC_1	7	11	PF00917	0.532
DOC_CKS1_1	92	97	PF01111	0.252
DOC_CYCLIN_yCln2_LP_2	46	52	PF00134	0.467
DOC_MAPK_gen_1	109	118	PF00069	0.304
DOC_MAPK_MEF2A_6	109	118	PF00069	0.320
DOC_MAPK_MEF2A_6	180	188	PF00069	0.362
DOC_MAPK_RevD_3	96	111	PF00069	0.469
DOC_USP7_MATH_1	7	11	PF00917	0.663
DOC_WW_Pin1_4	166	171	PF00397	0.459
DOC_WW_Pin1_4	45	50	PF00397	0.513
DOC_WW_Pin1_4	91	96	PF00397	0.266
LIG_14-3-3_CanoR_1	45	49	PF00244	0.394
LIG_AP2alpha_1	160	164	PF02296	0.410
LIG_deltaCOP1_diTrp_1	197	204	PF00928	0.456
LIG_FHA_1	101	107	PF00498	0.317
LIG_FHA_1	124	130	PF00498	0.443
LIG_FHA_1	268	274	PF00498	0.587
LIG_FHA_1	92	98	PF00498	0.470
LIG_FHA_2	173	179	PF00498	0.324
LIG_FHA_2	192	198	PF00498	0.363
LIG_FHA_2	243	249	PF00498	0.534
LIG_FHA_2	252	258	PF00498	0.532
LIG_LIR_Apic_2	255	261	PF02991	0.608
LIG_LIR_Gen_1	128	138	PF02991	0.379
LIG_LIR_Gen_1	158	166	PF02991	0.328
LIG_LIR_Gen_1	68	79	PF02991	0.302
LIG_LIR_Nem_3	128	134	PF02991	0.373
LIG_LIR_Nem_3	135	141	PF02991	0.388
LIG_LIR_Nem_3	158	164	PF02991	0.330
LIG_Pex14_2	160	164	PF04695	0.337
LIG_SH2_CRK	131	135	PF00017	0.497
LIG_SH2_CRK	138	142	PF00017	0.514
LIG_SH2_CRK	258	262	PF00017	0.605
LIG_SH2_CRK	263	267	PF00017	0.587
LIG_SH2_STAP1	112	116	PF00017	0.283
LIG_SH2_STAT3	226	229	PF00017	0.425
LIG_SH2_STAT5	182	185	PF00017	0.299
LIG_SH2_STAT5	242	245	PF00017	0.638
LIG_SH3_2	105	110	PF14604	0.442
LIG_SH3_3	102	108	PF00018	0.446
LIG_SUMO_SIM_par_1	3	11	PF11976	0.400
LIG_TYR_ITIM	129	134	PF00017	0.484
MOD_CK1_1	100	106	PF00069	0.528
MOD_CK1_1	130	136	PF00069	0.473
MOD_CK1_1	218	224	PF00069	0.535
MOD_CK1_1	227	233	PF00069	0.470
MOD_CK1_1	48	54	PF00069	0.450
MOD_CK2_1	130	136	PF00069	0.293
MOD_CK2_1	166	172	PF00069	0.469
MOD_CK2_1	191	197	PF00069	0.460
MOD_CK2_1	242	248	PF00069	0.568
MOD_CK2_1	7	13	PF00069	0.526
MOD_GlcNHglycan	122	126	PF01048	0.294
MOD_GlcNHglycan	254	257	PF01048	0.643
MOD_GlcNHglycan	50	53	PF01048	0.408
MOD_GSK3_1	121	128	PF00069	0.412
MOD_GSK3_1	218	225	PF00069	0.502
MOD_GSK3_1	252	259	PF00069	0.606
MOD_GSK3_1	274	281	PF00069	0.576
MOD_GSK3_1	44	51	PF00069	0.401
MOD_GSK3_1	60	67	PF00069	0.431
MOD_GSK3_1	8	15	PF00069	0.620
MOD_NEK2_1	1	6	PF00069	0.622
MOD_NEK2_1	12	17	PF00069	0.580
MOD_NEK2_1	198	203	PF00069	0.388
MOD_NEK2_1	241	246	PF00069	0.558
MOD_NEK2_1	97	102	PF00069	0.322
MOD_PK_1	60	66	PF00069	0.449
MOD_PKA_2	227	233	PF00069	0.600
MOD_PKA_2	44	50	PF00069	0.323
MOD_Plk_1	256	262	PF00069	0.499
MOD_Plk_1	60	66	PF00069	0.400
MOD_Plk_2-3	172	178	PF00069	0.250
MOD_Plk_4	1	7	PF00069	0.400
MOD_Plk_4	15	21	PF00069	0.294
MOD_Plk_4	184	190	PF00069	0.220
MOD_ProDKin_1	166	172	PF00069	0.463
MOD_ProDKin_1	45	51	PF00069	0.509
MOD_ProDKin_1	91	97	PF00069	0.259
MOD_SUMO_for_1	209	212	PF00179	0.352
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.365
TRG_DiLeu_BaLyEn_6	228	233	PF01217	0.643
TRG_ENDOCYTIC_2	131	134	PF00928	0.412
TRG_ENDOCYTIC_2	138	141	PF00928	0.367
TRG_ENDOCYTIC_2	71	74	PF00928	0.427
TRG_ER_diArg_1	108	110	PF00400	0.299
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY2	Leptomonas seymouri	56%	97%
A0A0S4KGV5	Bodo saltans	29%	100%
A0A1X0NK20	Trypanosomatidae	32%	90%
A0A3R7M8M9	Trypanosoma rangeli	39%	100%
A0A3S7WPB5	Leishmania donovani	79%	100%
A4HSR3	Leishmania infantum	79%	100%
C9ZTB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AKQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q13938	Homo sapiens	29%	100%
Q4QJ57	Leishmania major	75%	100%
V5B5T8	Trypanosoma cruzi	38%	100%