Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4I5_LEIBR

TriTrypDb:

LbrM.06.0170 , LBRM2903_060007100

Length:

689

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4I5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	403	407	PF00656	0.562
CLV_C14_Caspase3-7	532	536	PF00656	0.573
CLV_C14_Caspase3-7	57	61	PF00656	0.529
CLV_NRD_NRD_1	350	352	PF00675	0.566
CLV_PCSK_KEX2_1	350	352	PF00082	0.566
CLV_PCSK_SKI1_1	142	146	PF00082	0.579
CLV_PCSK_SKI1_1	462	466	PF00082	0.618
DEG_SPOP_SBC_1	100	104	PF00917	0.555
DEG_SPOP_SBC_1	675	679	PF00917	0.683
DOC_CKS1_1	452	457	PF01111	0.672
DOC_CYCLIN_RxL_1	637	648	PF00134	0.654
DOC_CYCLIN_yCln2_LP_2	558	564	PF00134	0.549
DOC_MAPK_gen_1	363	372	PF00069	0.446
DOC_MAPK_gen_1	440	448	PF00069	0.584
DOC_MAPK_MEF2A_6	643	651	PF00069	0.455
DOC_PP1_RVXF_1	308	315	PF00149	0.496
DOC_PP2B_LxvP_1	558	561	PF13499	0.752
DOC_PP2B_LxvP_1	647	650	PF13499	0.472
DOC_PP4_FxxP_1	607	610	PF00568	0.610
DOC_USP7_MATH_1	222	226	PF00917	0.577
DOC_USP7_MATH_1	329	333	PF00917	0.775
DOC_USP7_MATH_1	362	366	PF00917	0.679
DOC_USP7_MATH_1	547	551	PF00917	0.748
DOC_USP7_MATH_1	59	63	PF00917	0.567
DOC_USP7_MATH_1	675	679	PF00917	0.629
DOC_USP7_MATH_1	82	86	PF00917	0.617
DOC_USP7_MATH_1	89	93	PF00917	0.599
DOC_USP7_MATH_1	99	103	PF00917	0.466
DOC_USP7_UBL2_3	264	268	PF12436	0.593
DOC_USP7_UBL2_3	530	534	PF12436	0.653
DOC_WW_Pin1_4	101	106	PF00397	0.546
DOC_WW_Pin1_4	290	295	PF00397	0.762
DOC_WW_Pin1_4	336	341	PF00397	0.623
DOC_WW_Pin1_4	451	456	PF00397	0.645
DOC_WW_Pin1_4	479	484	PF00397	0.588
DOC_WW_Pin1_4	502	507	PF00397	0.704
DOC_WW_Pin1_4	679	684	PF00397	0.755
LIG_14-3-3_CanoR_1	205	211	PF00244	0.541
LIG_14-3-3_CanoR_1	271	277	PF00244	0.690
LIG_14-3-3_CanoR_1	350	359	PF00244	0.623
LIG_14-3-3_CanoR_1	673	683	PF00244	0.771
LIG_14-3-3_CanoR_1	90	96	PF00244	0.573
LIG_APCC_ABBA_1	603	608	PF00400	0.615
LIG_Clathr_ClatBox_1	226	230	PF01394	0.458
LIG_deltaCOP1_diTrp_1	317	322	PF00928	0.628
LIG_EVH1_2	238	242	PF00568	0.773
LIG_FHA_1	153	159	PF00498	0.466
LIG_FHA_1	195	201	PF00498	0.426
LIG_FHA_1	272	278	PF00498	0.558
LIG_FHA_1	351	357	PF00498	0.553
LIG_FHA_1	646	652	PF00498	0.476
LIG_FHA_1	92	98	PF00498	0.579
LIG_FHA_2	143	149	PF00498	0.596
LIG_FHA_2	297	303	PF00498	0.656
LIG_FHA_2	32	38	PF00498	0.511
LIG_FHA_2	55	61	PF00498	0.504
LIG_FHA_2	561	567	PF00498	0.677
LIG_LIR_Gen_1	165	175	PF02991	0.573
LIG_LIR_Gen_1	406	413	PF02991	0.603
LIG_LIR_Gen_1	52	59	PF02991	0.468
LIG_LIR_Nem_3	165	171	PF02991	0.536
LIG_LIR_Nem_3	182	186	PF02991	0.449
LIG_LIR_Nem_3	190	195	PF02991	0.400
LIG_LIR_Nem_3	319	325	PF02991	0.553
LIG_LIR_Nem_3	406	411	PF02991	0.601
LIG_LIR_Nem_3	52	56	PF02991	0.436
LIG_PCNA_TLS_4	402	409	PF02747	0.605
LIG_PCNA_yPIPBox_3	609	620	PF02747	0.676
LIG_PCNA_yPIPBox_3	630	639	PF02747	0.506
LIG_Pex14_1	203	207	PF04695	0.477
LIG_REV1ctd_RIR_1	604	609	PF16727	0.615
LIG_SH2_CRK	207	211	PF00017	0.592
LIG_SH2_NCK_1	620	624	PF00017	0.657
LIG_SH2_STAP1	106	110	PF00017	0.556
LIG_SH2_STAP1	297	301	PF00017	0.672
LIG_SH2_STAT5	153	156	PF00017	0.631
LIG_SH2_STAT5	186	189	PF00017	0.576
LIG_SH3_1	323	329	PF00018	0.601
LIG_SH3_2	457	462	PF14604	0.657
LIG_SH3_3	122	128	PF00018	0.558
LIG_SH3_3	23	29	PF00018	0.573
LIG_SH3_3	323	329	PF00018	0.601
LIG_SH3_3	449	455	PF00018	0.681
LIG_SH3_3	550	556	PF00018	0.775
LIG_SUMO_SIM_par_1	637	642	PF11976	0.641
LIG_SxIP_EBH_1	502	516	PF03271	0.585
LIG_TRAF2_1	401	404	PF00917	0.381
MOD_CDK_SPK_2	481	486	PF00069	0.576
MOD_CDK_SPxK_1	679	685	PF00069	0.754
MOD_CDK_SPxxK_3	479	486	PF00069	0.577
MOD_CDK_SPxxK_3	679	686	PF00069	0.754
MOD_CK1_1	104	110	PF00069	0.595
MOD_CK1_1	111	117	PF00069	0.565
MOD_CK1_1	147	153	PF00069	0.590
MOD_CK1_1	35	41	PF00069	0.536
MOD_CK1_1	519	525	PF00069	0.596
MOD_CK1_1	526	532	PF00069	0.692
MOD_CK1_1	54	60	PF00069	0.521
MOD_CK1_1	62	68	PF00069	0.506
MOD_CK1_1	676	682	PF00069	0.747
MOD_CK1_1	74	80	PF00069	0.462
MOD_CK1_1	8	14	PF00069	0.667
MOD_CK2_1	142	148	PF00069	0.613
MOD_CK2_1	279	285	PF00069	0.558
MOD_CK2_1	296	302	PF00069	0.580
MOD_CK2_1	31	37	PF00069	0.490
MOD_CK2_1	362	368	PF00069	0.693
MOD_CK2_1	426	432	PF00069	0.473
MOD_CK2_1	560	566	PF00069	0.605
MOD_CK2_1	82	88	PF00069	0.591
MOD_GlcNHglycan	110	113	PF01048	0.497
MOD_GlcNHglycan	250	253	PF01048	0.727
MOD_GlcNHglycan	261	264	PF01048	0.661
MOD_GlcNHglycan	331	334	PF01048	0.783
MOD_GlcNHglycan	346	349	PF01048	0.467
MOD_GlcNHglycan	37	40	PF01048	0.572
MOD_GlcNHglycan	440	443	PF01048	0.775
MOD_GlcNHglycan	467	470	PF01048	0.749
MOD_GlcNHglycan	479	482	PF01048	0.615
MOD_GlcNHglycan	498	501	PF01048	0.540
MOD_GlcNHglycan	506	509	PF01048	0.722
MOD_GlcNHglycan	518	521	PF01048	0.646
MOD_GlcNHglycan	549	552	PF01048	0.668
MOD_GlcNHglycan	670	673	PF01048	0.810
MOD_GlcNHglycan	8	11	PF01048	0.592
MOD_GlcNHglycan	84	87	PF01048	0.593
MOD_GlcNHglycan	97	100	PF01048	0.585
MOD_GSK3_1	100	107	PF00069	0.526
MOD_GSK3_1	31	38	PF00069	0.520
MOD_GSK3_1	350	357	PF00069	0.635
MOD_GSK3_1	434	441	PF00069	0.782
MOD_GSK3_1	473	480	PF00069	0.712
MOD_GSK3_1	492	499	PF00069	0.540
MOD_GSK3_1	519	526	PF00069	0.638
MOD_GSK3_1	543	550	PF00069	0.668
MOD_GSK3_1	59	66	PF00069	0.566
MOD_GSK3_1	674	681	PF00069	0.698
MOD_GSK3_1	68	75	PF00069	0.582
MOD_GSK3_1	89	96	PF00069	0.682
MOD_LATS_1	514	520	PF00433	0.814
MOD_LATS_1	528	534	PF00433	0.582
MOD_N-GLC_1	29	34	PF02516	0.542
MOD_N-GLC_1	477	482	PF02516	0.811
MOD_N-GLC_1	530	535	PF02516	0.573
MOD_N-GLC_1	6	11	PF02516	0.773
MOD_N-GLC_1	77	82	PF02516	0.567
MOD_NEK2_1	110	115	PF00069	0.537
MOD_NEK2_1	152	157	PF00069	0.444
MOD_NEK2_1	257	262	PF00069	0.567
MOD_NEK2_1	272	277	PF00069	0.581
MOD_NEK2_1	296	301	PF00069	0.497
MOD_NEK2_1	31	36	PF00069	0.495
MOD_NEK2_1	418	423	PF00069	0.670
MOD_NEK2_1	438	443	PF00069	0.457
MOD_NEK2_1	645	650	PF00069	0.689
MOD_NEK2_1	72	77	PF00069	0.553
MOD_NEK2_1	95	100	PF00069	0.629
MOD_NEK2_2	194	199	PF00069	0.475
MOD_PKA_1	350	356	PF00069	0.557
MOD_PKA_2	270	276	PF00069	0.724
MOD_PKA_2	349	355	PF00069	0.623
MOD_PKA_2	465	471	PF00069	0.724
MOD_PKA_2	89	95	PF00069	0.574
MOD_PKB_1	521	529	PF00069	0.738
MOD_Plk_1	32	38	PF00069	0.497
MOD_Plk_1	462	468	PF00069	0.623
MOD_Plk_1	51	57	PF00069	0.473
MOD_Plk_4	19	25	PF00069	0.643
MOD_Plk_4	222	228	PF00069	0.457
MOD_Plk_4	272	278	PF00069	0.558
MOD_ProDKin_1	101	107	PF00069	0.547
MOD_ProDKin_1	290	296	PF00069	0.759
MOD_ProDKin_1	336	342	PF00069	0.623
MOD_ProDKin_1	451	457	PF00069	0.644
MOD_ProDKin_1	479	485	PF00069	0.587
MOD_ProDKin_1	502	508	PF00069	0.706
MOD_ProDKin_1	679	685	PF00069	0.754
MOD_SUMO_for_1	401	404	PF00179	0.381
TRG_DiLeu_BaEn_2	306	312	PF01217	0.496
TRG_DiLeu_BaEn_3	403	409	PF01217	0.366
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.754
TRG_ENDOCYTIC_2	207	210	PF00928	0.477
TRG_ENDOCYTIC_2	487	490	PF00928	0.591
TRG_ENDOCYTIC_2	620	623	PF00928	0.558
TRG_ER_diArg_1	349	351	PF00400	0.553
TRG_ER_diArg_1	521	524	PF00400	0.640
TRG_ER_diLys_1	685	689	PF00400	0.798
TRG_NES_CRM1_1	403	416	PF08389	0.611
TRG_NLS_MonoExtN_4	683	689	PF00514	0.747

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W1	Leptomonas seymouri	46%	92%
A0A3S7WPD9	Leishmania donovani	70%	100%
A4HSR0	Leishmania infantum	70%	100%
E9AKP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QJ60	Leishmania major	71%	100%