Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin-like protein

Species:

Leishmania braziliensis

UniProt:

A4H4I4_LEIBR

TriTrypDb:

LbrM.06.0160 , LBRM2903_060007000

Length:

661

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	2
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1

Expansion

Sequence features

A4H4I4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4I4

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	14
GO:0007018	microtubule-based movement	3	14
GO:0009987	cellular process	1	14

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003774	cytoskeletal motor activity	1	14
GO:0003777	microtubule motor activity	2	14
GO:0005488	binding	1	14
GO:0005515	protein binding	2	14
GO:0005524	ATP binding	5	14
GO:0008017	microtubule binding	5	14
GO:0008092	cytoskeletal protein binding	3	14
GO:0015631	tubulin binding	4	14
GO:0017076	purine nucleotide binding	4	14
GO:0030554	adenyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032559	adenyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:0140657	ATP-dependent activity	1	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14
GO:0003824	catalytic activity	1	3
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	3
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.326
CLV_NRD_NRD_1	205	207	PF00675	0.374
CLV_NRD_NRD_1	211	213	PF00675	0.356
CLV_NRD_NRD_1	214	216	PF00675	0.354
CLV_NRD_NRD_1	220	222	PF00675	0.310
CLV_NRD_NRD_1	511	513	PF00675	0.458
CLV_NRD_NRD_1	519	521	PF00675	0.505
CLV_PCSK_KEX2_1	205	207	PF00082	0.374
CLV_PCSK_KEX2_1	211	213	PF00082	0.356
CLV_PCSK_KEX2_1	220	222	PF00082	0.340
CLV_PCSK_KEX2_1	519	521	PF00082	0.529
CLV_PCSK_SKI1_1	205	209	PF00082	0.427
CLV_PCSK_SKI1_1	215	219	PF00082	0.423
CLV_PCSK_SKI1_1	363	367	PF00082	0.390
CLV_PCSK_SKI1_1	391	395	PF00082	0.307
CLV_PCSK_SKI1_1	413	417	PF00082	0.289
CLV_PCSK_SKI1_1	501	505	PF00082	0.572
CLV_PCSK_SKI1_1	519	523	PF00082	0.376
CLV_PCSK_SKI1_1	53	57	PF00082	0.576
CLV_PCSK_SKI1_1	63	67	PF00082	0.661
CLV_Separin_Metazoa	72	76	PF03568	0.578
DEG_APCC_KENBOX_2	512	516	PF00400	0.404
DEG_SCF_FBW7_1	20	27	PF00400	0.491
DEG_SPOP_SBC_1	613	617	PF00917	0.682
DOC_CKS1_1	185	190	PF01111	0.305
DOC_CYCLIN_RxL_1	387	395	PF00134	0.409
DOC_CYCLIN_RxL_1	517	525	PF00134	0.389
DOC_CYCLIN_yCln2_LP_2	173	179	PF00134	0.326
DOC_MAPK_DCC_7	484	494	PF00069	0.294
DOC_MAPK_gen_1	287	296	PF00069	0.397
DOC_MAPK_gen_1	303	312	PF00069	0.248
DOC_MAPK_gen_1	360	369	PF00069	0.340
DOC_MAPK_gen_1	482	491	PF00069	0.507
DOC_MAPK_MEF2A_6	11	18	PF00069	0.578
DOC_MAPK_MEF2A_6	360	369	PF00069	0.356
DOC_MAPK_MEF2A_6	487	494	PF00069	0.540
DOC_PP1_RVXF_1	361	367	PF00149	0.334
DOC_PP2B_LxvP_1	137	140	PF13499	0.326
DOC_PP2B_LxvP_1	173	176	PF13499	0.302
DOC_PP2B_LxvP_1	403	406	PF13499	0.169
DOC_PP2B_LxvP_1	429	432	PF13499	0.169
DOC_PP2B_LxvP_1	74	77	PF13499	0.592
DOC_USP7_MATH_1	124	128	PF00917	0.464
DOC_USP7_MATH_1	22	26	PF00917	0.759
DOC_USP7_MATH_1	231	235	PF00917	0.437
DOC_USP7_MATH_1	271	275	PF00917	0.326
DOC_USP7_MATH_1	33	37	PF00917	0.793
DOC_USP7_MATH_1	333	337	PF00917	0.266
DOC_USP7_MATH_1	408	412	PF00917	0.442
DOC_USP7_MATH_1	437	441	PF00917	0.265
DOC_USP7_MATH_1	564	568	PF00917	0.693
DOC_USP7_MATH_1	581	585	PF00917	0.725
DOC_USP7_MATH_2	555	561	PF00917	0.437
DOC_USP7_UBL2_3	387	391	PF12436	0.378
DOC_WW_Pin1_4	184	189	PF00397	0.409
DOC_WW_Pin1_4	20	25	PF00397	0.610
DOC_WW_Pin1_4	345	350	PF00397	0.410
DOC_WW_Pin1_4	421	426	PF00397	0.396
DOC_WW_Pin1_4	461	466	PF00397	0.301
DOC_WW_Pin1_4	605	610	PF00397	0.714
DOC_WW_Pin1_4	622	627	PF00397	0.489
DOC_WW_Pin1_4	64	69	PF00397	0.755
LIG_14-3-3_CanoR_1	211	217	PF00244	0.440
LIG_14-3-3_CanoR_1	268	276	PF00244	0.411
LIG_14-3-3_CanoR_1	374	380	PF00244	0.393
LIG_14-3-3_CanoR_1	439	443	PF00244	0.334
LIG_14-3-3_CanoR_1	53	61	PF00244	0.611
LIG_14-3-3_CanoR_1	605	609	PF00244	0.734
LIG_14-3-3_CanoR_1	63	68	PF00244	0.645
LIG_14-3-3_CanoR_1	89	93	PF00244	0.524
LIG_14-3-3_CterR_2	657	661	PF00244	0.608
LIG_Actin_WH2_2	196	213	PF00022	0.450
LIG_Actin_WH2_2	362	378	PF00022	0.367
LIG_Actin_WH2_2	504	521	PF00022	0.522
LIG_APCC_ABBA_1	246	251	PF00400	0.301
LIG_APCC_ABBA_1	321	326	PF00400	0.367
LIG_BRCT_BRCA1_1	273	277	PF00533	0.326
LIG_Clathr_ClatBox_1	15	19	PF01394	0.455
LIG_Clathr_ClatBox_1	364	368	PF01394	0.410
LIG_EVH1_2	431	435	PF00568	0.169
LIG_FHA_1	1	7	PF00498	0.564
LIG_FHA_1	163	169	PF00498	0.319
LIG_FHA_1	185	191	PF00498	0.326
LIG_FHA_1	384	390	PF00498	0.296
LIG_FHA_1	410	416	PF00498	0.169
LIG_FHA_1	442	448	PF00498	0.301
LIG_FHA_1	455	461	PF00498	0.301
LIG_FHA_1	627	633	PF00498	0.747
LIG_FHA_1	76	82	PF00498	0.645
LIG_FHA_2	126	132	PF00498	0.339
LIG_FHA_2	615	621	PF00498	0.663
LIG_LIR_Gen_1	131	142	PF02991	0.375
LIG_LIR_Gen_1	244	253	PF02991	0.281
LIG_LIR_Gen_1	290	296	PF02991	0.367
LIG_LIR_Gen_1	47	55	PF02991	0.439
LIG_LIR_Nem_3	131	137	PF02991	0.346
LIG_LIR_Nem_3	244	248	PF02991	0.281
LIG_LIR_Nem_3	251	257	PF02991	0.269
LIG_LIR_Nem_3	290	295	PF02991	0.348
LIG_LIR_Nem_3	358	364	PF02991	0.387
LIG_LIR_Nem_3	47	51	PF02991	0.462
LIG_MAD2	398	406	PF02301	0.169
LIG_MLH1_MIPbox_1	273	277	PF16413	0.326
LIG_NRBOX	252	258	PF00104	0.367
LIG_NRBOX	442	448	PF00104	0.330
LIG_Pex14_2	321	325	PF04695	0.410
LIG_REV1ctd_RIR_1	322	332	PF16727	0.326
LIG_SH2_CRK	197	201	PF00017	0.326
LIG_SH2_CRK	254	258	PF00017	0.367
LIG_SH2_CRK	361	365	PF00017	0.403
LIG_SH2_NCK_1	556	560	PF00017	0.434
LIG_SH2_PTP2	245	248	PF00017	0.357
LIG_SH2_SRC	249	252	PF00017	0.444
LIG_SH2_STAP1	118	122	PF00017	0.403
LIG_SH2_STAP1	479	483	PF00017	0.397
LIG_SH2_STAP1	48	52	PF00017	0.529
LIG_SH2_STAT5	118	121	PF00017	0.381
LIG_SH2_STAT5	122	125	PF00017	0.375
LIG_SH2_STAT5	202	205	PF00017	0.367
LIG_SH2_STAT5	245	248	PF00017	0.324
LIG_SH3_1	580	586	PF00018	0.562
LIG_SH3_2	434	439	PF14604	0.410
LIG_SH3_3	182	188	PF00018	0.300
LIG_SH3_3	26	32	PF00018	0.631
LIG_SH3_3	343	349	PF00018	0.324
LIG_SH3_3	404	410	PF00018	0.302
LIG_SH3_3	428	434	PF00018	0.369
LIG_SH3_3	563	569	PF00018	0.632
LIG_SH3_3	580	586	PF00018	0.706
LIG_SH3_3	70	76	PF00018	0.658
LIG_SUMO_SIM_anti_2	150	156	PF11976	0.302
LIG_SUMO_SIM_anti_2	290	298	PF11976	0.372
LIG_SUMO_SIM_par_1	290	298	PF11976	0.342
LIG_SUMO_SIM_par_1	398	404	PF11976	0.410
LIG_SUMO_SIM_par_1	645	652	PF11976	0.565
LIG_TRAF2_1	128	131	PF00917	0.410
LIG_TRAF2_1	497	500	PF00917	0.466
LIG_TRAF2_1	503	506	PF00917	0.516
LIG_TYR_ITIM	195	200	PF00017	0.326
LIG_TYR_ITIM	46	51	PF00017	0.488
LIG_WRC_WIRS_1	117	122	PF05994	0.314
MOD_CDK_SPxK_1	421	427	PF00069	0.169
MOD_CK1_1	162	168	PF00069	0.301
MOD_CK1_1	169	175	PF00069	0.301
MOD_CK1_1	232	238	PF00069	0.402
MOD_CK1_1	241	247	PF00069	0.350
MOD_CK1_1	25	31	PF00069	0.796
MOD_CK1_1	314	320	PF00069	0.295
MOD_CK1_1	38	44	PF00069	0.694
MOD_CK1_1	380	386	PF00069	0.355
MOD_CK1_1	392	398	PF00069	0.440
MOD_CK1_1	417	423	PF00069	0.404
MOD_CK1_1	441	447	PF00069	0.301
MOD_CK1_1	473	479	PF00069	0.367
MOD_CK1_1	567	573	PF00069	0.632
MOD_CK1_1	616	622	PF00069	0.749
MOD_CK1_1	91	97	PF00069	0.764
MOD_CK2_1	125	131	PF00069	0.337
MOD_CK2_1	241	247	PF00069	0.348
MOD_CK2_1	379	385	PF00069	0.367
MOD_CK2_1	44	50	PF00069	0.654
MOD_CK2_1	612	618	PF00069	0.654
MOD_DYRK1A_RPxSP_1	605	609	PF00069	0.499
MOD_GlcNHglycan	161	164	PF01048	0.312
MOD_GlcNHglycan	168	171	PF01048	0.304
MOD_GlcNHglycan	177	180	PF01048	0.308
MOD_GlcNHglycan	231	234	PF01048	0.304
MOD_GlcNHglycan	24	27	PF01048	0.656
MOD_GlcNHglycan	269	272	PF01048	0.400
MOD_GlcNHglycan	335	338	PF01048	0.431
MOD_GlcNHglycan	352	355	PF01048	0.424
MOD_GlcNHglycan	403	406	PF01048	0.376
MOD_GlcNHglycan	416	419	PF01048	0.323
MOD_GlcNHglycan	465	468	PF01048	0.410
MOD_GlcNHglycan	570	573	PF01048	0.673
MOD_GlcNHglycan	592	595	PF01048	0.629
MOD_GlcNHglycan	626	629	PF01048	0.630
MOD_GSK3_1	162	169	PF00069	0.310
MOD_GSK3_1	180	187	PF00069	0.310
MOD_GSK3_1	20	27	PF00069	0.764
MOD_GSK3_1	221	228	PF00069	0.275
MOD_GSK3_1	234	241	PF00069	0.380
MOD_GSK3_1	267	274	PF00069	0.412
MOD_GSK3_1	375	382	PF00069	0.339
MOD_GSK3_1	385	392	PF00069	0.293
MOD_GSK3_1	409	416	PF00069	0.306
MOD_GSK3_1	417	424	PF00069	0.348
MOD_GSK3_1	437	444	PF00069	0.347
MOD_GSK3_1	522	529	PF00069	0.414
MOD_GSK3_1	564	571	PF00069	0.560
MOD_GSK3_1	59	66	PF00069	0.610
MOD_GSK3_1	604	611	PF00069	0.594
MOD_GSK3_1	612	619	PF00069	0.640
MOD_GSK3_1	622	629	PF00069	0.684
MOD_GSK3_1	649	656	PF00069	0.631
MOD_N-GLC_1	389	394	PF02516	0.301
MOD_NEK2_1	157	162	PF00069	0.293
MOD_NEK2_1	210	215	PF00069	0.400
MOD_NEK2_1	312	317	PF00069	0.370
MOD_NEK2_1	350	355	PF00069	0.228
MOD_NEK2_1	356	361	PF00069	0.453
MOD_NEK2_1	375	380	PF00069	0.232
MOD_NEK2_1	470	475	PF00069	0.384
MOD_NEK2_1	522	527	PF00069	0.525
MOD_NEK2_1	590	595	PF00069	0.665
MOD_NEK2_1	604	609	PF00069	0.741
MOD_NEK2_1	649	654	PF00069	0.671
MOD_NEK2_2	249	254	PF00069	0.404
MOD_NEK2_2	272	277	PF00069	0.410
MOD_PIKK_1	126	132	PF00454	0.287
MOD_PIKK_1	441	447	PF00454	0.282
MOD_PIKK_1	495	501	PF00454	0.463
MOD_PIKK_1	557	563	PF00454	0.696
MOD_PKA_1	211	217	PF00069	0.326
MOD_PKA_2	210	216	PF00069	0.440
MOD_PKA_2	267	273	PF00069	0.310
MOD_PKA_2	304	310	PF00069	0.398
MOD_PKA_2	438	444	PF00069	0.301
MOD_PKA_2	59	65	PF00069	0.608
MOD_PKA_2	604	610	PF00069	0.726
MOD_PKA_2	88	94	PF00069	0.748
MOD_Plk_1	389	395	PF00069	0.305
MOD_Plk_1	470	476	PF00069	0.320
MOD_Plk_4	113	119	PF00069	0.248
MOD_Plk_4	150	156	PF00069	0.300
MOD_Plk_4	234	240	PF00069	0.340
MOD_Plk_4	241	247	PF00069	0.293
MOD_Plk_4	249	255	PF00069	0.275
MOD_Plk_4	272	278	PF00069	0.334
MOD_Plk_4	389	395	PF00069	0.351
MOD_Plk_4	438	444	PF00069	0.299
MOD_Plk_4	592	598	PF00069	0.757
MOD_Plk_4	608	614	PF00069	0.705
MOD_ProDKin_1	184	190	PF00069	0.409
MOD_ProDKin_1	20	26	PF00069	0.612
MOD_ProDKin_1	345	351	PF00069	0.410
MOD_ProDKin_1	421	427	PF00069	0.396
MOD_ProDKin_1	461	467	PF00069	0.301
MOD_ProDKin_1	605	611	PF00069	0.712
MOD_ProDKin_1	622	628	PF00069	0.489
MOD_ProDKin_1	64	70	PF00069	0.755
MOD_SUMO_rev_2	380	389	PF00179	0.286
MOD_SUMO_rev_2	500	508	PF00179	0.564
TRG_DiLeu_BaEn_1	290	295	PF01217	0.444
TRG_DiLeu_BaEn_3	131	137	PF01217	0.326
TRG_ENDOCYTIC_2	197	200	PF00928	0.326
TRG_ENDOCYTIC_2	245	248	PF00928	0.294
TRG_ENDOCYTIC_2	254	257	PF00928	0.285
TRG_ENDOCYTIC_2	361	364	PF00928	0.403
TRG_ENDOCYTIC_2	48	51	PF00928	0.540
TRG_ER_diArg_1	10	13	PF00400	0.470
TRG_ER_diArg_1	205	207	PF00400	0.374
TRG_ER_diArg_1	210	212	PF00400	0.357
TRG_ER_diArg_1	518	520	PF00400	0.520
TRG_NLS_Bipartite_1	205	219	PF00514	0.390
TRG_NLS_MonoExtN_4	212	219	PF00514	0.266
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P569	Leptomonas seymouri	27%	75%
A0A0N1HVM1	Leptomonas seymouri	27%	71%
A0A0N1HY56	Leptomonas seymouri	54%	96%
A0A0N1I0Y5	Leptomonas seymouri	26%	100%
A0A0N1I2F8	Leptomonas seymouri	25%	79%
A0A0S4ILK1	Bodo saltans	30%	77%
A0A0S4ILY1	Bodo saltans	28%	73%
A0A0S4JBC0	Bodo saltans	23%	71%
A0A0S4JIG8	Bodo saltans	27%	69%
A0A0S4JJ54	Bodo saltans	27%	94%
A0A1X0NJN6	Trypanosomatidae	39%	100%
A0A1X0NQ03	Trypanosomatidae	27%	80%
A0A1X0P0C2	Trypanosomatidae	27%	81%
A0A1X0P2B6	Trypanosomatidae	26%	100%
A0A1X0P9E3	Trypanosomatidae	28%	100%
A0A3Q8IBS7	Leishmania donovani	25%	100%
A0A3R7KHX7	Trypanosoma rangeli	27%	89%
A0A3R7MC35	Trypanosoma rangeli	38%	100%
A0A3R7RD86	Trypanosoma rangeli	27%	82%
A0A3S5H5N6	Leishmania donovani	76%	100%
A0A3S5IRH3	Trypanosoma rangeli	26%	100%
A0A3S7WX05	Leishmania donovani	25%	74%
A4HAQ7	Leishmania braziliensis	28%	100%
A4HCA1	Leishmania braziliensis	26%	74%
A4HSA6	Leishmania infantum	26%	100%
A4HSQ9	Leishmania infantum	75%	100%
A4HZT3	Leishmania infantum	25%	74%
A4I562	Leishmania infantum	25%	100%
C9ZL08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZQI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZTV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	74%
C9ZU98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	82%
E9AEA1	Leishmania major	28%	100%
E9AKP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9AVN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	74%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
O14343	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	75%
O59751	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	84%
Q4Q7S4	Leishmania major	26%	100%
Q4QBU1	Leishmania major	24%	74%
Q4QJ61	Leishmania major	76%	100%
Q5E913	Arabidopsis thaliana	25%	100%
Q8S905	Arabidopsis thaliana	28%	68%
Q8S950	Nicotiana tabacum	27%	69%
Q9AWM8	Oryza sativa subsp. japonica	24%	69%
Q9S7P3	Arabidopsis thaliana	27%	80%
V5B325	Trypanosoma cruzi	26%	80%
V5BCN9	Trypanosoma cruzi	25%	92%