Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4I6_LEIBR

TriTrypDb:

LbrM.06.0180 , LBRM2903_060007200

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4I6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4I6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.695
CLV_NRD_NRD_1	153	155	PF00675	0.679
CLV_NRD_NRD_1	156	158	PF00675	0.697
CLV_NRD_NRD_1	196	198	PF00675	0.518
CLV_NRD_NRD_1	211	213	PF00675	0.593
CLV_NRD_NRD_1	249	251	PF00675	0.600
CLV_NRD_NRD_1	66	68	PF00675	0.602
CLV_NRD_NRD_1	77	79	PF00675	0.746
CLV_PCSK_FUR_1	153	157	PF00082	0.546
CLV_PCSK_KEX2_1	133	135	PF00082	0.695
CLV_PCSK_KEX2_1	153	155	PF00082	0.679
CLV_PCSK_KEX2_1	156	158	PF00082	0.696
CLV_PCSK_KEX2_1	196	198	PF00082	0.516
CLV_PCSK_KEX2_1	211	213	PF00082	0.593
CLV_PCSK_KEX2_1	249	251	PF00082	0.600
CLV_PCSK_KEX2_1	289	291	PF00082	0.649
CLV_PCSK_KEX2_1	490	492	PF00082	0.491
CLV_PCSK_KEX2_1	66	68	PF00082	0.602
CLV_PCSK_KEX2_1	77	79	PF00082	0.746
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.549
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.644
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.491
CLV_PCSK_PC7_1	486	492	PF00082	0.433
CLV_PCSK_SKI1_1	196	200	PF00082	0.547
CLV_PCSK_SKI1_1	225	229	PF00082	0.704
CLV_PCSK_SKI1_1	457	461	PF00082	0.347
CLV_PCSK_SKI1_1	486	490	PF00082	0.408
CLV_PCSK_SKI1_1	67	71	PF00082	0.568
CLV_PCSK_SKI1_1	78	82	PF00082	0.591
DEG_APCC_DBOX_1	77	85	PF00400	0.612
DEG_COP1_1	364	372	PF00400	0.497
DEG_SPOP_SBC_1	463	467	PF00917	0.401
DOC_MAPK_DCC_7	250	260	PF00069	0.654
DOC_MAPK_gen_1	153	162	PF00069	0.540
DOC_MAPK_gen_1	66	74	PF00069	0.530
DOC_MAPK_MEF2A_6	153	162	PF00069	0.540
DOC_MAPK_MEF2A_6	4	11	PF00069	0.619
DOC_PP1_RVXF_1	414	421	PF00149	0.310
DOC_PP2B_LxvP_1	252	255	PF13499	0.683
DOC_PP4_FxxP_1	367	370	PF00568	0.507
DOC_USP7_MATH_1	105	109	PF00917	0.577
DOC_USP7_MATH_1	112	116	PF00917	0.591
DOC_USP7_MATH_1	117	121	PF00917	0.575
DOC_USP7_MATH_1	19	23	PF00917	0.665
DOC_USP7_MATH_1	297	301	PF00917	0.558
DOC_USP7_MATH_1	310	314	PF00917	0.579
DOC_USP7_MATH_1	340	344	PF00917	0.542
DOC_USP7_MATH_1	368	372	PF00917	0.564
DOC_USP7_MATH_1	435	439	PF00917	0.476
DOC_USP7_MATH_1	480	484	PF00917	0.364
DOC_USP7_MATH_1	73	77	PF00917	0.735
DOC_WW_Pin1_4	10	15	PF00397	0.644
DOC_WW_Pin1_4	295	300	PF00397	0.600
DOC_WW_Pin1_4	35	40	PF00397	0.604
LIG_14-3-3_CanoR_1	133	137	PF00244	0.699
LIG_14-3-3_CanoR_1	23	28	PF00244	0.617
LIG_14-3-3_CanoR_1	265	274	PF00244	0.747
LIG_14-3-3_CanoR_1	312	316	PF00244	0.576
LIG_14-3-3_CanoR_1	419	425	PF00244	0.456
LIG_14-3-3_CanoR_1	457	462	PF00244	0.460
LIG_14-3-3_CanoR_1	464	472	PF00244	0.376
LIG_14-3-3_CanoR_1	77	81	PF00244	0.670
LIG_Actin_WH2_2	404	421	PF00022	0.422
LIG_Actin_WH2_2	472	488	PF00022	0.318
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_BIR_III_4	354	358	PF00653	0.468
LIG_BRCT_BRCA1_1	363	367	PF00533	0.488
LIG_Clathr_ClatBox_1	408	412	PF01394	0.341
LIG_FHA_1	197	203	PF00498	0.631
LIG_FHA_1	226	232	PF00498	0.651
LIG_FHA_1	233	239	PF00498	0.575
LIG_FHA_1	255	261	PF00498	0.677
LIG_FHA_1	358	364	PF00498	0.635
LIG_FHA_1	39	45	PF00498	0.629
LIG_FHA_1	429	435	PF00498	0.520
LIG_FHA_1	442	448	PF00498	0.368
LIG_FHA_1	458	464	PF00498	0.402
LIG_FHA_2	476	482	PF00498	0.401
LIG_FHA_2	53	59	PF00498	0.531
LIG_Integrin_RGD_1	56	58	PF01839	0.539
LIG_LIR_Apic_2	364	370	PF02991	0.496
LIG_LIR_Gen_1	456	463	PF02991	0.429
LIG_LIR_Nem_3	456	462	PF02991	0.438
LIG_NRP_CendR_1	490	492	PF00754	0.480
LIG_SH2_NCK_1	102	106	PF00017	0.546
LIG_SH2_STAT3	316	319	PF00017	0.694
LIG_SH2_STAT5	170	173	PF00017	0.513
LIG_SH2_STAT5	389	392	PF00017	0.392
LIG_SH3_2	244	249	PF14604	0.507
LIG_SH3_3	241	247	PF00018	0.611
LIG_SH3_3	253	259	PF00018	0.734
LIG_SH3_3	326	332	PF00018	0.713
LIG_SH3_3	8	14	PF00018	0.646
LIG_SUMO_SIM_par_1	406	412	PF11976	0.360
LIG_SUMO_SIM_par_1	438	445	PF11976	0.486
LIG_SUMO_SIM_par_1	459	467	PF11976	0.350
LIG_WRC_WIRS_1	398	403	PF05994	0.419
MOD_CK1_1	115	121	PF00069	0.584
MOD_CK1_1	13	19	PF00069	0.619
MOD_CK1_1	217	223	PF00069	0.519
MOD_CK1_1	26	32	PF00069	0.637
MOD_CK1_1	269	275	PF00069	0.786
MOD_CK1_1	280	286	PF00069	0.745
MOD_CK1_1	404	410	PF00069	0.317
MOD_CK1_1	76	82	PF00069	0.758
MOD_CK2_1	146	152	PF00069	0.706
MOD_CK2_1	475	481	PF00069	0.403
MOD_Cter_Amidation	64	67	PF01082	0.627
MOD_GlcNHglycan	107	110	PF01048	0.590
MOD_GlcNHglycan	119	122	PF01048	0.567
MOD_GlcNHglycan	148	151	PF01048	0.770
MOD_GlcNHglycan	173	177	PF01048	0.711
MOD_GlcNHglycan	228	231	PF01048	0.722
MOD_GlcNHglycan	273	277	PF01048	0.713
MOD_GlcNHglycan	308	311	PF01048	0.649
MOD_GlcNHglycan	323	326	PF01048	0.603
MOD_GlcNHglycan	33	36	PF01048	0.771
MOD_GlcNHglycan	342	345	PF01048	0.665
MOD_GlcNHglycan	370	373	PF01048	0.617
MOD_GlcNHglycan	382	385	PF01048	0.565
MOD_GlcNHglycan	46	49	PF01048	0.704
MOD_GlcNHglycan	63	66	PF01048	0.587
MOD_GlcNHglycan	98	101	PF01048	0.689
MOD_GSK3_1	113	120	PF00069	0.620
MOD_GSK3_1	15	22	PF00069	0.612
MOD_GSK3_1	158	165	PF00069	0.642
MOD_GSK3_1	214	221	PF00069	0.553
MOD_GSK3_1	23	30	PF00069	0.665
MOD_GSK3_1	254	261	PF00069	0.702
MOD_GSK3_1	272	279	PF00069	0.772
MOD_GSK3_1	280	287	PF00069	0.606
MOD_GSK3_1	297	304	PF00069	0.587
MOD_GSK3_1	306	313	PF00069	0.595
MOD_GSK3_1	31	38	PF00069	0.564
MOD_GSK3_1	357	364	PF00069	0.523
MOD_GSK3_1	393	400	PF00069	0.393
MOD_GSK3_1	40	47	PF00069	0.723
MOD_GSK3_1	403	410	PF00069	0.399
MOD_GSK3_1	463	470	PF00069	0.411
MOD_N-GLC_1	146	151	PF02516	0.708
MOD_N-GLC_1	217	222	PF02516	0.578
MOD_N-GLC_1	233	238	PF02516	0.665
MOD_N-GLC_1	276	281	PF02516	0.743
MOD_NEK2_1	21	26	PF00069	0.546
MOD_NEK2_1	214	219	PF00069	0.519
MOD_NEK2_1	281	286	PF00069	0.723
MOD_NEK2_1	315	320	PF00069	0.519
MOD_NEK2_1	321	326	PF00069	0.509
MOD_NEK2_1	397	402	PF00069	0.439
MOD_NEK2_1	418	423	PF00069	0.517
MOD_NEK2_1	44	49	PF00069	0.641
MOD_NEK2_2	311	316	PF00069	0.521
MOD_NEK2_2	428	433	PF00069	0.535
MOD_PIKK_1	297	303	PF00454	0.664
MOD_PIKK_1	315	321	PF00454	0.519
MOD_PIKK_1	323	329	PF00454	0.511
MOD_PIKK_1	418	424	PF00454	0.503
MOD_PIKK_1	467	473	PF00454	0.407
MOD_PK_1	23	29	PF00069	0.617
MOD_PKA_1	196	202	PF00069	0.628
MOD_PKA_2	103	109	PF00069	0.629
MOD_PKA_2	113	119	PF00069	0.702
MOD_PKA_2	132	138	PF00069	0.699
MOD_PKA_2	196	202	PF00069	0.628
MOD_PKA_2	311	317	PF00069	0.695
MOD_PKA_2	418	424	PF00069	0.436
MOD_PKA_2	463	469	PF00069	0.408
MOD_PKA_2	76	82	PF00069	0.690
MOD_PKB_1	223	231	PF00069	0.529
MOD_Plk_1	158	164	PF00069	0.548
MOD_Plk_1	172	178	PF00069	0.632
MOD_Plk_1	221	227	PF00069	0.525
MOD_Plk_1	233	239	PF00069	0.658
MOD_Plk_1	27	33	PF00069	0.532
MOD_Plk_1	276	282	PF00069	0.655
MOD_Plk_1	480	486	PF00069	0.305
MOD_Plk_4	233	239	PF00069	0.538
MOD_Plk_4	27	33	PF00069	0.593
MOD_Plk_4	311	317	PF00069	0.695
MOD_Plk_4	40	46	PF00069	0.679
MOD_Plk_4	404	410	PF00069	0.317
MOD_Plk_4	435	441	PF00069	0.486
MOD_ProDKin_1	10	16	PF00069	0.640
MOD_ProDKin_1	295	301	PF00069	0.603
MOD_ProDKin_1	35	41	PF00069	0.606
TRG_ER_diArg_1	153	156	PF00400	0.604
TRG_ER_diArg_1	195	197	PF00400	0.517
TRG_ER_diArg_1	210	212	PF00400	0.595
TRG_ER_diArg_1	223	226	PF00400	0.612
TRG_ER_diArg_1	290	293	PF00400	0.731
TRG_NLS_MonoCore_2	153	158	PF00514	0.545
TRG_NLS_MonoExtC_3	153	159	PF00514	0.544
TRG_NLS_MonoExtC_3	288	293	PF00514	0.556
TRG_NLS_MonoExtN_4	153	158	PF00514	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H1	Leptomonas seymouri	39%	86%
A0A3S5H5N7	Leishmania donovani	69%	99%
A4HSR1	Leishmania infantum	70%	99%
E9AKP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QJ59	Leishmania major	71%	99%