Trm112p-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Trm112p-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H4I3_LEIBR

TriTrypDb:

LbrM.06.0150 , LBRM2903_060006900

Length:

141

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4I3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4I3

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	1
GO:0001510	RNA methylation	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006479	protein methylation	4	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	3
GO:0008213	protein alkylation	5	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0018364	peptidyl-glutamine methylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0030488	tRNA methylation	5	1
GO:0031167	rRNA methylation	5	1
GO:0032259	methylation	2	3
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0036211	protein modification process	4	1
GO:0036265	RNA (guanine-N7)-methylation	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0070475	rRNA base methylation	6	1
GO:0070476	rRNA (guanine-N7)-methylation	6	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0046982	protein heterodimerization activity	4	11
GO:0046983	protein dimerization activity	3	11
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	71	75	PF00656	0.354
CLV_NRD_NRD_1	39	41	PF00675	0.271
CLV_PCSK_KEX2_1	39	41	PF00082	0.271
CLV_PCSK_SKI1_1	2	6	PF00082	0.244
CLV_PCSK_SKI1_1	39	43	PF00082	0.210
DEG_APCC_DBOX_1	38	46	PF00400	0.410
DEG_Nend_UBRbox_1	1	4	PF02207	0.274
DOC_USP7_MATH_1	60	64	PF00917	0.483
LIG_14-3-3_CanoR_1	2	9	PF00244	0.244
LIG_14-3-3_CanoR_1	51	55	PF00244	0.500
LIG_Actin_WH2_2	38	53	PF00022	0.505
LIG_FHA_1	124	130	PF00498	0.489
LIG_FHA_1	14	20	PF00498	0.551
LIG_FHA_2	54	60	PF00498	0.461
LIG_LIR_Gen_1	52	60	PF02991	0.411
LIG_LIR_Gen_1	97	108	PF02991	0.354
LIG_LIR_Nem_3	15	20	PF02991	0.516
LIG_LIR_Nem_3	46	50	PF02991	0.410
LIG_LIR_Nem_3	52	57	PF02991	0.410
LIG_LYPXL_yS_3	17	20	PF13949	0.481
LIG_LYPXL_yS_3	47	50	PF13949	0.419
LIG_Pex14_2	132	136	PF04695	0.458
LIG_SH2_STAP1	106	110	PF00017	0.505
LIG_SH2_STAP1	33	37	PF00017	0.505
LIG_SH3_3	61	67	PF00018	0.569
LIG_SUMO_SIM_par_1	15	22	PF11976	0.442
LIG_TYR_ITIM	45	50	PF00017	0.466
MOD_CK1_1	49	55	PF00069	0.491
MOD_CK1_1	95	101	PF00069	0.416
MOD_CK2_1	19	25	PF00069	0.479
MOD_CK2_1	53	59	PF00069	0.472
MOD_CK2_1	65	71	PF00069	0.546
MOD_GlcNHglycan	21	24	PF01048	0.283
MOD_GlcNHglycan	96	100	PF01048	0.266
MOD_GSK3_1	46	53	PF00069	0.514
MOD_N-GLC_1	114	119	PF02516	0.256
MOD_NEK2_1	19	24	PF00069	0.487
MOD_NEK2_1	50	55	PF00069	0.469
MOD_NEK2_2	60	65	PF00069	0.465
MOD_PKA_2	50	56	PF00069	0.477
MOD_Plk_1	95	101	PF00069	0.483
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.481
TRG_ENDOCYTIC_2	17	20	PF00928	0.486
TRG_ENDOCYTIC_2	47	50	PF00928	0.410
TRG_ER_diArg_1	39	41	PF00400	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H9	Leptomonas seymouri	65%	100%
A0A0S4J2Y9	Bodo saltans	43%	100%
A0A1X0NJI9	Trypanosomatidae	44%	100%
A0A3S5H5N5	Leishmania donovani	82%	100%
A0A422NC88	Trypanosoma rangeli	43%	100%
A4HSQ8	Leishmania infantum	82%	100%
C9ZTA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AKP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O45241	Caenorhabditis elegans	30%	100%
Q2KIA2	Bos taurus	26%	100%
Q4QJ62	Leishmania major	83%	100%
Q8LFJ5	Arabidopsis thaliana	28%	100%
Q8X0S4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	100%
Q9C9R3	Arabidopsis thaliana	29%	100%
Q9DCG9	Mus musculus	31%	100%
Q9UI30	Homo sapiens	28%	100%